Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name NSA2P5
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr5). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:170077090-170078296  UCSC
Coordinates (T2T) chr2:170554571-170555777  UCSC
Coordinates (hg19) chr2:170933600-170934806  UCSC
Strand -
Parental Sequence NM_014886.6
Parental seq. overlap 750 bp
Parental seq. overlap (%) 17%
Genomic Region Intragenic (UBR3)
Retrocopy Summary NSA2P5, located on chr2:170077090-170078296, is a retrocopy of the parental gene NSA2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name NSA2
Full Name NSA2 ribosome biogenesis factor
Also known as CDK105|HCL-G1|HCLG1|HUSSY-29|HUSSY29|TINP1
Coordinate chr5:74767249-74780113
Strand +
Gene summary This gene encodes a nucleolar protein involved in cell cycle regulation and proliferation. This gene was identified based on sequence similarity to a highly conserved Saccharomyces cerevisiae gene encoding a pre-ribosomal protein, which is involved in large ribosomal subunit biogenesis. The encoded protein is found at elevated levels in diabetic nephropathy. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified. [provided by RefSeq, Nov 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes NSA2P2
Bonobo Pan paniscus NSA2P2
Gorilla Gorilla gorilla NSA2P2
Orangutan Pongo abelii NSA2P2
Gibbon Nomascus leucogenys NSA2P9
Green monkey Chlorocebus sabaeus NSA2P3
Crab-eating macaque Macaca fascicularis NSA2P6
Rhesus Macaca mulatta NSA2P6
Baboon Papio anubis NSA2P5
Golden snub-nosed monkey Rhinopithecus roxellana NSA2P6
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>NSA2P5
GTTATTCCAACAGGAAAGAGAAAGACGCAGGCATAGAGGAGGATGGTTACTAAAGTCTGCTTTGTTGGAGATGGCTTTACAAGAAAACTACTTATCTATGGAAGATTCATCAGGCCAATGGGCTTGCGTTTCAAGAAAGCCCATGTAACACATCCTGAACTGAAAGCCACCTTTTGCCTAACAATACTTGGTGTAAAGAAGAGTCCCTCATTCCCAATGTATATAACTTTGGATGTTATTACCAAAGGTACTGTTACTGAGGTGAATGTGAGTTGGGCCTTGTGACACAAGGAGGCAAGGTTATTTGGGGAAAATAGGCTGTGGTTACCAACAATCCTGAAAATGATGGATGTATAAATGCAGTCTTACTGGTCTGACAGCACTTTCATAGATATTTATTGAAGACTACACACCAACTGAAAAAACTGCCATTACTGTGATGTTTCTGAATACTACCAAACAGCCTTACATGTCTGCAATCAAGAGATTTATTAAATTGTAAACATTAAAACCATGCCACAGATCAAATATATTGAATTACACTGTAAATGCCATGGATATCATTTGGATTACCATGAGAAAAAGGGAAAGAAGGAAAGTTGAGAGGCTTATGAACATTCAAAGAAGTCAAAGAAAATGATTGGTCTGAAGGCTAAGCTTTATCTTAAACAGCACCATGCTGAGAAAATACAAATGAAAAAGACCATCAAGATGCATGAAAAGAGAAACACCAGACAAAAGAAAGACTCCACAGGGAGCAGTACCTGCCTATCTGCTGGACAGAGAGGGACAACCTCAAGCTAACGTACTTCCCAGTATGATTAAGCCGAAATGAAAAGAGAAAGCAGGAAAATGGAAAGTCCCTCTGTCTAAATGTAACTTGCCCAGGGAGATACAGAAGTGTTAAGAGTTATTTGAACAGAg
>NM_014886.6
ACTCTTTCCTGTCCCGGCCTGCGTGGTGTGGGCTTGTGGGTCTTTGAGACCCGAAAATTGAGAGCGTTTTCGCACTCCAGCGGCTGCTCCTGGCGGCTCTGCGGCCGTCACCATGCCACAGAATGAATATATTGAATTACACCGTAAACGCTATGGATACCGTTTGGATTACCATGAGAAAAAGAGAAAGAAGGAAAGTCGAGAGGCTCATGAACGTTCAAAGAAGGCAAAGAAAATGATTGGTCTGAAGGCTAAGCTTTACCATAAACAGCGTCATGCTGAGAAAATACAAATGAAAAAGACTATCAAGATGCATGAAAAGAGAAACACCAAACAAAAGAATGATGAAAAGACACCACAGGGAGCAGTACCTGCCTATCTGCTGGACAGAGAGGGACAATCTCGAGCTAAAGTACTTTCCAATATGATTAAACAGAAAAGAAAAGAGAAGGCGGGAAAATGGGAAGTCCCTCTGCCTAAAGTACGTGCCCAGGGAGAAACAGAAGTATTAAAAGTTATTCGAACAGGAAAGAGAAAGAAGAAGGCATGGAAGAGAATGGTTACTAAAGTGTGCTTTGTTGGAGATGGCTTTACAAGAAAACCACCTAAATATGAAAGATTCATCAGGCCAATGGGCTTGCGTTTCAAGAAAGCCCATGTAACACATCCTGAACTGAAAGCCACCTTTTGCCTACCAATACTTGGTGTAAAGAAGAATCCCTCATCCCCACTGTATACAACTTTGGGTGTTATTACCAAAGGTACTGTCATTGAAGTAAATGTGAGCGAATTGGGCCTTGTGACACAAGGAGGCAAAGTTATTTGGGGAAAATATGCCCAGGTTACCAACAATCCTGAAAATGATGGATGTATAAATGCAGTCTTACTGGTTTGACAGCAATTTCATATATAATTATTGAGGACTACACACCAATTGAAGAAACTGCCATTACTGTGATGTTTCTGAATACTACCAAACAGCCATACATGTCTGCAATGAAGAGATTTATTAAATTGTAAACATTAAAGTGGTCCAGTTTTATAAATGGTCTTTATTTTGAAATACGCTTTGACCCCATGTTCATAAAACTGAATGATTGAAAAAAAGCAAATATACAAATATCCTACTTCATCAATATCTGCATTTGTGAGTGGGTATTCAGCAATTTCCTGAAAAAACCACCAGTGTTCATTGAAAATGCCTTTCAAAAAGGTTAATACACAATTATGTGTCTGAGAATTTAACTGAAGTATCTTCAAAATCTCGTTAATCATTAATCCTAAAAAAGGTAGGTAGCATTAATACAGATGTTAAGTTTATAGTGTTTGTTTACACTAGAAGTATGTGAGAAGACACTAAAAGTTCAGAAATCTTAGAGAAATCTTTTCACCTGTGAAATCCAGTACAGCAAAGGTCTAGTGAATTCACATTCTAAACATTTTTTTCATCTCATTTACCATGTATAATAATACCTACTTGGCACTATTTTCTACTTGAATCATGAAAATGAAAAAAATATACTAAAGTCTTTGTACTCTCTTAGCATTTTCTGTATTCTAAACAATATATTTATACTTTCAGAATAGTATTAAGAATTAGTTTAAGTAACTCCAGCTAAGTTTTAAAAGGAAAAAGAAGACTGCACTGATTCCCTGAGGAGAAATTTATTTGCAGTTACTTAGATGATGTAAAAAGGTAAGGATTTACGGTTGTAACTTGGTGAAAGCACTTTTGTGATCTGTTATATGTTGTGGTTTTAAGGATGGCGTATATTACATTAATCTATAATCACCACATTGTTTTAAATTGTTTATTTTTTTTTTAAAGAAGTCTGTCTTCAGAGTACAACCAATGTGATTAATTGTGCCTTTAACAAAGTCATTCAATGTCTAAACAAATTCAGTATCTGAAACATCTTCATGAGGAAAACTGAAGGAAAGGAATTTAAAAACACAGACCAGGAAACAATCACAAAATATAGGTTTAATTACTACTTTTAAACTTAAAAAAAAATAAAAACCAAGAAAACAAACATAGGTACTCCAGTAAGACTTGCTACTCTGAATAATGTAACATTTTTTCTAAGTTCTATAAATATATACTGGAAGTTTTAGAACACATACAGACGCTTAGGAAAAGAAAGGCTAGTTCCTTGGAAATGACGATCCAGGATGATACAATCACTTGATGACAGAAGGTAAGCCTTTCTTACAATTAGATTTTAGCAGATAATTTTACCACTAATATAAATGGGTGATGTGTGGATCACAAGTTCTAGAAGGCGAATAAAAATACTGACTCCAGGTAATTTCTGGATACTACAAAAATGAAGTTTGCTTGTTTTTTTTAGAACCAAAAATACTATCTTGTAAGGTACAAAGAAAGCTTGATATTAAGTATGAAAACATAAGCATAACATTTGTAACTAATCACACCCATGAAAGACGACTAGATGACACCTGAAACATTTTTCAAAATACTGTAACACAGATGAGTAATATTAGTATAAATTTTTTATGTACATTAAGATCTGTTTCAGTTTGCTGGTGTGACCAAACCTTAGAAGGTAATCCCAAGGGATAAAGCAGAACATAAGAGCAGATATTTAGATATTAGTACAGGCTCAATTTGATGCAATCATAAACCTTCAAGATTTCTAGTCACTGAAACCCCATTGTAGGTAGTGTTCTGGAGTCTGCTATAAGTAAATCTTTAATGACTAGATGTTTTCCTTACCATCTACACTGAATGGAAATACCATGAATATAGACACATTTTAAGTAGAAGACTGACGTTCTAAATCATGCTGTTTGATTTTATAAAAAAATCATAATAGACCCTCTCACCTTTAAAAGTTGTAGAGGAGCTTTATAATAAATTCTTAAATATACTAATTTCTGTGATGTCTAGCAATTGAATAATTTAAACTTGAAAGAACTAAAATACTAATAACCATCTGCTTTATATTACACAAGGAAATATACACGTATGTACATAAAAAGTGAACTCCCTTCACAAATAAGTTCACAAAGGACTATGTGTAATGTGACTGGACATTCAACAACTAGACTAGCCGGTTGAAATCACATTTTCAGTCCTCTGTAATTGTGAAATTTTTTCTAATGCCTTGCAAAAACTACAGATAACTGATTAAGTTCATGTAGGTTCCTTATTGAAGATAAATTGTGGTATAAATTCTATACTCAAGTTACTGAACATGAGAGTTAGGTTTTTCCAAGTGATCTAACTTTTCCCTCTATAATCTATAAACCCCAAAATAACAATTTCTGTCAGAGAGAATCTGTAACAGAAGTGTTCTTGTGTGCTGAACAAAAAACTTCTAAATTGTTTACAATTCACTTACTATTTAACCCAAACAAGTTTAACAAGAATAAGTTTATACTGTTAGCCCCCAATGGTCATATATGATTAATAAACATTTTTTGTAAACTCAACTATATTCACACATCAAGAGTTGAGCCAGTGAGCTCAATCTTTAAAAAACTACACTTGTCTAAAGAAAGTCTTTTAgtgctcacttcggcagcacatatactaaaattagaacaatacagggaaaattagcatggcccctgtgcaaggatgacacaaattcatgaagcgtttccatgtttAAAATAATTTGAAAAGAAAGTATTTTAAACAAATCCAAGTAAAAATAAAATATCTACAAGTGTTTTCAAATCTAAGAAATGAAACATGTAAAGATTAAGAATTTACTGAATCTTAACAGAGTATTTCCCTTTGTGATATTGACAGAAGTTTCTCATAAAATGTATAAAACAGCATAAATGTTTGGTAGATTCACTAATAGTAGTCATACTTTTTTTTTTTTACTTAGTATTAGCATTTGTTGAAAAAATAAATGGCCAAAGTGCTTTAATTTTCATTTAGAATGAAATAATCTGGCTTACCTTTGACTAATTAAAGAAAATATAGGGTAATACAATTGTTCAAAATCTAACACAAATAGGAGCGTTTACTATTTTTGTCTGCTTTAAGATTTTAACTTGATCGAAAATACCAACATCCCCAAACAAAATTTACTGACCTGACATCAGCTTACTATAGACTGAATACACTTTCAACATCAGTCCTTAGCTACCTCAAATAATGACACAAAGTCTTAGTTTCTTTTGCATAAGGATCAAGATCAAGCTATTtttaaaacaatttaaatggtctcaaaacattctccaacttaagtgcaaatttgagtacacataatatttccaaagagtagaactgtttttagattatctttggattCTAATAACCATTTTGTCCATTTTTAAATAAATTACAAAAAATAACA

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