Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ZFYVE9P2
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:17284291-17285314  UCSC
Coordinates (T2T) chr2:17316115-17317138  UCSC
Coordinates (hg19) chr2:17465558-17466581  UCSC
Strand +
Parental Sequence NM_004799.4
Parental seq. overlap 937 bp
Parental seq. overlap (%) 18.2%
Genomic Region Intergenic
Retrocopy Summary ZFYVE9P2, located on chr2:17284291-17285314, is a retrocopy of the parental gene ZFYVE9. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ZFYVE9
Full Name zinc finger FYVE-type containing 9
Also known as MADHIP|NSP|PPP1R173|SARA|SMADIP
Coordinate chr1:52142001-52348664
Strand +
Gene summary This gene encodes a double zinc finger motif-containing protein that participates in the transforming growth factor-beta (TGFB) signalling pathway. The encoded protein interacts directly with SMAD2 and SMAD3, and recruits SMAD2 to the TGFB receptor. There are multiple pseudogenes for this gene on chromosomes 2, 15, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ZFYVE9P1
Bonobo Pan paniscus ZFYVE9P1
Gorilla Gorilla gorilla ZFYVE9P1
Orangutan Pongo abelii ZFYVE9P1
Gibbon Nomascus leucogenys ZFYVE9P2
Green monkey Chlorocebus sabaeus ZFYVE9P1
Crab-eating macaque Macaca fascicularis ZFYVE9P1
Rhesus Macaca mulatta ZFYVE9P1
Baboon Papio anubis ZFYVE9P1
Golden snub-nosed monkey Rhinopithecus roxellana ZFYVE9P2
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ZFYVE9P2
tCCAGATCACTGCAGAGAACATGGATTCCTTGAGGCAGGCAATGCGAGAGATAAAGGACTTCACCATCACCTGTGGGAAGACGGACGTGGAGGATCCCCAGGAGCACATCCACATCCAGTGGGTGGATGACGACAAGAACTTTAGCAAATGTGTCATAAGTCCTATAAATGAGAAGTCCATGGAGACTATAACAAATGTGAAGCTATTCCATGGATCAGAATGTAAAGCAAATGGAAAAGTTATCAGATGGACAGAGGTGTTTTTCCTAGAAAACACCTAAATGATCCTACAAAATGATCATTTTAGCAAATGATCCTGCAAATCAAATTAGATTGACTAAGCATGTTGCCAAGGCTTTTTGCCTTGCTCTCTGTCCTCACCTGAAGCTTCTGAAGGAAGATGGAATGACCAAACTGGGACTAAGTATGACACTTGACTCAGATCAGGTTTGCTATCAAGCAGGGAGCAATGGCCAGCCCCTTCCCTCACAGTATATGAATGATCTGGACAGCACCTTGGTGCCAGTGATCCCCGGAGGGGCCTGTCAGCTCAGTGAGGGCCCTGTCGTCATGGAACTCATCTTTTATATCCTGGAAAACATCGCATAAACAGAGGAGACTTCATTTTTTTCTTTTCAGGCCTGTTGCAATGGCAGTCATACCCAAATCAATTGCACTTTAAAACTCAAAAATTAAGCTTTTGTTAACACTGTTAATGGAATGGGGAATAGGGTGGGAGTGGCGGTTTGTGAGACTGGTAGGAAAGGGTGGATGGGGAGACAGATGTTCCATAATTCTAAGTCTTCTATGCATTGTCCACCAAGAAGATCTGGGCAGCTTCTGTTCCTGCACAACAGTTATGCTATCCTTGCAGCTAATCCCCTTCTCTTACTGTTTAGACAAGAATTCTGCTCCTCTCTCAAGATTTACTTATGGCCATGTGCTCAGAAATGCTCAAATGGGTACAACCATCACCAAGGGTGGGATGGGAAGGCAGAGGGGAAATAAAATATGAAGCAT
>NM_004799.4
ACCCGACGCTGGAGGCTTCGCTGAGGATCCCCGCCTGCCGCACCTCGGTCGTCCCGCCGCAGCCTTGCGCCCCCGGCCCGGCTCGGCGGCGCTCCTCCGGGATCCGCGTGGCTGCCGCGGCCCGGGCGCCGATGCGGCTGGGCGGGTGCCGGGCCTTagcagcagtagcagccgcagctgcggctaccgcagcTCCTACAGGAGTGGGAGGTTTCGCGGCGGCGCCTGGGGCCGCGCCGGTGCCCTCCGGAGGAGGCTTTCGGCTCAGGGACGACCCCCGTGGCCATGCTGAAGCGGAGGCGGCCGCTGCTCGAGGATCAAACAGAGCATACTGAATCAGCAGGACTGGCTGGTGGTGCAGCAGACATCATGAGTAAGCACCGAGAAGTCTGTTCCTTATCACGTGTGTAAGGGGAAAAAGGTTTAAACAAGTCTCTTAAGTGGTGTTTCCTCACCGATGGAGAATTACTTCCAAGCAGAAGCTTACAACCTGGACAAGGTGTTAGATGAATTTGAACAAAACGAAGATGAAACAGTTTCTTCTACTTTATTGGATACAAAGTGGAATAAGATTCTAGATCCCCCTTCTCACCGGCTGTCATTTAACCCTACTTTGGCCAGTGTGAATGAATCTGCAGTTTCTAATGAGTCACAACCACAACTGAAAGTCTTCTCCCTGGCTCATTCAGCTCCCCTGACCACAGAGGAAGAGGATCACTGTGCTAATGGACAGGACTGTAATCTAAATCCAGAGATTGCCACAATGTGGATTGATGAAAATGCTGTTGCAGAAGACCAGTTAATTAAGAGAAACTATAGTTGGGATGATCAATGCAGTGCTGTTGAAGTGGGAGAGAAGAAATGTGGAAACCTGGCTTGTCTGCCAGATGAGAAGAATGTTCTTGTTGTAGCCGTCATGCATAACTGTGATAAAAGGACATTACAAAACGATTTACAGGATTGTAATAATTATAATAGTCAATCCCTTATGGATGCTTTTAGCTGTTCACTGGATAATGAAAACAGACAAACTGATCAATTTAGTTTTAGTATAAATGAGTCCACTGAAAAAGATATGAATTCAGAGAAACAAATGGATCCATTGAATAGACCGAAAACAGAGGGGAGATCTGTTAACCATCTGTGTCCTACTTCATCTGATAGTCTAGCCAGTGTCTGTTCCCCTTCACAATTAAAGGATGACGGAAGTATAGGTAGAGACCCCTCCATGTCTGCGATTACAAGTTTAACGGTTGATTCAGTAATCTCATCCCAGGGAACAGATGGATGTCCTGCTGTTAAAAAGCAAGAGAACTATATACCAGATGAGGACCTCACTGGCAAAATCAGCTCTCCTAGGACAGATCTAGGGAGTCCAAATTCCTTTTCCCACATGAGTGAGGGGATTTTGATGAAAAAAGAGCCAGCAGAGGAGAGCACCACTGAAGAATCCCTCCGGTCTGGTTTACCTTTGCTTCTCAAACCAGACATGCCTAATGGGTCTGGAAGGAATAATGACTGTGAACGGTGTTCAGATTGCCTTGTGCCTAATGAAGTTAGGGCTGATGAAAATGAAGGTTATGAACATGAAGAAACTCTTGGCACTACAGAATTCCTTAATATGACAGAGCATTTCTCTGAATCTCAGGACATGACTAATTGGAAGTTGACTAAACTAAATGAGATGAATGATAGCCAAGTAAACGAAGAAAAGGAAAAGTTTCTACAGATTAGTCAGCCTGAGGACACTAATGGTGATAGTGGAGGACAGTGTGTTGGATTGGCAGATGCAGGTCTAGATTTAAAAGGAACTTGCATTAGTGAAAGTGAAGAATGTGATTTCTCCACTGTTATAGACACACCAGCAGCAAATTATCTATCTAATGGTTGTGATTCCTATGGAATGCAAGACCCAGGTGTTTCTTTTGTTCCAAAGACTTTACCCTCCAAAGAAGATTCAGTAACAGAAGAAAAAGAAATAGAGGAAAGCAAGTCAGAATGCTACTCAAATATTTATGAACAGAGAGGAAATGAGGCCACAGAAGGGAGTGGACTACTTTTAAACAGCACTGGTGACCTAATGAAGAAAAATTATTTACATAATTTCTGTAGTCAAGTTCCATCAGTGCTTGGGCAATCTTCCCCCAAGGTAGTAGCAAGCCTGCCATCTATCAGTGTTCCTTTTGGTGGTGCAAGACCCAAGCAACCTTCTAATCTTAAACTTCAAATTCCAAAGCCATTATCAGACCATTTACAAAATGACTTTCCTGCAAACAGTGGAAATAATACTAAAAATAAAAATGATATTCTTGGGAAAGCAAAATTAGGGGAAAACTCAGCAACCAATGTATGCAGTCCATCTTTGGGAAACATCTCTAATGTCGATACAAATGGGGAACATTTAGAAAGTTATGAGGCTGAGATCTCCACTAGACCATGCCTTGCATTAGCTCCAGATAGCCCAGATAATGATCTCAGAGCTGGTCAGTTTGGAATTTCTGCCAGAAAGCCATTCACCACTCTGGGTGAGGTGGCTCCAGTATGGGTACCGGATTCTCAGGCTCCAAATTGCATGAAATGTGAAGCCAGGTTTACATTCACCAAAAGGAGGCATCACTGCAGAGCATGTGGGAAGGTTTTCTGTGCTTCCTGCTGTAGCCTGAAATGTAAACTGTTATACATGGACAGAAAGGAAGCTAGAGTGTGTGTAATCTGCCATTCAGTGCTAATGAATGCTCAAGCCTGGGAGAACATGATGAGTGCCTCAAGCCAGAGCCCTAACCCTAACAATCCTGCTGAATACTGTTCTACTATCCCTCCCTTGCAGCAAGCTCAGGCCTCAGGAGCTCTGAGCTCTCCACCTCCCACTGTGATGGTACCTGTGGGAGTTTTAAAGCACCCTGGAGCAGAAGTGGCTCAGCCCAGAGAGCAGAGGCGAGTTTGGTTTGCTGATGGGATCTTGCCCAATGGAGAAGTTGCTGATGCAGCCAAATTAACAATGAATGGAACTTCCTCTGCAGGAACCCTGGCTGTGTCACACGACCCAGTCAAGCCAGTAACTACCAGTCCTCTACCAGCAGAGACGGATATTTGTCTATTCTCTGGGAGTATAACTCAGGTTGGAAGTCCTGTTGGAAGTGCAATGAATCTTATTCCTGAAGATGGCCTTCCTCCCATTCTCATCTCCACTGGTGTAAAAGGAGACTATGCTGTGGAAGAGAAACCATCACAGATTTCAGTAATGCAGCAGTTGGAGGATGGTGGCCCTGACCCACTTGTATTTGTTTTAAATGCAAATTTGttgtcaatggttaaaattgtaaattATGTGAACAGGAAGTGCTGGTGTTTCACAACCAAGGGAATGCATGCAGTGGGTCAGTCTGAGATAGTCATTCTTCTACAGTGTTTACCGGATGAAAAGTGTTTGCCAAAGGATATCTTTAATCACTTTGTGCAGCTTTATCGGGATGCTCTGGCAGGGAATGTGGTGAGCAACTTGGGACATTCCTTCTTCAGTCAAAGTTTCCTTGGCAGTAAAGAACATGGTGGATTCTTATATGTGACATCTACCTACCAGTCACTGCAAGACCTAGTACTCCCAACCCCACCTTACTTGTTTGGGATTCTTATCCAGAAATGGGAAACTCCTTGGGCTAAAGTATTTCCTATCCGTCTGATGTTGAGACTTGGAGCTGAATATCGACTTTATCCATGCCCACTATTCAGTGTCAGATTTCGGAAGCCATTGTTTGGAGAGACGGGGCATACCATCATGAATCTTCTTGCAGACTTCAGAAATTACCAGTATACCTTGCCAGTAGTTCAAGGTTTGGTGGTTGATATGGAAGTTCGGAAAACTAGCATCAAAATTCCCAGCAACAGATACAATGAGATGATGAAAGCCATGAACAAGTCCAATGAGCATGTCCTGGCAGGAGGTGCCTGCTTCAATGAAAAGGCAGACTCTCATCTTGTGTGTGTACAGAATGATGATGGAAACTATCAGACCCAGGCTATCAGTATTCACAATCAGCCCAGAAAAGTGACTGGTGCCAGTTTCTTTGTGTTCAGTGGCGCTCTGAAATCCTCTTCTGGATACCTTGCCAAGTCCAGTATTGTGGAAGATGGTGTTATGGTCCAGATTACTGCAGAGAACATGGATTCCTTGAGGCAGGCACTGCGAGAGATGAAGGACTTCACCATCACCTGTGGGAAGGCGGACGCGGAGGAACCCCAGGAGCACATCCACATCCAGTGGGTGGATGATGACAAGAACGTTAGCAAGGGTGTCGTAAGTCCTATAGATGGGAAGTCCATGGAGACTATAACAAATGTGAAGATATTCCATGGATCAGAATATAAAGCAAATGGAAAAGTAATCAGATGGACAGAGGTGTTTTTCCTAGAAAACGATGACCAGCACAATTGCCTCAGTGATCCTGCAGATCACAGTAGATTGACTGAGCATGTTGCCAAAGCTTTTTGCCTTGCTCTCTGTCCTCACCTGAAACTTCTGAAGGAAGATGGAATGACCAAACTGGGACTACGTGTGACACTTGACTCAGATCAGGTTGGCTATCAAGCAGGGAGCAATGGCCAGCCCCTTCCCTCGCAGTACATGAATGATCTGGACAGCGCCTTGGTGCCGGTGATCCATGGAGGGGCCTGCCAGCTTAGTGAGGGCCCCGTTGTCATGGAACTCATCTTTTATATTCTGGAAAACATCGTATAAACAGAGAAGACTTCATTTTTTTCTGTTCAGACTTGTTGCAACAGCAGTCATACCCAAATCATTTGCACTTTAAAACTGGAAGATTAAGCTTTTGTTAACACTATTAATGGGGTGGGGAATAGGGTGGGAGTGGGGGTTTGGGAGACGGGTGGGAAAGGGTGGTTGGGGGGACCGATGTTCCATAATTCTAAGTCTTCTATGCATTGTCCACCAAGAAGATCTGGGCAGCTTCTGTTCCTGCACAACAGTTATGCTATCCTTGCAGCTAATCCCCTTCTGTTACTGTTTAGACAAGAATTCCGCTCCTCTCTCAAGATTTACTTATGGTCATGTGCTCAGAAATGCTCAAATGGGTACAACCATCACCAAGGGTGGGATGGGAGGGCAGAGGGGAAATAAAATATAAAGCATCA

Publications

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