Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CBY1P1
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr22). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:173477989-173478468  UCSC
Coordinates (T2T) chr2:173964274-173964754  UCSC
Coordinates (hg19) chr2:174342717-174343196  UCSC
Strand -
Parental Sequence NM_015373.4
Parental seq. overlap 387 bp
Parental seq. overlap (%) 33%
Genomic Region Intergenic
Retrocopy Summary CBY1P1, located on chr2:173477989-173478468, is a retrocopy of the parental gene CBY1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CBY1
Full Name chibby family member 1, beta catenin antagonist
Also known as C22orf2|CBY|Chibby1|HS508I15A|PGEA1|PIGEA-14|PIGEA14|arb1
Coordinate chr22:38656638-38673850
Strand +
Gene summary Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CBY1P1
Bonobo Pan paniscus CBY1P1
Gorilla Gorilla gorilla LOC101129688P2
Orangutan Pongo abelii CBY1P1
Gibbon Nomascus leucogenys CBY1P1
Green monkey Chlorocebus sabaeus CBY1P1
Crab-eating macaque Macaca fascicularis CBY1P2
Rhesus Macaca mulatta CBY1P2
Baboon Papio anubis CBY1P1
Golden snub-nosed monkey Rhinopithecus roxellana CBY1P1
Marmoset Callithrix jacchus CBY1P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CBY1P1
GCTTGGACCCTGGCTTCTGGGACATGTCAGGAGAAGGGAGCATTGGCTTTTCCATCATCAAGCCAAAGATGCCCCTCTTTGGGGGTATCTTTAGTCCCAAGGAGATGCCTCCTTGGACGTCTGCTTCTCTCTCCAACCTGCATTCCTTTGATCAGTCAACCCAGGAGGTGGAGCTGGGCCTGGACTTGGAATTCCCACTATGAACCTGGAAAATGTTCATAAAACAAAAACAAACACAAAGCCAGAAGTTTGAAAATGGCCGGTGGATAGCAGAGACAGGGATTAGTGGAGGTGTGGACCGGAGGGAGGCCCAGTGCCTTCACAGGCAGAACTAGCAACTGGAGGAAGAGAACAGTCTCTTGCAGCTGAAAGTGGACATCCTGCTGGACATGTTTTCAGAGACCACTGCTAAATCCCTTTTAATGGAGAAGGAATTGGATGCATGGAAGAGTGTCAGCCAGAGGAGAAAATGAAGACCCT
>NM_015373.4
atgcgcgtggcgggcaggcggcaggaggcgggtggGTCAAGGTAACTCTGGGCTACAGAGTCCTTGCTGGGGGTTCGGGGAGCGCTTGGACCCCGGCTTCTGGGACGCGTCAGGAGAAGGGAGCACTGGCTTTGCTTTCATCAGGCCAAAGATGCCTTTCTTTGGGAATACGTTCAGTCCGAAGAAGACACCTCCTCGGAAGTCGGCATCTCTCTCCAACCTGCATTCTTTGGATCGATCAACCCGGGAGGTGGAGCTGGGCTTGGAATACGGATCCCCGACTATGAACCTGGCAGGGCAAAGCCTGAAGTTTGAAAATGGCCAGTGGATAGCAGAGACAGGGGTTAGTGGCGGTGTGGACCGGAGGGAGGTTCAGCGCCTTCGCAGGCGGAACCAGCAGTTGGAGGAAGAGAACAATCTCTTGCGGCTGAAAGTGGACATCTTATTAGACATGCTTTCAGAGTCCACTGCTGAATCCCACTTAATGGAGAAGGAACTGGATGAACTGAGGATCAGCCGGAAGAGAAAATGAAGACCCCAGAGACATTTATTGGGGAGTAGGATGTGGCTGAGTGCTTTTTTTTTGGCCAGACTAGCGGATTCAGTCCTGGAAGAGAGTATCATATAATGAGACCCACAGGCACTGGCACCCTTGGGTTGGCAATAGAAGGTGACATGGAATGGAGAAAACCAAGattccagatggggatagtaactagaaggtgcttcagatgcactgcctgcgggtgccagtctgaaaaccagaccgcacagaggcctggggctgctgatgagctttTTGGTGCTCTCCACACACAAGCTCGCAAACACACATGTCCCAGAATAGCTCTGTTGGGTTGTGTTGGGAGAAGCGGCTGGAGTTCATTCTCTCACCCCCTTATGTTGGTGTTTGGCGTGTGACAGCAGTTCTACAGAGCTCTGTGTTGGGGTCATGGATGAGCGGCTCTCTTGGCTCTTAAAGGCAGGCCTCTCTCTTCTTGCCTTTAAAGAATCCTCCTTCCTCACACCTGGCCTCCTCTGGCTTCAGCTTCTCAGCAGCAAGCACCAGCCTTCCACAACAACACTATATTTTTATGCTACTTTCCTGTTTGCACTACTACTTTTTTATTAAACGATGTTAAATAA

Publications

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