Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name FUCA1P1
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:176804992-176805871  UCSC
Coordinates (T2T) chr2:177287082-177287961  UCSC
Coordinates (hg19) chr2:177669720-177670599  UCSC
Strand -
Parental Sequence NM_000147.5
Parental seq. overlap 733 bp
Parental seq. overlap (%) 35.8%
Genomic Region Intergenic
Retrocopy Summary FUCA1P1, located on chr2:176804992-176805871, is a retrocopy of the parental gene FUCA1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name FUCA1
Full Name alpha-L-fucosidase 1
Also known as FUCA
Coordinate chr1:23845077-23868332
Strand -
Gene summary The protein encoded by this gene is a lysosomal enzyme involved in the degradation of fucose-containing glycoproteins and glycolipids. Mutations in this gene are associated with fucosidosis (FUCA1D), which is an autosomal recessive lysosomal storage disease. A pseudogene of this locus is present on chr 2.[provided by RefSeq, Oct 2009]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes FUCA1P1
Bonobo Pan paniscus FUCA1P1
Gorilla Gorilla gorilla FUCA1P1
Orangutan Pongo abelii FUCA1P1
Gibbon Nomascus leucogenys FUCA1P1
Green monkey Chlorocebus sabaeus FUCA1P1
Crab-eating macaque Macaca fascicularis FUCA1P1
Rhesus Macaca mulatta FUCA1P1
Baboon Papio anubis FUCA1P1
Golden snub-nosed monkey Rhinopithecus roxellana FUCA1P1
Marmoset Callithrix jacchus FUCA1P1
Pig Sus scrofa FUCA1P1
Dolphin Tursiops truncatus FUCA1P1
Horse Equus caballus FUCA1P1
Dog Canis familiaris FUCA1P1
Greater mouse-eared bat Myotis myotis FUCA1P1
Greater horseshoe bat Rhinolophus ferrumequinum FUCA1P1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>FUCA1P1
TTTGGTTGGTGAGTTGGAAACAGTCTGGAAGAGGAACATACACAATGAACTCTATCACTTCTTAGAATGGTTCCATCCACTCTAGCTACTTGATTTAAAAAAAAATGGCTTCAAAACACAGCATTTTGGCAGTGTAAAAACAATGCCACAGCTATATGATCTTGTTAACAGGCACAAGTCTGATATGATTTTGTCTAATAAAGTGAGACTGTCCTGATACTTATTTGAACTTGCCTCTACAATGATATCTATCAAGGAAGAGGTGGTAGTAAATGACTGATGGGGTCAGAAATGGTTCTGTCACCATGGACAGCACTACAACTGTCAAGAGAAACTTAAGCTGGGGAGGTTGCAAGACCACAAGTAAGAGATGTGTACCACCATTGACAAGAAATTCTGGGGCAATGGTTGCAACATGGCAATGTCTGACTTTGCAAGTGAATCTGAAATGGTTTTGGAACTGCTTCAGACAGCAAGTTTAAGAGGCAACTATCTTCTCAACATTGGACAAGCTAAAGATGATCTAACTGTTCCTGTCTTCCAAGAAAGGCTTCTTGCTTTTAGGAAGTGGCTGAGCATCAGTGGGGAAGCTATCTATGCCTCTAAACCATGGAAGGTGCAATTGGAAAAGAACATGACATCTGCATGGTATACCTCTAAAGGATCAGCTGTTTATGCGATTTTACAGCACTGGCCAGAAAATGGAGTCTTAAACCTTGAATCCCCCATAACCACCTTGACTAGAAAGCACACAGTGCTGGGAAAAAAGAATGTCTGAAGTGGTCCACAGGTCTGGACAAAGGCCTTCTTTTTCTGCCCCAGTTATCATCCTCTGCTTTCCCAGTTGAGTTTTCTTGGCCTGTAAAGCTGACAGGAGTGG
>NM_000147.5
AGCGATGCGGGCTCCGGGGATGAGGTCGCGGCCGGCGGGTCCCGCGCTGTTGCTGCTGCTGCTCTTCCTCGGAGCGGCCGAGTCGGTGCGTCGGGCCCAGCCTCCGCGCCGCTACACCCCAGACTGGCCGAGCCTGGATTCTCGGCCGCTGCCGGCCTGGTTCGACGAAGCCAAGTTCGGGGTGTTCATCCACTGGGGCGTGTTCTCGGTGCCCGCCTGGGGCAGCGAGTGGTTCTGGTGGCACTGGCAGGGCGAGGGGCGGCCGCAGTACCAGCGCTTCATGCGCGACAACTACCCGCCCGGCTTCAGCTACGCCGACTTCGGACCGCAGTTCACTGCGCGCTTCTTCCACCCGGAGGAGTGGGCCGACCTCTTCCAGGCCGCGGGCGCCAAGTATGTAGTTTTGACGACAAAGCATCACGAAGGCTTCACAAACTGGCCGAGTCCTGTGTCTTGGAACTGGAACTCCAAAGACGTGGGGCCTCATCGGGATTTGGTTGGTGAATTGGGAACAGCTCTCCGGAAGAGGAACATCCGCTATGGACTATACCACTCACTCTTAGAGTGGTTCCATCCACTCTATCTACTTGATAAGAAAAATGGCTTCAAAACACAGCATTTTGTCAGTGCAAAAACAATGCCAGAGCTGTACGACCTTGTTAACAGCTATAAACCTGATCTGATCTGGTCTGATGGGGAGTGGGAATGTCCTGATACTTACTGGAACTCCACAAATTTTCTTTCATGGCTCTACAATGACAGCCCTGTCAAGGATGAGGTGGTAGTAAATGACCGATGGGGTCAGAACTGTTCCTGTCACCATGGAGGATACTATAACTGTGAAGATAAATTCAAGCCACAGAGCTTGCCAGATCACAAGTGGGAGATGTGCACCAGCATTGACAAGTTTTCCTGGGGCTATCGTCGTGACATGGCATTGTCTGATGTTACAGAAGAATCTGAAATCATTTCGGAACTGGTTCAGACAGTAAGTTTGGGAGGCAACTATCTTCTGAACATTGGACCAACTAAAGATGGACTGATTGTTCCCATCTTCCAAGAAAGGCTTCTTGCTGTTGGGAAATGGCTGAGCATCAATGGGGAGGCTATCTATGCCTCCAAACCATGGCGGGTGCAATGGGAAAAGAACACAACATCTGTATGGTATACCTCAAAGGGATCGGCTGTTTATGCCATTTTTCTGCACTGGCCAGAAAATGGAGTCTTAAACCTTGAATCCCCCATAACTACCTCAACTACAAAGATAACAATGCTGGGAATTCAAGGAGATCTGAAGTGGTCCACAGATCCAGATAAAGGTCTCTTCATCTCTCTACCCCAGTTGCCACCCTCTGCTGTCCCCGCAGAGTTTGCTTGGACTATAAAGCTGACAGGAGTGAAGTAATCATTTGAGTGCAAGAAGAAAGAGGCGCTGCTCACTGTTTTCCTGCTTCAGTTTTTCTCTTATAGTACCATCACTATAATCAACGAACTTCTCTTCTCCACCCAGAGATGGCTTTTCCAACACATTTTAATTAAAGGAACTGAGTACATTACCCTGATGTCTAAATGGACCAAAGATCTGAGATCCATTGTGATTATATCTGTATCAGGTCAGCAGAAGAAGGAACTGAGCAGTTGAACTCTGAGTTCATCAATTGTAATATTTGGAAATTATCTACAATGGAATCTTCCCTCTGTTCTCTGATAACCTACTTGCTTACTCAATGCCTTTAAGCCAAGTCACCCTGTTGCCTATGGGAGGAGGTGGAAGGATTTGGCAAGCTCAACCACATGCTATTTAGTTAGCATCAGTTGTCACCAACAGTCTTTCTGCAAAGGGCAGGAGAGCTTTGGGGGAAAGGAAAAGGCTTACCAGGCTGCTATGGTCAACTCTTCAGAAATTTTCAGAGCAATCTAAAAGCGCCAAAATTCGCTATGTTTACAGTGATACTATTAAGAAAATGAATGTGATTCTGCTCTGTCTTTTTAAGTATGATCAAATAAAAAATTTGTACATCACAATCATTTCTACCAAAAAAA

Publications

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