RCPedia: Rtcs

Summary

Retrocopy Name	NUDCP2	Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species	Homo sapiens
Coordinates (hg38)	chr2:178454715-178455643 UCSC
Coordinates (T2T)	chr2:178937508-178938436 UCSC
Coordinates (hg19)	chr2:179319442-179320370 UCSC
Strand	+
Parental Sequence	NM_006600.4
Parental seq. overlap	863 bp
Parental seq. overlap (%)	48.2%
Genomic Region	Intragenic (PJVK)
Retrocopy Summary	NUDCP2, located on chr2:178454715-178455643, is a retrocopy of the parental gene NUDC. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name	NUDC
Full Name	nuclear distribution C, dynein complex regulator
Also known as	HNUDC\|MNUDC\|NPD011
Coordinate	chr1:26900569-26946871
Strand	+
Gene summary	This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The encoded protein is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2. [provided by RefSeq, Feb 2012]

Homology

Species	Scientific Name	Retrocopy
Chimpanzee	Pan troglodytes	NUDCP2
Bonobo	Pan paniscus	NUDCP2
Gorilla	Gorilla gorilla	NUDCP2
Orangutan	Pongo abelii	NUDCP2
Gibbon	Nomascus leucogenys	NUDCP2
Green monkey	Chlorocebus sabaeus	NUDCP2
Crab-eating macaque	Macaca fascicularis	NUDCP2
Rhesus	Macaca mulatta	NUDCP2
Baboon	Papio anubis	NUDCP2
Golden snub-nosed monkey	Rhinopithecus roxellana	NUDCP2
Marmoset	Callithrix jacchus	Without Homology
Mouse lemur	Microcebus murinus	Without Homology
Mouse	Mus musculus	Without Homology
Rat	Rattus norvegicus	Without Homology
Chinese hamster	Cricetulus griseus	Without Homology
Rabbit	Oryctolagus cuniculus	Without Homology
Pig	Sus scrofa	Without Homology
Cow	Bos taurus	Without Homology
Sheep	Ovis aries	Without Homology
Dolphin	Tursiops truncatus	Without Homology
Horse	Equus caballus	Without Homology
Dog	Canis familiaris	Without Homology
Panda	Ailuropoda melanoleuca	Without Homology
Cat	Felis catus	Without Homology
Pale spear-nosed bat	Phyllostomus discolor	Without Homology
Velvety free-tailed bat	Molossus molossus	Without Homology
Greater mouse-eared bat	Myotis myotis	Without Homology
Kuhl's pipistrelle	Pipistrellus kuhlii	Without Homology
Greater horseshoe bat	Rhinolophus ferrumequinum	Without Homology
Egyptian rousette	Rousettus aegyptiacus	Without Homology
Sloth	Choloepus didactylus	Without Homology
Tasmanian Devil	Sarcophilus harrisii	Without Homology
Opossum	Monodelphis domestica	Without Homology
Platypus	Ornithorhynchus anatinus	Without Homology
Chicken	Gallus gallus	Without Homology
Turkey	Meleagris gallopavo	Without Homology
Zebra Finch	Taeniopygia guttata	Without Homology
Budgerigar	Melopsittacus undulatus	Without Homology
Painted Turtle	Chrysemys picta	Without Homology
Lizard	Anolis Carolinensis	Without Homology
Frog	Xenopus tropicalis	Without Homology
Zebrafish	Danio rerio	Without Homology
Drosophila	Drosophila melanogaster	Without Homology

Expression

Related Sequence

>NUDCP2
GAAGTCAGAGACCTCAGGGCCCCAGATCAAGGAGCTAACTGATGAAGAGGCAGAGAGGCTGCAGCTAGAGATTGACCAGAAATAGGATGCAGAGAATCATGAGGCCCAGATCAAGAATGGCAGCCTTGACTCCCCAGGGAAGCAGAAGACTaCAAAGGAAAACTGAAGCCCAACCTAGGCAACAGGGCAGACCTGCCTGATTACCGCTGGACCAAGACCCTGTCGGAGCTGGACCTGGCGGTCCCTTTCTGTGTGGACTTCCAGCTGAAAGGGAAGGACGTGGTGGTGGCATCCAACGGCGGCACCTCCAGGTGGGGCTCAAGGGGCAGCCAGCGATCATCGATGGGGAGCTCTACAACGAAGTGAAGGCGGAGGAGAGCTCGTGGCTCATTGAGGACGGCAAGGTGGTGACTGTGCATCTGGAGAAGATCAAGAAGATGGAGTGGTGGAGCCGCTTGGTGTCCAGTGACCCTGAGATCAATACCAAGAAGATTAACCCTGAGAATTCCAAGCTGTCAGACCTGGACAGTGAGACTCACATCATGGTGGAAAAGACAATCTATGACCAGTAACAGAAGTCCATGGGGCTGCCAACCTCAGACGAACAGAAGAAACAGGAGATTCTGAAGAAGTTCATGGATCAGCATCCGGAGATGGATTTTTCCAAGGCTAAATTCAACTAGCCCCTGTTTTTCCCTCCCTGAACTCTTGGGGCTGAGCTGCAACCACCCAACTTTCTTTCCCACTCTTCTCTGGGACTTGTGGGCCTCAGGGCTTGGGGCAGGCATGGGACTGGCCCAGGCACACAGGTCCCAGGGCATCAGGAGAAAGGCTGGGGCTTGGGGTCTTGTCCTCCCCAGTTGGCCTACTGTTACACATTAAAATGATTTGCCCAGCT

>NM_006600.4
GCGGAAGGCGGACGACTAGAGTCGTTGGGCCCGGCGCGACCCGCAGGAGCGTAGAGAGCGCGGGACTAGAGTGCAGAGCTCCGGGACGTGGATCGGAGCCGGCGCGATGGGCGGAGAGCAGGAGGAGGAGCGGTTCGACGGCATGTTGCTGGCCATGGCTCAGCAGCACGAGGGCGGCGTGCAGGAGCTTGTGAACACCTTCTTCAGCTTCCTTCGACGCAAAACAGACTTTTTCATTGGAGGAGAAGAAGGGATGGCAGAGAAGCTTATCACACAGACTTTCAGCCACCACAATCAGCTGGCACAGAAGACCCGGCGGGAGAAGAGAGCCCGGCAGGAGGCCGAGCGGCGGGAGAAGGCGGAGCGGGCGGCCAGACTGGCCAAGGAAGCCAAGTCAGAGACCTCAGGGCCCCAGATCAAGGAGCTAACTGATGAAGAGGCAGAGAGGCTGCAGCTAGAGATTGACCAGAAAAAGGATGCAGAGAATCATGAGGCCCAGCTCAAGAACGGCAGCCTTGACTCCCCAGGGAAGCAGGATACTGAGGAAGATGAGGAGGAAGATGAGAAGGACAAAGGAAAACTGAAGCCCAACCTAGGCAACGGGGCAGACCTGCCCAATTACCGCTGGACCCAGACCCTGTCGGAGCTGGACCTGGCGGTCCCTTTCTGTGTGAACTTCCGGCTGAAAGGGAAGGACATGGTGGTGGACATCCAGCGGCGGCACCTCCGGGTGGGGCTCAAGGGGCAGCCAGCGATCATTGATGGGGAGCTCTACAATGAAGTGAAGGTGGAGGAGAGCTCGTGGCTCATTGAGGACGGCAAGGTGGTGACTGTGCATCTGGAGAAGATCAATAAGATGGAGTGGTGGAGCCGCTTGGTGTCCAGTGACCCTGAGATCAACACCAAGAAGATTAACCCTGAGAATTCCAAGCTGTCAGACCTGGACAGTGAGACTCGCAGCATGGTGGAAAAGATGATGTATGACCAGCGACAGAAGTCCATGGGGCTGCCAACTTCAGACGAACAGAAGAAACAGGAGATTCTGAAGAAGTTCATGGATCAACATCCGGAGATGGATTTTTCCAAGGCTAAATTCAACTAGCCCCTGTTTTTTCCTCCCTGAACTCTTGGGGCTGAGCTGCAACCACCCAACTTTCTTTCCCACTCTTCTCTGGGACTTGTGGGCCTCAGGGCTTGGGGCAGGCATGGGACTGGCCCAGGCACACAGGTCCCGGGGCATCAGGAGAAAGGCTGGGTCTTGGGACCTTGTCCTCCCCAGTTGGCCTACTGTTACACATTAAAACGATTTGCCCAGCTCCTTCTGTGTCCTCTCTTGCCTCTGGCCTTTCTCTGGGGCACAGGCCTCTTACGGCTGCTGctgggaactgggagtttggcttctagcccagattctgccatgtgacctagggcacatccttgcccctctctgggcctcagtttctcatTACTTAAAGATTAAAACAAGGCTTggccgggtgtgatggttcatgtctgtaatcccagcactttgggaggctgaggggagcagatcacctgatgtcaggagtttgagaccagcttggccaacatggagaaacccagtctctactaaaaatacaaaaattagccgggtgtggtggtgcacacctgtaatcccagctactcgggaggctgaggcaggagaatcgcttgaacccgggtggcggaggttgcagtgagccgagattgcactacttcactccagcatgggtgacagagactccatctcaaaaaaataaataaataaaacaaG

>NM_006600.4 

GCGGAAGGCGGACGACTAGAGTCGTTGGGCCCGGCGCGACCCGCAGGAGCGTAGAGAGCGCGGGACTAGAGTGCAGAGCTCCGGGACGTGGATCGGAGCCGGCGCGATGGGCGGAGAGCAGGAGGAGGAGCGGTTCGACGGCATGTTGCTGGCCATGGCTCAGCAGCACGAGGGCGGCGTGCAGGAGCTTGTGAACACCTTCTTCAGCTTCCTTCGACGCAAAACAGACTTTTTCATTGGAGGAGAAGAAGGGATGGCAGAGAAGCTTATCACACAGACTTTCAGCCACCACAATCAGCTGGCACAGAAGACCCGGCGGGAGAAGAGAGCCCGGCAGGAGGCCGAGCGGCGGGAGAAGGCGGAGCGGGCGGCCAGACTGGCCAAGGAAGCCAAGTCAGAGACCTCAGGGCCCCAGATCAAGGAGCTAACTGATGAAGAGGCAGAGAGGCTGCAGCTAGAGATTGACCAGAAAAAGGATGCAGAGAATCATGAGGCCCAGCTCAAGAACGGCAGCCTTGACTCCCCAGGGAAGCAGGATACTGAGGAAGATGAGGAGGAAGATGAGAAGGACAAAGGAAAACTGAAGCCCAACCTAGGCAACGGGGCAGACCTGCCCAATTACCGCTGGACCCAGACCCTGTCGGAGCTGGACCTGGCGGTCCCTTTCTGTGTGAACTTCCGGCTGAAAGGGAAGGACATGGTGGTGGACATCCAGCGGCGGCACCTCCGGGTGGGGCTCAAGGGGCAGCCAGCGATCATTGATGGGGAGCTCTACAATGAAGTGAAGGTGGAGGAGAGCTCGTGGCTCATTGAGGACGGCAAGGTGGTGACTGTGCATCTGGAGAAGATCAATAAGATGGAGTGGTGGAGCCGCTTGGTGTCCAGTGACCCTGAGATCAACACCAAGAAGATTAACCCTGAGAATTCCAAGCTGTCAGACCTGGACAGTGAGACTCGCAGCATGGTGGAAAAGATGATGTATGACCAGCGACAGAAGTCCATGGGGCTGCCAACTTCAGACGAACAGAAGAAACAGGAGATTCTGAAGAAGTTCATGGATCAACATCCGGAGATGGATTTTTCCAAGGCTAAATTCAACTAGCCCCTGTTTTTTCCTCCCTGAACTCTTGGGGCTGAGCTGCAACCACCCAACTTTCTTTCCCACTCTTCTCTGGGACTTGTGGGCCTCAGGGCTTGGGGCAGGCATGGGACTGGCCCAGGCACACAGGTCCCGGGGCATCAGGAGAAAGGCTGGGTCTTGGGACCTTGTCCTCCCCAGTTGGCCTACTGTTACACATTAAAACGATTTGCCCAGCTCCTTCTGTGTCCTCTCTTGCCTCTGGCCTTTCTCTGGGGCACAGGCCTCTTACGGCTGCTGctgggaactgggagtttggcttctagcccagattctgccatgtgacctagggcacatccttgcccctctctgggcctcagtttctcatTACTTAAAGATTAAAACAAGGCTTggccgggtgtgatggttcatgtctgtaatcccagcactttgggaggctgaggggagcagatcacctgatgtcaggagtttgagaccagcttggccaacatggagaaacccagtctctactaaaaatacaaaaattagccgggtgtggtggtgcacacctgtaatcccagctactcgggaggctgaggcaggagaatcgcttgaacccgggtggcggaggttgcagtgagccgagattgcactacttcactccagcatgggtgacagagactccatctcaaaaaaataaataaataaaacaaG

Publications

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