Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RAD52P1
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:179399179-179400893  UCSC
Coordinates (T2T) chr2:179882296-179884010  UCSC
Coordinates (hg19) chr2:180263906-180265620  UCSC
Strand -
Parental Sequence XM_017019770.1
Parental seq. overlap 1535 bp
Parental seq. overlap (%) 45.3%
Genomic Region Intergenic
Retrocopy Summary RAD52P1, located on chr2:179399179-179400893, is a retrocopy of the parental gene RAD52. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RAD52
Full Name RAD52 homolog, DNA repair protein
Also known as -
Coordinate chr12:911259-991195
Strand -
Gene summary The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. A pseudogene of this gene is present on chromosome 2. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RAD52P1
Bonobo Pan paniscus RAD52P1
Gorilla Gorilla gorilla RAD52P1
Orangutan Pongo abelii RAD52P1
Gibbon Nomascus leucogenys RAD52P1
Green monkey Chlorocebus sabaeus RAD52P1
Crab-eating macaque Macaca fascicularis RAD52P1
Rhesus Macaca mulatta RAD52P1
Baboon Papio anubis RAD52P1
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RAD52P1
AGGTCAACCAGAATCAAGATGTCTGGCACTGAGGAAGCAATTTTTGGAGAGCGTGACAGCCATACTGCTGCTCATGGCAGCTTGGTGTGCTTTGGACAGTGCCAGTACACAGCAGAAGAGTACCAGGCCATCCAGAAGGCCCCGAGGCAGAGGCTGGGCCCAGAATACATAAGTAGCCCATGACTGGAGGAGGCCAGAAGGTGTGTTACATTGAGGGTCATTGGGTAATTAATCTGGCCAATGACATGTTTGGTTACAACGGCAGGGCACACTCCATCACGCAGCAGAATGTGGATTTTGTTGACCTAAACAATGGCAAGTTCTACATGGGAGTCTGTGCATTTGTGAGGGTCCAGTTGTAGGATGGTTCATATCATGAAGTTGTGGGTTATGGTGTTAGGGCCTCAAGTCCAAGGCCTCATCTTTGGAGAAGGCAAGGAAGGAGGCGGTGACAGACGGGCTAAAGCAAGCCCCCAGGAGTTTTCGGAACGCACTTGGAAATTGTATTCTGGACAGAGACTACTTGAGGTCACTAAACAAGCTTCCACGCCAGCTGCCTCTTGAAGTGGATTAAACTAAAGCAAAGAGACAAGATTTTGAACCATCTGTGGAAGAGGCAAGATACAACAGCTGCCAACTGAACATGGCCCTGGGATACCCACAGCTTCAAGATGTGACCTCCCCTTGCAGATCAAGCCACGTTGTGATTCAGGGGGACAAGGACTGCAGCTTCCTGACTTCTGAGCTCATCCACTATTGGTGAGAGAGGCCACGAACCAGCAGAAGTTCTGGCAAAAGCAGCTGCTGCAGCAGTTCTGGGAGCAGATGGAGAAACAGCAAGTCCACACCTTTTCCCCATCAGTTGAGAAGAGTGAGGAGACTCTTGGAGACAACTCTGAAATGTGGGATGTGACTCCAGATGCAGGGGATGGTGTGGTCAAGCCTTGTCTAGAGAAGAACCACCCCAGACCTCTGACACACCAGCCTTGAACAACCAGATGGTGACCCAGAACAGGACTCCACACAGCCTTTGCTGTCAGAAACCACAAGCAAAATCTGGACCTTGAGACCTCCAAACTTACAGCACTGACCAATGCATAACAGGAAACTGGGAATCTCATAGGAAGGGCCAGGACATGAAGAAAAGGAAATTGGATCCATCTTAACTGAGCCTCTGGCCACATCATTGGACTCTGTCGCAAAGGGACTTTGGAAAACTACTTTTTAGTCATGAAGTTGTTCATCACTCGTGAAGAATTACCTTTATTGCTAAGGATTTATCTTGCTTCATTCTGAACCTCATCAATAGGATCTGACTGAGAGCCCACTGCAGTTAGAGCTGAGCACTTTTAAAAACCTCATCCCACACTCTAGCTGGGAGACGCTCCGGACAGATGAAATACCTTTTCTTTGGCCTGTGAGGCTTCCCACTATTTATTTCTAAACTATTATGTTAACACCAATGGACATTTTAGGAATCACCAATGGCTGCTTGCCCTCAAGCAATATAGGCCGGACTTATTACTAACCACCTGCCTCAGCAATTACCTACATTCAATTGCTTTGCATAACCTCTGCCTTCTTTCCTTTAGGGTACAAGGCCTTTAATGTTGTCCACGTTAAGCAATGAGGATCATGACAGGAAAAAGGTTGGAGTATTGCTTTTTATTGCTTTGTATCAATCCAGGCTACAATCTTCATTTGATATAAATAAA
>XM_017019770.1
ATCTAAGATCTCTTCCCCTTGTCCATAGCCTAGATCGAGCTCCCTGTGTGCACCGCGCGCTGCCCGAGGCGCAGGTCAACCAGAATCAAGATGTCTGGGACTGAGGAAGCAATTCTTGGAGGACGTGACAGCCATCCTGCTGCTGGCGGCGGCTCAGTGTTATGCTTTGGACAGTGCCAGTACACAGCAGAAGAGTACCAGGCCATCCAGAAGGCCCTGAGGCAGAGGCTGGGCCCAGAATACATAAGTAGCCGCATGGCTGGCGGAGGCCAGAAGGTGTGCTACATTGAGGGTCATCGGGTAATTAATCTGGCCAATGAGATGTTTGGTTACAATGGCTGGGCACACTCCATCACGCAGCAGAATGTGGATTTTGTTGACCTCAACAATGGCAAGTTCTACGTGGGAGTCTGTGCATTTGTGAGGGTCCAGCTGAAGGATGGTTCATATCATGAAGATGTTGGTTATGGTGTTAGTGAGGGCCTCAAGTCCAAGGCTTTATCTTTGGAGAAGGCAAGGAAGGAGGCGGTGACAGACGGGCTGAAGCGAGCCCTCAGGAGTTTTGGGAATGCACTTGGAAACTGTATTCTGGACAAAGACTACCTGAGATCACTAAATAAGCTTCCACGCCAGTTGCCTCTTGAAGTGGATTTAACTAAAGCGAAGAGACAAGATCTTGAACCGTCTGTGGAGGAGGCAAGATACAACAGCTGCCGACCGAACATGGCCCTGGGACACCCACAGCTGCAGCAGGTGACCTCCCCTTCCAGACCCAGCCATGCTGTGATACCGGCGGACCAGGACTGCAGCTCCCGAAGCCTGAGCTCATCCGCCGTGGAGAGCGAGGCCACgcaccagcggaagctccggcagaagcagctgcagcagcagttccgggagcggatggagaagcagcagGTTCGAGTCTCCACGCCGTCAGCTGAGAAGAGTGAGGAGACTCTTGAAGACAACTCTGAAAAGTGGGCTGTGACTCCCGATGCAGGGGATGGTGTGGTCAAGCCCTCGTCTAGAGCAGACCCAGCCCAGACCTCTGACACATTAGCCTTGAACAACCAGATGGTGACCCAGAACAGGACTCCACACAGCGTTTGCCACCAGAAACCACAAGCAAAATCTGGATCTTGGGACCTCCAAACTTATAGCGCTGACCAACGCACAACAGGAAACTGGGAATCTCATAGGAAGAGCCAGGACATGAAGAAAAGGAAATATGATCCATCTTAACTGAGGCTCAGGCCACATAATTGGACTCTGTCACAAAGGGACTTTGGAAAACTACTTTTTGGTCATGAAATTGTTCATCGCTGCTGGAGAATGAACGTCATTGCGATTTATCTTGCTTCATTCTGAACCTTATCAAGAGGATCTGACTGAGAGCCCACTGCAGTTAGAGCTGAGCACTTTTGAAAAGCTTGTCCATCACTCTAGTAGGGAGAGGCTCTGGACAGATGAATACCTTTTCTTCGGCTTGTGAGGCTTCCCACTATTTATTACTGAACTATTATGTTAATGAAGATGGACATTTTAGGAATCACCAATGGCTCCTTGCCCTCAAGCAATATAGGCCAGACTTGGTCCTAAGCACCTGCCTCAGCAATTGTCTACATTCAGTTGTTTTGCATAACGTCTGCCTTCTTTCCTTTACGGTCCATGCCTTTAATGTTGCCCACATTAAGCACTGTGGATCACGACAGGAAAAAGGTTGGAGCAGTGCTTTTCACTACTTTGTATCAATCCAGGCTACAATCTTCATTTAATATAAATAATTTATGGATTTATGACATTACAATCCTGCATTGTTTCAAGACTGACATTTTTTCCTAAGGAAGGAAATAATCATCTAAGACCACGAAAAAAGGCTGttttttgtttttttttttttttttttttttgagacggggtctggctgtgttgccctgactggagttcagtggtgcaaacacagctctctccacaacctcttgggcccaagtgatactcccacctctgccttacaaaatacagggattactggtgtgagccactgtgtctggcCAGAAAAGGCATTTTTGAGAAAGCAAATCGTATACCTTATTAACAAAATAGAATATATATAtattgcttatctgaaatgcttgaaaccagaattgttttgcattttttgaatatttgtatacacataatgagaccttggggatgggacccaagtctgaacgtggaattcacctgtgtttcgtgtatatgcctcatacacataattttgtgcatgaaacagagtttttgtataagaagatacactgcagctgaagagggctgggtttttttttctcttagggtcgctgcataaactgttgtatgcctggtgctttgcgacttgtcacacgaggtcacgtgtggaattttccacttctggcatcacgtcagtgctcagaaattttctgatctcagagcatttcaattagggatgctcaaACGCAACTGTTTCTACTTCCCCATTTCAGGTGTGAGATGTAACCCACCTTGACCATAAATTGGCTTTTCATAGTGCTCAGATGTTTCATAATTCTTCCCCCAAAATAATGAAGTTTGCAGTTTAACAACtttttttttgagagggggggtctggctctgtagcgcaggctggagtgcagcggtgccatcttgactcattgcagcctccgcctgccaggattcaagcaattctcctgcctcaggctcccgagtagctgggattacagacacccaccacgacgcccgactaatttttgtatttttagtagaggagacggggtttctccatgttggccaggctggtctcaaactgacctcaagtgatctgcccacctcggcctcccaaagtaaaaagtactagaattataggcatgagccattgcgcccagccAATTTAATAATTTTTTTAGACGTATTATTTTGGGCTGGGCTGTGGCTAATCTTGAAGCAGTGACTTCCTATTTTTTGGCTCAGACCCATTTGGGAAGCTGTGAACCTGAGATAAGGAAGTCTGAAAGTACTAGCCGGCAGCCGACCGTTTCTATTCCTTTCGAAGTTAAGGAGACAGCAAAGGAGCTCCCAGGAATTAGGGATCCAGTTATAAATTGCACTTAACTCAAAATAGTGCCAGTGAGAATGTGAAGGAATCTTCTGGAAATGAAACCCCACAGCTCAACAAAAGCAAGTTTGGTTTATTTGAATGGTTTCATTAAATAAGTCTACAAAGGTAACAAACTGAAGCACAAAGCGCAATCTTACAAGAAGCGCAACACCCAGAGTTAGTGCAAAATGTACAATTAACGGCTGCTGAGAAACCCCCAAAGTTTGAATTTTTATTTTTATTTTTAACAGTGTACATTGTTAAA

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