Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TXNL4AP1
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr18). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:179814257-179814831  UCSC
Coordinates (T2T) chr2:180297478-180298052  UCSC
Coordinates (hg19) chr2:180678984-180679558  UCSC
Strand +
Parental Sequence NM_006701.5
Parental seq. overlap 498 bp
Parental seq. overlap (%) 14.3%
Genomic Region Intragenic (ZNF385B)
Retrocopy Summary TXNL4AP1, located on chr2:179814257-179814831, is a retrocopy of the parental gene TXNL4A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TXNL4A
Full Name thioredoxin like 4A
Also known as BMKS|DIB1|DIM1|SNRNP15|TXNL4|U5-15kD
Coordinate chr18:79970813-80033936
Strand -
Gene summary The protein encoded by this gene is a member of the U5 small ribonucleoprotein particle (snRNP), and is involved in pre-mRNA splicing. This protein contains a thioredoxin-like fold and it is expected to interact with multiple proteins. Protein-protein interactions have been observed with the polyglutamine tract-binding protein 1 (PQBP1). Mutations in both the coding region and promoter region of this gene have been associated with Burn-McKeown syndrome, which is a rare disorder characterized by craniofacial dysmorphisms, cardiac defects, hearing loss, and bilateral choanal atresia. A pseudogene of this gene is found on chromosome 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TXNL4AP1
Bonobo Pan paniscus TXNL4AP1
Gorilla Gorilla gorilla TXNL4AP1
Orangutan Pongo abelii TXNL4AP1
Gibbon Nomascus leucogenys TXNL4AP1
Green monkey Chlorocebus sabaeus TXNL4AP1
Crab-eating macaque Macaca fascicularis TXNL4AP1
Rhesus Macaca mulatta TXNL4AP1
Baboon Papio anubis TXNL4AP2
Golden snub-nosed monkey Rhinopithecus roxellana LOC115895708P2
Marmoset Callithrix jacchus TXNL4AP1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TXNL4AP1
CACATGCTCCTGCACCTCCACAGCAGCTGGCAGGTGGACCAGGCCATCCTCCCAGGAGAGGACTGCATGGCTGTCATTCGCTTCGGCCACGGCTGGGACCCCACATGCATGAAAATGGATAAGGTCTTGTACAGCATCATTGAGAAGGTTAAAGATTTTGCAGTTATTTTTCTTGTGAATATTACCAAAGTACCTGACTTCAACAAAATGTATGAGTTATATGATCCATGCACTATCATGTTTTTCTTCAGGAACAAGCACATCATGGTTGTCTTGGGGACTGGCAACAACAAGATTAACTGGGCCATGGAGGACAAGCAGGAGATGGTCGACATCATAGAGACCGTGGACTGTAGGGCCCTCAATGGTGGCGACCTGGTCTTGTCCCCAAAAACTACTCCACCAAGTCCAGATACTGAAGCGCCCTCAGGCTGTGTGGATAAATGTTGTGGAGGCCTTTTCATGTAGAAACCTTTTAAACTATTTCAAGCCTTTGGAAAAGTACATGAAGTCCAGGGCTGGAGGACTTCTGAGATACAATTTACTACATGGCCTTAACTAGCTGAAATAAACAA
>NM_006701.5
AGACGTTCTGCCGGGTGGCAGTCCCAGCGGAGTTTGCGTGTGCGGGCGGGACCGGATTTCGTCCGTGGGCCCGGGGGCGGCGGGGGCCGGGGAGTGAGGGGCCGGCTGAGCCCACCTCGCTGGGCCCTCCCTGGCGCCCCGCCTTGGGCGGCGGCGAGCGCGCGGGCCGCCATGTCGTACATGCTCCCGCACCTGCACAACGGCTGGCAGGTGGACCAGGCCATCCTCTCGGAGGAGGACCGCGTGGTCGTCATCCGCTTCGGCCACGACTGGGATCCTACGTGCATGAAGATGGACGAGGTCCTGTACAGCATCGCCGAGAAGGTTAAAAATTTTGCAGTTATTTATCTTGTGGATATTACAGAAGTGCCTGACTTCAACAAAATGTATGAGTTATACGATCCATGTACTGTCATGTTTTTCTTCAGGAACAAGCACATCATGATTGACTTGGGGACTGGCAACAACAACAAGATTAACTGGGCCATGGAGGACAAGCAGGAGATGGTGGACATCATCGAGACGGTGTACCGCGGGGCCCGCAAAGGCCGCGGCCTGGTGGTGTCCCCCAAGGACTACTCCACCAAGTACCGCTACTGAGGCGCCCTCAGTCTGCGCGGATAAATGTCGTGGAGCCCTTTTTGTATGGAAACGTTTTAAGCTATTTAAAGCCTTTGGAAAATACAGGAAGCTCCAGGGCTGGAGCACCTCTGAGATGGAATTGATAACATGGTCTTAACTCACCGAAATAAACAAGCACGTGGTGAGAGGAGCAGGCCTACTTGTTTGTTCTCAGGAAACTTAATGAATAGATTACTGATTTTCCTAGTCAAAGTTAATTCTTACCCTTGGAGTAAAACGAAGGTGTTTATCCTGTGAGCCTGTGCGTTTTGCATACTGGGttggtttgctggggctgcggtgacagcatatgccgcgagctgggctttaacagagatgtgtgctctcacagctttgcaggcgggggtctgagatcagggtgtcgcgggtggggggtcactgctgaggccgtgaggggaatctgctcaggcctgtccctggcttctgggggctgctggtggtattttcagttccttggtgtgtggatacttcgccccatctctgccttcacctgtgtcctccctgtgtgggtgctggtgtccaaaatttccccttttcgtagtgacaccagctgtgttggattggggcccaccctgctccagcatggcctaatcttaactaattacatttgcaaggatcttatgtccacaaaagtcacagtctgaggtgctgggggttaggacttcaatatataaattttgcggttacacaattcaatccatgacaGAATCCAAAGGTTTACTCTGGTTATAAAAACAGTACAATAAAATATTGTTTATAGCCTTCCCTGTAAGGAATAGGAGAGCTATTTTTTATTCTTCCCAAGATTGTATTTGATGTAAACATATTTTCTGTAGAAGCCATGGCCCTTCAGTTCATATAGTTAGAAAATTTCCTTATTggccaggcacggtggctcacacctgtaatcccagcactttgggaggccgaggtgggcagatcacgaagtcaggtgttcgagaccagcctggccaacatggtgaaatcccgtctctactaaaaatacaaaaattagctgggcatggtggcgcgtgcctgtaatcccagctacttggaaggctgaggcaggagaattgcttgaacccgggaggtggaggtttcagtgagccgagatcacaccactgcactccagcctgggcaacagagcaagactccgtctcaaaaaaagaaaagaaaaTGTCCTTATTACAGTCTCAGGTTTCTCTTGCCCTCTGTCATCCTAGCAGTGTGGATGGTTGGTTGGGATCTTCGTGTCCCGTCTCAGCACACTCGAGCTCTGAAGTGAAAGTGaggaagggcagggatgggggcacttgagcacaccgtgggccctctgacctcagacccaggctctgccccaccaagtgaccttgggcagggtaccttctctgagctttgtttcctccttggtaaaggcggataatagtgtctgccctgcACACAGATGTGGACGCAGAAGCACGTGGTGCCTGCCGGGCACAGGAGTGGTGCACAGGGCTCGCTGCTGTCGGGAGATTGATTGCTGTTGTGGAAACGGGAGGGTACTTACAGAATGAAGCACATTTTTTACATACAGTACAAATGAGTGTGTGCTTTTTAAATGGATTTAAAATTCAAATGCAAATCTGCAGTTTAATCTCCCAAGTGCTGATTTTTCTATGTATAAAGTAGGAGAGTGCAACAGCGTATCGGAATGAGGGGCTAGGGAGAACGTGTATGTGACCTCGAGTACCTGGCATGTAACAGACACTCAGTATTACACTCCTGCTatttctccagagcaggtgaaacagacggccaggaagcacacgaagagacactcagcatcactgcttgttaaggaaggtgcaaatcaaaaccacagtgagacgccacttcacacctacaagttcggctagatacaaaaagatcgcaacaagcgtttgcaaggatgtggagaaattggagccctcacacactgctggtggcaaagtggtaacacaggcaggcaggtcgtcaaaaagttaaacatgggccgggtgcaggtgtctcaagcctgtaatcccagcactttggaaggctgagacaggcagattgcttgagcccaggagttcacgaccagcctgggcaacctggtgagaccctgtctctacaaaaaatacagaacaattagctgggcatggtggtgcgtgcctgtgggcccagctactcggcgggctgaggcaggaggatcacttaagccccagaggtcaaggctgcagtaagccatggttgtgccactgcactccagcctgggcaactgagcaagaccctgtctcaaaaaaataaaaaaagataaacatggtgttaccatttgacccagcagtttcatacccaggagaattgaacgcatatgtccacatagaaactcgtacacagaagccaaaatgtggaaacccacgtgtccatcaacagatgaacggttaaacaaaatgtccatccatagaacggaatattattcagtcataaacagaatgaagtactgtaagtgaaaagccagttactacatattgtgtgattccatttatacggaatttctagaataggcacatccatagagacggattagtggttgcttaagactgggagggagggggaaataggaggtgacagctaatgggcagttttatttttgatgtaatgaaaatgtgcttacataaGCCGAGCAGGCATAAACAGAAAAAGTGCCCTAAGATTGTGATAATGGTACAATTCTGTCAATTGCATAATTGGTGGATGATGTGTGAATTATGTCTCTTAGGATAACAGCTTTACTGGCGTTACCAGAAAAAGATAAAATAATTACATTCCA

Publications

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