Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name LIN28AP1
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:183260573-183265957  UCSC
Coordinates (T2T) chr2:183749637-183755027  UCSC
Coordinates (hg19) chr2:184125301-184130685  UCSC
Strand +
Parental Sequence NM_024674.6
Parental seq. overlap 3130 bp
Parental seq. overlap (%) 78.1%
Genomic Region Intergenic
Retrocopy Summary LIN28AP1, located on chr2:183260573-183265957, is a retrocopy of the parental gene LIN28A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name LIN28A
Full Name lin-28 homolog A
Also known as CSDD1|LIN-28|LIN28|ZCCHC1|lin-28A
Coordinate chr1:26410778-26429728
Strand +
Gene summary This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues. [provided by RefSeq, Sep 2015]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes LIN28AP1
Bonobo Pan paniscus LIN28AP1
Gorilla Gorilla gorilla LIN28AP1
Orangutan Pongo abelii LIN28AP1
Gibbon Nomascus leucogenys LIN28AP5
Green monkey Chlorocebus sabaeus LIN28AP3
Crab-eating macaque Macaca fascicularis LIN28AP2
Rhesus Macaca mulatta LIN28AP2
Baboon Papio anubis LIN28AP1
Golden snub-nosed monkey Rhinopithecus roxellana LIN28AP2
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>LIN28AP1
TCTTCGGAGTTCTCCGGGGCCAGCAGCTGCCTGACCAGGGGCCCGGGGCCACGGGCTCAGCCGACGACCATAGGCTCCGTGTCCACCCAGCAGTTTGCAAGTGGCTGCGCCAAGGCGGCAGAAGAGGCACCCGAGGAGGCGCCGGAGGATGCGGCCCGGGCGGCGGACGAGGCTCAGCTGCTGCACGGTGAGGGCATCTGTAAGTGGTTCAACTTGCGCATGGGATTCGGCTTACTGTCCGTGACTGCCCGCGCCGTGGTCGCGCTCGACCCACCAGTGGACGTCTTTGTGCACCAGAGTAAGCTGCCCATGGAAGGCTTCCGGAGCTTGAAGGAGGGTGAGGCAGTGGAGTTCACCTTTAAGAAGTCAGCCAAGGGTCTGGAATCCATCCGTGTCACCGGACCTGGTGGGGCGTTCCGTATTGGGAGTGAGAGGTAGCCAAAGGGGAAGAACATGCAAGAAGCGCAGATCAAAAGACAGGTGCTACAACTGTGGAGGTCTAGACCATCATGCCAAGGAATGCAAGATGCCACCCCAGGCCAAGAAGTGCCACTTCTGCCAGAGCATCAGTCATATGGTAGCTTCATGTCCACTGAAGGCCCAGCAGGGCCCTAGTGCACAGGGAAAGCCAACCTACTTTCGGGAGGAAGAAGAAATCCACAGCCCTGCCCTGCTCCCGGAGGCACAGAATTGAGCCACAATGGGTGGAGGCTATTCTTTTGCTATCAGGAAGTTTTGAGGAGCAGGCAGAGTGGAGAAAGTGGGAATAGGGTACATTGGGGCTAGTTGGCACTGCCATGTTTCTCAGGCTGGGGTTCACACCATCACCCTTTCTTCTCTCTGTTGGGGGAAAGGGTGAGTCAAAGGAACTCCAACCGTGCTCTGTCCAAATACAAGTGAGGGTTCTGGGGGCAACCAGGAGGTGGGAATCACCCTACAATCTGCATGCTTTATCTGAGGCTCCATCCCCAGAATTTCCAGCTTTTGAAAGTGGCCTGGATAGGGAAGTTGTTTTCCTTTAAAGAAGGATATGTAATAATTCCCATGCCAGAGTGAAATGATTAAGTATAAGACCAGATTCATGGAGCCAAGCCACTGCATCCTGTGGAAGGAAATCTATCAGGAGTAAGGCAGTGTTTTTTTCACATCTTGTATCCATATACCCACTTTTGGGATAGGGTGCTGGCAACTGTCCCAAGCAATGGGTACTGATGATGGCAAAAAGGATGTTTGGGGGAACAGCTGCAGACCTGCTGCTCCTATGCTTACCCCTGCCCCATTCTAGGCCAATGTGATTTTATTTATTTGCTCCCTTTGATACTGCACCTTGAGTCCCACTTTCTCCAGGATGCCAACTGAACTAGCTGTGTGCAAATGATGTATCTTGTGCAGTTTAACTTTTTTTTCCTTAATATAAATATTCTGGTTTTGTATTTTTGTATATTTTAGTCTGAGGCCATCATTTCCTGCACTGTATTCTCAGGTGCATGAGCAATCTCAGGGATAAGTCGGCAGCAGCTTGAGTTCTGCACAGCAGGAATACAAAACTATACTTTTTGTTGTTTTTGCCACTGTGGAGATTTATTATTTGGAGTGCACAGCCTATTGAACTACCTCATTTCTACCAATGAGAGCTGGCTTTTCTGCCATAGTGTCCTCTTGAAACCCCCTCTGCCTTGAAAATGTTTTATGGGAGACTAGGTTTTAACTGGGTTGCCCCATGACTTGATTGCCTCCTACTGGAAGATTGGGAATTAGTCTAAACAGTAAATGGTGGTACAGAGAGGCTAGGAGAGACTGGGCCAGGTGAAAGGCCCAGAGAGGAAGCCACGATTAGGTGAGGGGTGACTAATCCTAGGGCACAGGACATGCTTTACACCCCAGTTCCATTCTTCACCAGATTAGGCTAGGCCTTCCATGCACGACAGGGTATGTGTGCTCATAAAACTGGAGTTGGTAAGGATAAGTTTTAAGACCAGTACCCTTATACTTAATCCTGTGCTGTCGAGGGATGGATATATGAAGTAAGGTATCCTTAACCTTTCAAAATTCATGGGTTCCAGGTAGACACATAAGCAAGGGCTTTGTGGTGCCTGGGACCTGCGTCCCGCCCTGCTGCAGTAGTGATTAATATTGTCACGGTAGCTAAAGGAGAAAAAGGGGATTTCGTTTATATGCTGTGAGATCACCGCAAACCTACCTCACTGTGTTGAAACAGGACAAATGCAATAGAACGCATTGGGTGGTGTGTGTCTGATCCTGGGTTCTTGTCTCCCCTAAATGCTGCCCCCCCCCCCCCAGTTATTGTATTTGTCTGGGCTTTATAGGATTTCACTAAATTGGTGATTGCTAGGTGGCCTAGTTTGTATAAATATAATGTATTAGTCTTTCTCCGTGTTCTTTGGGGGTTTTGTTTACAAACTTCTTTTTGTATTGAAAGAAAAATAGCTAAAGCATCTTTGACAGAAGGTTCTATACCAGGCAAAAAGATCTGAAACATTAGTTTGGGGGGCCCTCTTCTTAAAGTGGGGATCTTGAACTGTCCTTTGTTTTGTATTCCCCTTCCCCTATTACCTATTAGACCAGATCTTCTGTCCTAAAAACTTGTCTTCTATCCTGCCCTCTTTTCTGTTCATCCCCCAAAAGAAAACTTACACACCCACACACATACACATTTAATGCTTGGAAAGTCTCCACAACTCTTAAACGATGTATGCAAAAATCCTGAAGAAGCTAAGAAAACCCTCCATCCCTTGTTCCCAACTTCCTGAGTCAAGACCATTATGACCATTTCTTGATGTATTCATGCCAAACACTTAAGACACTGCTGTAGCaGACACTGCTGTATTTTGGATGGCTCAAACCTACTTAATTTTTACTCCTAAAGTAGAGAGATGCAACTGGGGGCCTTCCATGTAGAAATTGAGGTCAGCAGGCCAAGAAAGAGAATATGAATGTATATACAAGTCACTCAGGAACTTTTATACAGAAACTTATGTCAAAGTGGCCACAAGATTGTTTAATAGGAGACAAATGAATATAACTCTATATTTACTGCTAGAAACCAAAGCTTTGTGTAAAATCTTGAATTTATGGGGAGGGAGGGTAGGAAAGCCTGTAGCTGTCTGTTCTTTTCCTGATCCCTTTCCCTCATTCCTGAACTGCAGGAGACTGAGCCCCTTTGGGCTTTGGTGACCCCATCACTGGGGTGTGTTTATTTGATGGTTGATTTTGCTGTACTGGGTATTTCCTTTCCCATTTTCTAGTCATTTTTTTAACACATGCTGACGCTTCCATTTCCTTCTCCTTTCCCTGGGAAAATACAATGAATAAATAAAGGCTTATTGGTACTCATACTGT
>NM_024674.6
CCTTTGCCTTCGGACTTCTCCggggccagcagccgcccgaccaggggcccggggccacgggctcagCCGACGACCATGGGCTCCGTGTCCAACCAGCAGTTTGCAGGTGGCTGCGCCAAGGCGGCAGAAGAGGCGCCCGAGGAGGCGCCGGAGGACGCGGCCCGGGCGGCGGACGAGCCTCAGCTGCTGCACGGTGCGGGCATCTGTAAGTGGTTCAACGTGCGCATGGGGTTCGGCTTCCTGTCCATGACCGCCCGCGCCGGGGTCGCGCTCGACCCCCCAGTGGATGTCTTTGTGCACCAGAGTAAGCTGCACATGGAAGGGTTCCGGAGCTTGAAGGAGGGTGAGGCAGTGGAGTTCACCTTTAAGAAGTCAGCCAAGGGTCTGGAATCCATCCGTGTCACCGGACCTGGTGGAGTATTCTGTATTGGGAGTGAGAGGCGGCCAAAAGGAAAGAGCATGCAGAAGCGCAGATCAAAAGGAGACAGGTGCTACAACTGTGGAGGTCTAGATCATCATGCCAAGGAATGCAAGCTGCCACCCCAGCCCAAGAAGTGCCACTTCTGCCAGAGCATCAGCCATATGGTAGCCTCATGTCCGCTGAAGGCCCAGCAGGGCCCTAGTGCACAGGGAAAGCCAACCTACTTTCGAGAGGAAGAAGAAGAAATCCACAGCCCTACCCTGCTCCCGGAGGCACAGAATTGAGCCACAATGGGTGGGGGCTATTCTTTTGCTATCAGGAAGTTTTGAGGAGCAGGCAGAGTGGAGAAAGTGGGAATAGGGTGCATTGGGGCTAGTTGGCACTGCCATGTATCTCAGGCTTGGGTTCACACCATCACCCTTTCTTCCCTCTAGGTGGGGGGAAAGGGTGAGTCAAAGGAACTCCAACCATGCTCTGTCCAAATGCAAGTGAGGGTTCTGGGGGCAACCAGGAGGGGGGAATCACCCTACAACCTGCATACTTTGAGTCTCCATCCCCAGAATTTCCAGCTTTTGAAAGTGGCCTGGATAGGGAAGTTGTTTTCCTTTTAAAGAAGGATATATAATAATTCCCATGCCAGAGTGAAATGATTAAGTATAAGACCAGATTCATGGAGCCAAGCCACTACATTCTGTGGAAGGAGATCTCTCAGGAGTAAGCATTGTTTTTTTTTCACATCTTGTATCCTCATACCCACTTTTGGGATAGGGTGCTGGCAGCTGTCCCAAGCAATGGGTAATGATGATGGCAAAAAGGGTGTTTGGGGGAACAGCTGCAGACCTGCTGCTCTATGCTCACCCCCGCCCCATTCTGGGCCAATGTGATTTTATTTATTTGCTCCCTTGGATACTGCACCTTGGGTCCCACTTTCTCCAGGATGCCAACTGCACTAGCTGTGTGCGAATGACGTATCTTGTGCATTTTAACTTTTTTTCCTTAATATAAATATTCTGGTTTTGTATTTTTGTATATTTTAATCTAAGGCCCTCATTTCCTGCACTGTGTTCTCAGGTACATGAGCAATCTCAGGGATAGCCAGCAGCAGCTCCAGGTCTGCGCAGCAGGAATTACTTTTTGTTGTTTTTGCCACCGTGGAGAGCAACTATTTGGAGTGCACAGCCTATTGAACTACCTCATTTTTGCCAATAAGAGCTGGCTTTTCTGCCATAGTGTCCTCTTGAAACCCCCTCTGCCTTGAAAATGTTTTATGGGAGACTAGGTTTTAACTGGGTGGCCCCATGACTTGATTGCCTTCTACTGGAAGATTGGGAATTAGTCTAAACAGGAAATGGTGGTACACAGAGGCTAGGAGAGGCTGGGCCCGGTGAAAAGGCCAGAGAGCAAGCCAAGATTAGGTGAGGGTTGTCTAATCCTATGGCACAGGACGTGCTTTACATCTCCAGATCTGTTCTTCACCAGATTAGGTTAGGCCTACCATGTGCCACAGGGTGTGTGTGTGTTTGTAAAACTAGAGTTGCTAAGGATAAGTTTAAAGACCAATACCCCTGTACTTAATCCTGTGCTGTCGAGGGATGGATATATGAAGTAAGGTGAGATCCTTAACCTTTCAAAATTTTCGGGTTCCAGGGAGACACACAAGCGAGGGTTTTGTGGTGCCTGGAGCCTGTGTCCTGCCCTGCTACAGTAGTGATTAATAGTGTCATGGTAGCTAAAGGAGAAAAAGGGGGTTTCGTTTACACGCTGTGAGATCACCGCAAACCTACCTTACTGTGTTGAAACGGGACAAATGCAATAGAACGCATTGGGTGGTGTGTGTCTGATCCTGGGTTCTTGTCTCCCCTAAATGCTGCCCCCCAAGTTACTGTATTTGTCTGGGCTTTGTAGGACTTCACTACGTTGATTGCTAGGTGGCCTAGTTTGTGTAAATATAATGTATTGGTCTTTCTCCGTGTTCTTTGGGGGTTTTGTTTACAAACTTCTTTTTGTATTGAGAGAAAAATAGCCAAAGCATCTTTGACAGAAGGTTCTGCACCAGGCAAAAAGATCTGAAACATTAGTTTGGGGGGCCCTCTTCTTAAAGTGGGGATCTTGAACCATCCTTTCTTTTGTATTCCCCTTCCCCTATTACCTATTAGACCAGATCTTCTGTCCTAAAAACTTGTCTTCTACCCTGCCCTCTTTTCTGTTCACCCCCAAAAGAAAACTTACACACCCACACACATACACATTTCATGCTTGGAGTGTCTCCACAACTCTTAAATGATGTATGCAAAAATACTGAAGCTAGGAAAACCCTCCATCCCTTGTTCCCAACCTCCTAAGTCAAGACCATTACCAtttctttctttcttttttttttttttttaaaatggagtctcactgtgtcacccaggctggagtgcagtggcatgatcggctcactgcagcctctgcctcttgggttcaagtgattctcctgcctcagcctcctgagtagctgggatttcaggcacccgccacactcagctaatttttgtatttttagtagagacggggtttcaccatgttgtccaggctggtctggaactcctgacctcaggtgatctgcccaccttggcttcccaaagtgctgggattacaggcatgagccaccatgctgggccAACCATTTCTTGGTGTATTCATGCCAAACACTTAAGACACTGCTGTAGCccaggcgcggtggctcacacctgtaatcccagcactttggaaggctgaggcgggcggatcacaaggtcacgagttcaaaactatcctggccaacacagtgaaaccccgtctctactaaaatacaaaaaaattagccgggtgtggtggtgcatgcctttagtcctagctattcaggaggctgaggcaggggaatcgcttgaacccgagaggcagaggttgcagtgagctgagatcgcaccactgcactccagcctggttacagagcaagactctgtctcaaacaaaacaaaacaaaacaaaaaCACACTACTGTATTTTGGATGGATCAAACCTCCTTAATTTTAATTTCTAATCCTAAAGTAAAGAGATGCAATTGGGGGCCTTCCATGTAGAAAGTGGGGTCAGGAGGCCAAGAAAGGGAATATGAATGTATATCCAAGTCACTCAGGAACTTTTATGCAGGTGCTAGAAACTTTATGTCAAAGTGGCCACAAGATTGTTTAATAGGAGACGAACGAATGTAACTCCATGTTTACTGCTAAAAACCAAAGCTTTGTGTAAAATCTTGAATTTATGGGGCGGGAGGGTAGGAAAGCCTGTACCTGTCTGTTTTTTTCCTGATCCTTTTCCCTCATTCCTGAACTGCAGGAGACTGAGCCCCTTTGGGCTTTGGTGACCCCATCACTGGGGTGTGTTTATTTGATGGTTGATTTTGCTGTACTGGGTACTTCCTTTCCCATTTTCTAATCATTTTTTAACACAAGCTGACTCTTCCCTTCCCTTCTCCTTTCCCTGGGAAAATACAATGAATAAATAAAGACTTATTGGTACGCAAACTGTCA

Publications

PMID - Link Title