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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SEC61GP1
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:193730408-193730765  UCSC
Coordinates (T2T) chr2:194222042-194222399  UCSC
Coordinates (hg19) chr2:194595132-194595489  UCSC
Strand -
Parental Sequence NM_014302.4
Parental seq. overlap 311 bp
Parental seq. overlap (%) 72.3%
Genomic Region Intergenic
Retrocopy Summary SEC61GP1, located on chr2:193730408-193730765, is a retrocopy of the parental gene SEC61G. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SEC61G
Full Name SEC61 translocon subunit gamma
Also known as SSS1
Coordinate chr7:54752253-54759211
Strand -
Gene summary The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SEC61GP1
Bonobo Pan paniscus SEC61GP1
Gorilla Gorilla gorilla SEC61GP1
Orangutan Pongo abelii SEC61GP1
Gibbon Nomascus leucogenys SEC61GP3
Green monkey Chlorocebus sabaeus SEC61GP1
Crab-eating macaque Macaca fascicularis SEC61GP2
Rhesus Macaca mulatta SEC61GP2
Baboon Papio anubis SEC61GP2
Golden snub-nosed monkey Rhinopithecus roxellana SEC61GP2
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SEC61GP1
AGGCAATCATGGATCATGTAATACAGTTTGTTGAGCCAAGTTGGCAGTTTGTAAAGGACTCAGTTCAGCTGGTTAAAGATGCTCCGAACCTGATAGAAAAAAATTTCAGAAGATTGCCATGGCAACAGCAATAAGATTTGCTATAATGGGATTCATTGGATTTTCTGTGCAATTGGTTCATATTCCTATTAATAACATAATTGCTGGTAGCTGAATATGTTTTGGAGGAGTGTTTTCCATCTTAGGGATGGGTGAACAAGTGAGGGTTTGAGAAGCTCATGGAGTGAAAATTTGCTGAATATTTTGTGGTTTCTTCCTTTTTATTTCTTCCAAGATGTTTTCTATTTCTAAATTAAAA
>NM_014302.4
ATCAGCAAGCTCCAGTGCTACGTGTCCCTGGCATTTTAGGTGTCGGTTGGGTAGGCAGTCATGGATCAGGTAATGCAGTTTGTTGAGCCAAGTCGGCAGTTTGTAAAGGACTCCATTCGGCTGGTTAAAAGATGCACTAAACCTGATAGAAAAGAATTCCAGAAGATTGCCATGGCAACAGCAATAGGATTTGCTATAATGGGATTCATTGGCTTCTTTGTGAAATTGATCCATATTCCTATTAATAACATCATTGTTGGTGGCTGAATACATTTTGGAAGAGAGTTTTTCATCTTAGAGATTGGTGAACAAGTGTGAGGGTGTGAGAAACTCACAGAATACAAATTTGCCTGTATGTTTTGTGGGTTTTTTTTTTTCCTTTCAAGATGTTTTCTATTTCTAAATTAAAGTAATTTCAAAGTAAA

Publications

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