Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CISD1P1
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr10). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:19826211-19826908  UCSC
Coordinates (T2T) chr2:19859774-19860471  UCSC
Coordinates (hg19) chr2:20025972-20026669  UCSC
Strand +
Parental Sequence NM_018464.5
Parental seq. overlap 618 bp
Parental seq. overlap (%) 26%
Genomic Region Intergenic
Retrocopy Summary CISD1P1, located on chr2:19826211-19826908, is a retrocopy of the parental gene CISD1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CISD1
Full Name CDGSH iron sulfur domain 1
Also known as C10orf70|MDS029|ZCD1|mitoNEET
Coordinate chr10:58269162-58289586
Strand +
Gene summary This gene encodes a protein with a CDGSH iron-sulfur domain and has been shown to bind a redox-active [2Fe-2S] cluster. The encoded protein has been localized to the outer membrane of mitochondria and is thought to play a role in regulation of oxidation. Genes encoding similar proteins are located on chromosomes 4 and 17, and a pseudogene of this gene is located on chromosome 2. [provided by RefSeq, Feb 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CISD1P1
Bonobo Pan paniscus CISD1P1
Gorilla Gorilla gorilla CISD1P1
Orangutan Pongo abelii CISD1P1
Gibbon Nomascus leucogenys CISD1P3
Green monkey Chlorocebus sabaeus CISD1P3
Crab-eating macaque Macaca fascicularis CISD1P3
Rhesus Macaca mulatta CISD1P3
Baboon Papio anubis CISD1P3
Golden snub-nosed monkey Rhinopithecus roxellana CISD1P5
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CISD1P1
TGGTATTCTAGTGCACACGCCTTGCAAGCAATGACGCCATGAGTCTGACTTCCAGTTCCAGCATACGAGTTGAATGGATCACAGCATTTACTATTGCTGCTGGGAGAGCTGCAACTGGTTATCTAGCTTACAAAAGATTTTATGACAAAGATCATCAGAATAAAGCTATGATGAACCTTCACATCCAGAAAGACAACCCCAAGATAGTACATGCTTTTGACATGGAGGATTTGGAAGATAAAGCTGTGTACTGCCATTGCTGGAGGTATAAAAAGTTCCCATTCTGTGATGGGTCTCACACAAAACACAACGAACAGACTGGAGACAACGTGGGACCTCTGATCATCGAGAAAAAAGAAACTTAACTGGACACTGTTGATGTTGCATATCAACTTGTGAAGTTAACTGATTGCTTAATTAGAATGACTACCACCTCTGTCTAATTCACCTCCCCTGGGTTCTAAATGCGGTATATTGCAAACTGCAGCTTTCGTATTGATGGCATTTGTCTTACTTTTTGAAACATCGTGGTGCACATTTGTTTaCCAACCTCATGGCCTGTGGGTTATTTTGGTCTTGTAAGGATCAGTTTCTTTAAAATATTGACATATACAGGTGTATCTTACACAGAATATAGTTGTATCTTGAAGTCAACATATTAAATTATTCTCAA
>NM_018464.5
AGCATCGCGGAGTCGGTGCTTTAGTACGCCGCTGGCACCTTTACTCTCGCCGGCCGCGCGAACCCGTTTGAGCTCGGTATCCTAGTGCACACGCCTTGCAAGCGACGGCGCCATGAGTCTGACTTCCAGTTCCAGCGTACGAGTTGAATGGATCGCAGCAGTTACCATTGCTGCTGGGACAGCTGCAATTGGTTATCTAGCTTACAAAAGATTTTATGTTAAAGATCATCGAAATAAAGCTATGATAAACCTTCACATCCAGAAAGACAACCCCAAGATAGTACATGCTTTTGACATGGAGGATTTGGGAGATAAAGCTGTGTACTGCCGTTGTTGGAGGTCCAAAAAGTTCCCATTCTGTGATGGGGCTCACACAAAACATAACGAAGAGACTGGAGACAATGTGGGCCCTCTGATCATCAAGAAAAAAGAAACTTAAATGGACACTTTTGATGCTGCAAATCAGCTTGTCGTGAAGTTACCTGATTGTTTAATTAGAATGACTACCACCTCTGTCTGATTCACCTTCGCTGGATTCTAAATGTGGTATATTGCAAACTGCAGCTTTCACATTTATGGCATTTGTCTTGTTGAAACATCGTGGTGCACATTTGTTTaaacaaaaaaaaaaaaaaaaaggaaaaaCCAACCTGCATGGCCTGTGGGTTATTTTGGTCTTGTAAGGATCCATTTCTTTAAAATACTGACATATAGAGTTGTACCTTATATAGAATATAGTTGTATCTTGAAGTCAACATATTAAATTATTCTCAAAATTATGTATTTGCAGATTGTACTTGTAAGTTTCAAAGAAAAATTACCATCTTTTCATATTGACCTGGAAACTAAATAGGATGTGATTCAGCTACATTAATTTCTTAATACAATCTAGGAAAGACCTGTTGTAGCCTTGATTTTCTTGACATTGGTAATGACACTGAGAAAATATGGCTTCTGTTTTTCACCGTTTTCAATCAAAATGATTGATAAATGTTATTCTGTTTAATTTCATAAGTCAGGTCAATAATAAAGGGGTGGTAACTTCCTCATATTTATCTTCACAGATATTTAATGAAGATGGATCCATTAAAGGAGCCAATAGTGAAAATTTAGTTAAAGGTGATATTAGATTTAAATTAGTCATGAAGAATGTCTTAAAATCTAATGTTCCAGAATTCTGGCCCAAGGAATGGTAAGCACTTGAACTGAGGATTTTGAAGGAATTGGAACATATAATGTCAAGTCTTTTGATCACTAAGCCACATATCCTGACAGAAATAGTAGTCACAAGATTAGATCAAAGGCGTGGGAAGATTTTTTTTTTTCCCACTCTAGCTAATCAAGCACATGGCTTTTAAATTGTATGATCTTTTTCTTAAAAGCAAAAATTTGAAGACAAGTGTTTGTTTATGTAATATTCTTCAAAGACTCCGAGCAGAAACATTGCATTCATTGTTGATTCAGAAAAAAGAAAATATAAAAACTGAAAATAATTAGCAATAAAAGATTTAAGACAAATAGTTCATAAATATTTTTAAAGAGATTAGGTTTTTGAATTTCATAGGTTAGAAGGAAAATCATGGCAAAATTTACAGAAAATTGGGCAAACAATTGAAATTGATAAAGCAGGTAAACATCATCATTTATTTTAGTATACATGAATTCTCAGTAGTAGTCAATCACAAATTTCTACTTGCTAAAATCCATTTACCTTGACAGGAATCAAACCTGACAGCAGCATATCCTATGTAATATATGATCATGGCTATTTTTAAATATGTAGTTTTGTGTATTACTGTAGATAAAAGTTGGTAACAAAATTGTACAGTGGTTTTAAGAAGCCCATGTAACTAACTTGGACATGTCTTTAAGTCACATATTCATCATAAAATCTAAAATCCTACAAACTGATTCTATTAGATTCTTAGGGTAAATTTTTTCTTTGCCCACCTCCTTCTTTTTAAGATAAGTATGCATGTCAGCAAAACAGAGCAATCATGCTTTTAAAGATGAACTGTTTTAAAGAAAAATAAATGCATCAACTCCCAGTGTTTCTGATAAAGGGACATCCTTCTAACTTAACAGACTATTCTTTATCTTGAATTTGAAATTATATTGTTAGTCATGCATTTTTGTAATGTCAGGGGGAACCTGGTACCAGTTCTCAAAACTATAGGATTATATGAGTGTGTGTATACATATGGCAAAATTATAAATGACCACCTTACTGTGAAATATAGATCTTGAGCATTTTGAAAGGCCAAAATAATTAGGTAAATGTATTTTCAAGGTCATGTTAAAATGTTTACATGCTTTTGAACTAGCATTCATTTATGATTAAAACCCTTTTCAGGTTATTTGACCTAAAAACCAAA

Publications

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