RCPedia: Rtcs

Summary

Retrocopy Name	SCYL2P1	Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species	Homo sapiens
Coordinates (hg38)	chr2:201409615-201413420 UCSC
Coordinates (T2T)	chr2:201890296-201894100 UCSC
Coordinates (hg19)	chr2:202274338-202278143 UCSC
Strand	-
Parental Sequence	NM_001317784.2
Parental seq. overlap	3025 bp
Parental seq. overlap (%)	51.4%
Genomic Region	Intragenic (TRAK2)
Retrocopy Summary	SCYL2P1, located on chr2:201409615-201413420, is a retrocopy of the parental gene SCYL2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name	SCYL2
Full Name	SCY1 like pseudokinase 2
Also known as	AMC4\|AMCNACC\|CVAK104
Coordinate	chr12:100267177-100341715
Strand	+
Gene summary	The protein encoded by this gene associates with clathrin-coated complexes at the plasma membrane and with endocytic coated vesicles. The encoded protein phosphorylates the beta2 subunit of the plasma membrane adapter complex AP2 and interacts with clathrin, showing involvement in clathrin-dependent pathways between the trans-Golgi network and the endosomal system. In addition, this protein has a role in the Wnt signaling pathway by targeting frizzled 5 (Fzd5) for lysosomal degradation. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]

Homology

Species	Scientific Name	Retrocopy
Chimpanzee	Pan troglodytes	SCYL2P2
Bonobo	Pan paniscus	SCYL2P1
Gorilla	Gorilla gorilla	SCYL2P1
Orangutan	Pongo abelii	SCYL2P1
Gibbon	Nomascus leucogenys	SCYL2P1
Green monkey	Chlorocebus sabaeus	SCYL2P1
Crab-eating macaque	Macaca fascicularis	SCYL2P1
Rhesus	Macaca mulatta	SCYL2P1
Baboon	Papio anubis	SCYL2P1
Golden snub-nosed monkey	Rhinopithecus roxellana	SCYL2P1
Marmoset	Callithrix jacchus	SCYL2P1
Mouse lemur	Microcebus murinus	Without Homology
Mouse	Mus musculus	Without Homology
Rat	Rattus norvegicus	Without Homology
Chinese hamster	Cricetulus griseus	Without Homology
Rabbit	Oryctolagus cuniculus	Without Homology
Pig	Sus scrofa	Without Homology
Cow	Bos taurus	Without Homology
Sheep	Ovis aries	Without Homology
Dolphin	Tursiops truncatus	Without Homology
Horse	Equus caballus	Without Homology
Dog	Canis familiaris	Without Homology
Panda	Ailuropoda melanoleuca	Without Homology
Cat	Felis catus	Without Homology
Pale spear-nosed bat	Phyllostomus discolor	Without Homology
Velvety free-tailed bat	Molossus molossus	Without Homology
Greater mouse-eared bat	Myotis myotis	Without Homology
Kuhl's pipistrelle	Pipistrellus kuhlii	Without Homology
Greater horseshoe bat	Rhinolophus ferrumequinum	Without Homology
Egyptian rousette	Rousettus aegyptiacus	Without Homology
Sloth	Choloepus didactylus	Without Homology
Tasmanian Devil	Sarcophilus harrisii	Without Homology
Opossum	Monodelphis domestica	Without Homology
Platypus	Ornithorhynchus anatinus	Without Homology
Chicken	Gallus gallus	Without Homology
Turkey	Meleagris gallopavo	Without Homology
Zebra Finch	Taeniopygia guttata	Without Homology
Budgerigar	Melopsittacus undulatus	Without Homology
Painted Turtle	Chrysemys picta	Without Homology
Lizard	Anolis Carolinensis	Without Homology
Frog	Xenopus tropicalis	Without Homology
Zebrafish	Danio rerio	Without Homology
Drosophila	Drosophila melanogaster	Without Homology

Expression

Related Sequence

>SCYL2P1
CCTCTTCAGGTTTTTAAAGACCCAACCCTTCCCAGTCTCAAAGAGAAAAAGGACAACTGAGTTATCTTGAATAGCTGAATTTTTTAATCAAATGTTTATTTTGGCTTGTGAATCTTGGTGTTATTTAAAAAATTGAGTTGATGGTCATTGCAAGCTCATCTATTTTAAGTACCACATGGTACACAGTCTACCTTCACAAGTCATTAGTGTTCACTTTAATATGTAAAAAATCTTGATGCTGTATTGATTTGCTTGCATTTAAGATGACAGTGAGAAAATGATAAGCATAAAGAGATCAGCTTATTTGCTTTTTCCGAGGTTACTTTTCAGATGAACTAATGTTTAGTACAAAGAGACTGAGCAAATACTACAAAATTTAACTTGACCTACATTTCGTTGGCGAAGGCAGAGCAGGAACAGCCTGTGTTTAGGGGGGTGGGGAAAAAGAGGCCCAGTTCTGCCCCTCCTGGAAGGAGAGGGAAAAGGTAACTATAACTACCCAATATTGCAGCCATGGAGTCCATGTTTAATAAATTGAAGAGTACTGTTACAGAAGTAACAGCTGATGTCACTAGTGCTGTAATGAGAAATCCTGTCACTAGAGAATTTGATGTTGGTCAGCACATTGCCAGTGGTGGCAGTGGGCTAGCTTGGAAGATTTTTAATGGCACAAAAAAGTCAACAAAGCAGTGGCTGTTTTTGTCTTTGATAAAAAATGATTGACAAATATCAAAAATTTGAAAAGGATCAAATAATTGATTCTCTAAAATGAGGAGTCCAACACTTAACTCGACTTCAACACCCTCGACTTCTTACTGTCCAGCATTCTTTAGAAGAATCCAGGGATTGCTTGGTGTTGTGTACAGAACCAGTTTTTTGCCAGTTTAGCCAGTGTTCTTGGTAACTGGGAAAATCTCCCTTTCCCTATATCTCCAGACATTAAGGATTATAAACTTTATGATGTAGAAACCAAATGTGGTTTGCTTCAGGTTTCTAAAGGATTGTCATTCTTGCATAGCAGTGTGAAAATGGTACATGGAAATATTACTCCTGAAAATACAATTTTGAATAAAAGTGGAGCCTGGAAAATAATGGGTTTTGATTGTTGTGTATCATCAACCAATCCTTCTGAACAAGAGCCTAAATTTCCTTGTAAAGAATGGGACCCAAATTTACCTTCATTGTGTCTTCCAAATCCTGAATATTTGCCTCCTGAATACATACTTTATGTGAGCTGTGAAACAGTCAGTGATATATATTCTTTAGGAACTGTTATGTATGCTGTATTTAATAAAAGGAAACATATATTTGAAGGCAATAAGCAAGACATTTATAAGAGTTTCAGTAGGCAGTTGGATCAGTTGAGTTATTTAGGATCTAGTTCACTTATAAATATACCTGAGGAAGTTCGTGAACATGTAAGGCTACTGTTAAATGTAACTCCAACTGTAAGACCAGATGCAGATCAAATGACAAAGATTCCCTTCTTTGATGATGTTGGTGCAGTAACACTGCAATATTTTGATACCTTATTCCAAAGAGATAATCTTCAGAAATCACAGTTTTTCAACGGACTGCCAAAGGTTCTACTGCCCAAGCATGTCATTGTACAGAGAATTTTGATTTGACTTCAGAATTTGTAAACCCTGACATGGTACCTTTTGTTTTGCCCAGTGTTCTACTGATCGTTGAGGAATGCACCAAAGAAGAATATGTCACATTAATTCCACCTGAACTTGGCCCTGTGTTTAAGCAGCAGGAGCCAATCCAGATTTTGTTAATTTTCCTACAAAAAATGGATTTGCTACTAACCAAAACCCCTCCCAATGAGATAAAGAACAGTGTTCTACCCATGGTTTACAGAGCACTAGAAGCTCCTTCCATTCAATACCAGGAGCTCTGTCTAAACATCATTCCAACCTTTGCAAATCTTATAGACTACCCATCATGAAACATACTTTGATACCAAGAATTAAAAATGCCTGTCTACAAATGTCTTCCCTTGCTGTTCCTGTAAATTCATTAGTGTGCTTAGGAAAGATTTTGGAATACTTGGATAAGTGGTTGGTACTTGATGGTATCCTACCCTTCTTACAACAAATTCCATCCAAAGAGTCTGCAGTCCTCATGGGTATTTTAGGCATTTACAAATGTACTTTTACTCATAAGTTGGGAATCACCAAAGAGCAGCTGACTGGAAAAGTATTGCCTCATCTTATTCCCCTGAGTATTGAAAACAATCTTAATCAGTTCAATTCTTTCATTTCCATCATAAAAGAGATGCTGAATAGGTTGGAGTCTGAACATAAGACTAAGCTGGAGCAACTTCATATAATGCAAGAACAACAGAAATCTTTGGACATAGGAAATCAAATGAATGTTTCTGAGGAGACAAAAGTTACAAATATTGGGAATCAGCAAATTGACAAGGTTTTTAGCCACATTGGAGCAGACCTTCTGACTGGCAGTGATTCCGAAAATAAAGAGGATGGGTTTCAGAATAAACATAAAAGAGCATCACTTACACTTGAAGAAAAACAAAAATTAGCAAGAGAACAAGAGCAGGCATAGAAGTTGAAAGGCCAGCAGCCTCTTAAACCCCAAGTGTACACACCTATTGCTGCTGTTAAACAGACTAAGGACTTGACAGACACATTGATGGATAATATGTCATCTTTGACTAGCCTTTCTGTTAGTACCCCTAAACCTTCTGCTTCAAGTACGTTCACTTCTGTTCCTTCCATGGGCATTGACATGATGTTTTCTACACCAGTTGATAATACAAAGAGAAATTTGACAAATGGCCTAAATGTCAATATGGGCTTTCAGACTTCAGGATTCAACATGCCCGTTACTACAAACCAGAACTTCTACAGTAGTCCAAGCACAGTTGGAGTGACCAAAATGACTCTGGAACACCTCCCACTTTGCCAAACTTCAGTGCTTTGAATGTTCCTCCTGCTGGTGCGAAGCCAACCCAACAAAGACCCACAGATATGTCTGCCCTTAATAATCTCTTTGGCCCTCAGAAACCCAAAGTTAGCATGAACCAATTATCACAACAGAAACCAAATCAGTGGCTTAATCAGTTTGTACCTCCTCAAGTTTCTCCAGCTACGGGCAGTTCAGTAATGGGAACACAGATGAACATGATAGGACAATCTGCCTTTGGTATGCAGGGTAATCCTTTCTTCAACCCACAGAACTTTGCATAGCCACCAACTGCTATGACCAATAGCAGTTCAGCTAGCAATGATTTTAAAGATCTTTTTGGGTGAGGTGTCTATTTTGAAGGATTATTTCAGTTCCAATCATGGGTGAGCTGATTTACATCTTTATGTAGTTGGCTTGGAGGAACTACTTCTATGGGACAGTGAATGGTTCTGTGACAGAAAACATCTGTGTCCATGCCAGCATAGTAGTTGTATGGACTTCTAACCAGTTGAGTTTTTTTAAAGCACTGAGGATTTTTTTCCTCTTACCAACTCCTCTCCAGGt

>NM_001317784.2
AGTCTTTTTCcccctcccttactcttcgtccccggtccctcccctccccacccctTTCCTTCTAGCTCCGACGTTTGCGGCCGCGGGGGCGGCGGAGGATATGGAGTAAAGCCAGAGTCAGTGGCCAGGCACGAAGGCAGAGCAGGAACAGCCAGGAGGCGTTTATTAGGGGGGCGGGGGGAAAGAGCCCCAGCACCGCCCCTCCTGGAAGAAGGAAGAGGTAACTATAACTACCCAATATTGCAGCCATGGAGTCCATGCTTAATAAATTGAAGAGTACTGTTACAAAAGTAACAGCTGATGTCACTAGTGCTGTAATGGGAAATCCTGTCACTAGAGAATTTGATGTTGGTCGACACATTGCCAGTGGTGGCAATGGGCTAGCTTGGAAGATTTTTAATGGCACAAAAAAGTCAACAAAGCAGGAAGTGGCAGTTTTTGTCTTTGATAAAAAACTGATTGACAAGTATCAAAAATTTGAAAAGGATCAAATCATTGATTCTCTAAAACGAGGAGTCCAACAGTTAACTCGGCTTCGACACCCTCGACTTCTTACTGTCCAGCATCCTTTAGAAGAATCCAGGGATTGCTTGGCATTTTGTACAGAACCAGTTTTTGCCAGTTTAGCCAATGTTCTTGGTAACTGGGAAAATCTACCTTCCCCTATATCTCCAGACATTAAGGATTATAAACTTTATGATGTAGAAACCAAATATGGTTTGCTTCAGGTTTCTGAAGGATTGTCATTCTTGCATAGCAGTGTGAAAATGGTGCATGGAAATATCACTCCTGAAAATATAATTTTGAATAAAAGTGGAGCCTGGAAAATAATGGGTTTTGATTTTTGTGTATCATCAACCAATCCTTCTGAACAAGAGCCTAAATTTCCTTGTAAAGAATGGGACCCAAATTTACCTTCATTGTGTCTTCCAAATCCTGAATATTTGGCTCCTGAATACATACTTTCTGTGAGCTGTGAAACAGCCAGTGATATGTATTCTTTAGGAACTGTTATGTATGCTGTATTTAATAAAGGGAAACCTATATTTGAAGTCAACAAGCAAGATATTTACAAGAGTTTCAGTAGGCAGTTGGATCAGTTGAGTCGTTTAGGATCTAGTTCACTTACAAATATACCTGAGGAAGTTCGTGAACATGTAAAGCTACTGTTAAATGTAACTCCGACTGTAAGACCAGATGCAGATCAAATGACAAAGATTCCCTTCTTTGATGATGTTGGTGCAGTAACACTGCAATATTTTGATACCTTATTCCAAAGAGATAATCTTCAGAAATCACAGTTTTTCAAAGGACTGCCAAAGGTTCTACCAAAACTGCCCAAGCGTGTCATTGTGCAGAGAATTTTGCCTTGTTTGACTTCAGAATTTGTAAACCCTGACATGGTACCTTTTGTTTTGCCCAATGTTCTACTTATTGCTGAGGAATGCACCAAAGAAGAATATGTCAAATTAATTCTTCCTGAACTTGGCCCTGTGTTTAAGCAGCAGGAGCCAATCCAGATTTTGTTAATTTTCCTACAAAAAATGGATTTGCTACTAACCAAAACCCCTCCTGATGAGATAAAGAACAGTGTTCTACCCATGGTTTACAGAGCACTAGAAGCTCCTTCCATTCAGATCCAGGAGCTCTGTCTAAACATCATTCCAACCTTTGCAAATCTTATAGACTACCCATCCATGAAAAACGCTTTGATACCAAGAATTAAAAATGCTTGTCTACAAACATCTTCCCTTGCGGTTCGTGTAAATTCATTAGTGTGCTTAGGAAAGATTTTGGAATACTTGGATAAGTGGTTTGTACTTGATGATATCCTACCCTTCTTACAACAAATTCCATCCAAGGAACCTGCGGTCCTCATGGGAATTTTAGGTATTTACAAATGTACTTTTACTCATAAGAAGTTGGGAATCACCAAAGAGCAGCTGGCCGGAAAAGTGTTGCCTCATCTTATTCCCCTGAGTATTGAAAACAATCTTAATCTTAATCAGTTCAATTCTTTCATTTCCGTCATAAAAGAAATGCTTAATAGATTGGAGTCTGAACATAAGACTAAACTGGAGCAACTTCATATAATGCAAGAACAGCAGAAATCTTTGGATATAGGAAATCAAATGAATGTTTCTGAGGAGATGAAAGTTACAAATATTGGGAATCAGCAAATTGACAAAGTTTTTAACAACATTGGAGCAGACCTTCTGACTGGCAGTGAGTCCGAAAATAAAGAGGACGGGTTACAGAATAAACATAAAAGAGCATCACTTACACTTgaagaaaaacaaaaattagcaaaagaacaagagcaggcacagaaGCTGAAAAGCCAGCAGCCTCTTAAACCCCAAGTGCACACACCTGTTGCTACTGTTAAACAGACTAAGGACTTGACAGACACACTGATGGATAATATGTCATCCTTGACCAGCCTTTCTGTTAGTACCCCTAAATCTTCTGCTTCAAGTACTTTCACTTCTGTTCCTTCCATGGGCATTGGTATGATGTTTTCTACACCAACTGATAATACAAAGAGAAATTTGACAAATGGCCTAAATGCCAATATGGGCTTTCAGACTTCAGGATTCAACATGCCCGTTAATACAAACCAGAACTTCTACAGTAGTCCAAGCACAGTTGGAGTGACCAAGATGACTCTGGGAACACCTCCCACTTTGCCAAACTTCAATGCTTTGAGTGTTCCTCCTGCTGGTGCAAAGCAGACCCAACAAAGACCCACAGATATGTCTGCCCTTAATAATCTCTTTGGCCCTCAGAAACCCAAAGTTAGCATGAACCAGTTATCACAACAGAAACCAAATCAGTGGCTTAATCAGTTTGTACCTCCTCAAGGTTCTCCAACTATGGGCAGTTCAGTAATGGGGACACAGATGAACGTGATAGGACAATCTGCTTTTGGTATGCAGGGTAATCCTTTCTTTAACCCACAGAACTTTGCACAGCCACCAACTACTATGACCAATAGCAGTTCAGCTAGCAATGATTTAAAAGATCTTTTTGGGTGAGGTGTCTTACTTCTATTTTGAAGGATTATTTCAGTTTCAATCATGGGTGAGCTGATTTACATCTTTATATAGTTGGCTTGGAGGAAGTACTTCTATGGGAAAGTGAACAGTTCTGTGACAGGAAACATCTCTGTCCATGCCAGCATAGTAGTTGTATGGACTTCTAACCAGTTGAGTTTTTTAAAGCATTGAGGATTTTTTCCTCTTACCAACTCCTCTTCAGGTTTTTAAAGACCCAGCCCTTCCCAATCTCAAAGAGAAAAAGGAAACTGAGTTATCTTGAATAACATAACTTTTTAATCAAATGTTTATTTTGGCTTGTGGATCTTGGTGTTATTTAAAAAATTGAGGTGATGGTCATTGCAAGCTCATCTATTAAGTACTATATGGTACACAGTCTATGAGTCATTAGTCTTCATTTTAATATGTAAAAAATCTTGATGCTGTATTGATTTGTTTGCATTTAAGATGACAGTGAGAAAATGATAAGCATAAAGAGAAGTATCAGGTTATTTGCTTTTTCCAAACTTTTCAGATGAACTATTGTTTAGTACAGAGACTGAGCAAATACTACAAAATTCAACTTAACCTTCATTTCATTGGTTTAAATGCGTTATTAACCATCTTAAGTGCAAACTAATCATTGTAAATTATATTTTAGCATGGTCTGCCTCAAATAGTAATGTATTTTTCTGCATTCACTTGGATATATTTAGAATCACTTTTTTCCTCCTGTATCAAGGAAGAGGTATGTGCTGATTTGTTTGGATATTTGACAAGGCACTCTGATGTGACTTCCCTGACTACTACCTTCATATTTCATTTCAAATTCAAACTTCTGAGGTTGCAGCATATATGAATTGCATTTTCAAAAGAAGATTTGTAAGAATTAAACTATATTTATGAGTAAACTTTTGAGGTTTCTGCTGTATTGTTTCAAATGTAATAAACTTTACTTCTGTAAAAATTGAGCAGTTGTATCTTCTGACCACCAACAGATTTTCAGCTTGCCATGATAGTCTGACCTCATTAATTACTGCTACTGAAGTTCAATTTTTTTCTAGGAATTTTAGGAACCTTTTGTTTAAATATTTTAATTTCTATTAGCCATTTTTAGGAAGGAAAGAATCAATTCTCTTAACAGGAAACATGCTTTATTTTTCAAAACCTTTCTCTGATATTTTTCTTTAATTTGCTGATTATTCAACCACAGAGCCTTATGCTATAAATGTCATTTGTATTTTAAAAAATAATATTCCACTCATAAAACTTTAAAACCATCTTTCAACGAACTATATATGTATTATAGTTGCTGCCATAGAGTTGATGGTTTTTAATTATCTGGAACCAGCAATCATTTAAAATAAACCATATTAAGTTTAGTATGCTGGTATTGTTTATTCATTTTATATGAATATTCATTGAAAATATATACACAATATATGTAATACACAGCACTTGATTACAAAATGTAATTTAATTATATTATTGCTGGCAGCATTCAGTTAAGAGGGTACTTTAAAAAATAGAAGTCAGCTTTCACATCTGATTTCTGTATGGGCTGTACTTGGTTAACTTGATTTTAGAAAAAGGACTAACAGAATTGCTAAAGAAATGCATCCAATAAATGAAAAACAGTAGGAAGATCAAATGTTTTTGTCAAATATATTCACAACTTGACCAGATTAGCTGTCCTGTTTGTAATGCAATATTAATATGTCTTTTGGGAAAAAGCCTACATATGGAATAAAATAAGTATTGAAGAATTTTTCTTTGTAACAATTTAGTAGTCACTGTTTATTGAGAAATTGTTTTTTATTTTGTAAAATAACATGATGTTAGTGTTGAACTCTTAAACAGAAAGAAAGCTTAATATAACAGCTTATAGAACTTGAACTACTAAATATGAAAATAAGTCATTTGAAAAAAATACAGTATGTAAAATTTGTTCATTCGTTGAGGTAATGGTGCTATGTTTTTACAAAATTGTTCCTACACCTTTTTTCTACTTCAGGTATTTTATTTCAACCATTTCCATCAATTGAACTGTTACCATTGCCTTTTTCTGTTGAGAAATTGCCTCTGAAAAATAGTGCTATTTTTCAGCTTAAGTGTTCTTAAGTGAATGAAATTTTCAAAGTACTAGATCACCTTAAAATTATTTCACGTACTGAAGACAATTAAGTCCGTTATGTTTAGAGTAGAAAATGTTTAGGTTAAAGAGCATCTGTCAACAGAATCTACAAAAAAGATTCCCTTGCATTTGAATTAGTTCTCTATTCTCCTATTGCTAAATGTGTGATATATAGAGAGGATGTATAAAAGGAAATGGAAATAGACTATGTACTTGTCTGGTTTTTGTTTGTTTTTATTTTGGAATGCTTATAAGCCTCCTTTACACTGAATAAGGAAGTAGTTTTTGTTTTCTTTTGACCTGTAAAATACCTCACATGGTTGTTTTTACACATGAAAGAAAAAGGTATATGCGAACATACCTGATATCAAGAGGAGTATGCACCAAATAAATTTTAGCTTTGATAAAA

>NM_001317784.2 

AGTCTTTTTCcccctcccttactcttcgtccccggtccctcccctccccacccctTTCCTTCTAGCTCCGACGTTTGCGGCCGCGGGGGCGGCGGAGGATATGGAGTAAAGCCAGAGTCAGTGGCCAGGCACGAAGGCAGAGCAGGAACAGCCAGGAGGCGTTTATTAGGGGGGCGGGGGGAAAGAGCCCCAGCACCGCCCCTCCTGGAAGAAGGAAGAGGTAACTATAACTACCCAATATTGCAGCCATGGAGTCCATGCTTAATAAATTGAAGAGTACTGTTACAAAAGTAACAGCTGATGTCACTAGTGCTGTAATGGGAAATCCTGTCACTAGAGAATTTGATGTTGGTCGACACATTGCCAGTGGTGGCAATGGGCTAGCTTGGAAGATTTTTAATGGCACAAAAAAGTCAACAAAGCAGGAAGTGGCAGTTTTTGTCTTTGATAAAAAACTGATTGACAAGTATCAAAAATTTGAAAAGGATCAAATCATTGATTCTCTAAAACGAGGAGTCCAACAGTTAACTCGGCTTCGACACCCTCGACTTCTTACTGTCCAGCATCCTTTAGAAGAATCCAGGGATTGCTTGGCATTTTGTACAGAACCAGTTTTTGCCAGTTTAGCCAATGTTCTTGGTAACTGGGAAAATCTACCTTCCCCTATATCTCCAGACATTAAGGATTATAAACTTTATGATGTAGAAACCAAATATGGTTTGCTTCAGGTTTCTGAAGGATTGTCATTCTTGCATAGCAGTGTGAAAATGGTGCATGGAAATATCACTCCTGAAAATATAATTTTGAATAAAAGTGGAGCCTGGAAAATAATGGGTTTTGATTTTTGTGTATCATCAACCAATCCTTCTGAACAAGAGCCTAAATTTCCTTGTAAAGAATGGGACCCAAATTTACCTTCATTGTGTCTTCCAAATCCTGAATATTTGGCTCCTGAATACATACTTTCTGTGAGCTGTGAAACAGCCAGTGATATGTATTCTTTAGGAACTGTTATGTATGCTGTATTTAATAAAGGGAAACCTATATTTGAAGTCAACAAGCAAGATATTTACAAGAGTTTCAGTAGGCAGTTGGATCAGTTGAGTCGTTTAGGATCTAGTTCACTTACAAATATACCTGAGGAAGTTCGTGAACATGTAAAGCTACTGTTAAATGTAACTCCGACTGTAAGACCAGATGCAGATCAAATGACAAAGATTCCCTTCTTTGATGATGTTGGTGCAGTAACACTGCAATATTTTGATACCTTATTCCAAAGAGATAATCTTCAGAAATCACAGTTTTTCAAAGGACTGCCAAAGGTTCTACCAAAACTGCCCAAGCGTGTCATTGTGCAGAGAATTTTGCCTTGTTTGACTTCAGAATTTGTAAACCCTGACATGGTACCTTTTGTTTTGCCCAATGTTCTACTTATTGCTGAGGAATGCACCAAAGAAGAATATGTCAAATTAATTCTTCCTGAACTTGGCCCTGTGTTTAAGCAGCAGGAGCCAATCCAGATTTTGTTAATTTTCCTACAAAAAATGGATTTGCTACTAACCAAAACCCCTCCTGATGAGATAAAGAACAGTGTTCTACCCATGGTTTACAGAGCACTAGAAGCTCCTTCCATTCAGATCCAGGAGCTCTGTCTAAACATCATTCCAACCTTTGCAAATCTTATAGACTACCCATCCATGAAAAACGCTTTGATACCAAGAATTAAAAATGCTTGTCTACAAACATCTTCCCTTGCGGTTCGTGTAAATTCATTAGTGTGCTTAGGAAAGATTTTGGAATACTTGGATAAGTGGTTTGTACTTGATGATATCCTACCCTTCTTACAACAAATTCCATCCAAGGAACCTGCGGTCCTCATGGGAATTTTAGGTATTTACAAATGTACTTTTACTCATAAGAAGTTGGGAATCACCAAAGAGCAGCTGGCCGGAAAAGTGTTGCCTCATCTTATTCCCCTGAGTATTGAAAACAATCTTAATCTTAATCAGTTCAATTCTTTCATTTCCGTCATAAAAGAAATGCTTAATAGATTGGAGTCTGAACATAAGACTAAACTGGAGCAACTTCATATAATGCAAGAACAGCAGAAATCTTTGGATATAGGAAATCAAATGAATGTTTCTGAGGAGATGAAAGTTACAAATATTGGGAATCAGCAAATTGACAAAGTTTTTAACAACATTGGAGCAGACCTTCTGACTGGCAGTGAGTCCGAAAATAAAGAGGACGGGTTACAGAATAAACATAAAAGAGCATCACTTACACTTgaagaaaaacaaaaattagcaaaagaacaagagcaggcacagaaGCTGAAAAGCCAGCAGCCTCTTAAACCCCAAGTGCACACACCTGTTGCTACTGTTAAACAGACTAAGGACTTGACAGACACACTGATGGATAATATGTCATCCTTGACCAGCCTTTCTGTTAGTACCCCTAAATCTTCTGCTTCAAGTACTTTCACTTCTGTTCCTTCCATGGGCATTGGTATGATGTTTTCTACACCAACTGATAATACAAAGAGAAATTTGACAAATGGCCTAAATGCCAATATGGGCTTTCAGACTTCAGGATTCAACATGCCCGTTAATACAAACCAGAACTTCTACAGTAGTCCAAGCACAGTTGGAGTGACCAAGATGACTCTGGGAACACCTCCCACTTTGCCAAACTTCAATGCTTTGAGTGTTCCTCCTGCTGGTGCAAAGCAGACCCAACAAAGACCCACAGATATGTCTGCCCTTAATAATCTCTTTGGCCCTCAGAAACCCAAAGTTAGCATGAACCAGTTATCACAACAGAAACCAAATCAGTGGCTTAATCAGTTTGTACCTCCTCAAGGTTCTCCAACTATGGGCAGTTCAGTAATGGGGACACAGATGAACGTGATAGGACAATCTGCTTTTGGTATGCAGGGTAATCCTTTCTTTAACCCACAGAACTTTGCACAGCCACCAACTACTATGACCAATAGCAGTTCAGCTAGCAATGATTTAAAAGATCTTTTTGGGTGAGGTGTCTTACTTCTATTTTGAAGGATTATTTCAGTTTCAATCATGGGTGAGCTGATTTACATCTTTATATAGTTGGCTTGGAGGAAGTACTTCTATGGGAAAGTGAACAGTTCTGTGACAGGAAACATCTCTGTCCATGCCAGCATAGTAGTTGTATGGACTTCTAACCAGTTGAGTTTTTTAAAGCATTGAGGATTTTTTCCTCTTACCAACTCCTCTTCAGGTTTTTAAAGACCCAGCCCTTCCCAATCTCAAAGAGAAAAAGGAAACTGAGTTATCTTGAATAACATAACTTTTTAATCAAATGTTTATTTTGGCTTGTGGATCTTGGTGTTATTTAAAAAATTGAGGTGATGGTCATTGCAAGCTCATCTATTAAGTACTATATGGTACACAGTCTATGAGTCATTAGTCTTCATTTTAATATGTAAAAAATCTTGATGCTGTATTGATTTGTTTGCATTTAAGATGACAGTGAGAAAATGATAAGCATAAAGAGAAGTATCAGGTTATTTGCTTTTTCCAAACTTTTCAGATGAACTATTGTTTAGTACAGAGACTGAGCAAATACTACAAAATTCAACTTAACCTTCATTTCATTGGTTTAAATGCGTTATTAACCATCTTAAGTGCAAACTAATCATTGTAAATTATATTTTAGCATGGTCTGCCTCAAATAGTAATGTATTTTTCTGCATTCACTTGGATATATTTAGAATCACTTTTTTCCTCCTGTATCAAGGAAGAGGTATGTGCTGATTTGTTTGGATATTTGACAAGGCACTCTGATGTGACTTCCCTGACTACTACCTTCATATTTCATTTCAAATTCAAACTTCTGAGGTTGCAGCATATATGAATTGCATTTTCAAAAGAAGATTTGTAAGAATTAAACTATATTTATGAGTAAACTTTTGAGGTTTCTGCTGTATTGTTTCAAATGTAATAAACTTTACTTCTGTAAAAATTGAGCAGTTGTATCTTCTGACCACCAACAGATTTTCAGCTTGCCATGATAGTCTGACCTCATTAATTACTGCTACTGAAGTTCAATTTTTTTCTAGGAATTTTAGGAACCTTTTGTTTAAATATTTTAATTTCTATTAGCCATTTTTAGGAAGGAAAGAATCAATTCTCTTAACAGGAAACATGCTTTATTTTTCAAAACCTTTCTCTGATATTTTTCTTTAATTTGCTGATTATTCAACCACAGAGCCTTATGCTATAAATGTCATTTGTATTTTAAAAAATAATATTCCACTCATAAAACTTTAAAACCATCTTTCAACGAACTATATATGTATTATAGTTGCTGCCATAGAGTTGATGGTTTTTAATTATCTGGAACCAGCAATCATTTAAAATAAACCATATTAAGTTTAGTATGCTGGTATTGTTTATTCATTTTATATGAATATTCATTGAAAATATATACACAATATATGTAATACACAGCACTTGATTACAAAATGTAATTTAATTATATTATTGCTGGCAGCATTCAGTTAAGAGGGTACTTTAAAAAATAGAAGTCAGCTTTCACATCTGATTTCTGTATGGGCTGTACTTGGTTAACTTGATTTTAGAAAAAGGACTAACAGAATTGCTAAAGAAATGCATCCAATAAATGAAAAACAGTAGGAAGATCAAATGTTTTTGTCAAATATATTCACAACTTGACCAGATTAGCTGTCCTGTTTGTAATGCAATATTAATATGTCTTTTGGGAAAAAGCCTACATATGGAATAAAATAAGTATTGAAGAATTTTTCTTTGTAACAATTTAGTAGTCACTGTTTATTGAGAAATTGTTTTTTATTTTGTAAAATAACATGATGTTAGTGTTGAACTCTTAAACAGAAAGAAAGCTTAATATAACAGCTTATAGAACTTGAACTACTAAATATGAAAATAAGTCATTTGAAAAAAATACAGTATGTAAAATTTGTTCATTCGTTGAGGTAATGGTGCTATGTTTTTACAAAATTGTTCCTACACCTTTTTTCTACTTCAGGTATTTTATTTCAACCATTTCCATCAATTGAACTGTTACCATTGCCTTTTTCTGTTGAGAAATTGCCTCTGAAAAATAGTGCTATTTTTCAGCTTAAGTGTTCTTAAGTGAATGAAATTTTCAAAGTACTAGATCACCTTAAAATTATTTCACGTACTGAAGACAATTAAGTCCGTTATGTTTAGAGTAGAAAATGTTTAGGTTAAAGAGCATCTGTCAACAGAATCTACAAAAAAGATTCCCTTGCATTTGAATTAGTTCTCTATTCTCCTATTGCTAAATGTGTGATATATAGAGAGGATGTATAAAAGGAAATGGAAATAGACTATGTACTTGTCTGGTTTTTGTTTGTTTTTATTTTGGAATGCTTATAAGCCTCCTTTACACTGAATAAGGAAGTAGTTTTTGTTTTCTTTTGACCTGTAAAATACCTCACATGGTTGTTTTTACACATGAAAGAAAAAGGTATATGCGAACATACCTGATATCAAGAGGAGTATGCACCAAATAAATTTTAGCTTTGATAAAA

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