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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RFC2P1
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Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:208135353-208135806  UCSC
Coordinates (T2T) chr2:208615371-208615824  UCSC
Coordinates (hg19) chr2:209000077-209000530  UCSC
Strand -
Parental Sequence NM_181471.3
Parental seq. overlap 389 bp
Parental seq. overlap (%) 23%
Genomic Region Intragenic (CRYGC)
Retrocopy Summary RFC2P1, located on chr2:208135353-208135806, is a retrocopy of the parental gene RFC2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RFC2
Full Name replication factor C subunit 2
Also known as RFC40
Coordinate chr7:74231502-74254405
Strand -
Gene summary This gene encodes a member of the activator 1 small subunits family. The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins, proliferating cell nuclear antigen (PCNA) and replication factor C (RFC). Replication factor C, also called activator 1, is a protein complex consisting of five distinct subunits. This gene encodes the 40 kD subunit, which has been shown to be responsible for binding ATP and may help promote cell survival. Disruption of this gene is associated with Williams syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been described. A pseudogene of this gene has been defined on chromosome 2. [provided by RefSeq, Jul 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RFC2P1
Bonobo Pan paniscus RFC2P1
Gorilla Gorilla gorilla RFC2P1
Orangutan Pongo abelii RFC2P1
Green monkey Chlorocebus sabaeus RFC2P1
Crab-eating macaque Macaca fascicularis RFC2P1
Rhesus Macaca mulatta RFC2P1
Baboon Papio anubis RFC2P1
Golden snub-nosed monkey Rhinopithecus roxellana RFC2P1
Gibbon Nomascus leucogenys Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Massive Mining of Publicly Available RNA-seq Data from Human and Mouse - (ARCHS4)

Related Sequence

>RFC2P1
GGCCTAGAAGCCATCATCCTCATGGGTCAGGGAGACATGAGACAGGCCCTGAACAACTTGCAGTCCATCTTCCCAGGATCTGGCTTCAGTTACAGCGAGAAGTATGTTCAGGGTCTGCGACGAGCCCCACCCCCTGCTCATGAAGGAGATGATCCAGCACTGTGTGAATGCCCATGTCAAGGAAACCTACAAGATTCCTGCTCACCTATGGCATCTGGGCTACTCACCAGAAGATGTCATTGGCAACATCTTCCAAGTGTGTAAAACTTTCCAAATGGCAGAATAACTGATAAAGTGGAGTTTGTCAAGGAAATTGGATACACTGGTATGAAAGCAGAGGAGGAGTGAACTCCCTTCTGCCGACAACGGGGCTCCTGGCCAGGCTACGTCAGAAGACAATGGCCCCAGTGGCCATAGAGCAGAGGCTTTATTGATTGAGTTACAAGAGCCCTAA
>NM_181471.3
AAGAGGAGGCGCGAGAATGGAGGTGGAGGCCGTCTGTGGTGGCGCGGGCGAGGTGGAGGCCCAGGACTCTGACCCTGCCCCTGCCTTCAGCAAGGCCCCCGGCAGCGCCGGCCACTACGAACTGCCGTGGGTTGAAAAATATAGGCCAGTAAAGCTGAATGAAATTGTCGGGAATGAAGACACCGTGAGCAGGCTAGAGGTCTTTGCAAGGGAAGGAAATGTGCCCAACATCATCATTGCGGGCCCTCCAGGAACCGGCAAGACCACAAGCATTCTGTGCTTGGCCCGGGCCCTGCTGGGCCCAGCACTCAAAGATGCCATGTTGGAACTCAATGCTTCAAATGACAGGGGCATTGACGTTGTGAGGAATAAAATTAAAATGTTTGCTCAACAAAAAGTCACTCTTCCCAAAGGCCGACATAAGATCATCATTCTGGATGAAGCAGACAGCATGACCGACGGAGCCCAGCAAGCCTTGAGGAGAACCATGGAAATCTACTCTAAAACCACTCGCTTCGCCCTTGCTTGTAATGCTTCGGATAAGATCATCGAGCCCATTCAGTCCCGCTGTGCAGTCCTCCGGTACACAAAGCTGACCGACGCCCAGATCCTCACCAGGCTGATGAATGTTATCGAGAAGGAGAGGGTACCCTACACTGATGACGGCCTAGAAGCCATCATCTTCACGGCCCAGGGAGACATGAGGCAGGCGCTGAACAACCTGCAGTCCACCTTCTCAGGATTTGGCTTCATTAACAGTGAGAACGTGTTCAAGGTCTGTGACGAGCCCCACCCACTGCTGGTAAAGGAGATGATCCAGCACTGTGTGAATGCCAACATTGACGAAGCCTACAAGATTCTTGCTCACTTGTGGCATCTGGGCTACTCACCAGAAGATATCATTGGCAACATCTTTCGAGTGTGTAAAACTTTCCAAATGGCAGAATACCTGAAACTGGAGTTTATCAAGGAAATTGGATACACTCACATGAAAATAGCGGAAGGAGTGAACTCTCTTTTGCAGATGGCAGGCCTCCTGGCAAGGCTGTGTCAGAAGACAATGGCCCCGGTGGCCAGTTAGAGCAGAGACTTCACTGACTGACTTACAGGTGCCCTATTCTGAGGTACAGGAGCCGCGGCTTTCTGATGGGGGAAAATGCCGCCTTAGGCTGGAGCCAACATGACTGTCCTTTAAACTCCAGTGGCTggccaggcacggtagctcacgcctgtaatcccaacactttgggaggccgaggcaggtggatcacctgaggtcagaagttcaagaccagcctggccaacatggggaaaccctgtctttactaaaaatataaaaattagctgggtgtggtggcgggcacctgtaatcccagctactcgggaggctgtggcaggagaatcgcttgaacccaggaggtggaggttgcagtgagccaagatcacaccattgcactccagcctgggcgacagagtctccatctggggaaaaaaattaaataaataaaCTCCCGTGACTTGCATGTTTGCTTCTGGGACGTCTGTGCCCCGCAAGTGTTTGAGTTTGGCCTCCACCCCATTGATGCGGTGACGGGGCGGAAAGGCGCAGAGAAGCTGAGGGCGGTCTCTGATCTGTGTGTGGGTTGACATTTTAGCTAATAAAGCCTTGCAGTGTTTGTTGGCAA

Publications

PMID - Link Title
No publications available for this retrocopy