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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name MYL6BP1
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Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:208269227-208270024  UCSC
Coordinates (T2T) chr2:208749021-208749818  UCSC
Coordinates (hg19) chr2:209133951-209134748  UCSC
Strand -
Parental Sequence NM_002475.5
Parental seq. overlap 709 bp
Parental seq. overlap (%) 84.5%
Genomic Region Intragenic (PIKFYVE)
Retrocopy Summary MYL6BP1, located on chr2:208269227-208270024, is a retrocopy of the parental gene MYL6B. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MYL6B
Full Name myosin light chain 6B
Also known as MLC1SA
Coordinate chr12:56152587-56157982
Strand +
Gene summary Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain expressed in both slow-twitch skeletal muscle and in nonmuscle tissue. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes MYL6BP1
Bonobo Pan paniscus MYL6BP1
Gorilla Gorilla gorilla MYL6BP1
Orangutan Pongo abelii MYL6BP1
Gibbon Nomascus leucogenys MYL6BP1
Green monkey Chlorocebus sabaeus MYL6BP1
Crab-eating macaque Macaca fascicularis MYL6BP1
Rhesus Macaca mulatta MYL6BP1
Baboon Papio anubis MYL6BP1
Golden snub-nosed monkey Rhinopithecus roxellana MYL6BP2
Marmoset Callithrix jacchus MYL6BP1
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Related Sequence

>MYL6BP1
CCCAGACACGGACCCTGCAAGAGATGGGTGCCCCCATCCGCACACTGTCCTTTGGCCACCAGACATCATGCCTCCCAAGGATATTCTGGGAGGAACCAGCAGGGCCCTCCATCTCCAAAGGTGCTGCCAAGCCAGCAGCAGCATGGGCCCCTCCAGCCAAGACCAAAGCTGAGCCAGCTATCCCATCCCCCAGGCCCCTGAGAAAACCAAGGAGCCCCCAGTTGATCTCTCCAAAGTGGTGATCAAGTTTAACAAGGATCAGCTGGAGGAGTTCAAGGTGGCCTTCAAGCTGTTTAACTGAGTGGGGGATGGCAAGATCCCATACAGCCAGTTTGGGGACATGATGGGGGCCCTGGACCAGAACCTCACCAGTGCCAAGGTGATGAAGGTCCTGGGGAACCCCAAGAGTGATGACCTGAAGTCCCGGCATGTGGACTTCAAGACTTTCCTGCCCATGCTCCAGGCAGCAGCCAAGAAGCAGAACCAAGGCACATATGAGGACTACCTGGAGGGGCTTCATGTGTTAGTCAAGGAGGGGAACAGCAAAGTCACGGGAGCAGAGCTCAGACAAGTCCTCACCACCCTGGGAGGGAAGATGGCTGAGGAGGAGATGGAGACTGTTCTGGCAGGACATGAGGACAGCATCAACTAGGAGGCCTTCCTGAAACACTTCCTAAGCCTACTGAGCTCTGTAGATCCCTAGGGCCCAGACAATGGGCCCCCTGCAGGCAGAAGCATGTTCCAGCCACCAGGAGGCTACCTACTGTTTCAAAATAAAGACAAGGTTCCTCCCTTGGA
>NM_002475.5
GCTATGccccgccccctccccagccccagacacggaccccgcAGGAGATGGGTGCCCCCATCCGCACACTGTCCTTTGGCCACCGGACATCATGCCTCCCAAGAAGGATGTTCCCGTGAAGAAACCAGCAGGGCCCTCCATCTCCAAACCTGCTGCTAAGCCAGCAGCAGCAGGGGCTCCTCCAGCCAAGACCAAAGCTGAGCCAGCTGTCCCCCAGGCCCCTCAGAAAACCCAGGAGCCTCCAGTCGATCTCTCCAAAGTGGTGATCGAGTTTAACAAGGACCAGCTGGAGGAGTTCAAGGAGGCCTTCGAGCTGTTTGACCGAGTGGGGGATGGCAAGATCCTGTACAGCCAGTGTGGGGACGTGATGAGGGCCCTGGGCCAGAACCCCACCAACGCCGAGGTGCTCAAGGTCCTGGGGAACCCCAAGAGTGATGAGCTGAAGTCGCGGCGTGTGGACTTTGAGACTTTCCTGCCCATGCTCCAGGCAGTGGCCAAGAACCGAGGCCAAGGCACATATGAGGACTACTTGGAGGGGTTTCGTGTGTTTGACAAGGAGGGGAACGGCAAAGTCATGGGAGCAGAGCTCAGACATGTTCTCACCACCCTTGGAGAGAAGATGACTGAGGAGGAGGTGGAGACCGTTCTGGCAGGACACGAGGACAGCAACGGCTGCATCAACTACGAGGCCTTCTTGAAACACATCCTAAGCGTCTGAGTGCTGCAGATCCAGTGGGGTCCGGACACTGGGCCCCGCAGGCGAAAGCACGTTCCAGCCACCAGGAGGCCACCTATTGTTTCAAAATAAAGACTGGGTTCCTCTCTTGG

Publications

PMID - Link Title
No publications available for this retrocopy