Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PKP4P1
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:209178960-209181803  UCSC
Coordinates (T2T) chr2:209658824-209661667  UCSC
Coordinates (hg19) chr2:210043684-210046527  UCSC
Strand +
Parental Sequence NM_001005476.4
Parental seq. overlap 2666 bp
Parental seq. overlap (%) 59.5%
Genomic Region Intergenic
Retrocopy Summary PKP4P1, located on chr2:209178960-209181803, is a retrocopy of the parental gene PKP4. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PKP4
Full Name plakophilin 4
Also known as p0071
Coordinate chr2:158456952-158681429
Strand +
Gene summary Armadillo-like proteins are characterized by a series of armadillo repeats, first defined in the Drosophila 'armadillo' gene product, that are typically 42 to 45 amino acids in length. These proteins can be divided into subfamilies based on their number of repeats, their overall sequence similarity, and the dispersion of the repeats throughout their sequences. Members of the p120(ctn)/plakophilin subfamily of Armadillo-like proteins, including CTNND1, CTNND2, PKP1, PKP2, PKP4, and ARVCF. PKP4 may be a component of desmosomal plaque and other adhesion plaques and is thought to be involved in regulating junctional plaque organization and cadherin function. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015]

Homology

Species Scientific Name Retrocopy
Baboon Papio anubis PKP4P1
Golden snub-nosed monkey Rhinopithecus roxellana PKP4P1
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PKP4P1
GCAGTAGGTATTGGAAATCTACAAAGGATGTCCAGCCAATGAAGTACCCGTACATACCAAAGAAATAATTATGCTCTGAATACAACAGCTACCTATGCGGAGCCCTCCAGGCCCATACAATACCAAGTGCAATAGTGTAATTATAACAGGCTTCAGCACGCAGTGCCGGCTAATGATGGCACCACAAGATCCCCATCAATAGACAGCATTCAGAAGGACCCCAGCGAGTTTGCCTGGCGTGATCCTGAGTTGCCTGAGGTCATTCACATCCTTCAGCACCAGTTCCCATCTGTTCAGGCAAATGCAGCAGCCTACCTGCAGCACCTGTGGTTTGGTGACAACAACGTGAAGATGAAGGTGTGTAGGTTATGGGGAATCAAGCTTCTGGTTTACCTTTTGGGCCACAGAGTTTTGGAAGTTCAGAAGAATGCTTGTGATGCCCTTCGAAATCTCTTTTTCGGCAAGTCTACAGGTGAAAATAAAATAACAATGAAGGATGTTGGTGAGATATCTGCCTTGTTGTGACTGTTGAGAAAATCAATATTGATGCAGAAATAAGGGAGCTTGTTACAGGAGTTCTTTGGAATTTATCCTCACGTGATGCTGCAAAAATGACAATTATTCGAGATGTTCTCTCAACTTTAACAAACAATGTGATCGTTCCACATTCTGGATGGAATAACTCTTCTTTTGATGATGGCCATAAAATTAAATTTCAGACTTCACTAGTTCTGCGTAGTACAACAGGTTGCCTGAGGAACCTCAGCTCTGTGGGGTAAGAAGCTCGGAAGCAAATGCGGGCCTGTGAGGGGCTGGTGGACTCGCTGTTGCATGTAACCTACACGTGTATGAACACATCCGATTACGACAGCAAGATGGAGAATTGCGTGTGCACCCTGAGGAACCTGTCCTATTGGCTGGAGCTGCAGGTGCCCCAGGCCCAGTTACTGGGACTGAACGAATGGGATGACTTACTAGAAAAAGTTTCCCAGCGAAGACTCTGAGCCAACCTGCTGGGGGAAGAAAAAAGAAAAAGAAAAAGAGGACTCCACAAGAAGATCAATAGGATGAAGTCGGTCCTATCCCAGCACTGTCGAAGTCCCCCAAAGGGGCTGAGATGCTGTAGCACCCATCGGTGGTGAAGCTGTATCTGACTCTTTTAGCAGAAAGTTCCAACCCAGCCACCTTGGAAGGCTCTGCCGGATCTCTCCAGAACCTCTCTGCTGGCAACTGTAAGTTTTCAGGATATATCTGGGCAGCCATCCGAAAATAAAAGGGGCTCCCCATCCTTGTGGAACTTCTGAGAATGGATAACGATAGAGTTGTTTCTTCCATGGCAACTGCCTTGAGGAAGATGACACTAGATGTTCGCAACAAGGAGCTCATAGGCAAATACACCATGCAAGACCTGGTCAACCAGCTTCTCTGTGGCAATGGCCCCAGTATCTTGTCTGATGAGTCCATGCAGCCATCTGCTGTGCTCTGCACGAGGTCACCAGCAAAAACATGGAGAAAGCCAAAGCCCTGGCCAACTCGGGAGGCATAAAGAAACTAGTGAACATAACCAAAGGCAGGGGCGACAGATCATCTCTGAAAGTAGTGAAGGCAGTAGCCCAGGTCTTGAATACATTATGGCAATATCGGGACCTCTGGAGCATTTATAAAAAGGATGGGTGTAATCAGAACCATTTTATTACACCTGTGTCGACATTGGAGCAAGACTGATTCAAATCACATCCTTCCTTGTCTACCACCAACCAAAAGATGTCACCCATCATTCAGTCAGGCTCCAGCAAACCTTCACCAATTTACATCAGTTCATATTCCTCACCAGCAAGAGAACTAAATAGACAGCTACAGCATCAACAGCTGTATTATAGTCAAGATAACTCCAACAAAATAACTTTGATTCATACAGATTGTATTTGCAGTCTCCTCATAGCTATGAAGACCCTTATTTTGATGACTGAGTTCACTTTCCAGCTTCTACTGATTAGTCAACAAGTATGGACTGAAATCGACCACAAATTATGTAGACTTTTATTCCATTAAACGACCTTCTTACAGAGCAGAACAGTACCCAGGATCCCCAGACTCATGGCTGCAGCATCAAGACACCCAACAGAAGAACTCTTTCTTTTTAACCTTGTTTGGATTGAGATGAAAAGTCCATCTTGCTGATTTGGTGATTGAAATGTGAAAGTGACGTGGAAGGAAAGAGTGAAGTGCATTTTTTTTCTTTTTTAAGGAATTATCAGGGAAGTGAGGAAACATTTGGGAGAGGACTTTCTAAGCTCTATTTAGGTGTTAGATCTAATTACTTGTAGATTCTGTAGTCTGGTGAAGGTGTGGGTGACGTGATGAGAGGTTTGAGAAATGGGTGAAATGAAATGGGGATGTGTAGATCAAATCAAATTAAAGATGATTTTTTAATGTAAATAAAGTCATGTTCTGATAGTTTGTACAGAAAAAATAAAATGATGCCCATGTTTTATTGCTATTACTAAATGTCAAGATTGTATGCTATTATGTCTTGTAAATTTCTTTTGTTGGTGTAAATATGGAAATGCCACATTGGTTAAGCGCCATCATTTGTAATGCAGTGTGTCACTTGAAGAGAGATTTGAAGAAACTGACAACTTCAAAAACAAATGGGAAGCCCAAGGAACTGTGAGAGATTAAAAACAAACTGCGACACCCTTTGTCTCCACCTTGCATAGTGTACTTTGGAAGCACAACGTCCAGGCTGGTACTGCAGTGCCATGCCCATTCCTTGCCTCGTTCATAGGACACTTCGCTGCCATTTTCTATGCACATGAAAGAAAAATAAAGGTGGAAATTTCA
>NM_001005476.4
AGTAGAGGGGGCTCCGGGGCTGAGTCCGCGTCGACGCCGGCCGCGGAGGCGGCACCATGGGCAAGGGGTAGAGGGGCAAGTTGGCCACCGCCGCCGCcgggggtggtgggagagccgctccgggggcgggggccggtgggggagggaggggcgggCAGCCGCGCCGCCGCGGCACTTTTTTAATTTTTTCGGGTGCCGCAGCGGCGACCCCTCGGCGCCGATGTCCCTGATCCCTGGAGCGACGACGGCCGCTGCCTAAGCTGGAAAGAGGAATGCCAGCTCCTGAGCAGGCCTCATTGGTGGAGGAGGGGCAACCACAGACCCGCCAGGAAGCTGCCTCCACTGGCCCAGGCATGGAACCCGAGACCACAGCCACCACTATTCTAGCATCCGTGAAGGAGCAGGAGCTTCAGTTTCAGCGACTCACCCGAGAACTGGAAGTGGAAAGGCAGATTGTTGCCAGTCAGCTAGAAAGATGTAGGCTTGGAGCAGAATCACCAAGCATCGCCAGCACCAGCTCAACTGAGAAGTCATTTCCTTGGAGATCAACAGACGTGCCAAATACTGGTGTAAGCAAACCTAGAGTTTCTGACGCTGTCCAGCCCAACAACTATCTCATCAGGACAGAGCCAGAACAAGGAACCCTCTATTCACCAGAACAGACATCTCTCCATGAAAGTGAGGGATCATTGGGTAACTCAAGAAGTTCAACACAAATGAATTCTTATTCCGACAGTGGATACCAGGAAGCAGGGAGTTTCCACAACAGCCAGAACGTGAGCAAGGCAGACAACAGACAGCAGCATTCATTCATAGGATCAACTAACAACCATGTGGTGAGGAATTCAAGAGCTGAAGGACAAACACTGGTTCAGCCATCAGTAGCCAATCGGGCCATGAGAAGAGTTAGTTCAGTTCCATCTAGAGCACAGTCTCCTTCTTATGTTATCAGCACAGGCGTGTCTCCTTCAAGGGGGTCTCTGAGAACTTCTCTGGGTAGTGGATTTGGCTCTCCGTCAGTGACCGACCCCCGACCTCTGAACCCCAGTGCATATTCCTCCACCACATTACCTGCTGCACGGGCAGCCTCTCCGTACTCACAGAGACCCGCCTCCCCAACAGCTATACGGCGGATTGGGTCAGTCACCTCCCGGCAGACCTCCAATCCCAACGGACCAACCCCTCAATACCAAACCACCGCCAGAGTGGGGTCCCCACTGACCCTGACGGATGCACAGACTCGAGTAGCTTCCCCATCCCAAGGCCAGGTGGGGTCGTCGTCCCCCAAACGCTCAGGGATGACCGCCGTACCACAGCATCTGGGACCTTCACTGCAAAGGACTGTTCATGACATGGAGCAATTCGGACAGCAGCAGTATGACATTTATGAGAGGATGGTTCCACCCAGGCCAGACAGCCTGACAGGCTTACGGAGTTCCTATGCTAGTCAGCATAGTCAGCTTGGGCAAGACCTTCGTTCTGCCGTGTCTCCCGACTTGCACATTACTCCTATATATGAGGGGAGGACCTATTACAGCCCAGTGTACCGCAGCCCAAACCATGGAACTGTGGAGCTCCAAGGATCGCAGACGGCGTTGTATCGCACAGGTTCAGTAGGTATTGGAAATCTACAAAGGACATCCAGCCAACGAAGTACCCTTACATACCAAAGAAATAATTATGCTCTGAACACAACAGCTACCTACGCGGAGCCCTACAGGCCTATACAATACCGAGTGCAAGAGTGCAATTATAACAGGCTTCAGCATGCAGTGCCGGCTGATGATGGCACCACAAGATCCCCATCAATAGACAGCATTCAGAAGGACCCCAGGGAGTTTGCCTGGCGTGATCCTGAGTTGCCTGAGGTCATTCACATGCTTCAGCACCAGTTCCCATCTGTTCAGGCAAATGCAGCGGCCTACCTGCAGCACCTGTGCTTTGGTGACAACAAAGTGAAGATGGAGGTGTGTAGGTTAGGGGGAATCAAGCATCTGGTTGACCTTCTGGACCACAGAGTTTTGGAAGTTCAGAAGAATGCTTGTGGTGCCCTTCGAAACCTCGTTTTTGGCAAGTCTACAGATGAAAATAAAATAGCAATGAAGAATGTTGGTGGGATACCTGCCTTGTTGCGACTGTTGAGAAAATCTATTGATGCAGAAGTAAGGGAGCTTGTTACAGGAGTTCTTTGGAATTTATCCTCATGTGATGCTGTAAAAATGACAATCATTCGAGATGCTCTCTCAACCTTAACAAACACTGTGATTGTTCCACATTCTGGATGGAATAACTCTTCTTTTGATGATGATCATAAAATTAAATTTCAGACTTCACTAGTTCTGCGTAACACGACAGGTTGCCTAAGGAACCTCAGCTCCGCGGGGGAAGAAGCTCGGAAGCAAATGCGGTCCTGCGAGGGGCTGGTAGACTCACTGTTGTATGTGATCCACACGTGTGTGAACACATCCGATTACGACAGCAAGACGGTGGAGAACTGCGTGTGCACCCTGAGGAACCTGTCCTATCGGCTGGAGCTGGAGGTGCCCCAGGCCCGGTTACTGGGACTGAACGAATTGGATGACTTACTAGGAAAAGAGTCTCCCAGCAAAGACTCTGAGCCAAGTTGCTGGGGgaagaagaagaaaaagaaaaagaggaCTCCGCAAGAAGATCAATGGGATGGAGTTGGTCCTATCCCAGGACTGTCGAAGTCCCCCAAAGGGGTTGAGATGCTGTGGCACCCATCGGTGGTAAAACCATATCTGACTCTTCTAGCAGAAAGTTCCAACCCAGCCACCTTGGAAGGCTCTGCAGGGTCTCTCCAGAACCTCTCTGCTGGCAACTGGAAGTTTGCAGCATATATCCGGGCGGCCGTCCGAAAAGAAAAGGGGCTCCCCATCCTTGTGGAGCTTCTGAGAATGGATAACGATAGAGTTGTTTCTTCCGTGGCAACAGCCTTGAGGAATATGGCACTAGATGTTCGCAACAAGGAGCTCATAGGCAAATACGCCATGCGAGACCTGGTCAACCGGCTCCCCGGCGGCAATGGCCCCAGTGTCTTGTCTGATGAGACCATGGCAGCCATCTGCTGTGCTCTGCACGAGGTCACCAGCAAAAACATGGAGAACGCAAAAGCCCTGGCCGACTCAGGAGGCATAGAGAAGCTGGTGAACATAACCAAAGGCAGGGGCGACAGATCATCTCTGAAAGTGGTGAAGGCAGCAGCCCAGGTCTTGAATACATTATGGCAATATCGGGACCTCCGGAGCATTTATAAAAAGGATGGGTGGAATCAGAACCATTTTATTACACCTGTGTCGACATTGGAGCGAGACCGATTCAAATCACATCCTTCCTTGTCTACCACCAACCAACAGATGTCACCCATCATTCAGTCAGGCTCCAGCAAACCTTCACCAATTTACATCAGTTCCTATTCCTCACCAGCAAGAGAACAAAATAGACGGCTACAGCATCAACAGCTGTATTATAGTCAAGATGACTCCAACAGAAAGAACTTTGATGCATACAGATTGTATTTGCAGTCTCCTCATAGCTATGAAGATCCTTATTTTGATGACCGAGTTCACTTTCCAGCTTCTACTGATTACTCAACACAGTATGGACTGAAATCGACCACAAATTATGTAGACTTTTATTCCACTAAACGACCTTCTTATAGAGCAGAACAGTACCCAGGGTCCCCAGACTCATGGGTGTAGCATCAAGATGCCCAACAGAGGAACTCTTTCTTTCTAACCTTGTTCAGATTGAGGTGAAAAGTCCATCTTGCTGATTTGATGATTGAAATGTGAAAGTGAAGTGGAAGGAATGAATGAAGTGTGTTTTTTTTTTCTTTTTTGAGGAATTATCAGGGAAGTGAGGAAATGTTTGGGAGAGGACTTTCTAAGCTCTATTTAGGTGTTAGATCTAATTACTTATAGATTCTGTAGTCTGGTGAAGGTGTGGGTGACGTGATGAGAGGTTTGAGAAATGGGTGAAATGAAATGGGGGATATGTAGGTCAAATCAAATTAAAGATGATTTTTTTAATGTGAATAAAGTTATGTTCTGATAGTTTGTACAGAAAAAATAAAATGGATGCCCATGTTTTATTGCTATTACTAAATGTCAAGATTGTATGCTATTATGTCTTGTAAATTTCTTTTGTTGGTGTAAATATGGAAATGCCACATTGGTTAAGTGCCATCATTTGTAATGCAATGTGTCACTTGAAAAGAGATTTGAAGAAACTGACAACTTCAAAAACAAATGAGAAGCCCAAGGAACTGTGAGCAATTAAAAGCAAACCGCGACACCCTTTGTCTCCACCACACATAGTGTACTTTGGAAGCACAACGTCCAGGCTGGTACCGCAGCGCCATGCCCATTCCTCGCCTCATTCATAGGACACTTCACTGCCATTTTCTATTCACATAAAAGAAAAATAAATGTGGAAATTTCATCCTTGGAAA

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