Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ENSAP3
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:214697729-214698965  UCSC
Coordinates (T2T) chr2:215182303-215183539  UCSC
Coordinates (hg19) chr2:215562453-215563689  UCSC
Strand +
Parental Sequence NM_207044.2
Parental seq. overlap 891 bp
Parental seq. overlap (%) 31.2%
Genomic Region Intergenic
Retrocopy Summary ENSAP3, located on chr2:214697729-214698965, is a retrocopy of the parental gene ENSA. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ENSA
Full Name endosulfine alpha
Also known as ARPP-19e
Coordinate chr1:150621246-150629612
Strand -
Gene summary The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ENSAP1
Bonobo Pan paniscus ENSAP1
Gorilla Gorilla gorilla ENSAP1
Orangutan Pongo abelii ENSAP2
Gibbon Nomascus leucogenys ENSAP2
Golden snub-nosed monkey Rhinopithecus roxellana ENSAP2
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ENSAP3
ATCCCAGTAACAAGAAAGAGAGAACCCTGTGGAGAAGACCAACAAGGAGAAACGAAGATGCAGGATAAAGAAGGTATTCTCTCTGAGAGAGTTGAGGCGGAGGCTCCAACTTCCTCATGAAGAGATTACAGAAAGGGAAAAGGTACTTTGTCTCAGGAGACTACAACATGGCCAAAGCCAAGATGAAGAGTAAGCAGCTTCCAAGTGCAGAACCAAAGAAGAACCTGGTGACTGGTGACCACATTCTGCCCCACAGAAAGTCCTTGGTTATCACCAGCAAGCTTGCAGGGTAACCCAGGCTGCCCTCTCCTCCTACTCCTCACCCCACTGGATGTTTACATATTATAGGCAGGGATGAAATGGACACCTAGTCAGATCTCAGTTACCAGGCAAAAATGACTATGATTCTCCTAGTGGCTTCTGAGAAGGTAATGTAAGTTGAAGGGGGACTCTGAGTCCATTTCTTTGGTTAAATTGAGACTCCTACATCCTCCCTATAATCCAGGTAGGGCCCAGAAATAGGAAAGACTAGGATTGGATAATGCTGCAAATGCTTTCTCTTTTGTGAGAAACTGGAGAGATGTGATTTCTCCTTTTGGAGGAGAATATCCCATAATTGATTAAGCTGAGCCTTGGGAATAATACGGCAGGTTTAACATCCAAAAGCTAACCTGACATAGTTGGGAAAGGTAGATTAAATAAGACATGTTTTTGTGCTTCTAAGTGTTTTGTCCCTTATGCTGCTATTGCTTCATGTTTCCATTACGGCAGGTTTAGAAAATCCTTACAAAGAAAGACAGACTTGCTTGCCTAAAACTACAATGTCCACTTAGCCCCCTTTACTTAGTATCTCTTGCAGTTTGCCCTGGCTCTCAAATAATGTAAAGATTGATGAACATTACTCACAGAAAATGGGCACTTTTTCTCTCTCTCTTCCAACATGTTGCTTTTGAAAATATtTCCAGCAGAAAAACGCTGTATTGATCATTGTAAAATTAAAAGTGAGGAAGGC
>NM_207044.2
ACGGGCAAGGGCCGCCATTTTGACTGAGCAACCCTAGTGACAGGAGCCGAAGCAGCAGCGCAGGTTGTCCCCGTTTCCCCTCCCCCTTCCCTTCTCCGGTTGCCTTCCCGGGCCCCTTACACTCCACAGTCCCGGTCCCGCCATGTCCCAGAAACAAGAAGAAGAGAACCCTGCGGAGGAGACCGGCGAGGAGAAGCAGGACACGCAGGAGAAAGAAGGTATTCTGCCTGAGAGAGCTGAAGAGGCAAAGCTAAAGGCCAAATACCCAAGCCTAGGACAAAAGCCTGGAGGCTCCGACTTCCTCATGAAGAGACTCCAGAAAGGGCAAAAGTACTTTGACTCAGGAGACTACAACATGGCCAAAGCCAAGATGAAGAATAAGCAGCTGCCAAGTGCAGGACCAGACAAGAACCTGGTGACTGGTGATCACATCCCCACCCCACAGGATCTGCCCCAGAGAAAGTCCTCGCTCGTCACCAGCAAGCTTGCGGGGTAACCTGAGCCCCCCTCTCCTCCCCTTCCTCAACCACTGGACGTTTATATATTATAGGCAGGGATGAAATGGGCACCTAGTCAGATCTTCTCAGCTTGCTAGCCAGAAATGACTGTGATTCTGCTGGGGGCTGCTGAGAAGGTAATGTAGGTTGAAAAGGGGCTCTAAGTTTATTTATTTCGTTAGATTGACACTTCCACACACTCCCTGTAGTCCAGGTAGGGCCCAGAAATAGGAAAGGCTAGGATTGGATAATGCTGCAAATGCTTTTTTTGTGTGAGAAACTGGAGAGATGTGATTTCTCCTTTTGGGAGAGAATGTCCCAAAATTGATTAGGCTGAGCCTTGGGAATAGTTTGGCAGGTTTAACATCCCAAGGCTAACCTAACGTAGTTGGGAAAGGTAGATTGAATGAGACATGTTTTCTGTGCTTCTAAGTGTTCTGTCCCTTAGGCTGCTATTGCTTCATGTTTCCATTATGGCAGGTTTAGAGAATCCTTAAAAAGAAAAATTGACTTGCTTGCCTAAAACTACAGTGCCCCCTTAGCCTCCATTACTTAGTATCTCTTACAGTTTGCTCTGGCTCTCAAATAATATAAAGATTGATGAACATTATTCACAGAAAATGGGCACCTTCTCTCTCTCTTCCAGCATGTTGCTTTTGAAAgtatcatgggatagtgggacgagcactggtttaggagtcaagatatctgggttctcactctactcagtcccagcagagctgttgtataaccttgattaagtcatttagcctctctggatttctatttcctcatctgtaaaatagagttaaatgtatgtaagattgattctgattctgaAGTCTTAACTGCCAGCAGAAAAACTCCATACTGTTCATTGTAAAACTAAAAGTGAGGAAGGCTCGTGGGTGGTGAACCTCTGCTCTGTAATACTGGGAAAGTACTACAGAGGGGAACCATTTGAGGGATACATGAGGAGAGAGTAAATTGAGGTTTGGGGATTATAAATTCAGGCAAGAGAACCTTATAGATATCACAGTCTTGAGGGTCAAAAAAAAATACTTAGGAAGCTAGCCATGGAAGCTTCTTGCCTCTGACCCAGCCCACTTTCCCAGCCTACCTCTGGGCCTTAGCTGCTAAAAAGCTTCTCTGGCAGCGGAGCTGCAGGCCTGAGGAAACATGCTCAGTCATGCACATGTGTTGACCCATGTTTCAGATGCAGTCTGATGCCAGGTATATTGTTAGGGAAAGAGGAAGAAGGGTAAACTGAGCTAGCCCCTGGGGCTGAGTACTCCTGCAGGGCTGGAGGAACAGGTTCTTAGAAGATGATTCACCTTGGAGGAAGCTGGGGAAAGTGGTTAGGGAGGGAGAGGAGGAAGACTGAGAAATCTCTGCATCCCCAGAACTCAGCAACCCAGCTCTTTTATCATGAGGAGAGGTAGCCATGCTGACTCATGAACAGGTGGAGGAAAGGGGTTGCAGGTGACCAGCATCTTCAATCTAGTTACCACCAGCTTGGCTAGAATTTTATTGAACGCAACTTGCTAGTTATGACAGAGAGGACCAGGGTGAGAACTAATGCTCAAGAGAGCAAGATTCTGTAATCCTCTTGCCCTCTCACATCACAAATTCTGATATGCCAAACATTTGGCCCAATGAGAATGACTGATAGACTTGCTGATGTGCATGTGGGGGGATGAGGTGTGTATATGCCTTTCTCCTGACTGGCCATTCAGTGTTCAGGCTGTCATTCAAATTGGATAGGAGAAAGTTGGTGAGGAAGGAATGGAGAGAGCAGGATCCCTGGACTCCCTGGTCCCCAAACTCCTTGACTGTCACTTGTAATTGTATATAATTTTTGTGTTTCTTGCTCCATTTCCTCATGCTGTCATCCTTAAAGTCCATCTGGGAAGGGGAAAATGCTGAACACCATTGTATAGTTTCTTCAACTGTCCCAGCCATGTTGtacatagatatgtcatgttattatatatataaatatatatataATTTTGTACGTTTTCTTCATCTCCGATCTTCTCAAATTCTGTACTTTTTTTCTTTTCTGTCTGAGCTGCCTTCTCTATCATTCAGCTTGAGTCCTCAAGACTACTGGTCACAATGAGTCTGATTTTTAGGAAGGAATAGGAGGAGCAGGGAAATCAGAAAAACTGTTGGTCTCACTCTGTCTCTCTACCTGGTCATCTTCAAGGCTAAGAAAACAAACAAGCTACATTCTGTATTTGCCAGTTTCCACAGCATGAAGTACATAGCTTCCTTAGCAAGGAGTGGTCATTCCAAAATCCAAATGCAAATTGCTTTGATTAAACCTAGATTATTAAATCCATTCAGAACAGCA

Publications

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