Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name KRT8P30
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:218953208-218954017  UCSC
Coordinates (T2T) chr2:219441581-219442390  UCSC
Coordinates (hg19) chr2:219817930-219818739  UCSC
Strand -
Parental Sequence NM_002273.4
Parental seq. overlap 625 bp
Parental seq. overlap (%) 34.5%
Genomic Region Intergenic
Retrocopy Summary KRT8P30, located on chr2:218953208-218954017, is a retrocopy of the parental gene KRT8. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name KRT8
Full Name keratin 8
Also known as CARD2|CK-8|CK8|CYK8|K2C8|K8|KO
Coordinate chr12:52897191-52949860
Strand -
Gene summary This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes KRT8P6
Bonobo Pan paniscus KRT8P6
Gorilla Gorilla gorilla KRT8P6
Orangutan Pongo abelii KRT8P6
Gibbon Nomascus leucogenys KRT8P42
Crab-eating macaque Macaca fascicularis KRT8P35
Rhesus Macaca mulatta KRT8P36
Baboon Papio anubis KRT8P33
Golden snub-nosed monkey Rhinopithecus roxellana KRT8P48
Green monkey Chlorocebus sabaeus Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>KRT8P30
CCAGGGCCATGGTTGGGGAGATCGAGACCCACAATGGGAAATGGGAAGCTGGTGTCCGAGTCCTCTGACGTCCTGCCCAAGTGAATAGCTGTGGCAGCCCCTCCCAGCCTGCCCCTTCTGTGGCTGCCCCAGAGTCCGGGAGGGAGGCCACTGTGCAGGGGAGCACAGGGAATGGGAGACCCACCTGAGGCTCAGCCCTAGCCCTCAGCCCACCTGCAGGGGAGTTTACTGCGTGGGACACCTCCTTTGCCCATATCTCCAGCTACAAAACAATTCCCGGGCTGAGGCTGAAAGCACGTACCAGATCAAGTATGAGGAGCTGCAGACGCTGGCTGGGAAGCATGGGGATGACCTGCGTTGTGCAAAGACAGATCTCCGAGATGAACCAGAACATCAGCAGGCTCCAGGCTGAGACTGAGGGCCTCAAAGGCCAGGGGGCTTCCCTGGAGGCCGCCATCGCAGATGCCGAGCAGTGGGGGGAGCTGGCCATTAAAGATGCCAACACCAAGCTGTCTGAGCTGGAGGCCGCCATGCAGCGGGCCAAGCAGGACATGGCACGCAGCTGGGTGAGTACCAGAAGCTGGCCCTGGACATCGAGATCGCCACCTACAGGAAGCTGCTGGAGGGCGAGGAGAGCCGTCTGGAGTCTGGGATGCAGAACGTGAGTATCCATAAGAAGACCACCAGTGGCTATGCAGGTGGTCTGAGCTCAGCCTATGGGGGCCTCACAAGCCCTTGGCCTc
>NM_002273.4
ATTCCTGAGAGCTCTCCTCACCAAGAAGCAGCTTCTCCGCTCCTTCTAGGATCTCCGCCTGGTTCGGCCCGCCTGCCTCCACTCCTGCCTCTACCATGTCCATCAGGGTGACCCAGAAGTCCTACAAGGTGTCCACCTCTGGCCCCCGGGCCTTCAGCAGCCGCTCCTACACGAGTGGGCCCGGTTCCCGCATCAGCTCCTCGAGCTTCTCCCGAGTGGGCAGCAGCAACTTTCGCGGTGGCCTGGGCGGCGGCTATGGTGGGGCCAGCGGCATGGGAGGCATCACCGCAGTTACGGTCAACCAGAGCCTGCTGAGCCCCCTTGTCCTGGAGGTGGACCCCAACATCCAGGCCGTGCGCACCCAGGAGAAGGAGCAGATCAAGACCCTCAACAACAAGTTTGCCTCCTTCATAGACAAGGTACGGTTCCTGGAGCAGCAGAACAAGATGCTGGAGACCAAGTGGAGCCTCCTGCAGCAGCAGAAGACGGCTCGAAGCAACATGGACAACATGTTCGAGAGCTACATCAACAACCTTAGGCGGCAGCTGGAGACTCTGGGCCAGGAGAAGCTGAAGCTGGAGGCGGAGCTTGGCAACATGCAGGGGCTGGTGGAGGACTTCAAGAACAAGTATGAGGATGAGATCAATAAGCGTACAGAGATGGAGAACGAATTTGTCCTCATCAAGAAGGATGTGGATGAAGCTTACATGAACAAGGTAGAGCTGGAGTCTCGCCTGGAAGGGCTGACCGACGAGATCAACTTCCTCAGGCAGCTATATGAAGAGGAGATCCGGGAGCTGCAGTCCCAGATCTCGGACACATCTGTGGTGCTGTCCATGGACAACAGCCGCTCCCTGGACATGGACAGCATCATTGCTGAGGTCAAGGCACAGTACGAGGATATTGCCAACCGCAGCCGGGCTGAGGCTGAGAGCATGTACCAGATCAAGTATGAGGAGCTGCAGAGCCTGGCTGGGAAGCACGGGGATGACCTGCGGCGCACAAAGACTGAGATCTCTGAGATGAACCGGAACATCAGCCGGCTCCAGGCTGAGATTGAGGGCCTCAAAGGCCAGAGGGCTTCCCTGGAGGCCGCCATTGCAGATGCCGAGCAGCGTGGAGAGCTGGCCATTAAGGATGCCAACGCCAAGTTGTCCGAGCTGGAGGCCGCCCTGCAGCGGGCCAAGCAGGACATGGCGCGGCAGCTGCGTGAGTACCAGGAGCTGATGAACGTCAAGCTGGCCCTGGACATCGAGATCGCCACCTACAGGAAGCTGCTGGAGGGCGAGGAGAGCCGGCTGGAGTCTGGGATGCAGAACATGAGTATTCATACGAAGACCACCAGCGGCTATGCAGGTGGTCTGAGCTCGGCCTATGGGGGCCTCACAAgccccggcctcagctacagcctgggctccagctttggctctggcgcgggctccagctccttcagccgcaccagctccTCCAGGGCCGTGGTTGTGAAGAAGATCGAGACACGTGATGGGAAGCTGGTGTCTGAGTCCTCTGACGTCCTGCCCAAGTGAACAGCTGCGGCAGCCCCTCCCAGCCTACCCCTCCTGCGCTGCCCCAGAGCCTGGGAAGGAGGCCGCTATGCAGGGTAGCACTGGGAACAGGAGACCCACCTGAGGCTCAGCCCTAGCCCTCAGCCCACCTGGGGAGTTTACTACCTGGGGACCCCCCTTGCCCATGCCTCCAGCTACAAAACAATTCAATTGCTTTTTTTTTTTGGTCCAAAATAAAACCTCAGCTAGCTCTGCCAA

Publications

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