Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

Advanced Search

Summary

Retrocopy Name KLHL12P1
Plot displaying the genomic locations of a retrocopy (in chr22) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr22:20449969-20453240  UCSC
Coordinates (T2T) chr22:20854255-20857526  UCSC
Coordinates (hg19) chr22:20804256-20807527  UCSC
Strand +
Parental Sequence NM_021633.4
Parental seq. overlap 3078 bp
Parental seq. overlap (%) 92.7%
Genomic Region Intragenic (KLHL22)
Retrocopy Summary KLHL12P1, located on chr22:20449969-20453240, is a retrocopy of the parental gene KLHL12. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name KLHL12
Full Name kelch like family member 12
Also known as C3IP1|DKIR
Coordinate chr1:202891116-202928628
Strand -
Gene summary This gene encodes a member of the KLHL (Kelch-like) family of proteins. This protein has been identified as an autoantigen in the autoimmune disease Sjogren's syndrome and as a potential biomarker in primary biliary cirrhosis. This protein may act as a substrate adaptor of the Cullin-3 ubiquitin ligase complex to promote substrate-specific ubiquitylation. Ubiquitylation by this complex has been shown to regulate the Wnt signaling pathway as well as COPII vesicle coat size. A pseudogene has been identified on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes KLHL12P1
Gorilla Gorilla gorilla KLHL12P1
Orangutan Pongo abelii KLHL12P1
Gibbon Nomascus leucogenys KLHL12P1
Green monkey Chlorocebus sabaeus KLHL12P1
Crab-eating macaque Macaca fascicularis KLHL12P1
Rhesus Macaca mulatta KLHL12P1
Baboon Papio anubis KLHL12P1
Golden snub-nosed monkey Rhinopithecus roxellana KLHL12P1
Bonobo Pan paniscus Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>KLHL12P1
CGGCGACGCTTCGGCTCCTCCTGAGCCACCTGCTGGACCCGCACCCCACTCCATCCCCACAGGCTGGGGACAGGCCCTGGCGCGGCTGTGTGGGATCAGAAGCAGAGTTGCAGAATCCAAGGACCTATTTTTGTTCTTTCTCCGCACTGCTTTATGGGAGGCATTATGGCCCCCAAAGACATAATGACAAATACTCATGCTAAATCAATCCTCAGTTCAATGAACTCCGTTGGGAAGAGCAATACCTTCTGTGATGTGACATTGAGTAGAGCAGAAAGACTTTCCTGCCCATGAGATTGTGCTGGCTGCCTGTAGTGATTACTTCTGTGCCATGTTCACTAGTGACCTTTATAGAAGGGGAAACCCTATGTTGACATCCAAGGTTTGACTGCCTCTACCATGGAAATTTTATTGGACTTTGTGTACACGGAAACAGTACATGTGACATGGAGAATGTACAGGAACTGCTTCCTGCAGCCTGTCTGCTTCAGTTGAAAGGTGTGAAACAAGCCTGCTGTGAGTTCTTAGAAAGTCAGTTGGACCCTTCTAATTGCCTGGGTATTAGGGATTTTGCTGAAACCCACAATTGTGTTGACCTGACACAAGCAGCTGAGGTTTTTAGCCAGAAGAATTTTCCTGAAGTGGTACAGCATGAAGAGTTCATTCTTCTGAGGCAAGGAGAGGTGGAAAAGCTAATCAAGTGCGATGAAATTCAGGTGGATCCTGAAGAACCAGTCTTTGAGGCTGTCATCAGTTGGGTGAAGCATGCCAAGAAAGAGCAGAAAGACTCCTTGCCCAGCCTGCTACAGTATATGCAGATGCCCCTGCTAACCCTCAGGTATATCACAGATGTAATAGATGCTGAGCCTTTCATCCACTATGGTTTACAATGCAGGGATCTGGTTGATGAAGCAAAGAAGTTTCATCTGAGGCCTGAACTTCAGAGTCAGATGCAGGGACCCAGGACAAGGGCTCGCCTAGGAGCCAATGAAGTGCTTTTGGTGGCTGGGGGCTTCGGAAGCCAGCAGTCTCCCATCGATGCAGTAGAGAAATATGACCCCAAGACTCAGGAGTGGAGCTTTTTGCCAAGCATCACTTGTAAGAGATGTTATGTGGCCTCAGTGTCCCTACATGACCAGATCTACGTCATTGGTGGCTGTGATGGTCGTTCCAGCCTTAGTTCAGTGGAATGTCTAGACTACACAGCAGATGAGGATGGGGTCTGGTATTCTGTGGCCCCTATGAATGTCTGATGAGGTCTTGCTGGAGCCACCACCCTGGGAGATTTGATCTATGTCTCTGGAGGCTTTGATGGAAGCAGGCGTCACACCAGTATGGAGCGGTATGATCCAAACATTGACCAGAGGAGCATGCTGGGAGATATGCAGACAGCCCGGGAAGGTGCCGGACTCGTAGTGGCCAGTGGAGTGATCCACTGTCTAGGAGGATATGACGGCTTGAATATCTTAAATTCAGTTGAGAAATATGACCCTCATACAGGACACTGGACTAATGTTACACCAATGGCCACCAAGCGTTCTGGTGCAGGAGTAGCCCTGCTGAATGACCGTATTTATGTGGTGGGGAGATTTGATGGTACAGCCCACCTTTCTTCCGTTGAAGCATACAACATTCGCACTGATTCCCGGACAACTGCCACCAGTATGACCACTCCACGATGCTATGTAGGGGCCACAGTGCTTCGGGGGAGACTCTATGCAATTGCAGGATATGAAGGTAAGTCCCTGCTAAGTAGCATTGAATGTTACAACCCTATCATCAACAGCTGGGAAGTCGTGACATCCATGGGAACCCAGCGCTGTGATGCTGGTGTGTGTGTTCTCCACAAGAAGTGACCATTGTTGGAGCACCATCCAGAGCTAGTGACCAGTCCAGTGGACAGTTAGTGGGAGAATCAAGAATCCTTTCTAGAATGTCTGTTTCTCACTATGTGCACAGGGTGATTACAGGCACCAGTGCAGTGATGATTGTACTTATTTGACACATACTCCCCCTCGTCCTGGTTGTTGTTCCTGAGAAGGGTGGGTAACAGATACTCCAGGGAAAAGAATGCACATTGAATGGATGTGAGAGACCACATTACCTCTCCCACTACTTTGGGGAGCACTTTCCTGTCATTTCTAACTTACCACGTGCTTGGTGTACTATATGTATGTTGTGCCTCATATGTTGCAAAGAACTAAGGTGAGTATAGCCTACTAGATGTGAGCAATATCCAGCCTAGATGATTGGAAAGATACCAATTTAAGTAAACTTGGTAAAATCCAAGTCTTTTTTTTTTCCAGGAACAAATACATTTTCTAATCTACAGGTAGCTAGGGGCAACACAGTTCCATTCTAAAGGGAAACAAAAGGGAGAGCCCCACAAAACTTTGGGGGCAAGGGAGAGATACTCATCTGACACTTCTTTTGGAGGTCAGGGTTTGTATATCAGAATTGAAGTTAGAATCAGTGAATTAAACTGAATTTGATGGAATGTGAGTGAACCTAGAACAGCACTGAAGTATTACATAACCTGGAAGACTGAGAAGGGTATATTCTTTGAATGATCTTTTTATTTCCCCAAGGTCTTTCACACTGGAGACAGCATAAAAGAGTGAACCAATGTTGGGATGAGAGAAGATGACATAAATGTGGGAGTTCAGTATAACTGGGGATAAACTAGAAGTACCTGTGATTTTACAGTCATCTTATTGCCTGCCAGGGGTCATCTAGCCATGGCAGTGTTAACCTTGAATGGGGGTGAAAGCCTTTCTTTGTTGAATCAAATACTACTACACTATTACACTTCCACACTATTTATTTGGGGATGGACTGGGAGTGACAGTAGCCTAGTAGTTCAGCTACCTGATTACTGCCCCATTCTTTTAGAAGCACACTTCTGCCAAGGAGTGGTTTGTACTGCTGTGATTGGTACATTTAGTCTTTTTTCTGCTATAAGTTTTCCTTACCTGTCCTTTAGTGTAGATTTTATTCATTACAGGACAGAATAATCAAGGACAACCAAAATCCTTTTGTTAGTTTCAGTACCTCAGCTATCAACATTTCTGAGCTATCATTCAATGTTCCTCTGTGTCATGGAGTGAAATTCTTGTTTTATGGGTATTGGGAGTGTGGGAATGTGATAACCTAAACAACCTTTGCTCTGAAATTCCATTTTTCCCTCTTTCCCTGAAGTGTACTGACCTGTACTACAGA
>NM_021633.4
AGACCCGGACGGCTCCAGAGCCTCCAGAGCCTCCGGGTCTGGGCGGCGCTTCGGCTCCTCCCGAGCCGCCTGCTAGCCCCGCGCCGCACTCCATCCCCACAGGCTGGGGACGGGCCCGGTGCGGCTGTGTGGGTTCGGGAGCGGAGTTGCAGAATCCAAGGACCCATTTTGTTCTTTCTCCGCACTGCTTTATGGGAGGCATTATGGCCCCCAAAGACATAATGACAAATACTCATGCTAAATCCATCCTCAATTCAATGAACTCCCTCAGGAAGAGCAATACCCTCTGTGATGTGACATTGAGAGTAGAGCAGAAAGACTTCCCTGCCCATCGGATTGTGCTGGCTGCCTGTAGTGATTACTTCTGTGCCATGTTCACTAGTGAGCTCTCAGAGAAGGGGAAACCTTATGTTGACATCCAAGGTTTGACTGCCTCTACCATGGAAATTTTATTGGACTTTGTGTACACAGAAACAGTACATGTGACAGTGGAGAATGTACAAGAACTGCTTCCTGCAGCCTGTCTGCTTCAGTTGAAAGGTGTGAAACAAGCCTGCTGTGAGTTCTTAGAAAGTCAGTTGGACCCTTCTAATTGCCTGGGTATTAGGGATTTTGCTGAAACCCACAATTGTGTTGACCTGATGCAAGCAGCTGAGGTTTTTAGCCAGAAGCATTTTCCTGAAGTGGTACAGCATGAAGAGTTCATTCTTCTGAGTCAAGGAGAGGTGGAAAAGCTAATCAAGTGCGACGAAATTCAGGTGGATTCTGAAGAGCCAGTCTTTGAGGCTGTCATCAACTGGGTGAAGCATGCCAAGAAAGAGCGGGAAGAATCCTTGCCTAACCTGCTACAGTATGTGCGGATGCCCCTACTAACCCCCAGGTATATCACAGATGTAATAGATGCTGAGCCTTTCATCCGCTGTAGTTTACAATGCAGGGATCTGGTTGATGAAGCAAAGAAGTTTCATCTGAGGCCTGAACTTCGGAGTCAGATGCAGGGACCCAGGACAAGGGCTCGCCTAGGAGCCAATGAAGTGCTTTTGGTGGTTGGGGGCTTTGGAAGCCAGCAGTCTCCCATTGATGTGGTAGAGAAATATGACCCCAAGACTCAGGAGTGGAGCTTTTTGCCAAGCATCACTCGTAAGAGACGTTATGTGGCCTCAGTGTCCCTTCATGACCGGATCTACGTCATTGGTGGCTATGATGGCCGTTCCCGCCTTAGTTCAGTGGAATGTCTAGACTACACAGCAGATGAGGATGGGGTCTGGTATTCTGTGGCCCCTATGAATGTCCGACGAGGTCTTGCTGGAGCCACCACCCTGGGAGATATGATCTATGTCTCTGGAGGCTTTGATGGAAGCAGGCGTCACACCAGTATGGAGCGCTATGATCCAAACATTGACCAGTGGAGCATGCTGGGAGATATGCAGACAGCCCGGGAAGGTGCCGGACTCGTAGTGGCCAGTGGAGTGATCTACTGTCTAGGAGGATATGACGGCTTGAATATCTTAAATTCAGTTGAGAAATACGACCCTCATACAGGACATTGGACTAATGTTACACCAATGGCCACCAAGCGTTCTGGTGCAGGAGTAGCCCTGCTGAATGACCATATTTATGTGGTGGGGGGATTTGATGGTACAGCCCACCTTTCTTCCGTTGAAGCATACAACATTCGCACTGATTCCTGGACAACTGTCACCAGTATGACCACTCCACGATGCTATGTAGGGGCCACAGTGCTTCGGGGGAGACTCTATGCAATTGCAGGATATGATGGTAATTCCCTGCTAAGTAGCATTGAATGTTATGACCCTATCATCGACAGCTGGGAAGTCGTGACATCCATGGGAACCCAGCGCTGTGATGCTGGTGTTTGTGTTCTCCGCGAGAAGTGACCATTGTTGGAGCACCATCCAGAGCTAGTGACCAGTCCAGTGGACAGTTAGTGGGAGAATCAAAAATCCTTTCCAGAATGTCTGTTTCTCACTATGTGCACCGGGTGATTACAGGCACCAGTGCAGTGATGATTGTACTTATTTGACACATACTCCCCGTCGTCCTGGTTCTTGTTCCTGAGAAGGGTGGGTAACAGATATTCCAGGAAAAAGAATGCACATTGAATGGATGTGAGAGACCACATTGCCTCTCCCACTGCTTTGGGGAGCACTTTCCTGTCATTTCTAACTTACCACATGCTTGGTGTACTATATGTATGTTGTGCCTCATATGTTGCAAAGAACTAAGGTGAGTATAGCCTACTAGATATGGGCAATATCCAGCCTAGATGATTGGAAAGATACCAGTTTAAGTAAACTTGGTAAAATCCAAGTCTTTTTTTTTTTTTCCAGGAACAACTACATTTTCTCATATACAGGTAGCTAGGGGCAACACAGTTCCATTCTAGAGGGAAACAAAAGGGAGAGCCCCACAAAACTTTGGGGACAAGGGAGAGAGAGACTCATCTGACACTTCTTTTGGAGGTCAGGATTTGTATATCAGAATTGAAGTTAGAATTAAGTGAATTAAACTGAATTTGATTGTGAGTGAACCTAGAACAGCACTGAAGTATTACATAACCTGGAAGACTGAGAAGGGTATATTATTTGAAGGATCTTTTTATTTCCCCGAGGTCTTTCGCACTGGAGACAGCATAAAAGAGTGAACAAATGTTGGGATGAGAGAAGATGACATCAATGTGGGAGTTCAGTATAACTGGGGATAAACTAGAAGAACCTGTGATTTTACAGTCATCTTATTACCTGCCAGGGCTCATCTAGCCATGGCAATGTTTGCCTTGAATGGGGGTGAAAGCCTTTCTTTGTTGGATCAAATACTACTACACTATTACACTTCCACACTATTTATTTGGGGATGGGCTGGGAGTGACAGTAGCCTAGTAGTTCAGCTACCTGATTACTGCCCCATTCTTTTAGAAGCACATGTCTGCCAAGGAGTGGTTTGTACTGCTGTGTTTGGTACATCTAGTCTTTTTTCTGCTATAAGTTTTCCTTACCTGTCCTTTAGTGTAGATTTTATTCATCACAGGACAGAATAATCAAGGACAACCAAAATCCTTTTGTTAGTTTCAGTACCTCAGCTATCAACATTTCTGAGCTACCATTCAATGTTCCTCTGTGTCATGGAGTGAAATTCTTGTTTTGTGGGTATTAGGAGTGTGGGAATGTGATAACCTAAACAACCTTTGCTCTGAAATTCCATTTTTCCCTCTTTCCCTGAGTTGTATTGACCTACAGAGTTAATTTCCTTTGTATTTTTTTAAGAAAATATTAAAAATCAACGGTCTCAAA

Publications

PMID - Link Title