Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name BMP6P1
Plot displaying the genomic locations of a retrocopy (in chr22) and its respective parental gene (in chr6). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr22:22185942-22187812  UCSC
Coordinates (T2T) chr22:22599475-22601345  UCSC
Coordinates (hg19) chr22:22540332-22542201  UCSC
Strand +
Parental Sequence NM_001718.6
Parental seq. overlap 1343 bp
Parental seq. overlap (%) 34.9%
Genomic Region Intergenic
Retrocopy Summary BMP6P1, located on chr22:22185942-22187812, is a retrocopy of the parental gene BMP6. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name BMP6
Full Name bone morphogenetic protein 6
Also known as VGR|VGR1
Coordinate chr6:7726099-7881728
Strand +
Gene summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients. [provided by RefSeq, Jul 2016]

Homology

Species Scientific Name Retrocopy
Gorilla Gorilla gorilla BMP6P1
Orangutan Pongo abelii BMP6P1
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>BMP6P1
AACTCTGACCTATTTTTTTTGGACATTTGCATAGTGTGGGCCTCAGAAGGAAGCTGGCTGGAATTTGACATCACAGCCACTAGTAGTCTGTGGGTTGTAACCCCACAGCATAACATGGGGCTTCAGCTGAGCGTAGTGACAGAGGATGGAGTCCACATCCACCCTCTAGCTGCAGACCTGGTGGGCAGAGACAGCACTTAGGCTATGCAGCCCTTCATGGTGGCTTTCTTCAAAGTCATTGTGGTCCATGTGTGCATCACCAGGTCAGCCTCTGGCTGGCGTTGACAGCAGAGTTGTACTCACTTTACCCAGTCCCACTACGTGGCTCAAGTCTCCAGTACTTCAGATTACATCAGCAGCAAATTAAAAACAGCCTGCAGGAAGCATGAGCTATATGTGAGCTTCCAAGACCTGGATGGCAGGACTGGTTCATCGCACCCAAGGGCTATGCTGCTAATTACTGTGATGTAGAATGCTCCTTCCCAATCAATGGACATGTGAATGCAATCAACCATGTGATCATTCAGACCTTGGTTCACCTTATAGATCCTGAATATGTCCCAAAGCTGTGCTGTGTGCCAACTAAACTCAATGCCATTTTGGTTCTTTACTTCAATGACAATTCCAAAATCACCTTtAAGCTGAGTTTGGTTGTCTGGTAACTACAGAAACTTAAACTTAAAAGGTACCCCCCAAGCCCACCAAATTTAATTTTAGCTATAGTTCAAGCTATTTGGGTTATTAGTGAGTAAATAGGGAAAATAATCTCAATGGAGTTAAATGTATTCTTGGGTAAAGTATCAGCTGGTTTATTAGTGTCTATCAAAGGTACATTTTACAGATAGTGAAAGTTGGGGAAGTAGGAATAACTCCTCTATTCACAGATTTCATTCCCAGGAAGGCAAATTTTATACTGGATCCACAGTCCAGGCCATAGCCCGGGCTCCTTGGGGATGCCTCTGTCTCAGTCTTTGCTGTTATGAGTTTGTGCTGGAGTTCTGTTGGTGTGAAAATATACTTATTTCAGTCAAAACAAACCATATCATTTTCACATCTCAGTCCTCCATTTGCTGTATTCTTTGCTAGTACCCAAAGTAGACTGATTAAACTTTGAAGTGAGGCTTAGAGGAGTGGAAAGCATTTGTGACAGGCTCCATGGTAACTGTGTAACATGTGAAAGCAATGCTGCACCTCTTCTTTATTGGAATGACTTTTTGACCAGCACATTAACTTGAGGACTGCCGACTCTAATATCTATTTCAGGAAAGCGGTGCTTTGTCTTTTTACTACAGAGCATACCACGTGATTGGGTTAGAACCAACAAAGGAAATAAAATGGGAAAGGGTGCCCCACCTTTAAGAATGGCTTTAGGGGGATGAGTGTGCCATTTATGAATGGAAATTATGATTTTCTCTTGTAGAAAGGAAGGCTCAGATTAAATTTTAGAATATTTTTAAAATATCTTTTTCACCAACATGTACTGGGAAAGCAATTTCATACTAAACTGATTAAATGATAGTTTTATAATCTATAACTGCAGTAATGGTTTTTTTGTAAATATGAAGTATAATTTATTTTATATCTGTTTTGCTGTAACATTGAAGGAAATACCAGAC
>NM_001718.6
AGAAAGCCCACGTTGGCCGCTGCGGGGAGCGCGGCGTGGAGAGGCGGGAGACCGAATTccggcgccgccgccgcggccgctgcTCGGTGCACTAGCCCCCTTCCTTCCCATCCTTTCTGCGAGCGGGTTTGCTGGGCAGCCGGGCGACCGCCGAACGGAAAGCAAGATCCTCGCCGCCTCCGCTTGAGGAGGCGTGCGGCGCGCGGAGATTTTGAGTGGGAGCGACGGTGCCCGAGAGCTCAGGGGCGCGGAGTTCGTGAGCGAGAAGGAAGTTAAACCTCGCGGAATAGACTGGCATTTCGGGACGCCTTGTCGCCGCAGCCTGGGCCCTGCAACGGGGTAAACTTCATGGTGGCCCTGCGATCTGGGGAGGGGCGTGCGCCACGGTGATGCCGGGCATCTCCCGCAGCTCGTGAGCGGCCCCGCTCCCCGCTGCCCCGGGTCCCACTCAGTCGCCAGGGAGAGCGCGGGGCAGCGCACGTGTGCGGCCAGCGAGGCCCAGAGTGACCGCGCCGCGACTCGCAGGAGCCAGGGCGCAGGCTGCAGTGCAGCCCGGACTCAGACGCACCTGGCCTGGACCGCGCGCCTCTAGAGACCTGCGCGAGGCTGTGAGGCTCCCCTTCCTCCCCTCCAAGCGGTTCTCCTGGTGATCGCCCCTTCGCCACCTCTCTAGCCTGGGCAACTGGGGGCGCCCCGGACGACCATGAGAGATAAGGACTGAGGGCCAGGAAGGGGAAGCGAGCCCGCCGAGAGGTGGCGGGGACTGCTCACGCCAAGGGCCACAGCGGCCGCGCTCCGGCCTCGCTCCGCCGCTCCACGCCTCGCGGGATCCGCGGGGGCAGCCCGGCCGGGCGGGGATGCCGGGGCTGGGGCGGAGGGCGCAGTGGCTGTGCTGGTGGTGGGGgctgctgtgcagctgctgcgggcccccgccgctgcggccgcccttgcccgctgccgcggccgccgccgccggggggcagctgctgggggacggcgggagccccggccgcacggagcagccgccgccgtcgccgcAGTCCTCCTCGGGCTTCCTGTACCGGCGGCTCAAGACGCAGGAGAAGCGGGAGATGCAGAAGGAGATCTTGTCGGTGCTGGggctcccgcaccggccccggcccctgcacggccTCcaacagccgcagcccccggcgctccggcagcaggaggagcagcagcagcagcagcagctgcCTCGCGGAGAGCCCCCTCCCGGGCGACTGAAGTCCGCGCCCCTCTTCATGCTGGATCTGTACAACGCCCTGTCCGCCGACAACGACGAGGACGGGGCGTCGGAGGGGGAGAGGCAGCAGTCCTGGCCCCACGAAGCAGCCAGCTCGTCCCAGCGTCGGCAGCCGCCCCCGGGCGCCGCGCACCCGCTCAACCGCAAGAGCCTTCTGGCCCCCGGATCTGGCAGCGGCGGCGCGTCCCCACTGACCAGCGCGCAGGACAGCGCCTTCCTCAACGACGCGGACATGGTCATGAGCTTTGTGAACCTGGTGGAGTACGACAAGGAGTTCTCCCCTCGTCAGCGACACCACAAAGAGTTCAAGTTCAACTTATCCCAGATTCCTGAGGGTGAGGTGGTGACGGCTGCAGAATTCCGCATCTACAAGGACTGTGTTATGGGGAGTTTTAAAAACCAAACTTTTCTTATCAGCATTTATCAAGTCTTACAGGAGCATCAGCACAGAGACTCTGACCTGTTTTTGTTGGACACCCGTGTAGTATGGGCCTCAGAAGAAGGCTGGCTGGAATTTGACATCACGGCCACTAGCAATCTGTGGGTTGTGACTCCACAGCATAACATGGGGCTTCAGCTGAGCGTGGTGACAAGGGATGGAGTCCACGTCCACCCCCGAGCCGCAGGCCTGGTGGGCAGAGACGGCCCTTACGACAAGCAGCCCTTCATGGTGGCTTTCTTCAAAGTGAGTGAGGTGCACGTGCGCACCACCAGGTCAGCCTCCAGCCGGCGCCGACAACAGAGTCGTAATCGCTCTACCCAGTCCCAGGACGTGGCGCGGGTCTCCAGTGCTTCAGATTACAACAGCAGTGAATTGAAAACAGCCTGCAGGAAGCATGAGCTGTATGTGAGTTTCCAAGACCTGGGATGGCAGGACTGGATCATTGCACCCAAGGGCTATGCTGCCAATTACTGTGATGGAGAATGCTCCTTCCCACTCAACGCACACATGAATGCAACCAACCACGCGATTGTGCAGACCTTGGTTCACCTTATGAACCCCGAGTATGTCCCCAAACCGTGCTGTGCGCCAACTAAGCTAAATGCCATCTCGGTTCTTTACTTTGATGACAACTCCAATGTCATTCTGAAAAAATACAGGAATATGGTTGTAAGAGCTTGTGGATGCCACTAACTCGAAACCAGATGCTGGGGACACACATTCTGCCTTGGATTCCTAGATTACATCTGCCTTAAAAAAACACGGAAGCACAGTTGGAGGTGGGACGATGAGACTTTGAAACTATCTCATGCCAGTGCCTTATTACCCAGGAAGATTTTAAAGGACCTCATTAATAATTTGCTCACTTGGTAAATGACGTGAGTAGTTGTTGGTCTGTAGCAAGCTGAGTTTGGATGTCTGTAGCATAAGGTCTGGTAACTGCAGAAACATAACCGTGAAGCTCTTCCTACCCTCCTCCCCCAAAAACCCACCAAAATTAGTTTTAGCTGTAGATCAAGCTATTTGGGGTGTTTGTTAGTAAATAGGGAAAATAATCTCAAAGGAGTTAAATGTATTCTTGGCTAAAGGATCAGCTGGTTCAGTACTGTCTATCAAAGGTAGATTTTACAGAGAACAGAAATCGGGGAAGTGGGGGGAACGCCTCTGTTCAGTTCATTCCCAGAAGTCCACAGGACGCACAGCCCAGGCCACAGCCAGGGCTCCACGGGGCGCCCTTGTCTCAGTCATTGCTGTTGTATGTTCGTGCTGGAGTTTTGTTGGTGTGAAAATACACTTATTTCAGCCAAAACATACCATTTCTACACCTCAATCCTCCATTTGCTGTACTCTTTGCTAGTACCAAAAGTAGACTGATTACACTGAGGTGAGGCTACAAGGGGTGTGTAACCGTGTAACACGTGAAGGCAATGCTCACCTCTTCTTTACCAGAACGGTTCTTTGACCAGCACATTAACTTCTGGACTGCCGGCTCTAGTACCTTTTCAGTAAAGTGGTTCTCTGCCTTTTTACTATACAGCATACCACGCCACAGGGTTAGAACCAACGAAGAAAATAAAATGAGGGTGCCCAGCTTATAAGAATGGTGTTAGGGGGATGAGCATGCTGTTTATGAACGGAAATCATGATTTCCCTTGTAGAAAGTGAGGCTCAGATTAAATTTTAGAATATTTTCTAAATGTCTTTTTCACAATCATGTACTGGGAAGGCAATTTCATACTAAACTGATTAAATAATACATTTATAATCTACAACTGTTTGCACTTACAGCTTTTTTTGTAAATATAAACTATAATTTATTGTCTATTTTATATCTGTTTTGCTGTAACATTGAAGGAAAGACCAGACTTTTAAAAAAAAAGAGTTTATTTAGAAAGTATCATAGTGTAAACAAACAAATTGTACCACTTTGATTTTCTTGGAATACAAGACTCGTGATGCAAAGCTGAAGTTGTGTGTACAAGACTCTTGACAGTTGTGCTTCTCTAGGAGGTTGGGTTTTTTTAAAAAAAGAATTATCTGTGAACCATACGTGATTAATAAAGATTTCCTTTAAGGCA

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