Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RRAS2P2
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:222677438-222678217  UCSC
Coordinates (T2T) chr2:223162520-223163299  UCSC
Coordinates (hg19) chr2:223542157-223542936  UCSC
Strand -
Parental Sequence NM_012250.6
Parental seq. overlap 678 bp
Parental seq. overlap (%) 28.8%
Genomic Region Intragenic (MOGAT1)
Retrocopy Summary RRAS2P2, located on chr2:222677438-222678217, is a retrocopy of the parental gene RRAS2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RRAS2
Full Name RAS related 2
Also known as NS12|TC21
Coordinate chr11:14277920-14364506
Strand -
Gene summary This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RRAS2P2
Bonobo Pan paniscus RRAS2P2
Gorilla Gorilla gorilla RRAS2P2
Gibbon Nomascus leucogenys RRAS2P2
Green monkey Chlorocebus sabaeus RRAS2P1
Crab-eating macaque Macaca fascicularis RRAS2P2
Rhesus Macaca mulatta RRAS2P1
Baboon Papio anubis RRAS2P2
Golden snub-nosed monkey Rhinopithecus roxellana RRAS2P2
Marmoset Callithrix jacchus RRAS2P4
Orangutan Pongo abelii Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RRAS2P2
GTGGGCAAGTCGGCACTCATCATCCAGTTAATCCAGTCCTTTTTTCTAATGGGTTATGACCCAATCACTTAAGATTCCTATGCAAAGCAGTGTGTGACAGATAACACAGCAGGCTGGCTAGATATTTTAGATAAAGCAGAACAAGAAGAGTTTGGTTGGAGCCATGAGACAACAGAATATCAAAACTGGTGAGGGCTTCCTGTTGGTCTTTTGAGTCACAGGTCAAGGCAGTTTTGGAAAAAATCTATACATTTCAAAGACAGATTCTCAGAGTAAAGGATTATGATGAGTTTCCAATGATTTTATTTGGCAATAAAGCAGATCTGGATCATTAAAGACAAGAAACACAGGAAGGACACAGTTAGTACGGCAACTTAAGGCAGCATACCCAGAAGGCATTAGCAAAGATTAGAATGAATGTAGATTAAGCTTTCCATTAACTTGTCCAAGTTATAAGGAAATTTCAAGAGCAGTAACTTCCTTCTTCACCAGAATCGACACGGAAAGAAAAAGACAAGAAAGGCTGCTACTGTGTCATTTTCTAGAATCCTTTGAGTTTTAGCTATCAGCCTCCAGGAAAAGCCCTCATCTTCTTTTTCTCTCCTTATAGTTTACATCTCATTAGTACCTTTCTAGCCTTAGACAAATGATCATCACGTTAGCCTTAGACCTAGAAGCTGGTAAGTCCTTCCCATGAAGCTAATATAACAGTCATTTCCAGACAAATTTAAAGGAAATGCCAAGGCTGCTTCAAAATTTCTGATTTCATTAAAATATATA
>NM_012250.6
AGACGGCCATTTGTGGCGGCGCTGGAGGCTGCGTTCGGCAGGCGCTGCGGAGACGCGTAGAGGAGCGCGCCCCCCGGCCGCTGCCGCCCCTGGCCCGTGCCGTCACCCCGCTTCTCCGCGCCTCGGGCGGTACCCAGCCAGTCCCCAGCGCCGCGCTACCGCGCTGACCGGCCCTCCAGACGCCTCCCGGTACCCGGGAccccagcccggccgctcgcccgcagcccgccggccgcaCACGTCCCCGGAGCCGGGCCTAGGGCGGGCGGCAGCGGCGGCTCGGCGCAGTCAGGCTGGGCTCTGTAGCGTCCCCATGGCCGCGGCCGGCTGGCGGGACGGCTCCGGCCAGGAGAAGTACCGGCTCGTGGTGGTCGGCGGGGGCGGCGTGGGCAAGTCGGCGCTCACCATCCAGTTCATCCAGTCCTATTTTGTAACGGATTATGATCCAACCATTGAAGATTCTTACACAAAGCAGTGTGTGATAGATGACAGAGCAGCCCGGCTAGATATTTTGGATACAGCAGGACAAGAAGAGTTTGGAGCCATGAGAGAACAGTATATGAGGACTGGCGAAGGCTTCCTGTTGGTCTTTTCAGTCACAGATAGAGGCAGTTTTGAAGAAATCTATAAGTTTCAAAGACAGATTCTCAGAGTAAAGGATCGTGATGAGTTCCCAATGATTTTAATTGGTAATAAAGCAGATCTGGATCATCAAAGACAGGTAACACAGGAAGAAGGACAACAGTTAGCACGGCAGCTTAAGGTAACATACATGGAGGCATCAGCAAAGATTAGGATGAATGTAGATCAAGCTTTCCATGAACTTGTCCGGGTTATCAGGAAATTTCAAGAGCAGGAATGTCCTCCTTCACCAGAACCAACACGGAAAGAAAAAGACAAGAAAGGCTGCCATTGTGTCATTTTCTAGAATCCCTTCAGTTTTAGCTACCAACGGCCAGGAAAAGCCCTCATCTTCTCTTTCTCTCCTCAGTTTACATCTTGTTGGTACCTTTCTAGCCTTAGACAAATGATCACCATGTTAGCCTTAGACGAAGAAGCTGGCTAGTCCTTTCTGTGAAGCTAATACAATGGTCATTTCCAGACAAATTTAAAGGAAACACTAAGGCTGCTTCAAAGATTATCTGATTCCTTTAAAATATATGTCTATATACACAGACATGCTCTTTTTTTAAGTGCTTACATTTTAATAGAGATGAATCAGTTTTGGAATCTAAGCTGTTTGCCAAGCTGAAGCTACAGGTTGTGAAATAATTTTTAACTTTTGGAATCATACTGCCTACTGTTACTCTAAATAGAAATATAGGGTTTTTTTTAATGTGAATTTTTGCCTATCTTTAAACATTTCAATGTCAGCCTTTGTTAACCTTAAATACACTGAATTGAATCTACAAAAGTGAACCATCTCAGACCTTTACTGATACTACAACTTTTGTTTTCTGATGGCCAAAATACCAAATGCCTGTTGTATTTATGGATTAAAAACTGCTTATAAAACCCTGTGTTACTACTCCTACTCTTGGAGATGATAATATTCTATGTGGTCAAATATTTGGACTCATTTAGGACTTAGATATTTCAGTGTACTTGATTTTTTAATTTAACTCTTTTTCACAGCCACGCTAAGGGTAAAAAGGAATAATTTCCTTCTGTCTTCCTTTTCAAGTATTTCTGGGTAAGGGATTCAAAAAACTAAAACTGTTTTTGTTTGTAATATAAAATATGGAATTGATCTTTCCAGGGTCAGAGATGATTAATGTTTTTGCTATATACTTTTATACATTATTTTCTTATCAAACTAGTTAACAAGTATTTTTATATGTTTGTAAGCAGATATGCTTTCATAGCATACCTTGTGTATATGTAAAGATAAGTATTTAATTCTCACTGTTCACTTTTAACTGACAAAGAAAAACAAGTGGAAACTACAGAAACTGTGGTAGAACTTTTACTTGCTGGTCTGGTCTTGGTTGTACCCATCTTTGGCCAGTCACATAACTACTCAAGAAACCTTCCCAATAGAGTACAACAGGATGAGACTCTGAAATCACTTTCAGTATTCCCTGCTAGATATTGATTGTTATTTCAAGTATTAAGTGTAAGCTTTTAATGGATAATTAGTATAACTGTGGATGGCATCTGATTTTGTTTTTAATTCTGTGGATTGTGTTTAAGCAATTCAATAGTATGTTCCTGATTTTGAGATGCTAAGTGGTATTGCACAGTTGTCACTTTATCAAGTGTGTACAACAGTCCCATGAAGTTTATAGAGCATACCCTTGTATAGCTTCAGGTGCTAGAATTAAAATTGATCTGTTATCACAA

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