Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name FBXW4P1
Plot displaying the genomic locations of a retrocopy (in chr22) and its respective parental gene (in chr10). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr22:23262707-23264986  UCSC
Coordinates (T2T) chr22:23685570-23687849  UCSC
Coordinates (hg19) chr22:23604894-23607173  UCSC
Strand +
Parental Sequence NM_022039.4
Parental seq. overlap 2122 bp
Parental seq. overlap (%) 88.2%
Genomic Region Intragenic (BCR)
Retrocopy Summary FBXW4P1, located on chr22:23262707-23264986, is a retrocopy of the parental gene FBXW4. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name FBXW4
Full Name F-box and WD repeat domain containing 4
Also known as DAC|FBW4|FBWD4|SHFM3|SHSF3
Coordinate chr10:101610664-101695295
Strand -
Gene summary This gene is a member of the F-box/WD-40 gene family, which recruit specific target proteins through their WD-40 protein-protein binding domains for ubiquitin mediated degradation. In mouse, a highly similar protein is thought to be responsible for maintaining the apical ectodermal ridge of developing limb buds; disruption of the mouse gene results in the absence of central digits, underdeveloped or absent metacarpal/metatarsal bones and syndactyly. This phenotype is remarkably similar to split hand-split foot malformation in humans, a clinically heterogeneous condition with a variety of modes of transmission. An autosomal recessive form has been mapped to the chromosomal region where this gene is located, and complex rearrangements involving duplications of this gene and others have been associated with the condition. A pseudogene of this locus has been mapped to one of the introns of the BCR gene on chromosome 22. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes FBXW4P1
Gorilla Gorilla gorilla FBXW4P1
Orangutan Pongo abelii FBXW4P1
Gibbon Nomascus leucogenys FBXW4P1
Green monkey Chlorocebus sabaeus FBXW4P1
Crab-eating macaque Macaca fascicularis FBXW4P1
Rhesus Macaca mulatta FBXW4P1
Baboon Papio anubis FBXW4P1
Golden snub-nosed monkey Rhinopithecus roxellana FBXW4P1
Bonobo Pan paniscus Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>FBXW4P1
GGGCGGGCCCGGGTGAGGGCGGGGGCGGAGAGGCGAAGAAGCTGCAGGAAGGGAGGGTGACGAGGGGGAAGCGAAGGAAGGGGAAGAGGAAGGGAAAAGCGAGCGAGAGGGGCAAGGCGGAAGAGGAAGCAGGGCGGAAGGGAAGCCCGGGCCGCAGACGGCGAAGGAGGCAGCGGGCCGGGGGCTGAGGCGGGAGCGAGGACACGCCCAAGAGAGGAAGCAGAGGGAGGCGGAAGCGTGGAGGAAGGGGCGAGAGGCATCATCAAAGGAGATGAGGGGAGCGTAGGGGCCGGGAAAGAGGCACAAGGAAGAAAGTATGGGAAGGAGGAATGGAGGGTCAGGGCTAGGCGGCGGGAGGGCGCCAGGCCGGGAAGAGTACAAGGACAAGGAGGTCAGGTTTGGGCCTACATCCCGGGGACAGGGGCGGCCATGGCGGCGGCAGCCAGGGAGGAGGAGGAGGAGGCGGCTCGGGAGTCAGCCGCCTGCCCGGCTGCGGGGCCAGCGCTCTGGCGCCTGCCGGAAGTGCTGCTGCTGCACATGTGCTCCTACCTCGACATGCGGGCCCTCGGCCGCCTGGCCCAGGTGTACCGCTGGCTGTGGCACTTCACCAACTGCGACCTGCTCCGGCGCCAGATAGCCTGGGCCTCGCTCAACTCCGGCTTCACGCGGCTCGGCACCAACCTGATGACCAGTGTCCCAGTGAAGGTGTCTCAGAACTGGATAGTGGGGTGCTGCCGAGAGGGGATTCTGCTGAAGTGGAGATGCAGTCAGATGCCCTGGATGCAGCTAGAGGATGATGCTTTGTACATATCCCAGGCTAATTTCATCCTGGCCTACCAGTTCCGTCCAGATGGTGCCAGCTTGAACCGTCAGCCTCTGGGAGTCTGCTGGGCATGATGAGGACGTTTGCCACTTTGTGCTGGCCACCTCGCATATTGTCAGTGCAGGAGGAGATGGGAAGATTGGCCTTGGTAAGATTCACAGCACCTTCGCTGCCAAGTACTGGGCTCATGAACAGGAGGTGAACTGTGTGGATTGCAAAGGGGGCATCATATCATTGTGAGTGGCTCCAGGGACAGGACGGCCAAGGTGTGGCCTTTGGCCTCAGGCCAGCTGGGGTAGTGTTTATACACCATCCAGACTGAAGACCAAATCTGGTCTGTTGCTATCAGGCCATTACTCAGCTCTTTTGTGACAGGGACGGCTTGTTGTGGGCACTTCTCACCCCTGAAAATCTGGGACCTCAACAGTGGGCAGCTGATGACACACTTGGACAGAGACTTTCCCCCAAGGGCTGGGGTGCTGGATGTCATATATGAGTCCCCTTTCGCACTGCTCTCCTGTGGCTATGACACCTATGTTCGCTACTGGGACTGCCGCACCAGTGTCCGGAAATGTGTCATGGAGTGGGAGGAGCCCCACAACAGCACCCTGTACTGCCTGCAGACAGATGGCAACCACTTGCTTGCCACAGGTTCCTCCTTCTATAGCGTTGTACGGCTGTGGGACCGGCACCAAAGGGCCTGCCCGCACACCTTCCCGCTGACGTCGACCCGCCTCGGCAGCCCTGTGTACTGCCTGCATCTCACCACCAAGCATCTCTATGCTGCGCTGTCTTACAACCTCCACGTCCTGGATATTCAAAACCCGTGACCGTCAGGGCCACCCCTGCCTGTGGGCCAAGGAGACCAGTGAGTCAGGGACCTCTCTTGCATGAAGGGTGCAGTGATAGTTCCTCCCCACTGCCCCACTGTGCTCCTGGGCCTGTGACCCCAGTGCTCAGGCACCTTGCAGTAGAGGCTTCTGACTCCTGGAGCTTTGTGGCTTACCAGAGATGCAGTCCCTCCCAGGAACCTGTTGGAGAGGCAGGACCTGCTGCTTTAGAGGAGTGCAGCTGAACCTCGGCCCTGCGACTCTGTTTGGCCAGAGCAAGGATCTGGCCTGGAGAGGCCCATCCTACACCCCTTATTAGAGCCGTGATAGCCTACAGAGTGAGGTGAGGTTCTCCCGCCTTCCCAGGTGGTTTCTTTCTGCCACTTCCTGGAAAGAAAGGTGAGGCTGCCAATAGCCCGCTAGCACCAGCCAGACCTCACGCTTGACCAACCTCTCGGGGCCAGAGGTTCATTCCTGGGGCACTGTGGCCTGGTTTTGTTTTGAAACCAAGAGAGGGCAAAGGGAACCCAGCAGTTCTGAGTGAGTTCTAGCCAGCCCTACCTCAGGCTGGCTGTTGAGAGATTTTACAATTTTCATTTTTGTAAAAATAAAGCTTGATTGTTCACA
>NM_022039.4
CTCCCGGGGCGGCGGCGGTGGCggctcgggctgggctccgcgtcgggccggccccgcggcCGCTCATGGGCAGCCAGGGCCGCTCGGGGCCCCCCGGGAACGGCGGGCCCGGCGAGGGCGAGGGCGGAGAGGCGAGGAAGCTGCAGGAAGGGAGGGTGGCGAGGGGGAAGCGAAGGAAGGGGAAGGGGAAGGGAAAAGCGAGAGCGGGGCAAGGCGGAAGAGGAAGCGGGGCGGAAGGGAAGCCCGGGCCGCAGACGGCGAAGGAGGCAGCCGGGCCGGGGGCTGACGCGGGAGCGAGGGCATGCCCAAGGGAGGAAGCAGAGGGAGGCAGAAGCGTGGAGGAAGGGGCGAGAGGCATCGTCAAGGGAGTCGAGGGGAGCGCAGGGGCCGGGAAGGAGGCACAAGGAAGAGAGTATGGGAAGAAGGAGGAATGGAGGGTCAGGGCTAGGCGGCGGGAGGGCGCCAGGCCGGGAAGAGCACAGGGACGAGGGGGTCAGGCTTGGGCCGACATCGCGGGGACAGGGGTGGCCATGGCGGCGGCGGCCGGggaggaggaggaggaggaggaggcggCTCGGGAGTCGGCTGCCCGCCCGGCCGCGGGGCCTGCGCTCTGGCGCCTGCCGGAGGAGCTGCTGCTGCTCATCTGCTCCTACCTGGACATGCGGGCCCTCGGCCGCCTGGCCCAGGTGTGCCGCTGGCTGCGGCGCTTCACCAGCTGCGATCTGCTCTGGCGCCGGATAGCCCGGGCCTCGCTCAACTCCGGCTTCACGCGGCTCGGCACCGACCTGATGACCAGTGTCCCAGTGAAGGAACGAGTGAAGGTGTCTCAGAACTGGAGACTGGGGCGCTGCCGAGAGGGGATTCTGCTGAAGTGGAGATGCAGTCAGATGCCCTGGATGCAGCTAGAGGATGATTCTCTGTACATATCCCAGGCTAATTTCATCCTGGCCTACCAGTTCCGTCCAGATGGTGCCAGCTTGAATCGTCGGCCTCTGGGAGTCTTTGCTGGGCATGATGAGGACGTTTGCCACTTTGTGCTGGCCAACTCGCATATTGTTAGTGCAGGAGGGGATGGGAAGATTGGCATTCATAAGATTCACAGCACCTTCACTGTCAAGTACTCGGCTCATGAACAGGAGGTGAACTGTGTGGATTGCAAAGGGGGCATCATTGTGAGTGGCTCCAGGGACAGGACGGCCAAGGTGTGGCCTTTGGCCTCAGGCCGGCTGGGGCAGTGCTTACACACCATCCAGACTGAAGACCGAGTCTGGTCCATTGCTATCAGCCCATTACTCAGCTCTTTTGTGACAGGGACGGCTTGTTGCGGGCACTTCTCACCCCTGAGAATCTGGGACCTCAACAGTGGGCAGCTGATGACACACTTGGGCAGTGACTTTCCCCCAGGGGCTGGGGTGCTGGATGTCATGTATGAGTCCCCTTTCACACTGCTGTCCTGTGGCTATGACACCTATGTTCGCTACTGGGACCTCCGCACCAGCGTCCGGAAATGTGTCATGGAGTGGGAGGAGCCCCACGACAGCACCCTGTACTGCCTGCAGACAGATGGCAACCACCTGCTGGCCACAGGTTCCTCCTACTACGGTGTTGTACGGCTGTGGGACCGGCGTCAAAGGGCCTGCCTGCACGCCTTCCCGCTGACGTCGACTCCCCTCAGCAGCCCTGTGTACTGCCTGCGTCTCACCACCAAGCATCTCTATGCTGCCCTGTCTTACAACCTCCACGTCCTGGATTTTCAAAACCCATGACCGTCAGGGCCACCCCTGCCTCTGGGCCAGGGAAACCAGCTACTCAGGGACTTCTCTTGCCTGGAGGGTGCAGTGATAGCTCCTCCTCACTGCCCCACTGTGCTCCTGGGCCTGTGACCCCAGTGCTCAGGCACCTTGCACTAGAGGCTTCTGACTCCTGGGACTTTGGAGCTTACCAGAGATGCAGTCCCTCCCAGGAACCTGTTGGAGAGGCAGGACCTGCTGCTTTAGAGTGCGGCTGAACCCGGGCCTTGCGTCCCTGTTTGGCCAGAGCAAGGATCTGGCCTGGAGAGGCCCATCCTATACCCCTTATTAGAGCCATGACAGCCTACAGAGTGAGGTGAGGTGCTCCCACCTTCCCAGATGGTTCCTTTCTGCCCCTTCCTGGAAGGAAAGGTGAGGCTGCCAATAGCCTCCTGGCACCAGCCAGACCTCACCCTTGACCAACCTCTCGGGGCTGGGGGTTCATTCCTGGGGCACTGTGGCCTGGTTTTGCTTTGAAACCAAGAAAGAGCAAAGGGAACCCAGCAGTTCTGAGTGAGTTCTGAGCCAGCCCTACCTCAGGCTGGCTGTTGAGACATGCTACAATTTTCATTTTTGTAAAAATAAAGCTTGATTGTTCACA

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