Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name USP21P1
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:224170715-224171807  UCSC
Coordinates (T2T) chr2:224653941-224655033  UCSC
Coordinates (hg19) chr2:225035432-225036524  UCSC
Strand +
Parental Sequence NM_001014443.3
Parental seq. overlap 964 bp
Parental seq. overlap (%) 41.3%
Genomic Region Intergenic
Retrocopy Summary USP21P1, located on chr2:224170715-224171807, is a retrocopy of the parental gene USP21. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name USP21
Full Name ubiquitin specific peptidase 21
Also known as USP16|USP23
Coordinate chr1:161159487-161165723
Strand +
Gene summary This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes USP21P1
Bonobo Pan paniscus USP21P1
Gorilla Gorilla gorilla USP21P1
Orangutan Pongo abelii USP21P1
Gibbon Nomascus leucogenys USP21P2
Green monkey Chlorocebus sabaeus USP21P1
Rhesus Macaca mulatta USP21P1
Baboon Papio anubis USP21P1
Golden snub-nosed monkey Rhinopithecus roxellana USP21P1
Crab-eating macaque Macaca fascicularis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>USP21P1
TCTTCTCTGGATACAGCCAGCAGGATACCCAAGAGTTCCTGACATTCCTTATGGGAGCGGCTACACCTTGAAATCAACCACGGAGGCCGCGGGGCTCCACCAGTCCCTGCCCATGGTCCAGCTCCCTCTCCACCCCACCAAGGGGAGTGCTCTGCTAAAAGAGTCTGAGTTAAATGATGCTGACTGGGCCAACCTAATGTGGAAGCGTTATCTGGAAGAACAAGAGGACAGCAAGATGGTGGATCTGTTTGTGGGCCAGATGAAAAGTTATCTCAAGTGCCAGGCCTGTGGGTACCACTCTATGACCTTCAAGGTTTTTTTTTTTTGTGACCTCTCCCTGACCATCCCCAAGAAAGGATTTGCTGGGGGCAAGGTGTCTCTGCGGGATTGTTTAAGCCTTTTCACCAAGGAAGAAGAGCTAGAGTTAGAGAATGCCTCAGTGTGTGACCCACATTGGCAGAAAACACATGGTGCCAAAAGTTGACAGTACAAAGATTCCCTTGAATCTTCATGCTCCATCTGAATCAATTTTCTGCCTCCTGAGGCTCCATCAAGAAAAGTTCTGTAGGTGTAGACTTCCCACTGCAGTGACTGAGCCTAGGGGACTTTGCCAGTGACAAAGTCGGAAGTCCTGTCTACCAGCTGTGTGCCCTTTGGAACCACTCAGGCAGCATCCACTGTGGCCACTACACAACCCTGTGCCAGTGCCAGACTGGTTGGCACGTTTACAATGACTCTTGTGTCTCCCCTGTAAGTGAAAACCAGGTGGCATCCAGTGAAGCCTACTGTTCTACCAACTGACGCAGGAGCCACCCCAGTGCCTGTGACACCCCCTCTAAGCCCTGGCCCCTGTGAAGCCCTTTAAACACCCTTAAGCCCCAGGCTCCCCATATATCTCAGAGACATCTATTTTTGTGTCTTTTAAGTCAGAGAGTGGGGAGAGGGTGGTTGTAGCTCCCATTATATATTTTTTCAAATTAAAAAGTACCTTTCCAAGTGGAGGATCCCTGGTCTCCCAGTCCCATGTACAGAGCTCACCAGGCCCCTGCACATGTACAGCCCCCAGACCCTCTGTAATCTCATTTTTTGTGAA
>NM_001014443.3
GGTGGCCGGGCGGGACCAACAAAGATGGCGGCGGCCCCTGCGGCGGGAGCGATCTGGGCAACGGCTGCGGCTAAAGCTGCAGCCGGGCCCACGGGGGGGCTGCACGGGGGTAGTAGGGGGTGGCCCTGAACTGGGGCCTGGCCCTGGCTGGCCTCTCCCGCCGCCTCACTGGGGGACAGgtactggggatacgatggctgattcgatagatctggttcctgccctcaGTGCGTATACTGCTCCCCACTTTCGTTGATGTGGTAGTGGTGATGACTGAGCCAACCACCTAATGTGGAAATGAGAGGACAGCAAGATTGTGGGTCCAGCCTGTGGTGTCCACAATGCCCCAGGCCTCTGAGCACCGCCTGGGCCGTACCCGAGAGCCACCTGTTAATATCCAGCCCCGAGTGGGATCCAAGCTACCATTTGCCCCCAGGGCCCGCAGCAAGGAGCGCAGAAACCCAGCCTCTGGGCCAAACCCCATGTTACGACCTCTGCCTCCCCGGCCAGGTCTGCCTGATGAACGGCTCAAGAAACTGGAGCTGGGACGGGGACGGACCTCAGGCCCTCGTCCCAGAGGCCCCCTTCGAGCAGATCATGGGGTTCCCCTGCCTGGCTCACCACCCCCAACAGTGGCTTTGCCTCTCCCATCTCGGACCAACTTAGCCCGTTCCAAGTCTGTGAGCAGTGGGGACTTGCGTCCAATGGGGATTGCCTTGGGAGGGCACCGTGGCACCGGAGAGCTTGGGGCTGCACTGAGCCGCTTGGCCCTCCGGCCTGAGCCACCCACTTTGAGACGTAGCACTTCTCTCCGCCGCCTAGGGGGCTTTCCTGGACCCCCTACCCTGTTCAGCATACGGACAGAGCCCCCTGCTTCCCATGGCTCCTTCCACATGATATCCGCCCGGTCCTCTGAGCCTTTCTACTCTGATGACAAGATGGCTCATCACACACTCCTTCTGGGCTCTGGTCATGTTGGCCTTCGAAACCTGGGAAACACGTGCTTCCTGAATGCTGTGCTGCAGTGTCTGAGCAGCACTCGACCTCTTCGGGACTTCTGTCTGAGAAGGGACTTCCGGCAAGAGGTGCCTGGAGGAGGCCGAGCCCAAGAGCTCACTGAAGCCTTTGCAGATGTGATTGGTGCCCTCTGGCACCCTGACTCCTGCGAAGCTGTGAATCCTACTCGATTCCGAGCTGTCTTCCAGAAATATGTTCCCTCCTTCTCTGGATACAGCCAGCAGGATGCCCAAGAGTTCCTGAAGCTCCTCATGGAGCGGCTACACCTTGAAATCAACCGCCGAGGCCGCCGGGCTCCACCGATACTTGCCAATGGTCCAGTTCCCTCTCCACCCCGCCGAGGAGGGGCTCTGCTAGAAGAACCTGAGTTAAGTGATGATGACCGAGCCAACCTAATGTGGAAACGTTACCTGGAGCGAGAGGACAGCAAGATTGTGGACCTGTTTGTGGGCCAGTTGAAAAGTTGTCTCAAGTGCCAGGCCTGTGGGTATCGCTCCACGACCTTCGAGGTTTTTTGTGACCTGTCCCTGCCCATCCCCAAGAAAGGATTTGCTGGGGGCAAGGTGTCTCTGCGGGATTGTTTCAACCTTTTCACTAAGGAAGAAGAGCTAGAGTCGGAGAATGCCCCAGTGTGTGACCGATGTCGGCAGAAAACTCGAAGTACCAAAAAGTTGACAGTACAAAGATTCCCTCGAATCCTCGTGCTCCATCTGAATCGATTTTCTGCCTCCCGAGGCTCCATCAAAAAAAGTTCAGTAGGTGTAGACTTTCCACTGCAGCGACTGAGCCTAGGGGACTTTGCCAGTGACAAAGCCGGAAGTCCTGTATACCAGCTGTATGCCCTTTGCAACCACTCAGGCAGCGTCCACTATGGCCACTACACAGCCCTGTGCCGGTGCCAGACTGGTTGGCATGTCTACAATGACTCTCGTGTCTCCCCTGTCAGTGAAAACCAGGTGGCATCCAGCGAGGGCTACGTGCTGTTCTACCAACTGATGCAGGAGCCACCCCGGTGCCTGTGACACCTCTAAGCTCTGGCACCTGTGAAGCCCTTTAAACACCCTTAAGCCCCAGGCTCCCCGTTTACCTCAGAGACGTCTATTTTTGTGTCTTTTTAATCGGGGAGGGGGGAGGGGGTGGTTGTAGCTCCATTATTTTTTTTATTAAAAAATACCCTTCCACCTGGAGGCTCCCTTGTCTCCCAGCCCCATGTACAAAGCTCACCAAGCCCCTGCCCATGTACAGCCCCCAGACCCTCTGCAATATCACTTTTTGTGAATAAATTTATTAAGAAAAAA

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