Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TDGF1P2
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:227869175-227870556  UCSC
Coordinates (T2T) chr2:228351505-228352886  UCSC
Coordinates (hg19) chr2:228733891-228735272  UCSC
Strand -
Parental Sequence NM_001174136.2
Parental seq. overlap 1280 bp
Parental seq. overlap (%) 71.1%
Genomic Region Intergenic
Retrocopy Summary TDGF1P2, located on chr2:227869175-227870556, is a retrocopy of the parental gene TDGF1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TDGF1
Full Name teratocarcinoma-derived growth factor 1
Also known as CR|CR-1|CRGF|CRIPTO
Coordinate chr3:46574535-46582457
Strand +
Gene summary This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TDGF1P1
Bonobo Pan paniscus TDGF1P1
Gorilla Gorilla gorilla TDGF1P1
Orangutan Pongo abelii TDGF1P1
Gibbon Nomascus leucogenys TDGF1P5
Green monkey Chlorocebus sabaeus TDGF1P3
Crab-eating macaque Macaca fascicularis TDGF1P3
Rhesus Macaca mulatta TDGF1P3
Baboon Papio anubis TDGF1P3
Golden snub-nosed monkey Rhinopithecus roxellana TDGF1P5
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TDGF1P2
GGCTGAGCCATCGGGAACTTGTGCGTCCATCTCAGGGAGACCTGGCCTTCAGAGATGACAGCATTCAGCCCCAGGAGGAGCCTGCAATTCGTCCTCGGTCTTCCCAGCTTGTGCCCCCCATGGGGATACAGGACAGTAAGGAGCCAAACAGAACCTGCTGCCTGAATGGGGGAACCTGCATGCTGGGGTCCTTTTGTGCCTGCCTCCCCTCCTTCTATGGATGGAACTGTGAGCACGGTGTACGCAAAGAGAATTGTGGGTCTGTGCCCCATGACACCCGGCTGCCCAAGAAGTGTTCCATGTGTAAATGCTGGCACGGGCAGCTCCGCTGCTTTCCTCAGGCATTTCTACCTGGCTGTGATGGCCTTGTGATGGATGAGCACCTCATGGCTCCCAGGACTCCAGAACTACCACCGTCTGCATGCACCACTTTTATATGCTAGCTGGCATCTGCCTTTCTATACAAAGTTACTATTAATTGACATTGACCTATTTCCAGAAATATGATTTTAGATATCATTCAAATTTCATGACCAGTAAAGGCTGCTGCTATAATGTCCTAACTGAAAGATGATCATTTGTTAGTTGCCTTAAAATAATGAATACATTTCCAAAATGGTCTCTAACATTTCCTTGTAGTACCAAATACTTCTTACCTCTTTGCCCTGCCCTCCCCACAAAAACTACTTCTTTTTTCAAAAGAAAGTCAGCCATATCTCCATTGTGCCTAAGTCATGTTTCTTGATACATGTAATTCTACCAAGGTCTTCTTAAAAGTTCTTTTAAACAATTGAATATTATCTTCAGATTATTAAAGACCAATCCTAATGTGGACCTTAGGATACAGTTTTGAGTAGAGTTGATAAAAATCAATTAAAATAGTCTCTTTAAATGGAAAGAAAGCCTCTTTAAGGGGAGGAAACAGAGGGCTGAAGGAATGGAAGTTCATCTGCATGTATGCAGGGAGACTGGGTAGGAAAGAGGAAGCAAATGGGAGAGAGAGGTTGGAAAACATAAAATGGGTTACTTGATGGTGATTAGGTGGGTGTAGAGAAGAAAGTTAAAAGGCTAAATGGAAGGGTAAGTTTCCGTCATCTATAGAAAGCTATATGAGACAAGGACTCCAATTTTTTTCCCAAAGGTGTTGTAAAAAGAATGAAGTCTCCTTATAAAAAAAAAATTATACCTCAATGTCCCCAACAAGACTGCTTAATAAATTATGTTTCCTCCAAGCTATGCAATTCTTTTAACTGTTGTAGAAGAGAAAATGTTCACAATATATTTAGTTGTAAACCAAATGATAAAACTACATATTGTAAAGCCAACTTTTAAAATACATTGTATATATGCGTATGCACAGTAAAAATGGAAAATATATTGAC
>NM_001174136.2
CTCTCTTATCTTCTGGCCTGCCTGGATGTTCAAGGGAACAATGACAGAGTGTGATTTGGATCATGGCCATTTCTAAAGTCTTTGAACTGGGATTAGTTGCCGGGCTGGGCCATCAGGAATTTGCTCGTCCATCTCGGGGATACCTGGCCTTCAGAGATGACAGCATTTGGCCCCAGGAGGAGCCTGCAATTCGGCCTCGGTCTTCCCAGCGTGTGCCGCCCATGGGGATACAGCACAGTAAGGAGCTAAACAGAACCTGCTGCCTGAATGGGGGAACCTGCATGCTGGGGTCCTTTTGTGCCTGCCCTCCCTCCTTCTACGGACGGAACTGTGAGCACGATGTGCGCAAAGAGAACTGTGGGTCTGTGCCCCATGACACCTGGCTGCCCAAGAAGTGTTCCCTGTGTAAATGCTGGCACGGTCAGCTCCGCTGCTTTCCTCAGGCATTTCTACCCGGCTGTGATGGCCTTGTGATGGATGAGCACCTCGTGGCTTCCAGGACTCCAGAACTACCACCGTCTGCACGTACTACCACTTTTATGCTAGTTGGCATCTGCCTTTCTATACAAAGCTACTATTAATCGACATTGACCTATTTCCAGAAATACAATTTTAGATATCATGCAAATTTCATGACCAGTAAAGGCTGCTGCTACAATGTCCTAACTGAAAGATGATCATTTGTAGTTGCCTTAAAATAATGAATACATTTCCAAAATGGTCTCTAACATTTCCTTACAGAACTACTTCTTACTTCTTTGCCCTGCCCTCTCCCAAAAAACTACTTCTTTTTTCAAAAGAAAGTCAGCCATATCTCCATTGTGCCTAAGTCCAGTGtttctttttttttttttttttgagacggagtctcactctgtcacccaggctggactgcaatgacgcgatcttggttcactgcaacctccgcatccggggttcaagccattctcctgcctcagcctcccaagtaactgggattacaggcatgtgtcaccatgcccagctaatttttttgtatttttagtagagatgggggtttcaccatattggccagtctggtctcgaactcctgaccttgtgatccactcgcctcagcctctcgaagtgctgagattacacacgtgagcaactgtgcaaggccTGGTGTTTCTTGATACATGTAATTCTACCAAGGTCTTCTTAATATGTTCTTTTAAATGATTGAATTATATGTTCAGATTATTGGAGACTAATTCTAATGTGGACCTTAGAATACAGTTTTGAGTAGAGTTGATCAAAATCAATTAAAATAGTCTCTTTAAAAGGAAAGAAAACATCTTTAAGGGGAGGAACCAGAGTGCTGAAGGAATGGAAGTCCATCTGCGTGTGTGCAGGGAGACTGGGTAGGAAAGAGGAAGCAAATAGAAGAGAGAGGTTGAAAAACAAAATGGGTTACTTGATTGGTGATTAGGTGGTGGTAGAGAAGCAAGTAAAAAGGCTAAATGGAAGGGCAAGTTTCCATCATCTATAGAAAGCTATATAAGACAAGAACTCCCCTTTTTTTCCCAAAGGCATTATAAAAAGAATGAAGCCTCCTTAGAAAAAAAATTATACCTCAATGTCCCCAACAAGATTGCTTAATAAATTGTGTTTCCTCCAAGCTATTCAATTCTTTTAACTGTTGTAGAAGACaaaatgttcacaatatatttagttgtaaaccaagtgatcaaactacatattgtaaagcccatttttaaaatacattgtatatatgtgtatgcacagtaaaaatggaaactatattga

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