Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SIRPAP1
Plot displaying the genomic locations of a retrocopy (in chr22) and its respective parental gene (in chr20). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr22:30542214-30544935  UCSC
Coordinates (T2T) chr22:31005619-31008340  UCSC
Coordinates (hg19) chr22:30938201-30940922  UCSC
Strand +
Parental Sequence NM_001040022.1
Parental seq. overlap 2438 bp
Parental seq. overlap (%) 58%
Genomic Region Intergenic
Retrocopy Summary SIRPAP1, located on chr22:30542214-30544935, is a retrocopy of the parental gene SIRPA. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SIRPA
Full Name signal regulatory protein alpha
Also known as BIT|CD172A|MFR|MYD-1|P84|PTPNS1|SHPS1|SIRP
Coordinate chr20:1894167-1940592
Strand +
Gene summary The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SIRPAP1
Bonobo Pan paniscus SIRPAP1
Gorilla Gorilla gorilla SIRPAP1
Orangutan Pongo abelii SIRPAP1
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SIRPAP1
CTCCGGCCCGCACCCACCCCCAAGAGGGGCCTTCAGCTTTGGGGCTCAGAGGCACGACCTCTTGGGGAGGGTTAAAAGGCAGACACCCCCCCACCCCCGCGCCTCCACTCCCCGACTCCTTCGCCGCCTCCAGCCTCTCGCCAGTGGGAAGCGGGAGTAGCCGCGCGGCCGGAGTCCGGAGGCGAGGGGAGGTCGGCCGCAACTTCCCCAGGCCACCTTAAGAGGACGATGTAGCCAGCTCGCAGCGCTGACCTCAGAAAAACAAGTTTGCGCAAAGTGGAGCGGGGACCCGGCCTCTGGGCAGCCCCGGCGGCGCTTCTAGTGCCTTCCAGCCCTCGCGGGCGGCGTAGCCGCGGCCCATGGAGCCCGCGGGCCGGTCCCCGGCCGCCTCGGGCCGCTGCTCTGCCTGCTGCTCCCCGCGTCCTGCGCCTGGTCAGGAGTGGCGGGTGAGGAGGAGCTGCAGGTGATTCAGCCTGAGAAGTCTGTATCAGTTGCAGCTGGAGAGTCGGCCGCTCTGCAGTGCACTGTGACCTCCCTGAACCCTGTGGGGCCCATCCAACGGTTCAGAGGAGCTGGACCAGGCCGGAAATTAATCTACCATCAAAAAGAAGGCCACTTCCCCCGGGTAACAACTGTTTCAGATCTCACAAAGAGAACCAACATGGACTTTTCCATCTGCATCAGTAACATCACCCCAGCAGATGCCGGCACCTACTACTGTGTGAAGTTCCAGAAAGGGAGCCCTGACGTGGAGTTGAAGTCTGGAGCAGGCACTGAGCTGTCTGTGCGTGCCAAACCCTCTGCCCCCGTGGTATCGGGCCCCGCAGCGAGGGCCACACCTGACCACACAGTGAGCTTCACCTGCGAGTCTCATGGCTTCTCACCCAGAGACATCAGCCTGAAATGGTTCAAAAATGGGAATCAGCTCTCAGACTTCCAGACCAACGTGGACCCCGCAAGAGAGAGCGTGTCCTACAGCATCCACAGCACAGCCAATGTGGTGCTGACCCGCGGGGACATTCACTCTCAAGTCATCTGCGAGGTGGCCCACGTCACCTTGCGGGGGGACTCTTTTCGTGGGACTGCCAACTTGTCTGAGACTATCCAAGTTCCACCCACCTTGGAGGTTACTCAACAGCCCATGAGGGCAGAGAACCAGGTGAATATCACCTGCCAGGTGACGAAATTCTACCCCCAGAGACTACAGTTGACCTGGTTGGAGAACGGCAATGTGTCCCGGACAGAAACGGCCTCAACTCTTACAGAGAACAAGGATGGCACCTACAACTGGATGAGCTGGCTCCTGGTGAATGTATCTGCCCACAGGGATGATGTGAAGCTCACCTGCCAGGTGGAGCATGACGGGCAGTCAGCGGTCAGCAAAAGCCATGACCTGAAGGTCTCAGCCCACCTGAAGGAGCAGAGCTCAAATACCGCCGCTGAGAACACTGGACCTAATGAACAGAACATCTATATTGTGGTGGGCGTGGTGTGCACCTTGCTGGTGGCCCTACTGATGGAGGCTCTCTACCTCGTCCGAATCAGACAGAAGAAAGCCCAGGGCTCCACTTCTTCTACAAGGTTGCATGAACCCGAGAAGAATGCCAGAAAAATAACCCAGGACACAAATGATATCACATATGCGGACCTGAACCTGCCCAAGGGGAAGAAGCCTGCTCCCCGGGCCGCGGAGCCCAACAACCACACAGAGTATGCCAGCATTCAGACCAGCCTGCAGCCTGCGTCGGAGGACACCCTCACCTATGCTGACCTGGACATGGTGCACCTCAACCGGACCCCCAAGCAGCTGGCCCCCAAGCCCGAGCTGTCCTTCTCAGAGTATGCCAGCATCCAGGTCCCGAGGAAGTGAATGGGACCGTGGTTTGCTCTAGCACCCATCTCCATGCTCTTCCTTGTCCCACAAGGAGCCGCCATGATGAGCACAGCCAGCCCAGTTCCCGGAGGGCTGGGGCGGTGCAGGCTCTGGGACCCAGGGGCCAGGGTGGCTCTTCTCTCCCCACCCCTCCTTGGCTCTCCAGCAGCCACGGCCCCCTCTCCCCACATTGCCACACACCTGGAGGCTGACGTTGCCAAACCAGCCAGGGAACCGACCTGGGAAGCGGCCAGAACTGCCTGGGGTCCAAGAACTCTTGTGCCTCCGTCCATCACCATGTGGGTTTTGAAGACCCTTGACTACCTCCCCGATGCTCCGAAGCCTGATCTTCCAGGGTGGGGAGGAGAAAATCCCTCAACTGGGGCTTGAGTGGGGAAGATTTCCCCTTTAGATCAAACTACCACTTCCATGGAAAAGCTGGAAAAAAACTCTGGAACCCATATCCAGACCTGGTGAGGTTGCTGCCAACAGTCCTGGCCTCCCCCATCCCTAGGCTAAAGAGCCATGAGTCCTGGAGGAGGAGAGGATCCCTCCCAAAGGACTGGAGACAAAACCCTCCGCTTCCTCAGGTCCCTCCAAGACTCCCTGGGGCCCAACTGTGTTGCTCCACCCGGACGtGGTGTTTTGTTTTGTTTTTTTCTTAAAACAACAACAACGTGA
>NM_001040022.1
TCCGGCCCGCACCCACCCCCAAGAGGGGCCTTCAGCTTTGGGGCTCAGAGGCACGACCTCCTGGGGAGGGTTAAAAGGCAGACGcccccccgccccccgcgcccccgcgccccgactccttcgccgcctccagcctctcgccAGTGGGAAGCGGGGAGCAGCCGCGCGGCCGGAGTCCGGAGGCGAGGGGAGGTCGGCCGCAACTTCCCCGGTCCACCTTAAGAGGACGATGTAGCCAGCTCGCAGCGCTGACCTTAGAAAAACAAGTTTGCGCAAAGTGGAGCGGGGACCCGGCCTCTGGGCAGCCCCGGCGGCGCTTCCAGTGCCTTCCAGCCCTCGCGGGCGGCGCAGCCGCGGCCCATGGAGCCCGCCGGCCCGGCCCCCGGCCGCCTCGGGCCGCTGCTCTGCCTGCTGCTCGCCGCGTCCTGCGCCTGGTCAGGAGTGGCGGGTGAGGAGGAGCTGCAGGTGATTCAGCCTGACAAGTCCGTGTTGGTTGCAGCTGGAGAGACAGCCACTCTGCGCTGCACTGCGACCTCTCTGATCCCTGTGGGGCCCATCCAGTGGTTCAGAGGAGCTGGACCAGGCCGGGAATTAATCTACAATCAAAAAGAAGGCCACTTCCCCCGGGTAACAACTGTTTCAGACCTCACAAAGAGAAACAACATGGACTTTTCCATCCGCATCGGTAACATCACCCCAGCAGATGCCGGCACCTACTACTGTGTGAAGTTCCGGAAAGGGAGCCCCGATGACGTGGAGTTTAAGTCTGGAGCAGGCACTGAGCTGTCTGTGCGCGCCAAACCCTCTGCCCCCGTGGTATCGGGCCCTGCGGCGAGGGCCACACCTCAGCACACAGTGAGCTTCACCTGCGAGTCCCACGGCTTCTCACCCAGAGACATCACCCTGAAATGGTTCAAAAATGGGAATGAGCTCTCAGACTTCCAGACCAACGTGGACCCCGTAGGAGAGAGCGTGTCCTACAGCATCCACAGCACAGCCAAGGTGGTGCTGACCCGCGAGGACGTTCACTCTCAAGTCATCTGCGAGGTGGCCCACGTCACCTTGCAGGGGGACCCTCTTCGTGGGACTGCCAACTTGTCTGAGACCATCCGAGTTCCACCCACCTTGGAGGTTACTCAACAGCCCGTGAGGGCAGAGAACCAGGTGAATGTCACCTGCCAGGTGAGGAAGTTCTACCCCCAGAGACTACAGCTGACCTGGTTGGAGAATGGAAACGTGTCCCGGACAGAAACGGCCTCAACCGTTACAGAGAACAAGGATGGTACCTACAACTGGATGAGCTGGCTCCTGGTGAATGTATCTGCCCACAGGGATGATGTGAAGCTCACCTGCCAGGTGGAGCATGACGGGCAGCCAGCGGTCAGCAAAAGCCATGACCTGAAGGTCTCAGCCCACCCGAAGGAGCAGGGCTCAAATACCGCCGCTGAGAACACTGGATCTAATGAACGGAACATCTATATTGTGGTGGGTGTGGTGTGCACCTTGCTGGTGGCCCTACTGATGGCGGCCCTCTACCTCGTCCGAATCAGACAGAAGAAAGCCCAGGGCTCCACTTCTTCTACAAGGTTGCATGAGCCCGAGAAGAATGCCAGAGAAATAACACAGGACACAAATGATATCACATATGCAGACCTGAACCTGCCCAAGGGGAAGAAGCCTGCTCCCCAGGCTGCGGAGCCCAACAACCACACGGAGTATGCCAGCATTCAGACCAGCCCGCAGCCCGCGTCGGAGGACACCCTCACCTATGCTGACCTGGACATGGTCCACCTCAACCGGACCCCCAAGCAGCCGGCCCCCAAGCCTGAGCCGTCCTTCTCAGAGTACGCCAGCGTCCAGGTCCCGAGGAAGTGAATGGGACCGTGGTTTGCTCTAGCACCCATCTCTACGCGCTTTCTTGTCCCACAGGGAGCCGCCGTGATGAGCACAGCCAACCCAGTTCCCGGAGGGCTGGGGCGGTGCAGGCTCTGGGACCCAGGGGCCAGGGTGGCTCTTCTCTCCCCACCCCTCCTTGGCTCTCCAGCACTTCCTGGGCAGCCACGGCCCCCTCCCCCCACATTGCCACATACCTGGAGGCTGACGTTGCCAAACCAGCCAGGGAACCAACCTGGGAAGTGGCCAGAACTGCCTGGGGTCCAAGAACTCTTGTGCCTCCGTCCATCACCATGTGGGTTTTGAAGACCCTCGACTGCCTCCCCGATGCTCCGAAGCCTGATCTTCCAGGGTGGGGAGGAGAAAATCCCACCTCCCCTGACCTccaccacctccaccaccaccaccaccaccaccaccaccactaccaccaccaccCAACTGGGGCTAGAGTGGGGAAGATTTCCCCTTTAGATCAAACTGCCCCTTCCATGGAAAAGCTGGAAAAAAACTCTGGAACCCATATCCAGGCTTGGTGAGGTTGCTGCCAACAGTCCTGGCCTCCCCCATCCCTAGGCTAAAGAGCCATGAGTCCTGGAGGAGGAGAGGACCCCTCCCAAAGGACTGGAGACAAAACCCTCTGCTTCCTTGGGTCCCTCCAAGACTCCCTGGGGCCCAACTGTGTTGCTCCACCCGGACCcatctctcccttctagacctgagcttgcccctccagctagcactaagcaacatctcgctgtggacgcctgtaaattactgagaaatgtgaaacgtgcaatcttgaaactgaggtgttagaaaacttgatctgtGGTGTTTTGTTTTGTTTTTTTTCTTAAAACAACAGCAACGTGATCTTGGCTGTCTGTCATGTGTTGAAGTCCATGGTTGGGTCTTGTGAAGTCTGAGGTTTAACAGTTTGTTGTCCTGGAGGGATTTTCTTACAGCGAAGACTTGAGTTCCTCCAAGTCCCAGAACCCCAAGAATGGGCAAGAAGGATCAGGTCAGCCACTCCCTGGAGACACAGCCTTCTGGCTGGGACTGACTTGGCCATGTTCTCAGCTGAGCCACGCGGCTGGTAGTGCAGCCTTCTGTGACCCCGCTGTGGTAAGTCCAGCCTGCCCAGGGCTGCTGAGGGCTGCCTCTTGACAGTGCAGTCTTATCGAGACCCAAtgcctcagtctgctcatccgtaaagtggggatagtgaagatgacacccctCCCCACCACCTCTCATAAGCACTTTAGGAACACACAGAGGGTAGGGATAGTGGCCCTGGCCGTCTATCCTACCCCTTTAGTGACCGCCCCCATCCCGGCTTTCTGAGCTGATCCTTGAAGAAGAAATCTTCCATTTCTGCTCTCAAACCCTACTGGGATCAAACTGGAATAAATTGAAGACAGCCAGGGGGATGGTGCAGCTGTGAAGCTCGGGCTGATTCCCCCTCTGTCCCAGAAGGTTGGCCAGAGGGTGTGACCCAGTTACCCTTTAACCCCCACCCTTCCAGTCGGGTGTGAGGGCCTGACCGGGCCCAGGGCAAGCAGATGTCGCAAGCCCTATTTATTCAGTCTTCACTATAACTCTTAGAGTTGAGACGCTAATGTTCATGACTCCTGGCCTTGGGATGCCCAAGGGATTTCTGGCTCAGGCTGTAAAAGTAGCTGAGCCATCCTGCCCATTCCTGGAGGTCCTACAGGTGAAACTGCAGGAGCTCAGCATAGACCCAGCTCTCTGGGGGATGGTCACCTGGTGATTTCAATGATGGCATCCAGGAATTAGCTGAGCCAACAGACCATGTGGACAGCTTTGGCCAGAGCTCCCGTGTGGCATCTGGGAGCCACAGTGACCCAGCCACCTGGCTCAGGCTAGTTCCAAATTCCAAAAGATTGGCTTGTAAACCTTCGTCTCCCTCTCTTTTACCCAGAGACAGCACATACGTGTGCACACGCATGCACACACACATTCAGTATTTTAAAAGAATGTTTTCTTGGTGCCATTTTCATTTTATTTTATTTTTTAATTCTTGGAGGGGGAAATAAGGGAATAAGGCCAAGGAAGATGTATAGCTTTAGCTTTAGCCTGGCAACCTGGAGAATCCACATACCTTGTGTATTGAACCCCAGGAAAAGGAAGAGGTCGAACCAACCCTGCGGAAGGAGCATGGTTTCAGGAGTTTATTTTAAGACTGCTGGGAAGGAAACAGGCCCCATTTTGTATATAGTTGCAACTTAAACTTTTTGGCTTGCAAAATATTTTTGTAATAAAGATTTCTGGGTAATAATGA

Publications

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