Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PPP1R14BP6
Plot displaying the genomic locations of a retrocopy (in chr22) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr22:31276439-31277415  UCSC
Coordinates (T2T) chr22:31740420-31741399  UCSC
Coordinates (hg19) chr22:31672425-31673401  UCSC
Strand +
Parental Sequence NM_138689.3
Parental seq. overlap 924 bp
Parental seq. overlap (%) 92.4%
Genomic Region Intergenic
Retrocopy Summary PPP1R14BP6, located on chr22:31276439-31277415, is a retrocopy of the parental gene PPP1R14B. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PPP1R14B
Full Name protein phosphatase 1 regulatory inhibitor subunit 14B
Also known as PHI-1|PLCB3N|PNG|SOM172
Coordinate chr11:64244479-64246943
Strand -
Gene summary Predicted to enable protein serine/threonine phosphatase inhibitor activity. Predicted to be involved in innate immune response. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PPP1R14BP6
Bonobo Pan paniscus PPP1R14BP5
Gorilla Gorilla gorilla PPP1R14BP6
Orangutan Pongo abelii PPP1R14BP4
Gibbon Nomascus leucogenys PPP1R14BP1
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PPP1R14BP6
TAGAGAAAGCGCTTCGGCGGCGGCAGCCCCGGCGGCGGCCGCAGGGGACAAAGGGCGGGCGGATCGGCGGGGAGGGGGCGGGGCGCGACCAGGCCAGGCCCGGGGGCTCCGCATGCTGCAGCTGCCCCCGGGCGCCCCCGCCGCCGCCCTCGCCGCGGAGCCGGCGAGCTAACCTGAGCCAGCCGGCGGGCGTCACGGAGGCGGCGGCACAAGGAGGGGCCCCACGCGCGCACGTGGCCCCGGAGGCCGCCGTGGCGGACAGCGGCACCGCGGGGGGCGCGGCGTTGGCGGCCCCGGCCCCGGCCCCCAGGCCAGGCAGTGGCGGCCAAGGACCACGCATCTACTTTCAGAGCCCCCCCCGGGGCCGCAGGAGAGGGCCCGGGCTGCGCGGATGATGAGGGCCCAGTGAGGCGCCAAGGGAAGGTCACCATCAAGTATGACCCCAAGGAGCTACGGAAGCACCTCAACCTAGAGGAGTGGATCCTGGAGCAGCTCACGCGCCTCTACGACTGCCAGGAAGAGGAGATCTCAGAACTAGAGATTGACGTGGATGAGCTCCTGGACATGGAGAGTGACGATGCCTGGGCTTCCAGGGTCAAGGAGCTGCTGGTTGACTGTTACAAACCCACAGAGGCCTTCATCTCTGGCCTGCTGGACAAGATCCGGGCCATGCAGAAGCTGAGCACACCCCAGAAGAAGTGAGGGTCCCCGACCCAGGCGAACGGTGGCTCCCATAGGACAATCGCTACCCCCCGACCTCGTAGCAACAGCAATACCGGGGGACCCTGCGGCCAGGCCTGGTTCCATGAGCAGGGCTCCTCGTGCCCCTGGCCCAGGGGTCTCTTCCCCTGCCCCCTCAGTTTTCCACTTTTGGATTTTTTTATTGTTATTAAACTGATGGGACTTTGTGTTTTTATATTGACTCTGCGGCACGGGCCCTTTAATAAAGCGAGGTAGGGTACGCCTTTGGTGCAGCT
>NM_138689.3
GAGACAGAGAAAGCGCTTCGGCGGCTGCAGCTcgggcggcggccgcgggggacaaagggcgggcggatcggcggggagggggcggggcgcggCCAGGCCAAGCCCGGGGGCTCCGCATgctgcagctgcccccgggcgcccccgccgccgccctcgccgcggagccgcGCGGAGCGGAGCCGGCGAGCTAACCCGAGCCAGCCGGCGGGCGTCCCGGAGGCGGTGGCGCAGGGAGGGGCCCGACGCTCGCACGTGGCCCCGGCGGCCGCCATGGCGGACAGCGGCACCGCGGGGGGCGCGGCGTTGGCGGCCCCGGCCCCCGGGCCGGGCAGTGGCGGCCCAGGACCACGCGTCTACTTTCAGAGCCCCCCCGGGGCCGCAGGAGAGGGCCCGGGCGGGGCGGACGATGAGGGCCCAGTGAGGCGCCAAGGGAAGGTCACCGTCAAGTATGACCGCAAGGAGCTACGGAAGCGCCTCAACCTAGAGGAGTGGATCCTGGAGCAGCTCACGCGCCTCTACGACTGCCAGGAAGAGGAGATCCCAGAACTGGAGATTGACGTGGATGAGCTCCTGGACATGGAGAGTGACGATGCCCGGGCTGCCAGGGTCAAGGAGCTGCTGGTTGACTGTTACAAACCCACAGAGGCCTTCATTTCTGGCCTGCTGGACAAGATCCGGGGCATGCAGAAGCTGAGCACACCCCAGAAGAAGTGACGGTCCCCGACCCAGGAGAACGGTGGCTCCCACAGGACAATCGCTGCCCCCCAACCTCGTAGCAACAGCAATACCGGGGGACCCTGCGGCCAGGCCTGGTGCCATGAGCAGGGCTCCTCGTGCCCCTGGCCCAGGGGTCTCTTCCCCTGCCCCCTCAGTTTTCCACTTTTGGGGTTTTTTATTGTTATTAAACTGATGGGACTTTTTGTGTTTTTATATTGACTCTGCGGCGCGGGCCCTTTAATAAAGCTAGGATACGCCTTTGGTGCAGCTAA

Publications

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