Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ACO2P3
Plot displaying the genomic locations of a retrocopy (in chr22) and its respective parental gene (in chr22). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr22:34589094-34591285  UCSC
Coordinates (T2T) chr22:35047903-35050094  UCSC
Coordinates (hg19) chr22:34985086-34987277  UCSC
Strand -
Parental Sequence NM_001098.3
Parental seq. overlap 2011 bp
Parental seq. overlap (%) 73.5%
Genomic Region Intergenic
Retrocopy Summary ACO2P3, located on chr22:34589094-34591285, is a retrocopy of the parental gene ACO2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ACO2
Full Name aconitase 2
Also known as ACONM|HEL-S-284|ICRD|OCA8|OPA9
Coordinate chr22:41468756-41528979
Strand +
Gene summary The protein encoded by this gene belongs to the aconitase/IPM isomerase family. It is an enzyme that catalyzes the interconversion of citrate to isocitrate via cis-aconitate in the second step of the TCA cycle. This protein is encoded in the nucleus and functions in the mitochondrion. It was found to be one of the mitochondrial matrix proteins that are preferentially degraded by the serine protease 15(PRSS15), also known as Lon protease, after oxidative modification. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ACO2P3
Bonobo Pan paniscus ACO2P3
Gorilla Gorilla gorilla ACO2P3
Orangutan Pongo abelii ACO2P3
Gibbon Nomascus leucogenys ACO2P2
Green monkey Chlorocebus sabaeus ACO2P2
Crab-eating macaque Macaca fascicularis ACO2P3
Rhesus Macaca mulatta ACO2P3
Baboon Papio anubis ACO2P3
Golden snub-nosed monkey Rhinopithecus roxellana ACO2P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ACO2P3
TGCACAAAATGGTGCCCTACAGCCTACTGGTTACTTGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGCATCAGTCCTGTGCCAACGGGCCAAGGTGGCGATGAGACCCTTTGAGCCTAAGTACATCCACTATGACCTGCTAGAGAAGAACATTAACATTGTTTGCAAATGATTGAACCGGCCTCTGACCCTCTCAGAGAAGATCGTGTACAGACACCCGGATGACCCCACCAGCCAGGAAATTGAGCGGGGCGGGACGTACCTGCAGCAGTGGCCGGACAGCGTGACCATGCAGGATGGACGGCCCAGATGGCCATGCTGCAGTTCATCAGCAGCAGGCTCCCAAGGTGACCATGCCATCCACCATCCACTGTGACCATCTGATTGAGGCCCAGCTCGGGAGTGAGAAAGACCTGCACCAGGCCAAGGACATCAACCACGAAGTTTATAATTTCCTGGCAACTGGAAGTGTCAAATATGGCTTGAGCTTCTGGAAGCCTGGATCTGGAATCATTCACCAGATTATTCTGGAAAACTATGAATATCCTGGGGTTCTTCTGATTGGCACTGACTCCCACACCCCCAATGGTGGCAGCCTGGGGGGCATCTGCATTGGAGTTGGGGGTGCCGAGCTGTGGATGTCATGACTGGGATCCCCTGGGAGCTGAAGTGCCCCAAGGTGATTGGCGTGAAGCTGATGGGCTCCCTCTCTGGTTGGACCTCACCCAAAGATGTGATCCTGAAGGTGGCAGGCATCCTCACCATGAAAGGTGGCACAGGTGCAATCGTGGAATACCACGGGCCTGTTGTAGACTCCATCTCCTGCACTGGCATGGTGACAGTCTGCAACATGGGCTTAGAAATTGGGACCACCACTTCCGTGTTCCATTACAACCTCAGGATGAAGAAGTACATGAGCAAGACCTGCCAGGCAGACATTGCCAATCTAGCTGATGAATTCAAAGATCACTTGGTGCCTGACCCTGGGTGCCATTATGACCAACTAATTGAAGTTAACCCCAGTGAACTGAAGCTGCACATCAATGGGCCCTTCACCCCTGACCTGGCTCACCCTGTGGCAGAAGTGGGCAAGGTGGCAGAGAAGGAAGAATGGCCTCTGGACATCTGAGTGGGTCTGTGGGGCAGCTGCACCAATTCAAGCTATGAAGATATGGGGTGCTCAGCAGGTGTGGCCAAGCAGGCACTGGCCCATGGCCTCAAGTGCAAGTCCCAGTTCACTATTACTCCATGCTCCGAGCAGATCCGTGCCTCCATTGAGCAGGATGGCTATGCACAGACCTTGAGGGATGTGGGTGGCATCGTCCTGGCCAATGCTTGTGGCCCCTGCATTGGTCAGTTGCACAGAAAGGACATCAACAAGCAGGAGAAGAACATAATTGTCACCTCCTACAACAGGAACTTCATGGGCCACAATGACACGAACCCCGAGACCCATGCCTTCATCACATCCCCAGAGACTGTCACAGCCCTGGCCATTGTGGGAACCCTCAAGTTCAACCCAGAGACCAACTACCTGACAGGCAAGGATGGCAAGAAGTTCAAGCTGGAGGCTCCGGATGCAGATGAGCTTCCCCAAGCAGAGTTTGGCCCAGGGCAGGACACCTACCAGCACCCCCGCATGGGGTACCACTGACCACATCTCAGCTGCCGGCCCCTGACTCAAGTTCCGTGGGCACTTGGACACCATCTCCAACAACTTGCTCAGTGGTGCCATCAACATTGAAAATGGCAAGGCCAACTCTGTGCACGATGCTGTCACCCACGAGTTTGGCCCCTTCCCTGACACTGCCCGCTACAAGAAATATGGCATCAGTTGGGTGGTGATTGGGGACTAGAACTATGGCAAGGGCTCAAGCTGGGAGCACGCCGCGCTGGAGCCTCGCCACCTCAGGGGGCCGGGCCATCATCACCAAGAGCTTTGCCAGGATTCACGAGACCAACCTGAGGAGGCAGGGCCTGCTGCCCCTGACCTTCGCTGACCCAGCTGACAACAAGATTCACCTTGTGGACAAGCTGACCATTCAGAGCCTGAAGGACTTGACGCTGGCAAGCCCCTGAAGTACATCGTCAAGCACCCCAGGAAATCAACCTCCTGAACCACACCTTCAACGAGACGGAGATCGAGTGGTTCAGGGCCGGCAGTGCCCTCTACAGAACGAAGGAG
>NM_001098.3
AATGCGACCTCATCTTTGTCAGTGCACAAAATGGCGCCCTACAGCCTACTGGTGACTCGGCTGCAGAAAGCTCTGGGTGTGCGGCAGTACCATGTGGCCTCAGTCCTGTGCCAACGGGCCAAGGTGGCGATGAGCCACTTTGAGCCCAACGAGTACATCCATTATGACCTGCTAGAGAAGAACATTAACATTGTTCGCAAACGACTGAACCGGCCGCTGACACTCTCGGAGAAGATTGTGTATGGACACCTGGATGACCCCGCCAGCCAGGAAATTGAGCGAGGCAAGTCGTACCTGCGGCTGCGGCCGGACCGTGTGGCCATGCAGGATGCGACGGCCCAGATGGCCATGCTCCAGTTCATCAGCAGCGGGCTGTCCAAGGTGGCTGTGCCATCCACCATCCACTGTGACCATCTGATTGAAGCCCAGGTTGGGGGCGAGAAAGACCTGCGCCGGGCCAAGGACATCAACCAGGAAGTTTATAATTTCCTGGCAACTGCAGGTGCCAAATATGGCGTGGGCTTCTGGAAGCCTGGATCTGGAATCATTCACCAGATTATTCTGGAAAACTATGCGTACCCTGGTGTTCTTCTGATTGGCACTGACTCCCACACCCCCAATGGTGGCGGCCTTGGGGGCATCTGCATTGGAGTTGGGGGTGCCGATGCTGTGGATGTCATGGCTGGGATCCCCTGGGAGCTGAAGTGCCCCAAGGTGATTGGCGTGAAGCTGACGGGCTCTCTCTCCGGTTGGTCCTCACCCAAAGATGTGATCCTGAAGGTGGCAGGCATCCTCACGGTGAAAGGTGGCACAGGTGCAATCGTGGAATACCACGGGCCTGGTGTAGACTCCATCTCCTGCACTGGCATGGCGACAATCTGCAACATGGGTGCAGAAATTGGGGCCACCACTTCCGTGTTCCCTTACAACCACAGGATGAAGAAGTACCTGAGCAAGACCGGCCGGGAAGACATTGCCAATCTAGCTGATGAATTCAAGGATCACTTGGTGCCTGACCCTGGCTGCCATTATGACCAACTAATTGAAATTAACCTCAGTGAGCTGAAGCCACACATCAATGGGCCCTTCACCCCTGACCTGGCTCACCCTGTGGCAGAAGTGGGCAAGGTGGCAGAGAAGGAAGGATGGCCTCTGGACATCCGAGTGGGTCTAATTGGTAGCTGCACCAATTCAAGCTATGAAGATATGGGGCGCTCAGCAGCTGTGGCCAAGCAGGCACTGGCCCATGGCCTCAAGTGCAAGTCCCAGTTCACCATCACTCCAGGTTCCGAGCAGATCCGCGCCACCATTGAGCGGGACGGCTATGCACAGATCTTGAGGGATCTGGGTGGCATTGTCCTGGCCAATGCTTGTGGCCCCTGCATTGGCCAGTGGGACAGGAAGGACATCAAGAAGGGGGAGAAGAACACAATCGTCACCTCCTACAACAGGAACTTCACGGGCCGCAACGACGCAAACCCCGAGACCCATGCCTTTGTCACGTCCCCAGAGATTGTCACAGCCCTGGCCATTGCGGGAACCCTCAAGTTCAACCCAGAGACCGACTACCTGACGGGCACGGATGGCAAGAAGTTCAGGCTGGAGGCTCCGGATGCAGATGAGCTTCCCAAAGGGGAGTTTGACCCAGGGCAGGACACCTACCAGCACCCACCCAAGGACAGCAGCGGGCAGCATGTGGACGTGAGCCCCACCAGCCAGCGCCTGCAGCTCCTGGAGCCTTTTGACAAGTGGGATGGCAAGGACCTGGAGGACCTGCAGATCCTCATCAAGGTCAAAGGGAAGTGTACCACTGACCACATCTCAGCTGCTGGCCCCTGGCTCAAGTTCCGTGGGCACTTGGATAACATCTCCAACAACCTGCTCATTGGTGCCATCAACATTGAAAACGGCAAGGCCAACTCCGTGCGCAATGCCGTCACTCAGGAGTTTGGCCCCGTCCCTGACACTGCCCGCTACTACAAGAAACATGGCATCAGGTGGGTGGTGATCGGAGACGAGAACTACGGCGAGGGCTCGAGCCGGGAGCATGCAGCTCTGGAGCCTCGCCACCTTGGGGGCCGGGCCATCATCACCAAGAGCTTTGCCAGGATCCACGAGACCAACCTGAAGAAACAGGGCCTGCTGCCTCTGACCTTCGCTGACCCGGCTGACTACAACAAGATTCACCCTGTGGACAAGCTGACCATTCAGGGCCTGAAGGACTTCACCCCTGGCAAGCCCCTGAAGTGCATCATCAAGCACCCCAACGGGACCCAGGAGACCATCCTCCTGAACCACACCTTCAACGAGACGCAGATTGAGTGGTTCCGCGCTGGCAGTGCCCTCAACAGAATGAAGGAACTGCAACAGTGAGGGCAGTGCCTCCCCGCCCCGCCGCTGGCGTCAAGTTCAGCTCCACGTGTGCCATCAGTGGATCCGATCCGTCCAGCCATGGCTTCCTATTCCAAGATGGTGTGACCAGACATGCTTCCTGCTCCCCGCTTAGCCCACGGAGTGACTGTGGTTGTGGTGGGGGGGTTCTTAAAATAACTTTTTAGCCCCCGTCTTCCTATTTTGAGTTTGGTTCAGATCTTAAGCAGCTCCATGCAACTGTATTTATTTTTGATGACAAGACTCCCATCTAAAGTTTTTCTCCTGCCTGATCATTTCATTGGTGGCTGAAGGATTCTAGAGAACCTTTTGTTCTTGCAAGGAAAACAAGAATCCAAAACCA

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