Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name TARDBPP5
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:238231809-238234345  UCSC
Coordinates (T2T) chr2:238721551-238724087  UCSC
Coordinates (hg19) chr2:239140450-239142986  UCSC
Strand +
Parental Sequence NM_007375.4
Parental seq. overlap 2439 bp
Parental seq. overlap (%) 58.2%
Genomic Region Intergenic
Retrocopy Summary TARDBPP5, located on chr2:238231809-238234345, is a retrocopy of the parental gene TARDBP. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name TARDBP
Full Name TAR DNA binding protein
Also known as ALS10|TDP-43
Coordinate chr1:11012654-11030528
Strand +
Gene summary HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes TARDBPP1
Bonobo Pan paniscus TARDBPP1
Gorilla Gorilla gorilla TARDBPP1
Orangutan Pongo abelii TARDBPP1
Gibbon Nomascus leucogenys TARDBPP5
Green monkey Chlorocebus sabaeus TARDBPP4
Crab-eating macaque Macaca fascicularis TARDBPP4
Rhesus Macaca mulatta TARDBPP4
Baboon Papio anubis TARDBPP3
Golden snub-nosed monkey Rhinopithecus roxellana TARDBPP4
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>TARDBPP5
GGCGCTTGGGTCCGTCGCTGCCTCGGTGTCCCTGTCGGGCTTCCCAGCAGCGGCCTAGTGGAAAAGTAAAAGATGTCTGAATATATTCGGGTAACCGAAGATGAGAACGATGAGCCCATTGAAATACCATCGGAAGACGATGGGACGGTGCTGCTGTCCACGGTTACAGCCCAGTTTCCAGGGGCGTGTGGGCTTCGCTGCAGGAATCCGGTGTCTCAATGTATGAGAGGTGTCCGGCTGGTAGAAGGAATTCTGCATGCCCCCGATGCTGGCTGGAGAAATCCGGTGTATGTTGTCAACTATCCGAAAGATAACAAAAGAAAAATGGGTGAGACAGAAGCTTCATCAGCAGTGAAAGTGAAAAGACCAGTCCGATTTAATAGTGTTGGGTCTCCCATGGAAAACAACTGAACAGGACCTGAAAGAGTACTGTAGTACCTTTGGAGACGTTCTTATGGTGCGGCAAAGCCAAGATGAGCCTTTGAGAAGCAGAAAAGTGTTTGTGGGGCGCCGTACGGAGGACATGACTGAGGATGAGCTGTGGGAGTTCTTCTCTCAGTATGGGGATGTGATGGATGTCTTCGTCCCCAAGCCGTTCAGGGCCTTTGCCTTTGTTCCATTTGCAGATGATCAGATTGCGCGGTCTCTTTGTGGAGAGGACTCGATGAAAGGAATCAGCGTTCACATATCCAATGCCGAACCCAAGCGCAATAGCAATAGACAGCAAGAAGTGGAAGATTTGGTGGTAATCCAGGTGGCTTTGGGAATCAGGGTGGATTTGGTAAGAGTAGAGGGGGTGGAGCTGGTTTGGGAAACAATCAAGGTAGTAATATGGGTGGTGGGATAAACTTTGGTGCGTTCAGCATTAATCCAGCCATGATGGCTGCCCCCCAGGCAGTGCTGCAGAGCAGTTGGTGTACGATGGGTGTGTTAGCCAGCCAGCGAAGCAGCCAGGCCCATCGGATGATAACCAAAGCCAAGGCAACATGCAGAGGGAGCCAAACCAGGCCTTCGGTTCTGGAAATAACTCTTGTAGTGGTTCTAATTTTGGTGCAACAATTGGTTGGGGATCAGCATCCAATGCAGGGTCGGGCAGTGGTTTTAATGGCGGCTTTGGCTCAAGCATGGATTCTAAGTCTTCTGGCTGGGAACGTAGACAGTGGGGTTGTGGTTGGTTGGTATAGAATGGTTGGAATTCAAATTTTTCTAAACTCATGGTAAGTATATTGTAAAATACATATGTACTAAGAATTTTCAAAATTGGTTTCTTCAGTGTGGAGTATATTCAGTAGTATTTTTGACATTTTTCTTTAGAAAAAGGAACAGCTAAAGGAATTTTATAAGTTTTGTTACATGAAAGGTTGAAATATTGAGTGGTTGAAAGTGAACTGCTGTTTGCCTGATTGGTAAACCAACACACTACAATTGATATCAGAAGGTTTCTCCTGTAATATTTTATCCCTGGACTTGTCAAGTGAGTTCTTTGCATGTTCAAAATGGAAGCCATGAATTAGAACTACATTCTTTATTCCTTGTTTTAATTTGAACCCCACCATATGGATTTTTTTCCTTAAGAAAATCTCCTTTTAGAAGATCATGGTGTCACAGTTTGGTTCTTTTGTTTTGTTTTTTAACACTTGTCTCCCCTCAAACACAAAAGTACAATATGAAGCCTTCATTTAATCTCTGCAGTTCATCTCATTTCAAATGTTTATGGAAGAAGCACTTGGTTGAAAGTAGTGCTGTAAATATTCTGCCATAGGAACACTTCTGTCTACATGCCTTCTCATTCAAGAATTCGTCATCACGCATCACAGGCCGCGTCTTTGACGGTGGGTGTCCCATTTTTATCTGCTACTCTTTATTTCATAGAGTCGTATCAACGCTGTGAACGCAAGGCTGTGATATGGAACTAGAAGGCTGTTTGAACTTTTGAAACCTTGTGTGGGATTGACGGTGGTGCTGAGGCATGAAAGGCTAGTATGAGTGAGAAAAGGAGAGAGCACGTGCAGAGACTTGGTGGTGCATAACGGATATTTTTTAACTTGGCGAGATGTGTTTCTCAATCCTGCGGCTTTGGTGACAGTGTGCAGACAGCAATGATAGCAAATAATGTACGAATGTTTTTTGCATTCAAAGGACATCCACATCTGTTGGAAGACTTTGAGTTTTTGTTCTTAGATAACCCACTTTATTTGAATGTGTTAAGTGAAATGATACTTGTACTCCCCCTACCCCTTTGTCAACTGCTGTGAATGCTGTATGGTGTGTGTTCTCTTCTGTTACTGATATGTAAGTGTGGCAATGTGAACTGAAGCTGATGGGCTGAGAACATGGACTGAGCTTGTGGTGTGCTTTGCAGGAGGACTTGGAAGCAGAGTTCAGCAGTGAACTCTGGTGTCTCAAAGAAGGGTAGAAGTTCTAATGTCTGTTAGCTACCCATAAGAATGCTGTTTGCTGCAGTTCTGTGTCCTGTGCTTGGATGCTTTTTATAAGAGTTGTCATTGTTGGAAATTCTTAAATAAAACTGATTTAAA
>NM_007375.4
ATTTTGTGGGAGCGAAGCGGTGGCTGGGCTGCGCTTGGGTCCGTCGCTGCTTCGGTGTCCCTGTCGGGCTTCCCAGCAGCGGCCTAGCGGGAAAAGTAAAAGATGTCTGAATATATTCGGGTAACCGAAGATGAGAACGATGAGCCCATTGAAATACCATCGGAAGACGATGGGACGGTGCTGCTCTCCACGGTTACAGCCCAGTTTCCAGGGGCGTGTGGGCTTCGCTACAGGAATCCAGTGTCTCAGTGTATGAGAGGTGTCCGGCTGGTAGAAGGAATTCTGCATGCCCCAGATGCTGGCTGGGGAAATCTGGTGTATGTTGTCAACTATCCAAAAGATAACAAAAGAAAAATGGATGAGACAGATGCTTCATCAGCAGTGAAAGTGAAAAGAGCAGTCCAGAAAACATCCGATTTAATAGTGTTGGGTCTCCCATGGAAAACAACCGAACAGGACCTGAAAGAGTATTTTAGTACCTTTGGAGAAGTTCTTATGGTGCAGGTCAAGAAAGATCTTAAGACTGGTCATTCAAAGGGGTTTGGCTTTGTTCGTTTTACGGAATATGAAACACAAGTGAAAGTAATGTCACAGCGACATATGATAGATGGACGATGGTGTGACTGCAAACTTCCTAATTCTAAGCAAAGCCAAGATGAGCCTTTGAGAAGCAGAAAAGTGTTTGTGGGGCGCTGTACAGAGGACATGACTGAGGATGAGCTGCGGGAGTTCTTCTCTCAGTACGGGGATGTGATGGATGTCTTCATCCCCAAGCCATTCAGGGCCTTTGCCTTTGTTACATTTGCAGATGATCAGATTGCGCAGTCTCTTTGTGGAGAGGACTTGATCATTAAAGGAATCAGCGTTCATATATCCAATGCCGAACCTAAGCACAATAGCAATAGACAGTTAGAAAGAAGTGGAAGATTTGGTGGTAATCCAGGTGGCTTTGGGAATCAGGGTGGATTTGGTAATAGCAGAGGGGGTGGAGCTGGTTTGGGAAACAATCAAGGTAGTAATATGGGTGGTGGGATGAACTTTGGTGCGTTCAGCATTAATCCAGCCATGATGGCTGCCGCCCAGGCAGCACTACAGAGCAGTTGGGGTATGATGGGCATGTTAGCCAGCCAGCAGAACCAGTCAGGCCCATCGGGTAATAACCAAAACCAAGGCAACATGCAGAGGGAGCCAAACCAGGCCTTCGGTTCTGGAAATAACTCTTATAGTGGCTCTAATTCTGGTGCAGCAATTGGTTGGGGATCAGCATCCAATGCAGGGTCGGGCAGTGGTTTTAATGGAGGCTTTGGCTCAAGCATGGATTCTAAGTCTTCTGGCTGGGGAATGTAGACAGTGGGGTTGTGGTTGGTTGGTATAGAATGGTGGGAATTCAAATTTTTCTAAACTCATGGTAAGTATATTGTAAAATACATATGTACTAAGAATTTTCAAAATTGGTTTGTTCAGTGTGGAGTATATTCAGCAGTATTTTTGACATTTTTCTTTAGAAAAAGGAAGAGCTAAAGGAATTTTATAAGTTTTGTTACATGAAAGGTTGAAATATTGAGTGGTTGAAAGTGAACTGCTGTTTGCCTGATTGGTAAACCAACACACTACAATTGATATCAAAAGGTTTCTCCTGTAATATTTTATCCCTGGACTTGTCAAGTGAATTCTTTGCATGTTCAAAACGGAAACCATTGATTAGAACTACATTCTTTACCCCTTGTTTTAATTTGAACCCCACCATATGGATTTTTTTCCTTAAGAAAATCTCCTTTTAGGAGATCATGGTGTCACAGTGTTTGGTTCTTTTGTTTTGTTTTTTAACACTTGTCTCCCCTCATACACAAAAGTACAATATGAAGCCTTCATTTAATCTCTGCAGTTCATCTCATTTCAAATGTTTATGGAAGAAGCACTTCATTGAAAGTAGTGCTGTAAATATTCTGCCATAGGAATACTGTCTACATGCTTTCTCATTCAAGAATTCGTCATCACGCATCACAGGCCGCGTCTTTGACGGTGGGTGTCCCATTTTTATCCGCTACTCTTTATTTCATGGAGTCGTATCAACGCTATGAACGCAAGGCTGTGATATGGAACCAGAAGGCTGTCTGAACTTTTGAAACCTTGTGTGGGATTGATGGTGGTGCCGAGGCATGAAAGGCTAGTATGAGCGAGAAAAGGAGAGAGCGCGTGCAGAGACTTGGTGGTGCATAATGGATATTTTTTAACTTGGCGAGATGTGTCTCTCAATCCTGTGGCTTTGGTGAGAGAGTGTGCAGAGAGCAATGATAGCAAATAATGTACGAATGTTTTTTGCATTCAAAGGACATCCACATCTGTTGGAAGACTTTTAAGTGAGTTTTTGTTCTTAGATAACCCACATTAGATGAATGTGTTAAGTGAAATGATACTTGTACTCCCCCTACCCCTTTGTCAACTGCTGTGAATGCTGTATGGTGTGTGTTCTCTTCTGTTACTGATATGTAAGTGTGGCAATGTGAACTGAAGCTGATGGGCTGAGAACATGGACTGAGCTTGTGGTGTGCTTTGCAGGAGGACTTGAAGCAGAGTTCACCAGTGAGCTCAGGTGTCTCAAAGAAGGGTGGAAGTTCTAATGTCTGTTAGCTACCCATAAGAATGCTGTTTGCTGCAGTTCTGTGTCCTGTGCTTGGATGCTTTTTATAAGAGTTGTCATTGTTGGAAATTCTTAAATAAAACTGATTTAAATAATATGTGTCTTTGTTTTGCAGCCCTGAATGCAAAGAATTCATAGCAGTTAATTCCCCTTTTTTGACCCTTTTGAGATGGAACTTTCATAAAGTTTCTTGGCAGTAGTTTATTTTGCTTCAAATAAACTTATTTGAAAAGTTGTCTCAAGTCAAATGGATTCATCACCTGTCATGCATTGACACCTGATACCCAGACTTAATTGGTATTTGTTCTTGCATTGGCCAAAGTGAAAATTTTTTTTTTTCTTTTGAAATCTAGTTTTGAATAAGTCTGGGTGACCGCACCTAAAATGGTAAGCAGTACCCTCCGGCTTTTTCTTAGTGCCTCTGTGCATTTGGGTGATGTTCTATTTACATGGCCTGTGTAAATCTCCATTGGGAAGTCATGCCTTCTAAAAAGATTCTTATTTGGGGGAGTGGGCAAAATGTTGATTATTTTCTAATGCTTTGTAGCAAAGCATATCAATTGAAAAGGGAATATCAGCACCTTCCTAGTTTGGGATTTGAAAAGTGGAATTAATTGCAGTAGGGATAAAGTAGAAGAAACCACAAATTATCTTGTGCCTGAAATCCATTAAGAGGCCTGATAGCTTTAAGAATTAGGGTGGGTTGTCTGTCTGGAAGTGTTAAGTGGAATGGGCTTTGTCCTCCAGGAGGTGGGGGAATGTGGTAACATTGAATACAGTTGAATAAAATCGCTTACAAAACTCACACTCTCACAATGCATTGTTAAGTATGTAAAAGCAATAACATTGATTCTCTGTTGTACTTTTTTGTAACTAATTCTGTGAGAGTTGAGCTCATTTTCTAGTTGGAAGAATGTGATATTTGTTGTGTTGGTAGTTTACCTAATGCCCTTACCTAATTAGATTATGATAAATAGGTTTGTCATTTTGCAAGTTACATAAACATTTATCAATGAAGTCATCCTTTAGACTTGTAATCGCCACATTGTTTCATTATTCAGTTTCCTCTGTAAAGGGATCTTGAGTTGTTTTAATTTTTTTTTTCTGCATCTGAATCTGCATGATTTCCAAACCCTGTACCATCTGAATTTTGCATTTTAGCACTTGCACTATTACTCAGCAGCAGTAACATGGTAACACTTAAAATGGTACTCGGGGACCTCCAAAGACTAAACTGACAAGCCTTCAAGGAGCCCAGGGGTAAGTTAACTTGTCAACGGCATGGTTTAATCCCTTCTTTACACTTGTGTAAATTTCAGTTACTGGTCATAGAAGGCTTTCAATGTTGAGTGGCCTTTTATTAACATGTTTATGGTACTGCATAGATACGGGTATTTATTTTACCCTAAGAAGATTTTGAAGTTTAAAAGTACTTAAACTATTTGGCAAAGATTTGTTTTTAAAAATCTATTTGGTCAATCTAAATGCATTCATTCTAAAAAATTTTTTGAACCAGATAAATAAAATTTTTTTTTGACACCACA

Publications

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