Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ANP32BP2
Plot displaying the genomic locations of a retrocopy (in chr22) and its respective parental gene (in chr9). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr22:44651806-44652391  UCSC
Coordinates (T2T) chr22:45135535-45136120  UCSC
Coordinates (hg19) chr22:45047686-45048271  UCSC
Strand +
Parental Sequence NM_006401.3
Parental seq. overlap 501 bp
Parental seq. overlap (%) 33.8%
Genomic Region Intergenic
Retrocopy Summary ANP32BP2, located on chr22:44651806-44652391, is a retrocopy of the parental gene ANP32B. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ANP32B
Full Name acidic nuclear phosphoprotein 32 family member B
Also known as APRIL|PHAPI2|SSP29
Coordinate chr9:97983341-98015943
Strand +
Gene summary Enables RNA polymerase binding activity and histone binding activity. Involved in several processes, including activation of cysteine-type endopeptidase activity involved in apoptotic process; nucleosome assembly; and positive regulation of protein export from nucleus. Located in cytoplasm and nucleoplasm. Colocalizes with nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ANP32BP4
Bonobo Pan paniscus ANP32BP4
Gorilla Gorilla gorilla ANP32BP4
Orangutan Pongo abelii ANP32BP3
Gibbon Nomascus leucogenys ANP32BP4
Baboon Papio anubis ANP32BP2
Golden snub-nosed monkey Rhinopithecus roxellana ANP32BP2
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ANP32BP2
AAAGTTTGAAGAGTGGAGAAGAGGGGAACGTGAACATGAGGAGGAGACTCCACGTGGAGCTGAAATACCAGACCCCACCCGCTGTTCTAAAACTTGTCTTGGACAATTGCCAATCAAGTGATGGAAAAATTGAGGGCTTTACAGTTGAATTTGTGAACTTAGAGTTCCTTCATTTAATAACTGCAGGCTTGATTTCATTTTCAAATCTCCCCTGGCTGCCATGACAATAGAGTCTTTGGAGATCTGGACATGTTAGAAACTCACACATCTAAACTTGGATGGAAATACACTGAAAGATATCAGAACTTTAGAACCTTTGAAAAAGTTGGAACGTCTAAAGAGCCTGGACCTCTTAAACCGTGAGGTTACTAGCCTGAATGAAGACTGGGAGAGGGTCTTCAAGCTCCTGCCCCAGCTGACCTACCTTGATCACTATGACCAAGAGGACCAGGAAGCCCCCAACTCAGATGCTGAGGGGGATGATGTAGATGATGAAGAGGAGGATGAAGAAGGAGGAAACAAGGAAAATGAGGAGGATAAGGATAGTGAAGAGGAAGAGTTTGATGGCGACGAGGATGAAGATGAA
>NM_006401.3
CTTTTCCCTCCATGGTTTCTCTCCGCTCCCGTGAGTAACTTGGCTCCGGGGGCTccgctcgcctgcccgcacgccgcccgccacccaggaccgcgccgccggccTCCGCCGCTAGCAAACCCTTCCGACGGCCCTCGCTGCGCAAGCCGGGACGCCTCTCCCCCCTCCGCCCCCGCCGCGGAAAGTTAAGTTTGAAGAGGGGGGAAGAGGGGAACATGGACATGAAGAGGAGGATCCACCTGGAGCTGAGGAACCGGACCCCGGCAGCTGTTCGAGAACTTGTCTTGGACAATTGCAAATCAAATGATGGAAAAATTGAGGGCTTAACAGCTGAATTTGTGAACTTAGAGTTCCTCAGTTTAATAAATGTAGGCTTGATCTCAGTTTCAAATCTCCCCAAGCTGCCTAAATTGAAAAAGCTTGAACTCAGTGAAAATAGAATCTTTGGAGGTCTGGACATGTTAGCTGAAAAACTTCCAAATCTCACACATCTAAACTTAAGTGGAAATAAACTGAAAGATATCAGCACCTTGGAACCTTTGAAAAAGTTAGAATGTCTGAAAAGCCTGGACCTCTTTAACTGTGAGGTTACCAACCTGAATGACTACCGAGAGAGTGTCTTCAAGCTCCTGCCCCAGCTTACCTACTTGGATGGCTATGACCGAGAGGACCAGGAAGCACCTGACTCAGATGCCGAGGTGGATGGTGTGGATGAAGAGGAGGAGGACGAAGaaggagaagatgaggaagacgaggacgatgaggatggtgaagaagaggagtttgatgaagaagatgatgaagatgaagatgtagaaggggatgaggacgacgatgaagtcagtgaggaggaagaagaatttggacttgatgaagaagatgaagatgaggatgaggatgaAGaggaggaagaaggtgggaaaggtgaaaagaggaagagagaaacagatgatgaaggagaagatgattaagaCCCCAGATGACCTGCAGAAACAGAACTGTTCAGTATTGGTTGGACTGCTCATGGATTTTGTAGCTGTTTAAAAAAAAAAAAAAGGTAGCTGTGATACAAACCCCAGGACACCCACCCACCCAAAGAGCCAAAGAATAGTTCCTGTGACATTCCGCCTTCCTTCCATGTAGTCCCTCTTGGTAATCTACCACCAAGCTTGTGGACTTCACCCCAACAAAATTGTAAGCGTTGTTAGGTTTTTGTGTAAGATTCTTGCTGTAGCGTGGATAGCTGTGATTGGTGAGTCAACCGTCTGTGGCTACCAGTTACACTGAGATTGTAACAGCATTTTTACTTTCTGTACAACAAAAAAGCTTTGTAAATAAAATCTTAACATTTTGGGTCTGTTTTTTCATGCTTTGCTTTTTAattattattattattttttttaCATTAGGACATTTTATGTGACAACTGCCAAAAAAGTATTTTTAAGAATTTAAGCGAAATAAACAGTTACTCTTTGGTAAA

Publications

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