Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name FAM136EP
Plot displaying the genomic locations of a retrocopy (in chr22) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr22:46479631-46481736  UCSC
Coordinates (T2T) chr22:46966943-46969049  UCSC
Coordinates (hg19) chr22:46875528-46877633  UCSC
Strand -
Parental Sequence NM_032822.3
Parental seq. overlap 1140 bp
Parental seq. overlap (%) 48.8%
Genomic Region Intragenic (CELSR1)
Retrocopy Summary FAM136EP, located on chr22:46479631-46481736, is a retrocopy of the parental gene FAM136A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name FAM136A
Full Name family with sequence similarity 136 member A
Also known as -
Coordinate chr2:70295976-70302067
Strand -
Gene summary This gene encodes a mitochondrially localized protein that is highly conserved across species. The gene is expressed in a variety of tissues including human lymphoblast cells and rat neurosensorial epithelium of the cristaampullaris. A mutation in this gene has been associated with familial Meniere's disease, a chronic disorder of the inner ear. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes FAM136AP6
Gorilla Gorilla gorilla FAM136AP6
Orangutan Pongo abelii FAM136AP7
Gibbon Nomascus leucogenys FAM136AP4
Green monkey Chlorocebus sabaeus FAM136AP6
Crab-eating macaque Macaca fascicularis FAM136AP8
Baboon Papio anubis FAM136AP5
Golden snub-nosed monkey Rhinopithecus roxellana FAM136AP7
Bonobo Pan paniscus Without Homology
Rhesus Macaca mulatta Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>FAM136EP
GGAATTTTAGTCTTTTAAGCAAAGTTTATGAATGAAGAAATGAAGGATGGTCGTAAGTGTAAAGCATATGTCACTTGCCTCTGGACACTGGTTCTTTTATGTTTTAGTCCTAAAAAATGAAACGGAAAAAAGTGGTGCTAAATTGGGTCAGAGATATTACAGGAGAGTTTTAGAGCTTATATTTCCTGTGGCCAGTGCTTGTCCTGGCAGTAAGGATCTCCCCTGTAACAAGCCAGAGCCCCCAAGGCACCAGACTCTTCTTACTACACAGGTACCAACAGGCTGGCAGGTTAGAGTTGGTGGAGTTTGCAGAGAGATATTTCCTCTTCGTTGCCAACATCCTGTTTACCAGAAGTGTTTCTGCATCACTTTCCATAAGCTGTGAAACAAAATCCATGAGGTCACTCACTTAGAAGGGAAAAAATGTTTTCTGTGTCTTTGTTTTCCTGGTTTTGTGTAATTTATACAAGGGCATACAAGTTGATTTTAAGATGTGGAATTGGGAGGGAAACTCATTTGGATAAGAACTTTGAAAGGTTCCTTATCATTTGGATAAGAACTTTGAAAGGATCCCCATTTCTGGTCATCAGGATGTGGATGTACTTTTCTTAAAATTTTGACATGCTGCATCTTGAGACATGGACCTCTTCTTGGGAGGTGAGGGGGAGACATTATTTCGTCTACCACAGCTTGGAGACCATGCAAAAACATGACAGGCGACGACACACTAATTGTGGGAAGCAGAATTACTGGCTGATGGGCCTTGAGGCTGTGTGTAGCAAAACGACAGGACAATCTTGCAGTAACACTTTGCCCGTGAAGAGAAGGGGATTTTGATTGTGATACATACTAGTATATAGGAGTGAACAGTAGAAGAGGAGCATTTGGCTACTTGATTATAACAGAGTTATGAAGTACTGGATTTGGAAAAACCTGGTTTTTGTAGAACAGATGGAATGAAGACCTAAACCGAGCATTGCCTACTTAGCCCCTGAATTAACAGAGTCCAGTCGAGACAAACCCCTGGCAACAGGAAATTCAAGGGAGGAAAAGGAAGCAACTTGGGCTAGGATGAGCTGACTCCCTGAGAGTGAAGGAGAGGCAGCCCCCGTTACCAAATACCATTTCTGCCTGGGGCTTTCGCAGCTTGCAGTGTTCCTGCTCCGGCATGGCACCTTATTGTTTTGATAGCAACCTCATTGTATTCTCACCAGCTTATTACTTGAAATGATAAGACAGCCTGTCCATTTGCTGCTTCCCGGCTGTGATATATTTTCCTAGTGGTTTGGTTTTAAAAATAAATAAGGTTTAATTTTCTACCCACGAGCTGCAGCAGCTGCGGGTGCAGGAGGTGGTGGACTCCATGGTGAAGAGTCTGGAGAGAGAGAACATCTGGAAGATGCATTGTCTCATGTTCTGGTGCAGCACCAGCTGTTGTGAGGACAGTCAGGCCTCCACGGAGCAGGTGCACCAGTGCATCGAGTGCCACCATGTGCCTCTGGCTTAAGCCCAGGCTTTGATCACCAGTGAGCTGGAGAAGTTCCAGGACCACCTGGTCCGGTGCACCACGCATTGCAACGACAAAGCCAAAGATTCAATAGATGCTGGGAGTAAGGAGCTTCAGTTGAAGCAGAAGCTGGAAGGTGGTGTGACCAAGTGTGTGGATGACCACATGCACCTGCTCCCAACTATGACCGAGAAGGTGAAGGAGGCTCTCTCATCCATTGGGAAATAAAAGTCTTTGCCAGTGGCCATCGGGGCTGAGGGCAATAATGTATTTTTTATAAGGAATTGGGAAt
>NM_032822.3
ACGCCGATTCCATATGggcgccggcgcggagcgccgcggggcagcgcggGGTCGCCATGGCTGAGCTGCAGCAGCTCCGGGTGCAGGAGGCGGTGGAGTCCATGGTGAAGAGTCTGGAAAGAGAGAACATCCGGAAGATGCAGGGTCTCATGTTCCGGTGCAGCGCCAGCTGTTGTGAGGACAGCCAGGCCTCCATGAAGCAGGTGCACCAGTGCATCGAGCGCTGCCATGTGCCTCTGGCTCAAGCCCAGGCTTTGGTCACCAGTGAGCTGGAGAAGTTCCAGGACCGCCTGGCCCGGTGCACCATGCATTGCAACGACAAAGCCAAAGATTCAATAGATGCTGGGAGTAAGGAGCTTCAGGTGAAGCAGCAGCTGGACAGTTGTGTGACCAAGTGTGTGGATGACCACATGCACCTCATCCCAACTATGACCAAGAAGATGAAGGAGGCTCTCTTATCAATTGGAAAATAAAAGTATTTGCCAGTGGCCATCAGGGCTGAGGGCAAGAATATATTTTTTATAAGGAATTGGGAATTTTAGTCTTTTAAGCAAAGTTTACGAATGAAGAAATGAAGGATGGCCACAAGCGTAAGGCATATGTCACTTGCCTCTGGACACTGGTTATTTTATGTTTCAGTCCCTAAAAAATGAAATGGAAAAAAGTGGTGCTAAATCGAGTCAGAGATATTACAGGAGAGTTTTAGAGCTTATTATTTCCTGTGGCCAGTGCTTGTCCTGGCAGTAAGGCTTTCCCCTGTAACAAGCCAGAGCCCTCCAAGGTACCAGACTCTTCTTACTACACAGGTACTAACAGGCTGGCAGGTTAGAGTTGGTGGAGTCTGAGGAGAGATATTTTCTCTTTGTTGCCAACATCCTGTTTACCAAAAGTGTCACCCCACCATCTTCCATAAGCTGTGAAACAAAATCAATGAGGTCACTAACTTAGAAGGGAAAGAAAGTTTTCTGGGTCTTTGTTTTCTTGATTTGGGGTAATTTATACAAGGGCATACAAGTTGATTTTAAGATGTGGAACTGGGAGGTAGACTAGTTTGGATAAGAACTTTGAAATGTTCCTTGTGGATCCCCATTTCTGGTCATCAAGATGTGGATGTACATTTCTTAAAATTATTACATGCTGCATCTTTCAGCCTGGAGACTGTGCAGAAACATGAGAGGTGATGACACACTAATTATGGGAAGCAGAATTACTGGCTGATGGCCCCTGAGGCTGTGTGTAACAAAATGACAGGACAATCTTGCAGTAACACTTTCCCCTTGAAGAGAAGGGGGTTTTGATTGTGATATATACTAGTATCTAGGAATGAACAGTAAAAGAGGAGCAGTTGGCTACTTGATTACAACAGAGTAAATGAAGTACTGGATTTGGGAAAACCTGGTTTTATTAGAACATATGGAATGAAAGCCTACACCTAGCATTGCCTACTTAGCCCCCTGAATTAACAGAGCCCAATTGAGACAAACCCCTGGCAACAGGAAATTCAAGGGAGAAAAAGTAAGCAACTTGGGCTAGGATGAGCTGACTCCCTTAGAGCAAAGGAGAGACAGCCCCCATTACCAAATACCATTTTTGCCTGGGGCTTGTGCAGCTGGCAGTGTTCCTGCCCCAGCATGGCACCTTATTGTTTTGATAGCAACTTCGTTGAATTTTCACCAACTTATTACTTGAAATTATAATATAGCCTGTCCGTTTGCTGTTTCCAGGCTGTGATATATTTTCCTAGTGGTTTGACTTTAAAAATAAATAAGGTTTAATTTTCTCCCCA

Publications

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