Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PPIL1P1
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr6). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:26162048-26163714  UCSC
Coordinates (T2T) chr2:26197351-26199017  UCSC
Coordinates (hg19) chr2:26384917-26386583  UCSC
Strand +
Parental Sequence NM_016059.5
Parental seq. overlap 1209 bp
Parental seq. overlap (%) 78%
Genomic Region Intergenic
Retrocopy Summary PPIL1P1, located on chr2:26162048-26163714, is a retrocopy of the parental gene PPIL1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PPIL1
Full Name peptidylprolyl isomerase like 1
Also known as CGI-124|CYPL1|PCH14|PPIase|hCyPX
Coordinate chr6:36854829-36874803
Strand -
Gene summary This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PPIL1P1
Bonobo Pan paniscus PPIL1P1
Gorilla Gorilla gorilla PPIL1P1
Orangutan Pongo abelii PPIL1P1
Gibbon Nomascus leucogenys PPIL1P1
Marmoset Callithrix jacchus PPIL1P1
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PPIL1P1
ACTTCACTATGGCGGCACTTCCTCCAGACTCCTGGCAGCCACCCAGTGTTTACTTGGAGACCAGCATGGGAATAATTGTACCGGAGCTGTATCGGAAGCATGCTCCAAAGACCTGTAAGAACTGCTGAGATGACTCGTCGAGGTTACTACAGTGGCACAAAATTCCACAGAATCATCGAGGATTTCATGATCCAAAAAGGTGACCCAACAGGGACAGGTTGAGGTGGTGCATTTATCTATGGCAAACAGTTTGAAGATGAGCTGCATCCAGACTTGAAATTCACGGGGCCTGGAATTCTCGCAATGGCCAATGCAGGGCCAGACACCAATGGCAGCCAGTTCTTTGTGACCCTCGCACCCACCCAGTGGATCGACAGCAAACACACCATTTTTGGCCAAGTGTGCCAGGGGATAGGAATGGTGAATCGAGTAGGAATGGTAGAAACAAACTCCCAGGACCGCCCCGTGAACGCTGTGAAGATCATTAAGGCATACCCTTCTGGGTAGACTTGCTGCTCTCTTGAGCAGGTCTTCTGAGATGTCCCCAGTGAACCAGCTTCCCAATGACCTAGAATGACATGTAATGCTAAATTTCACTTTGGCCTTGCAAATCACGATGCTTAGGAAGCCTGCATCCTAAGGTGAGTTAGGGATGGAAGTGCATTTTAATAGGATGCTTCTTTTCTCTTCCCCCATTGCCTAGGTTGACAGAGCATTTGCACAGATGCCCCTGTTTATCCATAGGTTACTACTTACTGCACATGACCCATAATGCTCCTTGTGCCTGGCTGCTCTGATATTCTTGGAACAAAATGCAGCAGACGCTGTCATTTCTCAGTGTTTTTGCCTAACCAAACTTCTTCCTGATTTATATTCTGGCCTACACTGCAGTCTTTGATGGCTGACAGTCACAGAATTCAAAACCAAGTAGTGGCAGTGTCTATCAGCCCTCTTAACTTTGTGCACACTATATTTCAGTCTCCTATGTTTGTTCTTCTAGGGGATGTATGCATCTGTCTCTATATTTTCCCTCTCAAAACCAGAACATCTaCCCACAAAAGCCAGAACATCAACCCTGCTGTTTCTGACACCTAGACATCCCACGCAAAGCCACACTGACTTTTTGCCAAATGAAAAACATATCCAAAAATCAAGTTTCTAAGAAGTGGGGAATAATAATGTGTAATAATCAAAAAATGAATTTATTAAAAGGAAGCAGAAGAATTGACCATCTTTGTCCCAGAGAAGAGGGAAATCTGTAGTGAGCACAAGGACAGACTATGAATTCTCCGTAAAATTAGTACTCTCAAAAAGGAGAGGTGTCACTTAAGTTTTCTTAACCTAAGACTTTAGAGAAATTAG
>NM_016059.5
ACTAGACAAGCATTCCGCCGCCGGCTTCGCTATGGCGGCAATTCCCCCAGATTCCTGGCAGCCACCCAACGTTTACTTGGAGACCAGCATGGGAATCATTGTGCTGGAGCTGTACTGGAAGCATGCTCCAAAGACCTGTAAGAACTTTGCTGAGTTGGCTCGTCGAGGTTACTACAATGGCACAAAATTCCACAGAATTATCAAAGACTTCATGATCCAAGGAGGTGACCCAACAGGGACAGGTCGAGGTGGTGCATCTATCTATGGCAAACAGTTTGAAGATGAACTTCATCCAGACTTGAAATTCACGGGGGCTGGAATTCTCGCAATGGCCAATGCGGGGCCAGATACCAATGGCAGCCAGTTCTTTGTGACCCTCGCCCCCACCCAGTGGCTTGACGGCAAACACACCATTTTTGGCCGAGTGTGTCAGGGCATAGGAATGGTGAATCGCGTGGGAATGGTAGAAACAAACTCCCAGGACCGCCCTGTGGACGACGTGAAGATCATTAAGGCATACCCTTCTGGGTAGACTTGCTACCCTCTTGAGCAGCTCTTCTGAGATGGCCCCAGTGAACCAGCTTCTAGATGACATAGAATGACATGTAATGCTAAATTCATTTTGGCTTTGCAAGTCATGAAGCTTAGGAGGCCTGGCATCTTGGGTGAGTTAGAGATGGAAGTACATTTTAATAGGATGCTTCTTTTCTCTTCCCCCAGTGCCTAGGTTGCCAGAGCATTTGCACAAATGCCCCTGTTTATCAATAGGTGACTACTTACTACACATGAACCATAATGCTGCTTCTTGTGCATGTCTGCTCTGATATACGTCGAACAATGTAGCAGCCACTGTCATTTCTCAGTGGTTTTGCCTAACCAAACTTCTTCCTAAGGAGATTTATATTCTGGCCTACACAGCAGTCCTTGATGGCTGACAGCCACAGAATTCCAAACCAAGTAGTGTCTGTCAGCCCTCTTAACTCTGTGCACGCCCTATTTCAGTCTTTTACATTTGTTCTTCTAGGGAATGTATGCATCTCTATATATATTTTCCCTCTCAAAACCAGAACATCAACAGTGCTGTTTCTGACACTTCAGACATCCCACGCAAAGCCACATTGAATTTTTGCCAAATGAAAAACACATCCAACAATCAAGTTTCTAAGAAGGTGTCAAGTGGGGAATAATAATAATGTATAATAATCAAGAAATTAGTTTATTAAAAGGAAGCAGAAGCATTGACCATTTTTTCCCAGAGAAGAGGAGAAATCTGTAGTGAGCAAAGGACAGACCATGAATCCTCCTTGAGAAGTAGTACTCTCAGAAAGGAGAAGCGCCACTCAAGTTCTTTTAACCCAAGACTTTAGAGAAATTAGGTCCAAGATTTTTATATGTTCAGTTGTTTATGTATAAAAATAACTTTCTGGATTTTGTGGGGAGGAGCAGGAGAGGAAGGAAGTTAATACCTATGTAATACATAGAAACTTCCACAATAAAATGCCATTGATGGTTGAAA

Publications

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