Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name MYCBPP1
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Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:42679855-42680233  UCSC
Coordinates (T2T) chr2:42685121-42685499  UCSC
Coordinates (hg19) chr2:42906995-42907373  UCSC
Strand -
Parental Sequence NM_012333.5
Parental seq. overlap 327 bp
Parental seq. overlap (%) 12.9%
Genomic Region Intragenic (MTA3)
Retrocopy Summary MYCBPP1, located on chr2:42679855-42680233, is a retrocopy of the parental gene MYCBP. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name MYCBP
Full Name MYC binding protein
Also known as AMY-1
Coordinate chr1:38862493-38873348
Strand -
Gene summary The protein encoded by this gene binds to the N-terminus of the oncogenic protein C-MYC, enhancing the ability of C-MYC to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates to the nucleus during S phase of the cell cycle and associates with C-MYC. This protein may be involved in spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one protein-coding and the other probably not protein-coding, have been found for this gene. [provided by RefSeq, Nov 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes MYCBPP1
Bonobo Pan paniscus MYCBPP1
Gorilla Gorilla gorilla MYCBPP1
Golden snub-nosed monkey Rhinopithecus roxellana RPL27P17
Mouse lemur Microcebus murinus MYCBPP2
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

The Genotype-Tissue Expression project - (GTEx)

Massive Mining of Publicly Available RNA-seq Data from Human and Mouse - (ARCHS4)

Related Sequence

>MYCBPP1
AAGGTGCTGGTAGCCTTAGAAAAGAACCAGAGAAACCTAATACTGCTTTGGTTTTTTTAAAGCATCACTTAGGAGTTGCTATCCCAGAAAATCCAGAAATAGAAGTGCTTCCCCTAGAATTGACAGAAATGAAAGATAAATATGAACGACCTCAGGTGAAGTGTGCCAGATAGGATTCTTCTCAGTGGAAAAGACACTAAAAAATGGTTTTGTATAACTTGAATAGTTTGTATATTATATAATCTTTTCTAGATAGATGCTACAGAATTCTTTTAATCTGTTACATTCACCTACCACACTTTATTATAAACACACTTAGAATCATCTATAAATACTCAATGTAAATTGTTTTGAGTCTTAAAGAAAAGAATCCAAAGTG
>NM_012333.5
AGTCGCGGTCTCCGGCGCCAGCTACGCCGCTGCCGCTGTCACTATGGCCCATTACAAAGCCGCCGACTCGAAGCGTGAGCAGTTCCGGAGGTACTTGGAGAAGTCGGGGGTGCTGGACACGCTGACCAAGGTGTTGGTAGCCTTATATGAAGAACCAGAGAAACCTAACAGTGCTTTGGATTTTTTAAAGCATCACTTAGGAGCTGCTACTCCAGAAAATCCAGAAATAGAGCTGCTTCGCCTAGAACTGGCCGAAATGAAAGAGAAGTATGAAGCTATTGTAGAAGAAAATAAAAAACTGAAAGCAAAGCTTGCTCAGTATGAACCACCTCAGGAGGAGAAGCGTGCTGAATAGGATTCTTCTCAGTTTGAAAGACAATGAAAAATGGTTTTGTATGACTTGAATAGTTTGTATAGTATATAATCTTTTCTGAACAGATGCTATAGAACTCTTTTAATATGTTTAATTCACCTATCACACTCTGTTAAAAACACATAGAATCATCAATAAAAACTCAATATAACTTTCTTTGGGTCTTAAAGCAGGAGAATCCAAAGTAAATCCTGAACAAAACCTAAACACAGCCATCTAACTCATTACCTTAAAAGACATTCTGTTTATTAGTCTGATTAGGAATGATGGCACTGGTTGTATTTTAGCCAAGACAGTTTAGCATGGAGCTATTCCTTGGTGCAGTTCAGGATATGAACACAGGTACAGTCATTCTTTGAAGGTGACACTGTTCTGTATATTCCCTATAGGCAGCTGGAGAGATCTGTGTGACACAAGATGCTTTTGTACGGGTTCCCATGAATCTTCTGCTCTTGTTTGTGTGACATGGAACAAATAACTTCTTTGCCACCACTTTGCCTTAGATAACTGTGTGTGTGTGTGCCAGTTTGAACTCTGACACCACATTTTCCTTCTATGCAATCATGCCTGTCTGATAATCTTGCATTGCTTTCCTCTGAGCTTTAGTGGGTCCTAGTTGCACACTGGCCTTTCTGTGCTGTTTTTCAATTTGCCTAATAATAGCAGTTACCCTGATTGTAATTTATGTAACTTTAAACAGGATCACACTGTACCCCCTGCCTGCCTTATTTGCTTACTGAGCACAGGACAGAGGCAATATACAACTCTGGGTTCACACACAAGCTGAGATGAGAAGAGGAATGAGCCATATATTGGGGAAAATCATAGTTTGTAGGtataattatatagtgcttttctccctcaaagtatttttctagccttgaattcattttatcttcattatccctgtgaagtaggtgggacaagtatAAGGGGAAGAGGGGTGCTGAATTTTTAGGCCAAAGACTGATATTAATACAAATcactcactaactgtagagccttgggcattatcagtgaactactctgagatttactgtcttcatctgtttaatgagtagaatgtccgtgatgcctacctcacagggttgttgtgagggtcaaatgagaatgtatgtgaaagatttgtaaatggtaaagcactataTTCTTGTTTGTTAGTCCTTTTTCCTTTCTTTGGGTAGACCTACAGTCAGATGTTTTGTTTTATGGATCACTTATTTTCCTTACTGGTAGACTGTCGTTTTATAGACATATTCCTATTTCATATATTCTCTCCCTGTTGTTAGAGAACCTATCTTTGTTTTTGGTCAAAACACACATAGAAAACAAAATGATCCAATGAAAACTGGTTTAACTAGCAAAAGCCTTGGCACCTGTTGGAGACTATGACCAAGCCAATAAAAAGGGCATTTAAATCAGCCCTGTTAGTAGGAATGTGGCTATGGCTGGTGCCTCTTCTAGTCACAAGTTTGTTTTTGGAGGGGGTCCAGAAGATCATTCCCTTGCATAGATTTCTCTTTTACCAATTTGAGTGCCTCCTACATGGGCAGCAGTGGACTAAGTGCTGGGTGTGATAAAGAGGAATGACTTAATTATGAGACTGTATATAATCAAATACAGTGTGGGTTAGGACCTGTGGCAGACCATTATAATAAAGCATGGCCCCGTGAGGGTTTTGAAAGAGAGAGAGACTTGGCTTCCTTAGTTGGTATGATAGTTTCTTGGTAGATACAGGTTGAAAATTTTTTGTGGCAGCCAATCCTCATGGGCTTTTTACTCATTTGATTAGTATTAatatttatgtcagtaagccaggtgactgtgactgtctttggtaccatcctttttgaacagaaaggcaacatgtgggttggataatCACACTTTTAGGTGAAACTGACTTGCTTAAACTGTAACAGTCAGTGCTATTTAAGAATTCAGGATAAGCTTAGCCTCTAGAGgtcctcttcaacatttctgtcaaggatttggatgaatacaacaagatgctCCATGGAAGAGAAAATGGATAAATGGATCCCACCAGttaagctcctattatgcttcagctgctttgtctataaaatatcgacttcacatcttgcctatctcacaagttggttgtaagaatcaaattaaatataatggatgtaaaa

Publications

PMID - Link Title
No publications available for this retrocopy