Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name FTOP1
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Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr16). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:42797232-42798733  UCSC
Coordinates (T2T) chr2:42802801-42804310  UCSC
Coordinates (hg19) chr2:43024372-43025873  UCSC
Strand -
Parental Sequence XM_017023658.2
Parental seq. overlap 584 bp
Parental seq. overlap (%) 40.8%
Genomic Region Intergenic
Retrocopy Summary FTOP1, located on chr2:42797232-42798733, is a retrocopy of the parental gene FTO. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name FTO
Full Name FTO alpha-ketoglutarate dependent dioxygenase
Also known as ALKBH9|BMIQ14|GDFD
Coordinate chr16:53703963-54121941
Strand +
Gene summary This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes Without Homology
Bonobo Pan paniscus Without Homology
Gorilla Gorilla gorilla Without Homology
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>FTOP1
TACACCAAGGCTGAAATAGCTGCTGCTTGTCAGACCTTCCTCAAGGTCAATGACTACCTGCAGATAGAAATAATCTAGGCTTTGGAAGAACTTGCTGCCAAAGAGAAAGCTAATGAGGATGCTGTGCCAGTGTGTTTGGCTGCAGATTTCCCCAGTGCTGGCATGGGGTCATCCGGTGATGGACAAGAAGATGAACTGGACATAAAGAGTAGAGCAGCATACAACGTAACTTTGCTGAATTCATGGATCCTCCGAAAATCCCACACCTGAAAGAGAAACCTTATTTTGGCATGCGGAAAATGGCAGTGCGCTGGCATCATGCTGAAAATCTGGTGGACAGGCCCCAAAGAGGAAAGTGAGGACGACTCTCATCTTGAAGGCAGAGATCTTGATACTTGGCATGTTGGTGTTAAGATCTCATGGGATGTAAAGACACCTGGTTTGGCAACACCCCAAGGAGACTGCTATTTCATGCTTGGGAGGCTCAAGAAGCTTTTCTCACACTGCACAAGCATGGCTGCTTATTTTGAGCCCTGGTTAGGATCCAAGGCAAAGATTTGCTCACTTCAGTATCTCCCATCCTCATTGGTAATCCAGGTTGCACCTACAAGTCCCTGAACACTAGGTTCTTTATGGTACCATGGCCAGTGAAAGGGTCTAATATAAAATACACCGAGGAAGGTGGCTTTAGTGGCCGCATGAAGCACACCCTGATTGCCGAGGAACAAGAGTGCAAAGCTAAGAAACTGAGGCATTTTGAAGAGTTTGAAGACACTTGGCTTCCTTATCTGACCCCCAAAGATGAATTCTATCAGCCGTGGCAGCTGAAATATCCTAAATTAATTCTCCAAGAAGCCAGCAGTGTATCTGGGGAGCTCCATAAAGAGGCTCAAGAg
>XM_017023658.2
GATCTACGCAGCTTGCGGTGGCGAAGGCGGCTTTAGTGGCAGCATGAAGCGCACCCCGACTGCCGAGGAACGAGAGCGCGAAGCTAAGAAACTGAGGCTTCTTGAAGAGCTTGAAGACACTTGGCTCCCTTATCTGACCCCCAAAGATGATGAATTCTATCAGCAGTGGCAGCTGAAATATCCTAAACTAATTCTCCGAGAAGCCAGCAGTGTATCTGAGGAGCTCCATAAAGAGGTTCAAGAAGCCTTTCTCACACTGCACAAGCATGGCTGCTTATTTCGGGACCTGGTTAGGATCCAAGGCAAAGATCTGCTCACTCCGGTATCTCGCATCCTCATTGGTAATCCAGGCTGCACCTACAAGTACCTGAACACCAGGCTCTTTACGGTCCCCTGGCCAGTGAAAGGGTCTAATATAAAACACACCGAGGCTGAAATAGCCGCTGCTTGTGAGACCTTCCTCAAGCTCAATGACTACCTGCAGATAGAAACCATCCAGGCTTTGGAAGAACTTGCTGCCAAAGAGAAGGCTAATGAGGATGCTGTGCCATTGTGTATGTCTGCAGATTTCCCCAGGGTTGGGATGGGTTCATCCTACAACGGACAAGATGAAGTGGACATTAAGAGCAGAGCAGCATACAACGTAACTTTGCTGAATTTCATGGATCCTCAGAAAATGCCATACCTGAAAGAGGAACCTTATTTTGGCATGGGGAAAATGGCAGTGAGCTGGCATCATGATGAAAATCTGGTGGACAGGTCAGCGGTGGCAGTGTACAGTTATAGCTGTGAAGGTACAGTCTGCTCTTGGAAAAAGCAGCCCTGCCCTGAAGAGGAAAGTGAGGATGACTCTCATCTCGAAGGCAGGGATCCTGATATTTGGCATGTTGGTTTTAAGATCTCATGGGACATAGAGACACCTGGTTTGGCGATACCCCTTCACCAAGGAGACTGCTATTTCATGCTTGAGCCCATCACTTCTGCCCACAGTTCCACTAAACTGTGAAGACCAGAATCTCTCAAAGTTAATGAATGAAACAGAAGAAGCCACTTCAACCTCCAATTTCTGTTTCTATGTCTTCTGACCTCCTTCTTTACACATCCTATCTCATATCCAATTTTCCATTAGCAATTAAGAAGGATAGCTATGGTTTCTGGCTAATACCTGGGGAGAGAAAAAGGATGTTCTCTCCAAATATGTG

Publications

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