Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name GGCTP3
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr7). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:52473480-52474230  UCSC
Coordinates (T2T) chr2:52469773-52470523  UCSC
Coordinates (hg19) chr2:52700618-52701368  UCSC
Strand -
Parental Sequence NM_024051.4
Parental seq. overlap 622 bp
Parental seq. overlap (%) 52.2%
Genomic Region Intergenic
Retrocopy Summary GGCTP3, located on chr2:52473480-52474230, is a retrocopy of the parental gene GGCT. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name GGCT
Full Name gamma-glutamylcyclotransferase
Also known as C7orf24|CRF21|GCTG|GGC
Coordinate chr7:30496621-30504829
Strand -
Gene summary The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes GGCTP1
Bonobo Pan paniscus GGCTP1
Gorilla Gorilla gorilla GGCTP1
Orangutan Pongo abelii GGCTP1
Gibbon Nomascus leucogenys GGCTP3
Marmoset Callithrix jacchus GGCTP2
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>GGCTP3
TTGTAATAGAAGATAAAGTTTTTACTCAACAAGGAAGAGAAATAACCTGTCAAAATTACCTGAGGAGAAAGTACGAGAGTGCATCTCCATCACTACAGTATAAAAAGGTTGTTTGCCTGGGTACAAAAGAAGAGTTTGCCACTGGAGTATCAAAAGTAGTTAAAAGCAATAGAATGAAATGACCATATTGATATAATAGAACCATATTGATATAAAAGAAAGGTCTCAGAACAAATTAAAGACATTATCAAAAAGGGGGAATACAAACTCATTAGAACATAACAGAATATATCTAAGGTTGTTCTATTTGCTAATATAAAATATTTTCAACACTTGAGAACAAGGATCTGGGTTTTCTCCACGTTTGATCCATTTTCAACAATACTCTGAAGGAATATCTCACTTGGGTGATTCCTTGTTTACAGAGTATAAAAAGAGACTGGGTTAGGAGTTAGACCATTTAAAAGGGGGTTATGAAGCTCTGGAATGTGTGACAAATGGCTGTGAGTGCCCCTTGTGTAAACACTTAAAGCTGTTTTGTTGAATAGATCTTAAGTGTCTTCTTGCTCTAGCAAAGGATAGTTTTATAGCTCGCTGGTTGATGGTGCTGGTGAATTGGTCTGCTCAGACTGAGATTTCTAAAAATCAGCTTAGGAAGAGTAAGCAATCTCCAAAGACAATTGATAATAATATTTTAAAATTGAAGAGATGGCATACTCTTTCTAGAGGAATAAATGTATTTGTGGTTTAC
>NM_024051.4
CCCCTAACCCTGAGGCTGCCGCGCGGCGGTCACTGCGCCGGGGTAGTGGGCCCCAGTGTTGCGCTCTCTGGCCGTTCCTTACACTCTGCTTCAGGCTCCAGTGCAGGGGCGTAGTGGGATATGGCCAACTCGGGCTGCAAGGACGTCACGGGTCCAGATGAGGAGAGTTTTCTGTACTTTGCCTACGGCAGCAACCTGCTGACAGAGAGGATCCACCTCCGAAACCCCTCGGCGGCGTTCTTCTGTGTGGCCCGCCTGCAGGATTTTAAGCTTGACTTTGGCAATTCCCAAGGCAAAACAAGTCAAACTTGGCATGGAGGGATAGCCACCATTTTTCAGAGTCCTGGCGATGAAGTGTGGGGAGTAGTATGGAAAATGAACAAAAGCAATTTAAATTCTCTGGATGAGCAAGAAGGGGTTAAAAGTGGAATGTATGTTGTAATAGAAGTTAAAGTTGCAACTCAAGAAGGAAAAGAAATAACCTGTCGAAGTTATCTGATGACAAATTACGAAAGTGCTCCCCCATCCCCACAGTATAAAAAGATTATTTGCATGGGTGCAAAAGAAAATGGTTTGCCGCTGGAGTATCAAGAGAAGTTAAAAGCAATAGAACCAAATGACTATACAGGAAAGGTCTCAGAAGAAATTGAAGACATCATCAAAAAGGGGGAAACACAAACTCTTTAGAACATAACAGAATATATCTAAGGGTATTCTATGTGCTAATATAAAATATTTTTAACACTTGAGAACAGGGATCTGGGGGATCTCCACGTTTGATCCATTTTCAGCAGTGCTCTGAAGGAGTATCTTACTTGGGTGATTCCTTGTTTTTAGACTATAAAAAGAAACTGGGATAGGAGTTAGACAATTTAAAAGGGGTGTATGAGGGCCTGAAATATGTGACAAATGAATGTGAGTACCCCTTCTGTGAACACTGAAAGCTATTCTCTTGAATTGATCTTAAGTGTCTCCTTGCTCTGGTAAAAGATAGATTTGTAGCTCACTTGATGATGGTGCTGGTGAATTGCTCTGCTCTGTCTGAGATTTTTAAAAATCAGCTTAATGAGAGTAATCTGCAGACAATTGATAATAACATTTTGAAAATTGGAAAGATGGTATACTGTTTTTAGAGGAATAAACGTATTTGTGGTTTAA

Publications

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