Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name POMPP2
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr13). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:57429542-57429796  UCSC
Coordinates (T2T) chr2:57430121-57430375  UCSC
Coordinates (hg19) chr2:57656677-57656931  UCSC
Strand -
Parental Sequence NM_015932.6
Parental seq. overlap 212 bp
Parental seq. overlap (%) 15.8%
Genomic Region Intergenic
Retrocopy Summary POMPP2, located on chr2:57429542-57429796, is a retrocopy of the parental gene POMP. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name POMP
Full Name proteasome maturation protein
Also known as C13orf12|HSPC014|PNAS-110|PRAAS2|UMP1
Coordinate chr13:28659130-28678959
Strand +
Gene summary The protein encoded by this gene is a molecular chaperone that binds 20S preproteasome components and is essential for 20S proteasome formation. The 20S proteasome is the proteolytically active component of the 26S proteasome complex. The encoded protein is degraded before the maturation of the 20S proteasome is complete. A variant in the 5' UTR of this gene has been associated with KLICK syndrome, a rare skin disorder.[provided by RefSeq, Aug 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes POMPP1
Bonobo Pan paniscus POMPP1
Gorilla Gorilla gorilla POMPP1
Orangutan Pongo abelii POMPP1
Gibbon Nomascus leucogenys POMPP1
Dog Canis familiaris LOC477325P11
Panda Ailuropoda melanoleuca POMPP1
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>POMPP2
CAGCTCAAACAAAATAAAATGCCTTTCTCCACATTAAGAAACATCCAGGGTCTATTTGCCCCAGTAAAATGACAAATAGAATTCAGGGCAGGGCCATAAGTGCAGCATCTTCCACTTCATTCCAGTTCAAATCTTTCACTGGATGTTTGGAGGGGGCATGCTGAGACTAGTGGATTCAAAGATATTCTTATTGATCCATCACAAAGTGAAGTAATGAGAGAACCTCTCTTGATGATGGAATATAAATTGGTTTAA
>NM_015932.6
GGCGGGGTCGACTGACGGTAACGGGGCAGAGAGGCTGTTCGCAGAGCTGCGGAAGATGAATGCCAGAGGACTTGGATCTGAGCTAAAGGACAGTATTCCAGTTACTGAACTTTCAGCAAGTGGACCTTTTGAAAGTCATGATCTTCTTCGGAAAGGTTTTTCTTGTGTGAAAAATGAACTTTTGCCTAGTCATCCCCTTGAATTATCAGAAAAAAATTTCCAGCTCAACCAAGATAAAATGAATTTTTCCACACTGAGAAACATTCAGGGTCTATTTGCTCCGCTAAAATTACAGATGGAATTCAAGGCAGTGCAGCAGGTTCAGCGTCTTCCATTTCTTTCAAGCTCAAATCTTTCACTGGATGTTTTGAGGGGTAATGATGAGACTATTGGATTTGAGGATATTCTTAATGATCCATCACAAAGCGAAGTCATGGGAGAGCCACACTTGATGGTGGAATATAAACTTGGTTTACTGTAATAGTGTGCTGTTCATGGAAACCGAGGGCTGCATCTTGTTTATAGTCATCTTTGTACTGTAATTTGATGTACACAACATTAAAAGTACTGACACCTGAGAATTTCTGCTCAAGTAGTATCAGTGATCATTTAAAATTTGGAGGGGTCTTTGGTTTACAGCCATGTGACAATTAAAAGCACTAAAGGGAGATCATGTTAAAGCTCTTAATTTATATTAAAACAGTAGCCTTTGTCTTTAAAAAAGTTGTTGCTCATGAATATTATAAAATGATCTACAGGTTTCAATTCAACCTGTTTCTAGGTTTTTTTGTAAATTTAGTTTTGATTAAGCATTATAAGCATTTGAGTCTATAAACTTTATAGTAGCATCTTTCAGAATAAACATTTTTAATTGATTTCAGTGGCAACTCTCAAATTGATTACAATATGAGATATATCAGTGTCGTCCATTAACACTCATAAGAATAATATTTACTGTGTCAGTGCTATTTTAGGATTATAGTTATTGTTTGATTATTTCAGGTTGAAAAGTAGAAGTTCCAAGGTTTTGATTTTGGTCTGGTCTTTAAGTGAAAAATTAAAGCAACCAGTAGATGTAGGTTAAACTTTTACTTCATAGACTTAATATGTAATTAATATATTGCCAAGCAACACTGTTAAAGAAAAGTAAAACTCATTTTTTCTTGTTCTTAATTTATATATTACAAGATACTGTAAGGTATTCTTTATGAAGTTGATATATAAAAATTTACATTTTTAGAACATTAGTGAATGGATCATCTTTTACAATTAAAAGTATATTTTGATTATCAGTTTCTTAGGAACATCTTTGATTAGATAAATTACTGATTTgaaaca

Publications

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