Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ATP1B3P1
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:60734389-60735780  UCSC
Coordinates (T2T) chr2:60740200-60741591  UCSC
Coordinates (hg19) chr2:60961524-60962915  UCSC
Strand -
Parental Sequence NM_001679.4
Parental seq. overlap 1293 bp
Parental seq. overlap (%) 70%
Genomic Region Intergenic
Retrocopy Summary ATP1B3P1, located on chr2:60734389-60735780, is a retrocopy of the parental gene ATP1B3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ATP1B3
Full Name ATPase Na+/K+ transporting subunit beta 3
Also known as ATPB-3|CD298
Coordinate chr3:141876643-141926549
Strand +
Gene summary The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ATP1B3P1
Bonobo Pan paniscus ATP1B3P1
Gorilla Gorilla gorilla ATP1B3P1
Orangutan Pongo abelii ATP1B3P1
Gibbon Nomascus leucogenys ATP1B3P1
Green monkey Chlorocebus sabaeus ATP1B3P1
Crab-eating macaque Macaca fascicularis ATP1B3P2
Rhesus Macaca mulatta ATP1B3P2
Baboon Papio anubis ATP1B3P2
Golden snub-nosed monkey Rhinopithecus roxellana ATP1B3P2
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ATP1B3P1
CGCGCGCACACGATGAAGAAGGAGTCCCTCAACCAGAGCCTCGCCGAGTGGAAGCTCTTCATCTACAACCCGACCACCGGAGAGTTCCTGTGGCGCACCGCCAAGAGCTGGGGTTTGATCTTGCTCTTCTACCTAATTTTTTATGGGTTCCTGGCTGCACTCTTCTCATTCACGATGTGGGTTATGCTTCAGACTCAACGATGAGGTTCCAAAATACCGTGACCAGATTCTTAACCCAGGACTGATGGTTTTTCCAAAACCAGTCACTGCATTGGAATATGCATTCAGTAGGTCTGATCTAACTTCGTATGCAGGGTACACTGAAGACCTTAAGAAGTTTCTAAAACCATATACTTTAGAAGAACAGAAAAACCTCACAGTCTGTCCTGATGGAGCACTTTTTGAACAGAAGGGTCCAGTTTATGTTGCTTGTCAATCTCCCATTTCGTTACTTCAAGCATGCCGTGGTATGAATGATCTTGATTTCGGCTATTCTCAAAGAAACCCTTGTATTCTTGTGAAAATGAACAGAATAATTGGATTAAAGTCTGAAGGAGTGCCAAGGATAGATTGTGTTTCGAAGAATGAAGATATACCAAATGTAGCAGTTTATCCTCATAATGGAATTATAGACTTAAAATATTTCCCATATTATGGGGAAAAACTGCATGTGGGGTATCTACAGCCATTGGTTGCTGTTCAGGTCAGCTTTGCTCCTAACGATACTGGGAAAGAAGTAACAGTTGAATGCAAGATTGATGGATCAGCCAACCTTAAAAGTCAGGATGATCGTGACAAGTTTTTGGGACGAGTTATGTTCAAAATCACAGCATGTGCATAGTATGAGTAGGATGTCTCCACAGAGTAAATTTTGTGTTGTCTGTCTTCATTTTGTATCAGCTGGACCTTCCATTCTAGAATTATGAGACCACCTTGGAGAAAGGTGTGTGGTACATGACACTGGGTTACATCATAACGTGCTTCCAGATCATAGTGTTCAATGTCCTCTGAAGTAACTGCCTCTTGCCTCTGCTGCCCTTTGAACCAGTGTACAGTCACCAGATAGGGACCGGTGAACACCTGATTCCAAACATGTAGGATGGGGGTCTTGTCCTCTTTTTATGTGGTTTAATTGCCAAGTGTCTAAAGCTTAATATGCTGTGCTATGTAAATATTTTATGGCTATAACACTGTCATATTTTGATGTCAACAGAGTTTTAGGGATAAAATGGTACCCGGCCAACATCAAGTGACTTTATAGCTGCAAGAAATCTGGTATGTGGAGAAGTTCTGCATGTGAGGAAGGAAAAAAAGACAATAAAAATGTATTTGAAAAATATTT
>NM_001679.4
AGTCGGCTCGAGTACTCCCCGTAACGAGGAGGTGTTCTCGGCCGTCCCACCCTTCACTGCCGTCTCCGGGCTGCGCCGCCGGAGCCGGGACGCGCCTCCGCAGCCCTCGCCGCCTCCATCCCCGCGGCCGCAGCTCCTCTCGCCGTCCGCGCGCACACCATGACGAAGAACGAGAAGAAGTCCCTCAACCAGAGCCTGGCCGAGTGGAAGCTCTTCATCTACAACCCGACCACCGGAGAATTCCTGGGGCGCACCGCCAAGAGCTGGGGTTTGATCTTGCTCTTCTACCTAGTTTTTTATGGGTTCCTGGCTGCACTCTTCTCATTCACGATGTGGGTTATGCTTCAGACTCTCAACGATGAGGTTCCAAAATACCGTGACCAGATTCCTAGCCCAGGACTCATGGTTTTTCCAAAACCAGTGACCGCATTGGAATATACATTCAGTAGGTCTGATCCAACTTCGTATGCAGGGTACATTGAAGACCTTAAGAAGTTTCTAAAACCATATACTTTAGAAGAACAGAAGAACCTCACAGTCTGTCCTGATGGAGCACTTTTTGAACAGAAGGGTCCAGTTTATGTTGCATGTCAGTTTCCTATTTCATTACTTCAAGCATGCAGTGGTATGAATGATCCTGATTTTGGCTATTCTCAAGGAAACCCTTGTATTCTTGTGAAAATGAACAGAATAATTGGATTAAAGCCTGAAGGAGTGCCAAGGATAGATTGTGTTTCAAAGAATGAAGATATACCAAATGTAGCAGTTTATCCTCATAATGGAATGATAGACTTAAAATATTTCCCATATTATGGGAAAAAACTGCATGTTGGGTATCTACAGCCATTGGTTGCTGTTCAGGTCAGCTTTGCTCCTAACAACACTGGGAAAGAAGTAACAGTTGAGTGCAAGATTGATGGATCAGCCAACCTAAAAAGTCAGGATGATCGTGACAAGTTTTTGGGACGAGTTATGTTCAAAATCACAGCACGTGCATAGTATGAGTAGGATATCTCCACAGAGTAAATGTTGTGTTGTCTGTCTTCATTTTGTAACAGCTGGACCTTCCATTCTAGAATTATGAGACCACCTTGGAGAAAGGTGTGTGGTACATGACATTGGGTTACATCATAACGTGCTTCCAGATCATAGTGTTCAGTGTCCTCTGAAGTAACTGCCTGTTGCCTCTGCTGCCCTTTGAACCAGTGTACAGTCGCCAGATAGGGACCGGTGAACACCTGATTCCAAACATGTAGGATGGGGGTCTTGTCCTCTTTTTATGTGGTTTAATTGCCAAGTGTCTAAAGCTTAATATGCCGTGCTATGTAAATATTTTATGGATATAACAACTGTCATATTTTGATGTCAACAGAGTTTTAGGGATAAAATGGTACCCGGCCAACATCAAGTGACTTTATAGCTGCAAGAAATGTGGTATGTGGAGAAGTTCTGTATGTGAGGAAGGAAAAAAAGAAAATAAAAGTGTGTTTGAAAAATATTATCTTGGGTTCTTTGTAAAATTTATTTTTTACATGCTGAATTAGCCTCGATCTTTTTGATTAAGAGCACAAACTTTTTTTTGTAAAACATGTAAAAAAAAAAACTGGGATTAATTTTTAGTGTTGGAACTGCCTCTTATTTTAGGCTGTAGATAAAATAGCATTTTTAGGTTAGCCAGTGTGACTATGCACCTAATTTTTTATGAGATTAAATTCATAAGACTTAATTTGTACAATAGTTTGTGAAATATCTTGTTACTGCTTTTATTTAGCAGACTGTGGACTGTAATAAAGTATATAAATTGTGAAATATAAAAACTTGGAACTTATTCAAAGCTTCAAAGCAAA

Publications

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