Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name DNAJB12P1
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr10). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:65500576-65502199  UCSC
Coordinates (T2T) chr2:65510215-65511835  UCSC
Coordinates (hg19) chr2:65727710-65729333  UCSC
Strand -
Parental Sequence NM_017626.7
Parental seq. overlap 1013 bp
Parental seq. overlap (%) 33.1%
Genomic Region Intergenic
Retrocopy Summary DNAJB12P1, located on chr2:65500576-65502199, is a retrocopy of the parental gene DNAJB12. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name DNAJB12
Full Name DnaJ heat shock protein family (Hsp40) member B12
Also known as DJ10
Coordinate chr10:72332863-72354919
Strand -
Gene summary DNAJB12 belongs to the evolutionarily conserved DNAJ/HSP40 family of proteins, which regulate molecular chaperone activity by stimulating ATPase activity. DNAJ proteins may have up to 3 distinct domains: a conserved 70-amino acid J domain, usually at the N terminus; a glycine/phenylalanine (G/F)-rich region; and a cysteine-rich domain containing 4 motifs resembling a zinc finger domain (Ohtsuka and Hata, 2000 [PubMed 11147971]).[supplied by OMIM, Mar 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes DNAJB12P1
Bonobo Pan paniscus DNAJB12P1
Gorilla Gorilla gorilla DNAJB12P1
Orangutan Pongo abelii DNAJB12P1
Gibbon Nomascus leucogenys DNAJB12P1
Crab-eating macaque Macaca fascicularis DNAJB12P1
Rhesus Macaca mulatta DNAJB12P1
Baboon Papio anubis DNAJB12P1
Golden snub-nosed monkey Rhinopithecus roxellana DNAJB12P1
Marmoset Callithrix jacchus DNAJB12P1
Green monkey Chlorocebus sabaeus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>DNAJB12P1
AGAGGAAGCAGTATGACCACTTGGGCGATAACAGGAGTCAGGCAGTCAGGTCCAGCATCGTCATGGGGATTTCCACCACGGCTTTGAGGCTGACATCTCCCCTGAAGACCTCTTCAACATGTTCTTTGGCAATGGCTTCCCTTCTAGTAAAGTCTACGTCTACAGCAATGGCTGCATGCGCTATACCTACCAGCAAAGGCAGGGCTGCAGGGAGAAGCGGAGTGACGGCAGCTTGCGGGTGTTCGTGCAGCTGATACCCATCCTCATCCTCATGTCAGCTCTCAGCCAGCTCATGGTCTCCAGTCCACCCTACAGTCTGAGCCCAAGACTGTTTGTGGGCCACATCACAGGCGAGTCACTGACCACCTGAGTGTCATCTACTATGTGGCAGGCATTTTCTCCGAGGAGTACACAGGCTCCAGCCTCCAAACAGTCAAACCGAATGTGAAAGATGATTATATCGCCAACCTCTGGAACAACTGCTGGACGGAGAAGCAGCAGATGAAAGGCTTGCTGTACCGAGGCCGCTACTTTGGTGACACAGATATGTACCACAAAGCACAGAAGATGGGCAGCCCCCTGCTGCAGCCAGCTGTCACAGGATCAGGCCTCCCTGCATGGATAATCCAGGGCCAGCCATGCCACCAAGGTCCAAACTATGAAATTCCTGGAGAATTTTTGGTGACATGCACTAAGCCAAGGCGATGGACTATATATTTAAGGAAAGACATACAAAGAAACAAAATTAAAATGGAATTGGAATCTGGTTCTGCCATGTAATCCAATAAGGATGAAGCCGAGCTCTGTATCAGCATCACCCTCAAGCCATCCAGTGCAACCAGCCCAACCAGGCGCTCCTCATCCTGGAGAAGGCACAGTGGCTGTACCCAATGCCGCGAGTGTGTGGCCTGATGGAGTCTCTCAACTAGGAACCACAAACTGCTGGTGACCAACCCCAACCCACAGACACAACCCATGCCACCCACAGGAAAGCAGGTGGGACCGATGCTCCCTAGGCCAACGGTGAAGCTGGAGGAGGAGAGAGCACCAAAGGCTACACTGCAGAAGGAGTTGCAGCTGTGAAAAGGGTCAAGCAATGTAAGGATTATTATGAGATCCTGGAGGTGAGGAGAGGGGCCTCAGATGAGGACCTGAAGAAGGCCTACCACAAACTGGCCCTCAAATTCCACCCAGACAAGAACCATGCACCTGGCACCACTGGAGCTTTCAAAGCCATTGGCACAGCATATGCAGTACTCAGCAACCCGGAGAAGAGGAAGCAGTGTg
>NM_017626.7
GGTTCCGCGTTCTGGTTCCGCCATGGAATCCAACAAGGATGAAGCTGAGCGCTGTATCAGCATCGCCCTCAAGGCCATCCAGAGCAACCAGCCCGACCGGGCGCTCCGCTTCCTGGAGAAGGCACAGCGGCTGTATCCGACGCCGCGAGTTCGCGCCCTGATTGAGTCCCTCAACCAGAAACCACAGACTGCCGGTGACCAACCCCCACCCACAGACACAACCCATGCCACCCACAGGAAAGCAGGTGGGACCGATGCCCCCTCGGCCAACGGTGAAGCTGGAGGAGAGAGCACCAAAGGCTACACTGCAGAACAGGTTGCAGCTGTGAAAAGGGTCAAGCAATGTAAAGATTACTATGAGATCCTGGGGGTGAGCAGAGGGGCCTCGGATGAGGACCTGAAGAAGGCCTACCGCAGACTGGCCCTCAAATTCCACCCAGACAAGAACCACGCACCTGGTGCCACTGAAGCCTTCAAAGCCATTGGCACAGCATATGCGGTACTCAGCAACCCGGAGAAGAGGAAGCAGTATGACCAGTTCGGCGATGACAAGAGCCAGGCGGCCCGGCACGGCCATGGGCATGGGGATTTCCACCGTGGCTTTGAGGCCGACATCTCCCCTGAAGACCTCTTCAACATGTTCTTTGGCGGCGGCTTCCCTTCTAGTAACGTCCACGTCTACAGCAACGGCCGCATGCGCTATACCTACCAGCAAAGGCAGGACCGCAGGGACAACCAGGGTGATGGCGGGCTAGGGGTGTTTGTGCAGCTGATGCCTATCCTCATCCTGATTCTCGTGTCAGCTCTCAGCCAGCTCATGGTCTCCAGTCCACCCTACAGTCTGAGTCCAAGACCGTCCGTGGGCCACATCCACAGGCGAGTCACTGACCACCTGGGTGTCGTCTACTATGTGGGAGACACTTTCTCCGAAGAGTACACAGGCTCCAGCCTCAAAACAGTCGAGCGGAATGTGGAAGATGATTATATCGCCAACCTCCGGAACAACTGCTGGAAGGAGAAGCAGCAGAAGGAAGGCTTGCTGTACCGGGCACGCTACTTTGGCGACACAGATATGTACCACAGAGCACAGAAGATGGGCACCCCCAGCTGCAGCCGACTGTCAGAGGTGCAGGCCTCCCTGCATGGATAGTCCTGGGCCAGCCACACCACCGAGGTCCAAACTATGAAATCCCTGGAGAATTTTTGGTGACATGCACTGAGCCAAGGTGATGGACTGTATATTTGAGGAAAGACAAACAAAGAAACAAAATTAAAATGGAATTGGAGGCCGAACGCTGCACAGCTGCCCTCTCTCTCACCCAGTAAATGCAGAAAGCTCTTAGGACAGACAGAAAACCTGCCATGGGGCTGCTTCCCTCCCTCGCAGGGCTGGCGGAGGCTCCGCATCGCCTCTCTCCTAGGATACAGAAACCATGGCAACGAAAGTAGAATGTAAAACTCGCAGCAGATATCAGTGGGAAGGGCTGGGGGAGGGGGCACCCAGCTGCCTTTCCTCCCTCACAGGAGCCACCACCAGCCACCTCTCAGGAGAAGCCAGAGGCCCTGGCCAAAGATAGGAGGAAGAAAGAGAACTCTCCATAGAATGTAATTTATAGATGCGTGtatatgtatatatatctatttatatgtaaataggcatatatgaagatatatatatatataGTCTACTTTTTAAACTCTGCAGGGATTTGGTTAAGTTGTTGAGCTGATTTCTTCCATGTTTTAGAAAATGAGGCCTGTTTGGGGAAGGTACCCTGGTGATGTTTTTGCTAGACATTAGCTGTAGCTGACAGCATAAGGAGAGTCGCATCAGAGCTTTTCACAGCCCCCCGAAACCCCAGCCTGGTTTTGATGGCAGCAGTAATCATGATAGTGTGAACCCGCGAAGGCCTCAGGATTATGGTTAACCTGGAGAGGAGCAGGCCATGGAGGCAGGTGCCAGGTCAGTATTGAGTCACAGTAGAGGCCCCACAAGGACCTGCTTGGGTGAGACCACCTCTCCCCTCTCAGCAGCGCTGGTGGGCTCTTTGTCCTGGTGCCCAGGAGCCCTCCAGCCCCCTGCCCACAGAAGGGAAGGCCTGCAGAGGGGGCCAGGATCTACCTAACCATTTCCCCACCCCTAAGTCCCTCAGTGGGCTTTGCCTTATAGGTGCCACAGGGCACAGCTCCATCATTGCCACTGGTTTTTCCTAAGTCATGCACCAAGGACTTCAGAAAGTTCTTCCTCCGAGTCAGTCAGTGGTGCCGGGACCCCAGGGCAGCCTCCTCGACTCCTGAAGAAAAGGCAGTGCCCGTGGCTGCCTCTGTCTTCACTCGCTGTTGATGTGACCGCCAGGCCTCCTCTCGTACCTTGGACAAAGGATACACCTGAACCAGAATAGTTTTCTTACCCTCACATTGAAATGAGGATTTTGCTTAAAACAGCACTTGCCGCCAGTGGGAGGAGGGAGGTTTTATTTATTCCCACAGTTTCTCCTGGGCCTTCTGGAATGACCATGTTTTCCTGTGGCGGTGGGTGTGTCATTGCGCCCGCCGTCTTCCAAAGCCTTACTTCCCCAAGCTGCCAGCCAGGAGGTGATAACCACCCTCCCAGAGTTTCTCTCGGCTCTTTTTTTAAAAGTCCCCCAACAAATAGGATTCTTGCTGGGAAAGGAAGTTCGGTAAGGAAATGTCAAATCTGGTTTTTAAACAAGGTCCAACCCTGCAATGAAGCAGCCACTTCAGCCCAGAGAGATTATAAGAACTGATGTGGCCAGAGTGCCTACCCACTGTGGCCCCGGTGCTCTGCCCCCACGCCCCGACCATCTGGTCTTGGTAGATGTCCCTAGACGGGCTGAGCCATGTGCAATAAGAACATAGATCCTAAAGGATCCTCTGGAAGCTGTATTTCTTGAATTAGAATTCTCAAATTGTA

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