Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name DNMT3AP1
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr2). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:66819932-66822600  UCSC
Coordinates (T2T) chr2:66829342-66832010  UCSC
Coordinates (hg19) chr2:67047064-67049732  UCSC
Strand -
Parental Sequence NM_001375819.1
Parental seq. overlap 1700 bp
Parental seq. overlap (%) 46%
Genomic Region Intergenic
Retrocopy Summary DNMT3AP1, located on chr2:66819932-66822600, is a retrocopy of the parental gene DNMT3A. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name DNMT3A
Full Name DNA methyltransferase 3 alpha
Also known as DNMT3A2|HESJAS|M.HsaIIIA|TBRS
Coordinate chr2:25227874-25342590
Strand -
Gene summary CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes DNMT3AP1
Bonobo Pan paniscus DNMT3AP1
Gorilla Gorilla gorilla DNMT3AP1
Orangutan Pongo abelii DNMT3AP1
Gibbon Nomascus leucogenys DNMT3AP1
Green monkey Chlorocebus sabaeus DNMT3AP1
Crab-eating macaque Macaca fascicularis DNMT3AP1
Rhesus Macaca mulatta DNMT3AP1
Baboon Papio anubis DNMT3AP1
Marmoset Callithrix jacchus DNMT3AP1
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>DNMT3AP1
TGTAAGGAAAGAGAGAAGTATCAGCACCCAGAAGAGAAAAAAAGAATTCAAAACAAAAACTACAGAGGCAGAAATAACGGAGGGCTTCGCCTTGCAAAAAGGGTTGGACATCTTCTGATTTTTCAATGTTTTTCTTCAGTTCTATTTAAAAACAAAACAAGCTCGCTCGACATCAAGGAGATTGTTGATGAACACAGAAGAGTAGTTAGTGTACAAAGTGAGGAAGAAGTGCCAGAACATCAAGGACCTTTGTGTCTCTTGTGAGAGCCTCAATGTCACTCTGGAACAGCCCCTCTTCATGCTAGGAATATGACGACATTGCAAGAACTGCTTCCTGGAATATGCATACCAGTATGATGAAGAAGGCTATCAGTTCTGCTGCACCATCTGCTGCTGTGGGCACGAGGTGCTCATGTGCTGGAACAACTGCTGCAGGTGCTTTTGCGTGGAGTGTATAGACCTCTTGGTTGGGCCAGAGGTTGCCCAGGTGACCATTAAGGAAGATCCCTGGAACTGCTACATGTGTGAACACAAGGGCATCTGTGAGCTGCTGCAGTGGCGGGATGACTGGCCCTCTCAGCTCCAGATGTTCTTCCCCAATAACCCTAACCAGGAATTTGACCCTCTGGAAGTCTACTCGCCTGTCCCAGCTGAGAAAAGGAAGCCGCCCATCCAGGTGCTGTCTCTTTTTGACGGGATTGATATGAGGCTCCTGGTGCTGAATGGCTTGGGCATTTAGGTAGATCACTACATGTCTCAGAGGTGTGTGAGGACGCCATCATTGTGGGCATGCTGTGGCACCAGGGGAGGATCATGCACATCAGGGATACCCGAACCATCATACAGAAGCACAACCAGGAGTGGGGCCCATTCTCTGCAATGACCTCTCCATTGTCAACCCTGCCCACGAAGGACCCTACAAGGGCACTGGCCAGCAATTCTTTGAGTTTTCTCACCTGTGCATCATGCACAGCCCAAGGAGGGAGATGATCACCCTTCTTGTGGCTCCTTGAGAGTGTGGTGGCCATGGGCACTAGTCAAAAGAGAGACATCTCACAATTTTTTTATTCGAATTCCATGATGATTAATGCCAAGGAAGTGTCAGCTGCACACCAGAACTACTACATCTGTGGTAACCTTCCCAGTAAGAGCAGGCCATTGGCATTCACTATGAATGTAAGCTGGAGCTGCAGGAGTGTGTGGAGCATGGCAGAAAAGCCAAGGTCAGCAAAGCGAGGACCATTACTACCAGGTCAAACTCCATAATGCAGGGCAAAGACCAGCGTCTCCCTGTCTTCATGAATGAGAAGGACACCTTAGGTGCATTGAAATTGAAAGGGTATTTGGACTCCCTGTCCATTATACTGACATCTCCAACATAAGCCATTGGGCAAGGCAGAGACTGTTGCGTGAGTCATGGAGCATAGCAGTCACTTGCCAATTCTTCCCTCCACTGAAGGGGTATTTTGCTTGTGTGTAAGGGACATGGGGGCAAACTGAGGTAGTGACACAAGTTTGGGCTACACCTGGCCTCATGGGCTGAGAAGAAAGGCCGAGGTCACTGCAGTAATGAATGCTATGGAAGAAAACTAGGGCTCAGAGGAGTCTGCAAAGGTGGAGGAGGCCAGCCCTGCTGCTGTGCGGCAGCCCAGCAACCCCACATCCCCCACTGTCGTTACCACACCTGAGCCTGTGGGGACTGAGGCTGGGAACAAGTACATCAAAGCAGGTGACGATGAACCAGAGTACAAGGACAGCTGGGGCTTTGGCAATGGGGAGCTGGTGTGAGGAAAACTGCAGGGCTTCTCCTGGTGGCCGCATTGTGTCTTGGTGGATGACAGGCCAAAGCCGAGCAGCTGAAGGCACCCACTGTGTCATGTGGCTTGGAGAGGTGAGTTCTCAGTGCTGTGTGTAGAGAAGCTGATACCACTGAGCTCCTTTTGCAGTGTGTTCCACCAGACCACCTATAATACAACAAGCAGCCCATGTACCACAAAGCCATCTACGAAGTCCTGCCGGTGGCCAGCAGTGTACAGGGGAGCTGTTCTCAGGGAGCCATGACAGTGATGAGAGTGACACTGCCAAGGATACAGAGGTGCAGAGCAAGCAGATATTCAGATGGACCTTTGGGGGGTTCCAGCCTTCTGCCCCCAAGAGACTGGAGCCACAAGAAGAGGAGAAGAATCCCAGCAAAGAAGTTTATGCACACGTGAGGGGTGACCCTGAGGCAACTGCTTAGGCACCACCCCCACCAGCCAAAGAGCCCCGAAAGAGCACAGCTAAGAAGCTCAACATGGg
>NM_001375819.1
ACTTCCAGAGCTTCAGGGCCGCGGCTCACACCTGAGCGCGACTGCAGAGGGGCTGCACCTGGCCTTATGGGCTGAGAAGAAAGCCAAGGTCATTGCAGGAATGAATGCTGTGGAAGAAAACCAGGGGCCCGGGGAGTCTCAGAAGGTGGAGGAGGCCAGCCCTCCTGCTGTGCAGCAGCCCACTGACCCCGCATCCCCCACTGTGGCTACCACGCCTGAGCCCGTGGGGTCCGATGCTGGGGACAAGAATGCCACCAAAGCAGGCGATGACGAGCCAGAGTACGAGGACGGCCGGGGCTTTGGCATTGGGGAGCTGGTGTGGGGGAAACTGCGGGGCTTCTCCTGGTGGCCAGGCCGCATTGTGTCTTGGTGGATGACGGGCCGGAGCCGAGCAGCTGAAGGCACCCGCTGGGTCATGTGGTTCGGAGACGGCAAATTCTCAGTGGTGTGTGTTGAGAAGCTGATGCCGCTGAGCTCGTTTTGCAGTGCGTTCCACCAGGCCACGTACAACAAGCAGCCCATGTACCGCAAAGCCATCTACGAGGTCCTGCAGGTGGCCAGCAGCCGCGCGGGGAAGCTGTTCCCGGTGTGCCACGACAGCGATGAGAGTGACACTGCCAAGGCCGTGGAGGTGCAGAACAAGCCCATGATTGAATGGGCCCTGGGGGGCTTCCAGCCTTCTGGCCCTAAGGGCCTGGAGCCACCAGAAGAAGAGAAGAATCCCTACAAAGAAGTGTACACGGACATGTGGGTGGAACCTGAGGCAGCTGCCTACGCACCACCTCCACCAGCCAAAAAGCCCCGGAAGAGCACAGCGGAGAAGCCCAAGGTCAAGGAGATTATTGATGAGCGCACAAGAGAGCGGCTGGTGTACGAGGTGCGGCAGAAGTGCCGGAACATTGAGGACATCTGCATCTCCTGTGGGAGCCTCAATGTTACCCTGGAACACCCCCTCTTCGTTGGAGGAATGTGCCAAAACTGCAAGAACTGCTTTCTGGAGTGTGCGTACCAGTACGACGACGACGGCTACCAGTCCTACTGCACCATCTGCTGTGGGGGCCGTGAGGTGCTCATGTGCGGAAACAACAACTGCTGCAGGTGCTTTTGCGTGGAGTGTGTGGACCTCTTGGTGGGGCCGGGGGCTGCCCAGGCAGCCATTAAGGAAGACCCCTGGAACTGCTACATGTGCGGGCACAAGGGTACCTACGGGCTGCTGCGGCGGCGAGAGGACTGGCCCTCCCGGCTCCAGATGTTCTTCGCTAATAACCACGACCAGGAATTTGACCCTCCAAAGGTTTACCCACCTGTCCCAGCTGAGAAGAGGAAGCCCATCCGGGTGCTGTCTCTCTTTGATGGAATCGCTACAGGGCTCCTGGTGCTGAAGGACTTGGGCATTCAGGTGGACCGCTACATTGCCTCGGAGGTGTGTGAGGACTCCATCACGGTGGGCATGGTGCGGCACCAGGGGAAGATCATGTACGTCGGGGACGTCCGCAGCGTCACACAGAAGCATATCCAGGAGTGGGGCCCATTCGATCTGGTGATTGGGGGCAGTCCCTGCAATGACCTCTCCATCGTCAACCCTGCTCGCAAGGGCCTCTACGAGGGCACTGGCCGGCTCTTCTTTGAGTTCTACCGCCTCCTGCATGATGCGCGGCCCAAGGAGGGAGATGATCGCCCCTTCTTCTGGCTCTTTGAGAATGTGGTGGCCATGGGCGTTAGTGACAAGAGGGACATCTCGCGATTTCTCGAGTCCAACCCTGTGATGATTGATGCCAAAGAAGTGTCAGCTGCACACAGGGCCCGCTACTTCTGGGGTAACCTTCCCGGTATGAACAGGCCGTTGGCATCCACTGTGAATGATAAGCTGGAGCTGCAGGAGTGTCTGGAGCATGGCAGGATAGCCAAGTTCAGCAAAGTGAGGACCATTACTACGAGGTCAAACTCCATAAAGCAGGGCAAAGACCAGCATTTTCCTGTCTTCATGAATGAGAAAGAGGACATCTTATGGTGCACTGAAATGGAAAGGGTATTTGGTTTCCCAGTCCACTATACTGACGTCTCCAACATGAGCCGCTTGGCGAGGCAGAGACTGCTGGGCCGGTCATGGAGCGTGCCAGTCATCCGCCACCTCTTCGCTCCGCTGAAGGAGTATTTTGCGTGTGTGTAAGGGACATGGGGGCAAACTGAGGTAGCGACACAAAGTTaaacaaacaaacaaaaaacacaaaacataataaaacaccaagaaCATGAGGATGGAGAGAAGTATCAGCACCCAGAAGAGAAAAAGGAATTTAAAACAAAAACCACAGAGGCGGAAATACCGGAGGGCTTTGCCTTGCGAAAAGGGTTGGACATCATCTCCTGATTTTTCAATGTTATTCTTCAGTCCTATTTAAAAACAAAACCAAGCtcccttcccttcctcccccttcccttTTTTTTCGGTCAGACCTTTTATTTTCTACTCTTTTCAGAGGGGTTTTCTGTTTGTTTGGGTTTTGTTTCTTGCTGTGACTGAAACAAGAAGGTTATTGCAGCAAAAATCAGTAACAAAAAATAGTAACAATACCTTGCAGAGGAAAGGTGGGAGAGAGGAAAAAAGGAAATTCTATAGAAATCTATATATTGGGttgtttttttttttgttttttgttttttttttttgggtttttttttttactatatatcttttttttgttGTCTCTAGCCTGATCAGATAGGAGCACAAGCAGGGGACGGAAAGAGAGAGACACTCAGGCGGCAGCATTCCCTCCCAGCCACTGAGCTGTCGTGCCAGCACCATTCCTGGTCACGCAAAACAGAACCCAGTTAGCAGCAGGGAGACGAGAACACCACACAAGACATTTTTCTACAGTATTTCAGGTGCCTACCACACAGGAAACCTTGAAGAAAATCAGTTTCTAGAAGCCGCTGTTACCTCTTGTTTACAGTTtatatatatatgatagatatgagatatatatataAAAGGTACTGTTAACTACTGTACAACCCGACTTCATAATGGTGCTTTCAAACAGCGAGATGAGTAAAAACATCAGCTTCCACGTTGCCTTCTGCGCAAAGGGTTTCACCAAGGATGGAGAAAGGGAGACAGCTTGCAGATGGCGCGTTCTCACGGTGGGCTCTTCCCCTTGGTTTGTAACGAAGTGAAGGAGGAGAACTTGGGAGCCAGGTTCTCCCTGCCAAAAAGGGGGCTAGATGAGGTGGTCGGGCCCGTGGACAGCTGAGAGTGGGATTCATCCAGACTCATGCAATAACCCTTTGATTGTTTTCTAAAAGGAGACTCCCTCGGCAAGATGGCAGAGGGTACGGAGTCTTCAGGCCCAGTTTCTCACTTTAGCCAATTCGAGGGCTCCTTGTGGTGGGATCAGAACTAATCCAGAGTGTGGGAAAGTGACAGTCAAAACCCCACCTGGAGCAAATAAAAAAACATACAAAACGTA

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