Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name WDR4P2
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr21). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:68447922-68449168  UCSC
Coordinates (T2T) chr2:68458522-68459768  UCSC
Coordinates (hg19) chr2:68675054-68676300  UCSC
Strand -
Parental Sequence NM_018669.6
Parental seq. overlap 1071 bp
Parental seq. overlap (%) 50.5%
Genomic Region Intergenic
Retrocopy Summary WDR4P2, located on chr2:68447922-68449168, is a retrocopy of the parental gene WDR4. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name WDR4
Full Name WD repeat domain 4
Also known as GAMOS6|MIGSB|TRM82|TRMT82|Wuho|hWH
Coordinate chr21:42843075-42891695
Strand -
Gene summary This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes WDR4P1
Gorilla Gorilla gorilla WDR4P1
Orangutan Pongo abelii WDR4P1
Bonobo Pan paniscus Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>WDR4P2
ATGGCGGCGAGGCGGGTAGGCACAAGGCAGACTCTGCGGGGCTGGCGTTGTGCGGGCAGAAGCTGGTGGTGCAGGGGAGCAGCCGGTTCCAGACCACCTCCACTGCAAGCAGTGACGATGACAGCCTCTTCATCTATGACTGCAGTGCTTGAAAACAAGTCACAAGAAAATAAAGGGGACGACGAGCCGCCCTTGGTTCAGGGGAGCGGTGCAATTGTCGGTCCACCTTCTCCAAGTCTGGCAGCTGTTTTCTTTAACCGATGGCAGTAAGTGTCTGATTCTTTTCTGTACATAACCATGGCAATGTCTGAGTGTCAGGACCATGACAAGGAGGTGTACGGACCTGACCTTCACAGCCTCCGAAGAGAAGGTCTTGGTGGCTGACAAGTCTGGAGGCGTCTCCTCTTCGGTGCTGGAGCCACACGGATGCGGCCGACTGGAGCTGCAGCACCTTTCTGTCCATGCTATTAGACGTGGCTGTGCATCCTGATGACCACTTCGTCCTCACTGCGGACCGGGACGAGAAGATCCAGGTCAGCAGGGCCGCCATGCCCCGCAGCATTGAGTCCTCCTGCCTCGGGCACACAGTTTGTGAACTACATCTCCATGTTGCCCACTCAGCCTGAGCTGCTTCCATCCTCCTCCGGGGCCTGCACCCTGAGGCTCTGGGAGTACAGAAGCGGCCGCCAACTTCACTTCTGTCACCTCCACAGTCTCCAAGAGTCCGCGGACCTCCAGGTCCCCCCAGAGGTTTGCCGCGTCCAGGATTGCGTTCTGGTGCCAGGAGAACCGGGTGGTGCTTCTGAGCACCTGCATTGCTGTGGGATACATCTTCCAGTTTCACGCCGGTAGACAGAAGCTGGTGTACAGGCAGCAGCTGTCATTCCAGCATCGAGTGTGGGATGTAGCTTTTGAGGAAACCCAGGGGCTGTCGGTGCTCCAGGACTGCCTGGAAGCCCCCCTCCCCTGGTGCTCTGCAGGCCTGTGGGTGGCCAGTGGCAGTCTGTTCCTGAAAGTGCCATGTTAAAGAAAGTCTCCAGTGTTCTTTGTGGGAACCGGGCCATGCTGGAAGGCTCTGCCTGCGTGAACCCCAGCTTTAGCAGTCTCTACAAGGCCAACTTTGACAACATAACCTTCTACCTGAAGAAGAAAGAGGAGAGACTGCAGCAGCAGCTGAAGAAGCAGCAGCGCAGTTGAGTCCCCCACCTGGGCCAATGGGCAGGCCAAGAAGATAAGGCCGGGGGAGT
>NM_018669.6
GCTCTGGGCTGGCACATGTGTATGGCGGTGAGGCGGGCGGGTACATGGCGGGCTCTGTGGGACTGGCGTTGTGCGGGCAGACGTTGGTGGTGCGGGGCGGCAGCCGATTCCTGGCCACCTCCATAGCAAGCAGTGATGATGACAGCCTCTTCATCTATGACTGCAGTGCTGCAGAAAAGAAGTCACAAGAAAATAAAGGGGAGGACGCGCCCTTGGACCAGGGGAGCGGTGCGATTCTGGCGTCCACCTTCTCCAAGTCTGGCAGCTATTTTGCTTTAACCGATGACAGTAAGCGTCTGATTCTTTTCCGTACAAAACCATGGCAATGTCTGAGTGTCAGGACCGTGGCAAGGAGGTGTACAGCCCTGACTTTCATAGCCTCGGAGGAGAAGGTCTTGGTGGCCGACAAGTCTGGAGACGTCTACTCCTTTTCGGTGCTGGAGCCACACGGGTGTGGCCGTCTAGAGCTGGGGCACCTGTCTATGCTGTTAGATGTGGCTGTGAGTCCTGATGACCGCTTCATCCTCACTGCCGACCGGGACGAGAAGATCCGAGTCAGCTGGGCCGCGGCGCCCCATAGCATCGAGTCCTTCTGCTTGGGGCACACAGAGTTTGTGAGCCGTATCTCCGTGGTGCCAACTCAGCCCGGGCTGCTTCTGTCCTCCTCTGGGGACGGCACCCTGAGGCTCTGGGAGTACAGGAGCGGCCGCCAGCTGCACTGCTGTCACCTGGCCAGTCTGCAGGAGCTGGTGGACCCCCAGGCCCCCCAGAAGTTTGCCGCGTCCAGGATTGCATTCTGGTGCCAGGAGAACTGCGTGGCGCTCCTGTGCGACGGCACTCCTGTGGTCTACATCTTCCAGCTGGACGCCCGCAGACAGCAGTTGGTGTACAGGCAGCAGCTGGCGTTCCAGCACCAAGTGTGGGACGTGGCTTTCGAGGAGACCCAGGGGCTGTGGGTGCTCCAGGACTGCCAGGAAGCCCCCCTGGTGCTCTACAGGCCTGTGGGCGACCAGTGGCAGTCTGTTCCTGAGAGCACCGTGTTAAAGAAAGTCTCTGGTGTTCTTCGTGGGAACTGGGCCATGCTGGAAGGCTCTGCCGGCGCAGACGCCAGCTTCAGCAGTCTCTACAAGGCCACGTTCGACAACGTGACCTCCTACCTGAAGAAGAAAGAGGAGAGACTGCAGCAGCAGCTAGAGAAGAAGCAGCGGCGCCGGAGTCCCCCGCCTGGGCCCGACGGGCATGCCAAGAAGATGAGACCGGGGGAGGCGACGCTAAGTTGCTGATCGTGGCGGTCAGTGGTGTCTCTCACCTCAAATTAGGAAAAGCTTTTTAACTTGTTCCCCTGCATCCTGGCATGTCCCTTCAAGAAGGAAAAGGTGACATCAGTTGTGACCAGCTCAGAGGATGGGGCTGTCCCCTGGGCTCTAGAAAGAACATTCTGTGTCACCAGCACAGGCTCTTGCTGGGTGCCTGTGCCCCCTTTCTGGTTGAAGGGAAGCCAGACCAGTGGAGTGGAAGCTCTTGAAGCACTTTCTTTTCATGTCGGAGGCTGCGTGTGAGCCGGTGGTGGCGGCAGCTGTCTGTGTTTCTCCTGTTCTCATACCGCCCTTCGTGTCCGCTGCATCTTCCTCTAGGAGCATCTGTGGGCTGACGTTTCTGGCATGGTGGATGTTTTCATGTTGTTCCGCCGTCTCAGCATCCAGGTGACGTGCTGTCCCGCAGTAGCTGCTCGCCACACAGGCTGTTGAAACTCAGCACGAATGCTTGAGCCTGCCCCAGCCCCAGCCGTAGCCCTTGTGCTCAGGAGCTGCTCCTGGAGAGTGGCTCCCTTGTGGGAAGTGAGAAACACGTTTCGGAGTCGCAGGGAGCTCTGTCTGGCATCGGTGGCACAGATGGTGAACTTGTTTCAGGAAGTGTGAGCACGGGCCTGGCTGGCACCCGGTTTACAGGGAGGTGATTGAGGACGTCGTTATGATTTGATTTGACCTTGGCACACACTGCAGAGCCACAGGGATGTTGCTGAATTTCAATCACCGATCAGCAAGGATGAACCTTCTCAACTTCCTAGGAATGTTTAGCAGCAACCGAATATACCAGGCAAAACTC

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