Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CRLF3P3
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr17). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:84031345-84032101  UCSC
Coordinates (T2T) chr2:84032444-84033200  UCSC
Coordinates (hg19) chr2:84258469-84259225  UCSC
Strand +
Parental Sequence NM_015986.4
Parental seq. overlap 622 bp
Parental seq. overlap (%) 21.6%
Genomic Region Intergenic
Retrocopy Summary CRLF3P3, located on chr2:84031345-84032101, is a retrocopy of the parental gene CRLF3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CRLF3
Full Name cytokine receptor like factor 3
Also known as CREME-9|CREME9|CRLM9|CYTOR4|FRWS|p48.2
Coordinate chr17:30782684-30824692
Strand -
Gene summary This gene encodes a cytokine receptor-like factor that may negatively regulate cell cycle progression at the G0/G1 phase. Studies of the related rat protein suggest that it may regulate neuronal morphology and synaptic vesicle biogenesis. This gene is one of several genes located in the neurofibromatosis type I tumor suppressor region on the q arm of chromosome 17, a region that is subject to microdeletions, duplications, chromosomal breaks and rearrangements. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2 and 5. [provided by RefSeq, Aug 2012]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CRLF3P2
Bonobo Pan paniscus CRLF3P1
Gorilla Gorilla gorilla CRLF3P1
Gibbon Nomascus leucogenys CRLF3P2
Green monkey Chlorocebus sabaeus CRLF3P1
Crab-eating macaque Macaca fascicularis CRLF3P2
Rhesus Macaca mulatta CRLF3P2
Baboon Papio anubis CRLF3P2
Golden snub-nosed monkey Rhinopithecus roxellana CRLF3P2
Horse Equus caballus CRLF3P1
Orangutan Pongo abelii Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CRLF3P3
AAGATCAAAGAGTGAGCATCACAGACAAAGGATGTCCTAAAACAGCATTTTAATGATTTAAAGGAATCCTCGGGAAGCTCTGGGATGAGCAATTGAAGTCTCTTGCAAGAGCTGGGCACCATTAAACAGGGGACTATTAAGCCACTAGGTGACTGTCAGGAGTCATACAGCATGAAATTAACACCGCAGAGGACTTAATCCAAGAAAGTGAGATCACCATTGTTGGTGGCATGGGAGAACAGATTGAGAAACTGTGAACCGTTACCAAAAAGGCCTTCTGCATTTAGTTAGACAGGTTACCAGAAGTGTCTCTGCTGGTTGATGTGCCTTGTTTGTTTGCTCAGCTGAATGACTCAATTCTTATTTTAGTGAAAGGCTACATCTTTCACCATGGAATGGTGGCATCTCACCTACCAGTAGAAATGTAAGCACTAATAGAGAAAACTGGAAGCCTCATTGTATGATGATGTAAGATAGATGATGACACTATAGCTCAAGATTACAGATTCCAGCTCCATAAATGTACTTCAAATCATTTTAAGTATGTATGTGTAGGCTCTGAAACTGAATTTATAGCATTGCACATAGATCCCAATGTTGATTATCAGTTCAGAGTCTATGCCGGAGGGCAGAGGACCAGCTAACAGGAGTGGAGACCTTGGAGCATCCTCCAGATATGTTATTCCGTATTGATGCCTCCTGAGTGGACAGCTGGCCTTAAGGGGTATACTCTGAGCAACTGAAGAAATATATCACT
>NM_015986.4
AGTCGGGAACCCGCGCTAGGTTTCGCCGGCCGCGCGGCCAGATGAGGGGGGCGATGGAGCTGGAGCCTGAGCTGCTGTTGCAGGAGGCCCGCGAGAACGTGGAGGCAGCGCAGAGCTACCGGCGGGAGCTGGGTCACCGGCTTGAGGGGCTGCGTGAGGCGCGGAGGCAGATCAAAGAAAGTGCATCACAGACAAGGGATGTTCTCAAACAGCATTTTAATGATTTAAAGGGAACCCTTGGAAAGCTCCTGGATGAGCGATTGGTGACCCTTTTGCAAGAGGTGGACACCATTGAACAGGAGACCATTAAACCACTAGATGACTGCCAGAAGCTCATAGAACACGGAGTCAACACTGCAGAGGACTTAGTCCGAGAAGGTGAAATCGCCATGCTTGGTGGTGTGGGAGAAGAGAATGAGAAACTGTGGAGCTTTACCAAAAAGGCCTCGCACATTCAGTTGGACAGCTTACCAGAAGTACCTTTACTGGTTGATGTGCCTTGTTTATCTGCTCAGTTGGATGACTCAATTCTTAACATAGTGAAAGACCACATTTTTAAGCATGGAACAGTAGCATCTCGCCCACCAGTACAGATAGAAGAACTAATAGAGAAACCTGGAGGCATCATTGTACGATGGTGTAAGGTGGATGATGACTTTACAGCCCAAGATTACAGGCTCCAGTTTCGTAAATGTACTTCAAATCATTTTGAGGATGTATATGTAGGTTCTGAAACTGAATTCATAGTATTGCACATAGACCCCAACGTTGATTACCAGTTCAGAGTCTGCGCCCGAGGAGATGGCCGACAGGAGTGGAGTCCTTGGAGTGTCCCCCAGATAGGTCATTCCACATTGGTGCCTCATGAGTGGACAGCTGGTTTTGAGGGGTACAGTCTGAGCAGTCGAAGAAATATAGCACTTCGGAACGATTCTGAATCATCGGGTGTTCTCTACTCCAGAGCTCCGACTTATTTCTGTGGGCAGACATTAACATTCAGAGTTGAAACTGTGGGACAGCCAGACAGAAGAGATAGCATAGGAGTGTGTGCAGAAAAACAGGATGGATATGACTCTCTGCAGCGGGATCAAGCTGTGTGCATTAGTACAAATGGTGCAGTTTTTGTCAATGGAAAAGAAATGACAAATCAGTTACCCGCAGTTACTTCTGGGTCCACTGTCACGTTTGACATTGAAGCCGTGACTCTAGGAACCACCAGTAATAATGAAGGTGGACACTTCAAGCTTCGAGTAACTATAAGTTCAAATAATAGAGAAGTGGTTTTTGACTGGTTACTTGATCAGTCTTGTGGTTCTCTTTACTTTGGATGCTCATTTTTCTATCCTGGATGGAAAGTGTTAGTGTTTTAGATGTTTGGGTGCTTGGCTTTGGTTTTCAGGGTCTAACGTAGCTGTCCTCAGCCCAGCGTAGTTGTAATTGCTTTAAAAAAAAAGTTGAATTCATCTCTAACTTAGGCCATTGGAAAGTGTTTACTGGATTCATTTTGTAATATTTTAGCAAAAAGAGACTTCAATGTTGTGGACAAAATCATACAATTCAGTCAATTTTATTTTTAGCATACTGTTAAATATCACATCACAATAAAAATCAAATTGGCATTAAAAGTATAGAAGATATAGGAAGTTCTATACCCTTCCACTGTACTTCTCAAAGTTGGTTATTAGACCAGGAAAACTTAATGTAATATTATTTTTAAAATCATCTTAAAGGATCCAAGTCCATGTAACTCTTTAGAACAAGAGGAATAGGTCAGATAGAAGAAGCTGTGTAATGTATTAATACATCCGTTCATGTGCTGTCCACATGAATGTGTTGACTGTGCTCTCCATGTTCAGGTATTTGTAAGCAGTGTTGACTTTTATCCCCTCTTCAGTAATCTTTAAGTCCCCAAAACATTATAACtttttctttttttgttgagacggagtctcactcttgtcactcaggctggagtgcagtggtgtgatctcagttcactgcaacctctgcctcccacgttcaagcgatcctcctgcctcaggctcctgagtagctgggattacaggcgtcggccaccacacctggctaatttttgtatttttagtagagacagggtttcaccatgttggccaggctggtcttgaactcctgacctcaggtgttccacccacctcagccttccaaagtgctaggattacaggtgtgagccactgcAGTGGACCAATTTTTGTATTTTTTTAAATGCTTGACCAAGTGTCTAAAATAGGCAAGTAGTACCTTTTGTTCTTTCATTGCAATTTGATACAGTATAGGCTACAGTATTTTTACAGGGTAAAACTAGTTATGGCAGTAGTATGCACAGCAGTGTTAGCCATTTCATATGTATGTAATATGCACGTGTGTATCCAATCTGCCTGTGACATGCATTTTACTCTTTGCAGAGAATGAGCTGCAGTCCAGTTTAATGTCAGTTTAATAAGTGGTCTCTTTTTAGCAGAGCAAAAAAATATAGCGTAAATACTTATTTTTTTTAAAAACTTACTTAAATTTGTGTGTAAAATATTTATTTGAAGGACTTTAATATGTAAAAATAATTGTCTTCTATGCCACCCTACAGattttattttaatgtgaattatttttttcatttcattttTACCAGTATAGTAAAAAAGTAGAAAAGCAAGTATGATATTTTTGTAAGATAATTTATTTGGGGATTCATGTTCCCTGTTAGACAATCATGACCTTTTCTACTTGTCTTTTTATATATAAGTAGTAGATTTCCACTTGTTTAGGGATTAAGAAGATGTTCTAGAATGTAGATACCTTGTCCAGCCATAGGAATCAAAATAAAAAACTAAAAAAGTTCA

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