Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name LDHAP7
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr11). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:84775988-84778319  UCSC
Coordinates (T2T) chr2:84777761-84780092  UCSC
Coordinates (hg19) chr2:85003112-85005443  UCSC
Strand -
Parental Sequence NM_005566.4
Parental seq. overlap 986 bp
Parental seq. overlap (%) 34.8%
Genomic Region Intragenic (DNAH6)
Retrocopy Summary LDHAP7, located on chr2:84775988-84778319, is a retrocopy of the parental gene LDHA. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name LDHA
Full Name lactate dehydrogenase A
Also known as GSD11|HEL-S-133P|LDHM|PIG19
Coordinate chr11:18394563-18408425
Strand +
Gene summary The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes LDHAP3
Bonobo Pan paniscus LDHAP3
Gorilla Gorilla gorilla LOC101137282P2
Orangutan Pongo abelii HSPD1P2
Gibbon Nomascus leucogenys LOC100604698P4
Green monkey Chlorocebus sabaeus LOC103217070P2
Crab-eating macaque Macaca fascicularis LOC102118498P4
Rhesus Macaca mulatta LDHAP4
Baboon Papio anubis LDHAP3
Golden snub-nosed monkey Rhinopithecus roxellana LOC104667647P10
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>LDHAP7
GACCTGCAATTTTAAAGTCTTCTGATGTCAGATCATTTCACTGTCTAGGCTACAATAGGATTTTAGTTGGAGGTTGTGCATGTTGTCCTTTTTATCTGATCTGTGATCAAAGCAGTTATATTTTAAGATCCACTGGGAAAAACATCAATTCCTGAAGTTGGACATAGGAATGGTTTGTAAAATCCTACAGCTATATCCTGATGCTAGATGGTACTAATCTTGTGTAGTCCTAAACTGGTCAGTATGAAATAGTTCTACCACCTCTGAGGCACCACTGCCAATGCTGCACATGCTGCAGTTGCCCCTTGAGCCAGATGGATGTTTAGTGTGTCTTATATAACTTCCTGGCTCCTTCACTGGACATTTCTAGTCCAACATTCTTTCCCAATCAGTCACATCCTGGGATCCAGTGTATAAATCCAGTATCGTATGTCTTGTGCATAATTGTTCCAAAGGATCTTATTTTGTGATCTATATATGTCAATAGTGTACATTACAATATAATGTGAAAAGATCTACATATAAACAATACAACCAACTATCCAAGTGTCATACCAACTAAAACCCCCAATAAACCTTGAACAGCGCTGGAGCCACTGCCACCAAGTCCGGATCTCATTGCCACATGCCACCGATGCCCGCCGGACATGCATTCCTGATTCCTTTTGGTTCCAAGTCCAATATGGCAACTCTCAAGGATCAGCTGATTCATAATCTTCTACAGGAAGAAGAGACCTCCCCAGGATAAGATTATAGTTGTTGGGGTTGGTGCTGTTGGCATGGCCTGTGCCATGCCACAACTGACGGGCAGTTTAACTGGAAGATAAACTGAAGGGAGAGATGATGGATCTCTAACATGGCAGCCTTTTCCTTAGAACACCAAAGATTGTCTCTGGCAAAGACTATAATGTAACTGCAAATTCCAAGCTGGTCATTATCACTGCTTGGGCATGTGAGCAAGAGGGAGAAAGCCGTCTTAATTTGGTCCAGCCTAACGTGAACATCTTTAAATTCATCATTCCTAATGTTGTAAAATACAGCACGAACTGCAATTTGCTTATTGTTTCAAATCCAGTGGATATCTTGACCTATGTGGCTTGGAAGATAAGTGGCTTCCCCAAAAACTGTATTATTGGAAGTGGTTGCAATCTGGATTCAGCCCGATTCCGTTACCTGATGGGGGAAGGGCTGGGAGTTCACCCATTAAGCTGTCATGGGTAGGTCCTTGGGGAACGTGGAGATTCCAGTGTGCCTGTATGGAGTGGAGTGAATGTTGCTGATGTCTCCCTGAAGACTCTGCACCCAGATTTAGGGACTGATACAGATAAGTAACAGTGGAAAGAGGTTCACAAGTAGGTGGTTGAGAGTGCTTATGAGGTGATCAAACTCAAAGGCTGGGACATTGGACCCTCTGTGGCAGATTTGGCAGAAAGTATAATGAAGAATCTTAGGCGGTTGCACCTAATTTCCACCATGATTAAGGGTCTCTATGGAATAAAGGATAATGTCTTCCTTAATGTTCCTTGCATTTTGGGACAGAATGGAATCTCAGATCTTGTGAAGGTGAGTCTGACTCCTGAGGAAGAGATCTGTTTGAAGAAGAGTGCATTTACACTTTGGGGAATCCAAAAAACCTGCAATTTTATATTTAt
>NM_005566.4
GTGCTGCAGCCGCTGCCGCCGATTCCGGATCTCATTGCCACGCGCCCCCGACGACCGCCCGACGTGCATTCCCGATTCCTTTTGGTTCCAAGTCCAATATGGCAACTCTAAAGGATCAGCTGATTTATAATCTTCTAAAGGAAGAACAGACCCCCCAGAATAAGATTACAGTTGTTGGGGTTGGTGCTGTTGGCATGGCCTGTGCCATCAGTATCTTAATGAAGGACTTGGCAGATGAACTTGCTCTTGTTGATGTCATCGAAGACAAATTGAAGGGAGAGATGATGGATCTCCAACATGGCAGCCTTTTCCTTAGAACACCAAAGATTGTCTCTGGCAAAGACTATAATGTAACTGCAAACTCCAAGCTGGTCATTATCACGGCTGGGGCACGTCAGCAAGAGGGAGAAAGCCGTCTTAATTTGGTCCAGCGTAACGTGAACATCTTTAAATTCATCATTCCTAATGTTGTAAAATACAGCCCGAACTGCAAGTTGCTTATTGTTTCAAATCCAGTGGATATCTTGACCTACGTGGCTTGGAAGATAAGTGGTTTTCCCAAAAACCGTGTTATTGGAAGCGGTTGCAATCTGGATTCAGCCCGATTCCGTTACCTAATGGGGGAAAGGCTGGGAGTTCACCCATTAAGCTGTCATGGGTGGGTCCTTGGGGAACATGGAGATTCCAGTGTGCCTGTATGGAGTGGAATGAATGTTGCTGGTGTCTCTCTGAAGACTCTGCACCCAGATTTAGGGACTGATAAAGATAAGGAACAGTGGAAAGAGGTTCACAAGCAGGTGGTTGAGAGTGCTTATGAGGTGATCAAACTCAAAGGCTACACATCCTGGGCTATTGGACTCTCTGTAGCAGATTTGGCAGAGAGTATAATGAAGAATCTTAGGCGGGTGCACCCAGTTTCCACCATGATTAAGGGTCTTTACGGAATAAAGGATGATGTCTTCCTTAGTGTTCCTTGCATTTTGGGACAGAATGGAATCTCAGACCTTGTGAAGGTGACTCTGACTTCTGAGGAAGAGGCCCGTTTGAAGAAGAGTGCAGATACACTTTGGGGGATCCAAAAGGAGCTGCAATTTTAAAGTCTTCTGATGTCATATCATTTCACTGTCTAGGCTACAACAGGATTCTAGGTGGAGGTTGTGCATGTTGTCCTTTTTATCTGATCTGTGATTAAAGCAGTAATATTTTAAGATGGACTGGGAAAAACATCAACTCCTGAAGTTAGAAATAAGAATGGTTTGTAAAATCCACAGCTATATCCTGATGCTGGATGGTATTAATCTTGTGTAGTCTTCAACTGGTTAGTGTGAAATAGTTCTGCCACCTCTGACGCACCACTGCCAATGCTGTACGTACTGCATTTGCCCCTTGAGCCAGGTGGATGTTTACCGTGTGTTATATAACTTCCTGGCTCCTTCACTGAACATGCCTAGTCCAACATTTTTTCCCAGTGAGTCACATCCTGGGATCCAGTGTATAAATCCAATATCATGTCTTGTGCATAATTCTTCCAAAGGATCTTATTTTGTGAACTATATCAGTAGTGTACATTACCATATAATGTAAAAAGATCTACATACAAACAATGCAACCAACTATCCAAGTGTTATACCAACTAAAACCCCCAATAAACCTTGAACAGTGACTACTTTGGTTAATTCATTATATTAAGATATAAAGTCATAAAGCTGCTAGTTATTATATTAATTTGGAAATATTAGGCTATTCTTGGGCAACCCTGCAACGATTTTTTCTAACAGGGATATTATTGACTAATAGCAGAGGATGTAATAGTCAACTGAGTTGTATTGGTACCACTTCCATTGTAAGTCCCAAAGTATTATATATTTGATAATAATGCTAATCATAATTGGAAAGTAACATTCTATATGTAAATGTAAAATTTATTTGCCAACTGAATATAGGCAATGATAGTGTGTCACTATAGGGAACACAGATTTTTGAGATCTTGTCCTCTGGAAGCTGGTAACAATTAAAAACAATCTTAAggcagggtgcagtggctcatgcctataatcccagcactttgggaagcccaggtgggctgatcactggaggccaggaattggggaccagcctggccaacacaacaaaaccccatctgttaaaaaaacaaaaCAAAACCAAAAAAAACAAGTAACCTTGGTGGATGTCTACTCAAGTTTTCTGCACATTTTTCTGAAAATACAACTGTGACCCTTA

Publications

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