Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PEBP1P2
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:85340503-85341924  UCSC
Coordinates (T2T) chr2:85342494-85343915  UCSC
Coordinates (hg19) chr2:85567626-85569047  UCSC
Strand -
Parental Sequence NM_002567.4
Parental seq. overlap 1356 bp
Parental seq. overlap (%) 94.7%
Genomic Region Intergenic
Retrocopy Summary PEBP1P2, located on chr2:85340503-85341924, is a retrocopy of the parental gene PEBP1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PEBP1
Full Name phosphatidylethanolamine binding protein 1
Also known as HCNP|HCNPpp|HEL-210|HEL-S-34|HEL-S-96|PBP|PEBP|PEBP-1|RKIP
Coordinate chr12:118136124-118145584
Strand +
Gene summary This gene encodes a member of the phosphatidylethanolamine-binding family of proteins and has been shown to modulate multiple signaling pathways, including the MAP kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3) signaling pathways. The encoded protein can be further processed to form a smaller cleavage product, hippocampal cholinergic neurostimulating peptide (HCNP), which may be involved in neural development. This gene has been implicated in numerous human cancers and may act as a metastasis suppressor gene. Multiple pseudogenes of this gene have been identified in the genome. [provided by RefSeq, Jul 2015]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PEBP1P2
Bonobo Pan paniscus PEBP1P2
Gorilla Gorilla gorilla PEBP1P2
Orangutan Pongo abelii PEBP1P2
Gibbon Nomascus leucogenys PEBP1P2
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PEBP1P2
AGTGTGCTGAGCTCTCCATGTCGCTGTTGCCGCCCGCACCTGGCCTACCGCGGCACTCCCGGCTGCATGCTCTGCTTGGCCTTGCCATGCCGGTGGACCTCAGCAAGTGGTCCGGGCCCTTGAGCCTGCGAGAAATGGACGAGCGGTCACAGCACCTGCTGCATGTCACCTACGCCCGGGCGGTGGTGGACGAGCTGGGCAAAGTGCTGACGCCCACCCAGGTTAAGAATAGACCCACCAGCATTTAGTGGGATGGTCTTGATTCAGGGAAGCTCTACACCTTGGTCCTGACAGACCCTGATGCTCCCAGCAGGAAGGATCCCAAATACAGAGAATGGCATCATTTCCTGGTGGTCAACATGAAGGGCAATGACATCAGCAGTGACACACTCCTCTCCGATTATGTGGGCTCGGGGCCTCCCAAGGGCACAGGTCTCCACCGCTATGTCTGGCTGGTTTATGAGCAGGACAGGCCACTAAAGTGTGACGAGCCCATCCTCAGCAACCGATCTGGAGACCACCGTGGCAAATTTGAGGTGGTGTCCTTCCGTAAAAAGTACGAGCTCGGGGCCCCGGTGGCTGGCACGTGTTACCAGGCTGAGTGGGACGACTATGTGCCCAAACTGTACGAGCAACTCTCTGGGAACTAGTGGGTTAGCTTGGGGACCTGAACTGTTCTGGAGGCCCCAAGCCATGTTCCCCAGTTCAGTGTTGCATGTATAATAGGTTTCTCCTCTTCCTGCCCCCCTTGGCACAGGTGAGACCTGACCAGTCAGATGGTGGTTGAGGGTGACTTTTCCTGCTGCCTGGCCTTTATAATTTTACTCACTCACTCTGATTTATGTTTTGATCAAATTTGAACTTCATTTTGGGGGATATTTTGGTACTGTGATGGGGTCATCAAATTGTTAATCTGAAAATAGCAACCCAGAATGTAAAAAAGAAAAAACTAGGGGGAAAAAACCAGGTCTACAGTGATAGAGCAAAGCATCAAAGAATCTTTAAGGAAGGTTTTAAAAAAAAAAAGATTGGTTGCCTCTGCCTTTGTGATCCTGAGTCCAGAATGGTACACAATGTGTTTTTATGGTGATGTCACTCACCTAGACAACCAGAGGCTGGCATTGAGGCTAACCCCCAACACGGTGCATCTCAGATGCCTCAATAGGCATCAGTATGTCGCTCTGGTCCCTTTAAAGAGCAATCCTGGAAGAAGCAGGAGGGAGAGTGGCGCTGCTGTTGTTGGGACATGGCCATCTAGACCGGCAGCAGCGCTCGCTGACAGCTTGGGAGGAAACCTTAGATCGGTGTTTGTTAAACTGATCATTCTTCACGGGAGTAAGAAAAGCTGGTCTGGAGTTGCTGAACATTGCATTAATTGTGCTGTTTGCTTATAGTTGAATAAAAATAGAAACCTGAATGAAA
>NM_002567.4
AGTGTGCTGAGCTCTCCGCGTCGCCTCTGTCGCCCGCGCCTGGCCTACCGCGGCACTCCCGGCTGCACGCTCTGCTTGGCCTCGCCATGCCGGTGGACCTCAGCAAGTGGTCCGGGCCCTTGAGCCTGCAAGAAGTGGACGAGCAGCCGCAGCACCCGCTGCATGTCACCTACGCCGGGGCGGCGGTGGACGAGCTGGGCAAAGTGCTGACGCCCACCCAGGTTAAGAATAGACCCACCAGCATTTCGTGGGATGGTCTTGATTCAGGGAAGCTCTACACCTTGGTCCTGACAGACCCGGATGCTCCCAGCAGGAAGGATCCCAAATACAGAGAATGGCATCATTTCCTGGTGGTCAACATGAAGGGCAATGACATCAGCAGTGGCACAGTCCTCTCCGATTATGTGGGCTCGGGGCCTCCCAAGGGCACAGGCCTCCACCGCTATGTCTGGCTGGTTTACGAGCAGGACAGGCCGCTAAAGTGTGACGAGCCCATCCTCAGCAACCGATCTGGAGACCACCGTGGCAAATTCAAGGTGGCGTCCTTCCGTAAAAAGTATGAGCTCAGGGCCCCGGTGGCTGGCACGTGTTACCAGGCCGAGTGGGATGACTATGTGCCCAAACTGTACGAGCAGCTGTCTGGGAAGTAGGGGGTTAGCTTGGGGACCTGAACTGTCCTGGAGGCCCCAAGCCATGTTCCCCAGTTCAGTGTTGCATGTATAATAGATTTCTCCTCTTCCTGCCCCCCTTGGCATGGGTGAGACCTGACCAGTCAGATGGTAGTTGAGGGTGACTTTTCCTGCTGCCTGGCCTTTATAATTTTACTCACTCACTCTGATTTATGTTTTGATCAAATTTGAACTTCATTTTGGGGGGTATTTTGGTACTGTGATGGGGTCATCAAATTATTAATCTGAAAATAGCAACCCAGAATGTAAAAAAGAAAAAACTGGGGGGAAAAAGACCAGGTCTACAGTGATAGAGCAAAGCATCAAAGAATCTTTAAGGGAGGTTTaaaaaaaaaaaaaaaaaaaaaGATTGGTTGCCTCTGCCTTTGTGATCCTGAGTCCAGAATGGTACACAATGTGATTTTATGGTGATGTCACTCACCTAGACAACCAGAGGCTGGCATTGAGGCTAACCTCCAACACAGTGCATCTCAGATGCCTCAGTAGGCATCAGTATGTCACTCTGGTCCCTTTAAAGAGCAATCCTGGAAGAAGCAGGAGGGAGGGTGGCTTTGCTGTTGTTGGGACATGGCAATCTAGACCGGTAGCAGCGCTCGCTGACAGCTTGGGAGGAAACCTGAGATCTGTGTTTTTTAAATTGATCGTTCTTCATGGGGGTAAGAAAAGCTGGTCTGGAGTTGCTGAATGTTGCATTAATTGTGCTGTTTGCTTGTAGTTGAATAAAAATAGAAACCTGAATGAA

Publications

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