Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name ARL1P1
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:8757386-8758339  UCSC
Coordinates (T2T) chr2:8781125-8782078  UCSC
Coordinates (hg19) chr2:8897516-8898469  UCSC
Strand -
Parental Sequence NM_001177.6
Parental seq. overlap 536 bp
Parental seq. overlap (%) 16.6%
Genomic Region Intragenic (KIDINS220)
Retrocopy Summary ARL1P1, located on chr2:8757386-8758339, is a retrocopy of the parental gene ARL1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name ARL1
Full Name ADP ribosylation factor like GTPase 1
Also known as ARFL1
Coordinate chr12:101393116-101407820
Strand -
Gene summary The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes ARL1P1
Bonobo Pan paniscus ARL1P1
Gorilla Gorilla gorilla ARL1P1
Orangutan Pongo abelii ARL1P1
Gibbon Nomascus leucogenys ARL1P1
Green monkey Chlorocebus sabaeus ARL1P1
Crab-eating macaque Macaca fascicularis ARL1P1
Rhesus Macaca mulatta ARL1P1
Baboon Papio anubis ARL1P1
Golden snub-nosed monkey Rhinopithecus roxellana ARL1P1
Marmoset Callithrix jacchus ARL1P2
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>ARL1P1
CATACAGAATTCCAAGTCCAGGATTTAGGAGGACAGAGCCATACTGAAGATGTTATTATTCAAACACAGATGCTGTGGAGCAGACAGTTGTGACCGAGACCGAATTGGCATTTCCAAGTCAGTGTTAGTTGCCATGTTGATGGAGAGCTGAGAAAAGCCATTTTAATGGCATTTGCAAATAAGCAGGACATGGAACAGGCCATGACTCCCTCAGAGATGCACATTCACTTGGGTTATCTGCCTCGAAGGACTGAAAATGGCAAATATTCAAAACTTCAGCAACCAGAGGTACTGGCCTTCATGAGACAACGGAATGGGTAGTTGAAACATTAAAGAGCAAACAACAGTACAGTCACTTCTGCTCCTCTGAAATGAAGACGGCCTCACATATCCCTTTGGAAACAATCAAGTGTGCTTCTCATGACTAAAGGTTAAAGCTGTAAGACTGTTGGCATTTACTGAACTGACTGTTTTTTCTCAAGTATTTTTTCCAGTGTGTTTGGAACCTGGGAAGTGAGGATTTTAATTTGGGGATTACATAGACAGGAAAAACCACAATTTTATGCAGATTACAGGTTGGAAAAGTCATTACTAACATTCCTATCATCAGATTTAATGTTGAGACGGCAACTTATAAAAGCCATACAGg
>NM_001177.6
CCCGCCCCCGCCTGGAGTCCGACGTGGAAGTTGCTGGCTGACTGGGCTTGCGAGGAAACCGCCTCGGAGCTGCAGCCGAAGGCCAAGGAATCACTGAAGATCGGCGAGGGAGGACAGGGGGTTCATCATGGGTGGCTTTTTCTCAAGTATATTTTCCAGTCTGTTTGGAACTCGGGAAATGAGAATTTTAATTTTGGGATTAGATGGAGCAGGAAAAACCACAATTTTGTACAGATTACAAGTGGGAGAAGTTGTTACTACTATACCTACCATTGGATTTAATGTAGAGACGGTGACGTACAAAAACCTTAAATTCCAAGTCTGGGATTTAGGAGGACAGACAAGTATCAGGCCATACTGGAGATGTTACTATTCAAACACAGATGCAGTCATTTATGTAGTAGACAGTTGTGACCGAGACCGAATTGGCATTTCCAAATCAGAGTTAGTTGCCATGTTGGAGGAAGAAGAGCTGAGAAAAGCCATTTTAGTGGTGTTTGCAAATAAACAGGACATGGAACAGGCCATGACTTCCTCAGAGATGGCAAATTCACTTGGGTTACCTGCCTTGAAGGACCGAAAATGGCAGATATTCAAAACGTCAGCAACCAAAGGCACCGGCCTTGATGAGGCAATGGAATGGTTAGTTGAAACATTAAAAAGCAGACAGTAATTCAGTCCATTCTTCTCCCCTGAAATGAAGACTACATCACCTCTCTCCCTTTGGAAACAGTCAAGTGTACTTCACACTACTAGATGTTAAAACTATATGATTATTGGCATATACTGACTGACTGCAATATTTGTAGTAAATAGGGAAAATAAGTATTTAGTTGGAGGGATAATTTGATCGAATCACCTGAATGTTCTATGTAATGTAAAATATTCTTTTCTTGCTTTCTTGTGTTAAGGTATATATTCTATTTGTATGGAATTCTTATTCAAATACAGTTCTATTAAAGAGTATACTCCTATTGGATGAAAAAAACCTATTTTTGAATAGTAGTTGCAGCTTGTTTGTATAAATACTAAAAAATATCTTAACAGATTTTTTTCCCCTTAAAATGAATTATCTTTCCAAAGATTAGACTCAGTATGAGAGTAGGTGAGGAACATAGTTTGTGTAATATAATCTTTATTTGCTTACCTGACCACTTTTTATTAAGCTGTTTTGTTTAAAAGCTTTTGGTTATAGGCATGAATATTGTTTTGATGGTTAACTTCACTGACTTATCTGTAAGTGTcattttatagtactttacagttgtcaaaaaaaatcttacatatattgatctagttgatcggtagaggaagcttgtgaagtaggtaggacaggttatgatgtcttcactgtatggacgtgaacccagggttctaataggttggcttgcccaaggtcacctgctagcttgtaaggtaggaatagggctcaaagtaaaacttttggttcagaagcttgactcataaactatactataTATTCCCAAAAATGTCAGTATTGACAACACAGTCTAACTCTTAAATAAAATTATGCTAATTAGTTACATTCAAAATAATGTTTATAAATTTATTTGTCTATACTAGTAGAAGTGATCAGTGACATACTATAAATAATCCTAAATGGTTATATTTGATAGAATTCATAACACATTAAAGAGAAAATTTCACATTAAAGGAAGGTTTAAAAATCTATTTTCAGATTATAAAAGGTGTCTTTACTGGTTTTCATTCCTTTTATCTACATGTAATTGGACATGTAAACTTGTTAAAAATCAAAATCTTACTGATTGTACAGGGAGAAATTAAGCATTCTGTTTTAAAAATTAGGCTTATTGCTAGACTGTAAGTTTAAAAACAATTCATGTTCAAAGGAGCTTTTCAAATTACCCAGTCCACCACAGAATCAGCTAATGTGACAGAAGTAAATATAGTGCGTCATAATTGCTAAAAACAGGGTGAATTTCTTTCACTTAAGTTGGAAAACCAGCCTCTAAAAAATTAGGTGCTGGTAATGAGAGCTTAATACCATGGTTCCCTGCAGGTCTCAGAAACATTAGTAGTTCCTTTCTTGGCCCTCACTGTCCTTCCAGTGTTGGCCTCTGGCCTCTTCCCCTCACATTTATGTTCATTCTCCGGGCTTATATTCATTCTCTGCTGCTTTCTCCCTTCACCCGTGGGACTCTCACCCTTCTTGCTCATTCTCCAGCACCCATTCCTACTTTAGTCTCTTTGAAATCTTTTTTGGAGATTTTCCTTCAGCTACAAATGTTCCAGTACAACCAATATTActcctgaggggcaaagactttttcatatttatgtccctagtatctggtatggcgcctggcatatggcatttcagaatatgttcatagttgaaACAGTAGGATAGATATTTGTCATCTTGACAAGTAGCCCTTTGCAATTTATACTTGAGTTCACTCCTGGTCAATGGCACATGGCTGGAAAATGCAGAAAGCAAGTTCACTTACAGCCTGAGGCTTATAAAGCTTGTACAGCTGCCTCCCGGCAGTCCAGGAAAACTGCAAAAAATGGGAAGTAAGGTCCTGGCAGGCAGACCCGGCATGTAGCCGCTGGCCATCTTGAATCCTAGGGCATGAAGTTGCCCCAAAGTTCAGCACTTGGTTAAGCCTGATCCCTCTGGTTTATCACAAAGAATAGGATGGGATAAAGAAAGTGGACACTTAAATAAGCTATAAATTATATGGTCCTTGTCTAGCAGGAGACAACTGCACAGGTATACTACCAGCGTTTGGATATTGATATATACATGGCAAATCTGAATATTGTTTTATGAGAGGCCTGGCAATGGGTAAAACACCAAACTTGAAATCAGAACATAGGTGCAAATGGCCACTCCTGTagtttcttttctgtaaaatgggatctggacgaatgataccaaacgtttctttctaacattgtattttataactcTGGCCTATGATTGTGTTGTGTCTTGCATTAAAAAAAAAAATTTGAGAGTGGTAGAATTACTTCTGTTATCTGAAATACCTGAGATGCACTTTAAACTGTTGAaatgtaagctctgagggcagggaccgtatcttatttactgttagtatccgttgcatctagtgtggtgcacctggcacacagtaggcactcaataaatatgtattgattaaaAACAAAGACGTCTTCAATATGCCAGA

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