Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name SMC3P1
Plot displaying the genomic locations of a retrocopy (in chr2) and its respective parental gene (in chr10). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr2:99102017-99103083  UCSC
Coordinates (T2T) chr2:99560581-99561646  UCSC
Coordinates (hg19) chr2:99718480-99719546  UCSC
Strand +
Parental Sequence NM_005445.4
Parental seq. overlap 1040 bp
Parental seq. overlap (%) 18.8%
Genomic Region Intragenic (TSGA10)
Retrocopy Summary SMC3P1, located on chr2:99102017-99103083, is a retrocopy of the parental gene SMC3. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name SMC3
Full Name structural maintenance of chromosomes 3
Also known as BAM|BMH|CDLS3|CSPG6|HCAP|SMC3L1
Coordinate chr10:110567695-110606048
Strand +
Gene summary This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes SMC3P1
Bonobo Pan paniscus SMC3P1
Gorilla Gorilla gorilla SMC3P1
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>SMC3P1
AATTAAAGAAGTACAGCCATGTTAACAAAAAGGCTTTGGATCAGTTTGTAAATTTCTCTGAGCAGAAAGAAAAGTTAATAAAGCGACAAGAAGAGTTAGATAGGGGTTACAAATCGATCATGGAGCTGATGAATATACTTGAACTTCGGAAATATGAAGCTATTCAGTTAACTTTCAAACAGGTATCCAAGAACTTCAGTGAAGTATTCCAGAAGTTAGTACCTGGTGGCAAAGCTACTTTGGTGATGAAGAAAGGAGATGTGGAGGGCAGTCAGTCTCAAGATGAAGGAGAAGGGAGTGGTGAGAGTGAGAGGGGTTCTAGCTCACAAAGCAGTGTCCCATCAGTTGAGCAGTTTACTGGAGTTGGAATTAGGGTGTCATTTACAGGAAAACAAGGTGAAATGAGAGAAATGCAACAGCTTTCAGGTGGACAGAAATCCTTGGTAGCCCTTGCTCTGATTTTTGCCATTCAGAAATGTGACCCGGCTCCATTTTACTTGTTTGATGAGATTGACCAGGCTCTGGATGCTCAGCACAGAAAGGCTGTGTCAGATATGATTATGGAACTTGCTGTACATGCTCAGTTTATTACAACTACTTTTAGGCCTGAACTGCTTGAGTCAGCTGACAAATTCTATGGTGTAAAGTTCAGAAATAAGGTTAGTCATATTGATGTGATCACAGCGGAGATGGCCAAAGACTTTGTAGAAGATGATACCACACATGGTTAATTGGAAAATACTACTTACTGGTTTGGGAGTTGTGTATAGTAATATGATTCTCATACCCAGAACTGTAAATATAAACCTAAATATTTGGCCAATAGTTTTCAGACTTAAAGCATCATAGTCCTTTTATATTTGTCTTTGTATTTTATAAGATACTCTGTAATGTCATGTTTGTACTTACAGTTTTAGAATTTAATTTCCTGTACAACTTTTTGTAAAATGTTCTGCTCCTATTTTAAATGTTTTGAAACATGCTAAATATTCTTTCCTAATTATTTTATCGCTTATACTGCCTTTTTTATAGCTTCAATTAAATAATTGGTTTTATGACT
>NM_005445.4
GTTTGGCTGAGGGGAGCGAGCGGCGCTTTGGGGGAGGGGTCGCGTAGGCGCCTCACCTGACCCTGCGGCCGTGCGGTTGCTGCTCCGGGGCAGGTCTCCTTCCAGGCCAGGGGCCCGGAATCATGTACATAAAGCAGGTGATTATCCAGGGTTTTCGAAGTTACAGAGATCAAACAATTGTAGATCCCTTCAGTTCAAAACATAATGTGATTGTGGGCAGAAATGGATCTGGAAAAAGTAACTTTTTTTATGCAATTCAGTTTGTTCTCAGTGATGAGTTTAGTCATCTTCGTCCAGAACAGCGGTTGGCTTTATTGCATGAAGGTACTGGTCCTCGTGTTATTTCTGCTTTTGTGGAGATTATTTTTGATAATTCAGACAACCGGTTACCAATCGATAAAGAGGAAGTTTCACTTCGAAGAGTTATTGGTGCCAAAAAGGATCAGTATTTCTTAGACAAGAAGATGGTCACGAAAAATGATGTGATGAACCTCCTTGAAAGCGCTGGTTTTTCTCGAAGCAATCCTTATTATATTGTTAAACAAGGAAAGATCAACCAGATGGCAACAGCACCAGATTCTCAGAGATTAAAGCTATTAAGAGAAGTAGCTGGTACTAGAGTGTATGACGAACGAAAGGAAGAAAGCATCTCCTTAATGAAAGAAACAGAGGGCAAACGGGAAAAAATCAATGAGTTGTTAAAATACATTGAAGAGAGATTACATACTCTAGAGGAAGAAAAGGAAGAACTAGCTCAGTATCAGAAGTGGGATAAAATGAGACGAGCCCTGGAATATACCATTTACAATCAGGAACTTAACGAGACTCGTGCCAAACTTGATGAGCTTTCTGCTAAGCGAGAGACTAGTGGAGAAAAATCCAGACAATTAAGAGATGCTCAGCAGGATGCAAGAGATAAAATGGAGGATATCGAACGCCAAGTTAGAGAATTGAAAACAAAAATTTCAGCTATGAAAGAAGAAAAAGAACAGCTTAGTGCTGAAAGACAAGAGCAGATTAAGCAGAGGACTAAGTTGGAGCTTAAAGCCAAGGATTTACAAGATGAACTAGCAGGCAATAGTGAACAAAGGAAACGTTTATTAAAAGAGAGGCAGAAGCTGCTTGAAAAAATAGAAGAAAAGCAGAAAGAACTGGCAGAAACAGAACCCAAATTCAACAGTGTGAAAGAGAAAGAAGAACGAGGAATTGCTAGATTGGCTCAAGCTACCCAGGAAAGAACGGATCTTTATGCAAAGCAGGGTCGAGGAAGCCAGTTTACATCAAAAGAAGAAAGGGATAAGTGGATTAAAAAGGAACTCAAGTCTTTAGATCAGGCTATTAATGACAAGAAAAGACAGATTGCTGCTATACATAAGGATTTGGAAGACACTGAAGCAAATAAAGAGAAAAATCTGGAGCAGTATAATAAACTGGACCAGGATCTTAATGAAGTCAAAGCTCGAGTAGAAGAACTGGACAGAAAATATTACGAAGTAAAAAATAAGAAAGATGAACTACAAAGTGAAAGAAACTACTTGTGGAGAGAAGAGAATGCAGAACAGCAAGCACTTGCTGCTAAAAGAGAAGATCTTGAAAAGAAGCAACAACTTCTTAGAGCAGCAACAGGAAAGGCCATTTTAAATGGAATAGACAGCATAAACAAAGTGCTAGACCACTTCCGTCGAAAAGGAATAAACCAGCATGTTCAAAATGGCTATCATGGTATTGTAATGAATAACTTTGAATGTGAACCAGCTTTCTACACATGCGTGGAAGTCACTGCTGGAAACAGGTTATTTTATCACATTGTTGATTCAGATGAAGTCAGCACGAAGATTTTAATGGAGTTTAATAAAATGAATCTTCCTGGAGAGGTTACTTTTCTGCCTCTTAACAAGTTAGATGTCAGGGATACAGCCTATCCTGAAACCAATGATGCTATTCCTATGATCAGCAAACTGAGGTACAATCCCAGATTTGACAAAGCTTTCAAACATGTGTTTGGAAAGACTCTTATTTGTCGTAGCATGGAAGTTTCAACCCAGCTGGCCCGTGCTTTCACTATGGACTGTATTACTTTGGAAGGTGACCAAGTCAGCCATCGGGGTGCTCTAACTGGGGGTTATTATGACACAAGGAAGTCTCGACTTGAATTGCAAAAAGATGTTAGAAAAGCAGAAGAAGAACTAGGTGAACTTGAAGCAAAGCTCAATGAAAACCTGCGCAGAAATATTGAAAGGATTAATAATGAAATTGATCAGTTGATGAACCAAATGCAACAGATCGAGACCCAGCAAAGGAAATTTAAAGCATCTAGAGATAGCATATTATCAGAAATGAAGATGCTAAAAGAGAAGAGGCAGCAGTCAGAGAAAACCTTCATGCCTAAGCAACGTAGCTTACAGAGTTTGGAGGCAAGCTTGCATGCTATGGAGTCTACCAGAGAGTCATTGAAAGCAGAACTGGGAACTGATTTGCTTTCTCAACTGAGTTTGGAAGATCAGAAGAGAGTAGATGCACTGAATGATGAGATTCGTCAACTTCAGCAGGAAAACAGACAGTTGCTAAATGAAAGAATTAAATTAGAAGGTATTATTACTCGAGTAGAGACTTATCTCAATGAGAATCTGAGAAAACGCTTGGACCAAGTAGAACAGGAACTTAATGAGCTGAGAGAGACAGAAGGGGGTACTGTTCTCACAGCCACAACATCAGAACTTGAAGCCATCAATAAAAGAGTAAAAGACACTATGGCACGATCAGAAGATTTGGACAATTCCATTGATAAAACAGAAGCTGGAATTAAGGAGCTTCAGAAGAGTATGGAGCGCTGGAAAAATATGGAAAAAGAACATATGGATGCTATAAATCATGATACTAAAGAACTGGAAAAGATGACAAATCGGCAAGGCATGCTATTGAAGAAGAAAGAAGAGTGTATGAAGAAAATTCGAGAACTTGGATCACTTCCCCAGGAAGCATTTGAAAAGTACCAGACACTGAGCCTCAAACAGTTGTTTCGAAAACTTGAGCAGTGCAACACAGAATTAAAGAAGTACAGCCATGTTAACAAAAAGGCTTTGGATCAGTTTGTAAATTTCTCCGAGCAGAAAGAAAAGTTAATAAAGCGTCAAGAAGAGTTAGATAGGGGTTACAAATCAATCATGGAACTGATGAATGTACTTGAACTTCGGAAATATGAAGCTATTCAGTTAACTTTCAAACAGGTATCTAAGAACTTCAGTGAAGTATTCCAGAAGTTAGTACCTGGTGGCAAAGCTACTTTGGTGATGAAGAAAGGAGATGTGGAGGGCAGTCAGTCTCAAGATGAAGGAGAAGGGAGTGGTGAGAGTGAGAGGGGTTCTGGCTCACAAAGCAGTGTCCCATCAGTTGACCAGTTTACTGGAGTTGGAATTAGGGTGTCATTTACAGGAAAACAAGGTGAAATGAGAGAAATGCAACAGCTTTCAGGTGGACAGAAATCCTTGGTAGCCCTTGCTCTGATTTTTGCCATTCAGAAATGTGACCCGGCTCCATTTTACTTGTTTGATGAAATTGACCAGGCTCTGGATGCTCAGCACAGAAAGGCTGTGTCAGATATGATTATGGAACTTGCTGTACATGCTCAGTTTATTACAACTACTTTTAGGCCTGAACTGCTTGAGTCAGCTGACAAATTCTATGGTGTAAAGTTCAGAAATAAGGTTAGTCATATTGATGTGATCACAGCAGAGATGGCCAAAGACTTTGTAGAAGATGATACCACACATGGTTAATTGGAAAATACTACCTACTGGTTTGGGAGATGTATATAGTAATATGATTCTCATACCCAGGAACTGTAAATTTAAACCTAAATATTTGGCCAATAGTTTTCAGACTTAAAGCATCATAGTCCTTTTATATTTGTCTTTGTATTTTATAAGATACTCTGTAATGTCATGTTTGTACTGATAGTTTAAGAATTTAATTTCCTGTACAACTTTTTGTAAAATGTTCTGCTCCTATTTTAAATGTTTTGAAACATGCTAAATATTCTTTCCTAATTATTTTATCACTTATACTACCTTTTTTATAGCTTCAATTAAATAATCGGTTTTATGACTAATATAGTGTTTTATGTGGCTTTTCATTTGTCATAGTctcttccagtgagaacactaatcagattggatgtaaggcctcattttaacttaatcacctctttaaaagacctgtctccaaatacagttaaatttgaggtattgagggttaggacttcaacatgtgagtttgggaagggaagcacaaaatcagcccctaccaTGGTATATttatcattgatacattactatcaactaagctcaagattttattcagatttgactagtttttccactaaggccctttttcttttctaggatcccacagaggatacattacatttacttacatctcctctagtctgtgacaatttctctgtcattgtttatcatatcttgacaattttgaataatattcacatattttgtagaatgtccctcaaattaggtttgtctaatatttttctcatggttagattggagctaataccacagaagcgaagtattctcattacctcatataatagtacatattattaacatgttttatcactgatgtttaccttgatcacctacccaacattgtacttgccaggtttctttgttgtgaagttacatttttttccctttccatactactcttttctttgaaagtaggtctttaagCACTGGGGgtctcctgtgaccctggaaaactacctcaatagtcctcgtagctttttgtagattctttgagattttctacatagacagtcatgtcatttgcaagaaagaggcagttttatttcttccttttcaaatatttacctttaatttctttttcttgatttcccctggcctgagtttatactggttatctgcaggagaatttgttaggagctactcttccatcattggaaacCAGAAATACCTAAAGAGATACTTTTAAAATAAAGAAATAGTAATGGGACTTTAAATTGAATTTAAAAATGTGAGTTTACTTTGGGTTTTCATTTTGACTGGCTGAATCTTTAAATGTTCGGTGTATTATTTATACTTTGTAGCTTTGCTATAACATAACTGATCTATAATAGAGAATTTGGTATATGTTCTATCTATGACTACATTCAAAGGGTTACGTAACTATAATATCTTTCTAATATTTCTACCATTTTTCTTACACATTTACCCAAGAATTTTTCTCAAACAACTACCTAAGAATATTCATCATGAATGCTTGGTGTATAGTTTACGATTTGTAGAGTTGCTCTGATATGACCAACCCCTTATAATACAGAATTTGGTGTAAGGTAAGTTCCAGGATTCAATTCAAGGGATGTTACAAACATAACATCATTCTAGAACTTCTTAATATTGTTCTTAAGCATTTCCCCAAGGATATTAGTATAATGAAATGCCAGTAAATTTATAACAATAAAGCATCTAAATAATGAAACAAAA

Publications

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