Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name NFYBP1
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr12). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:109915224-109917061  UCSC
Coordinates (T2T) chr3:112635270-112637112  UCSC
Coordinates (hg19) chr3:109634071-109635908  UCSC
Strand -
Parental Sequence NM_006166.4
Parental seq. overlap 923 bp
Parental seq. overlap (%) 26.1%
Genomic Region Intergenic
Retrocopy Summary NFYBP1, located on chr3:109915224-109917061, is a retrocopy of the parental gene NFYB. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name NFYB
Full Name nuclear transcription factor Y subunit beta
Also known as CBF-A|CBF-B|HAP3|NF-YB
Coordinate chr12:104117086-104138241
Strand -
Gene summary The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes NFYBP1
Bonobo Pan paniscus NFYBP1
Gorilla Gorilla gorilla NFYBP1
Orangutan Pongo abelii NFYBP1
Gibbon Nomascus leucogenys NFYBP2
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>NFYBP1
AGGTATTAAAATATTTTTGTTTTGTCTGAGAGTTTGTTGGTCTGTATGACTCTCGAATGCATTGTATATTGCAATTTATTACTGTCAGAGATTTGTAGACAGTTTCTTATTGTCATATTGAATCATGTTACTTTTGTAACTCAAGTAAGCAGCTGGGCTAATTCATGATGTTTGCCCTTTTAATAAAATACAAGGGTAGAGTTCAACCATGTCTACCTTAGGCCTAGACAGTTACGTGGAACCTCTGAAATTATATCTTCAAAAATTCAGAGAGGCTATGAAAGGAGAAAAGGGAGTTGGTGGAGCAGTCACAGCTACAGATGGACTAAGTGAAGAGCTTACAGAAGAGGCATTTACTAACCAGTTACCAGCTGGCTTAATAACCACAGATGGTCAGCAACAAAATGTTATGGTTTACACAACAGATTTCTGGTGTTCAACAAATTCAGTTTACATGATCTGAAGAAATGATGGAATGAAGGGTATAGAGAAATAAGAGTCTGTATGATTCTGGAACACAGACATCAGAAGAAAATGACTGGTGAAAGATGTATCTTTGTATATTAAATAGCTGTAATGTAGCTTCCTGATGCTTCACTAATTGAGGTGTTAATTCTGACTTGAGAATCTTTTTCATCAATGATTTTAAAGAAAAATTTAGATTTTAAAGGTATTGAAAAAGAAAAAAAAAAAAGCAGATTGGAGATGGGAGCCAACCAGGACTGCATTGGAGGTTGAAATAGCAAACAGTAGACACCATTTTAGACAGGTGTTCTTCAGCACCACTGACAACAGTTTCGACAATATTTCATGACAATGGATGATGACAGTTCTACAACAGATGCCTCTCAACTAGGAACCTGTGCAGACTATATTGGAGGAAGTCATTATGTTATACAGCCTCATGATGATACTGAGGAGAGCATGAGTGATCAAGAGGACACAAATGGTTCAAAAGTAAGTTTCAGAGAACAAGATATGTATCTTCCAATAACAAACGTGGCTAGGATAATGAAAAATGCCATACCTCAAACAGGAAAGATTGCAAAAGATGTCAAAGAATGTGTTCAAGAATGTGTAAGTGAGCTCATCAGCTTTATAACATCTGAAGCAAGTGAAAGGTGCCATCAAGAGAAACAGAAAACAATCAATGGAGAAGACATTCTGTTTGCCATG
>NM_006166.4
CCTTCGCAGCCATTTTCTGTCCAACCAAACAGCCGATTGGAGACGGGAGCCAACCAGGGCTGCATTGGAGGTTGAAATCACAAAGATTAGACACCTTTTTAGATAGGTGTTCTTCAGCACCACTGACAACACGGTTCTGACAGTATTTCATGACAATGGATGGTGACAGTTCTACAACAGATGCTTCTCAACTAGGAATCTCTGCAGACTATATTGGAGGAAGTCATTATGTTATACAGCCTCATGATGATACTGAGGACAGCATGAATGATCATGAAGACACAAATGGTTCAAAAGAAAGTTTCAGAGAACAAGATATATATCTTCCAATAGCAAACGTGGCTAGGATAATGAAAAATGCCATACCTCAAACGGGAAAGATTGCAAAAGATGCCAAAGAATGTGTTCAAGAATGTGTAAGTGAGTTCATCAGTTTTATAACATCTGAAGCAAGTGAAAGGTGCCATCAAGAGAAACGGAAAACAATCAATGGAGAAGATATTCTCTTTGCTATGTCTACTTTAGGCTTTGACAGTTATGTGGAACCTCTGAAATTATACCTTCAGAAATTCAGAGAGGCTATGAAAGGAGAAAAGGGAATTGGTGGAGCAGTCACAGCTACAGATGGACTAAGTGAAGAGCTTACAGAGGAGGCATTTACTAACCAGTTACCAGCTGGCTTAATAACCACAGACGGTCAACAACAAAATGTTATGGTTTACACAACATCATATCAACAGATTTCTGGTGTTCAGCAAATTCAGTTTTCATGATCTGAAGAAATGATGGAATGGGGAGTGTAGAGAAATGAGAGTCTGTATGATTCTGGAACAGAGACATCAGAAGGAAAGACTGGTGAAAAGATGTATCTTTGTATATTAATAGCTGTAATGTAGCTTCCTGATGCTTGACTAATTGAGGTGTTAATTCTGACTTGAGAATCTTTTTCATGAATGATTTTAAAGAAAAATTTGGATTTTAAAGGTATTAAAATATTTTTGTTTTGTACGAGAGTTTGTTGCTCTGTATGACTCCTGTATGCATTGTATATTGCAATTTATTACTGTCAGAGATTTGTAGACAGTTTCTTATTTTCATATTGAATCATGTTACTTTTGTAATTCAAGTAAGCGGCTGGGTTAATTCATGATGTTTGCCCTTTTAATAAAATATAAGGGTAGAGTTCATTTTGAATGCAAGTTGCCTTTATTATAAATTTGAGTTTGTCTTGGTTATACCTTGCATGATAACCTAGCTAGATTTCTAGCATTTGCTGTATTTATTAAAATTATTATTTTTTTGGTAAAACATTAATAGTTTAAGCAGCATCATTTTTTTAAAAAATGTAATTGAATAAGTGTGAATGCAGAAGCAAATATTGTCTGCCCTGTTAAACTTGGTGCCCATTAACAGTGTTTACACTGTTCATCGTGCCTGTTAATGTAGTTTTAGTTACTGGAGCTTTTTTAAGACTAGATTTGGTTTTGAGTTACATTTTTAAGAATGTGGGAATATATTTAAGTTTAATGTAGTCCTAGTGCTCTTGAAATGGTGCCCCTTTCATTTGGTACATGATTTTTTTTCAAATCATATCTTCAAGTACTATAGTATTCTCTTACAGAAGAGGAGTTTTATAGTCTGATGGTAAATGTCTTCATTTTACCTTTTTAATTGAAATGTCAAGTTTCCTGTTACACTATGGAAACCAAGAAACATCAGACATCATTGCGTGTACAGACCTTTTGCATGGGTGAGTGGATGAAATGGAGAACAGAGTGAGTGCTGTGAACGGTGTGAAATAGAAGCCAACTTCTAGTATGCTGTCTTCATCTCTGCAATAAACTAAACGTAAATAATGTAACTTTGTATAATTTAGTAGTATGTACTTGGATTGTTTCTTTTTGAAAAGTGAGGATTTGTATTTTCTCATCTATTCTTTTTGGTGTTAATTAACTTGAGGGATTTCTTTTTTAAGTTTTTAATATCAAAAATTGCTATTGTATAGTTTGCCTAAAAGGAAGTTGGAGTGAATATCATCTTTGAAGGACACTCAAATTTATAAGGTAGAAGCAATTTCCCAGATATAGGCTGAACAGAAACATTTACTTTGCCAGAAGGAGCCTTTAGGAGTATATGTGGGCTAATCAGAGGTTAATAATGTCCTCATCTCCTACTCTCCATTTAAAAAACAAACTtcattgtagtaaattcaaataggaaaaaatgggggagtagttaagcaaaatcaacagtcatcctactatgttgaaagaaccaatgttaatattttgataaatatcatttgtccttttactttgctaaatatgtatatttttataaaaatgggctcatattgtgcataccattttgtaacctgcttttttcacttaacaatatattgggaacatcttttccaggtcatgcatagtcttctgcatcatttttattggtttattattctgctgtatgactcaatcataattcatttaatcttctattggatattttgactatttacatcttttcacagttataaacagcacttcactgaatcccatgtacatccatgactgttttcttaaattctttgaattgctgggttaccaaatatgcaaaattttaaggcttttgatacTTCGTTATGAGTGTATTTTTGAGATATTTTCCACTTGATCCAAGCAGTGTGTCACTATATAACTGATAAAAGCACTTGGTCTTTGATTATCAGATACTGTCTCTAAAATTATTTTAAAGATTAATATTTGTTCAAGTAGAGAATGAAGATAAAAAAGGAATTTGAggccaggtatggggtgtctcatgcctataattccagcactttgggaggccaaggcaggcagatcactttgaggtcaggagtttgagaccagcctggccaacatggagaaccccccgtctctacaaaaaatacaaaattagcagggtgtggtggtgcacacctgtagtcccttactccctggtggctgaggcattatcccttgaacctgggaggcagagcctaaagtgagccgagatcgcgccactgcactccagcctgggtgacacagcaagactcttgtctcaaacaaaCAGGAATTTGAGTAAATTTTAAATTAGTATATACTACAACAAATTTCCAAACTTCATAATTTGCTAGTAGTGCTAACTAAAATTTTACACCAGGTAAAATCAGGTCACCTTTTTTATGTATTGACTTCATTGTTGGACTTCATACTCTGATGGGAAAGAAAATGGACATTCTGAATGTGTCAGGTGCATAATATCCTAATTTATGCTTGTCAGAGCTGGGGTCTCTGTCTTCCTTGGCCCATGTTGCATTTAACTGAATGTCATGTTTTCTCCTCTGGAACTTCTTATGTATGCAAGCTCCCATGTTAACCTATCATAAAAATGTTTTTTATAA

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