Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name DNAJB1P2
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr19). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:113041234-113041816  UCSC
Coordinates (T2T) chr3:115762189-115762771  UCSC
Coordinates (hg19) chr3:112760081-112760663  UCSC
Strand -
Parental Sequence NM_001300914.2
Parental seq. overlap 504 bp
Parental seq. overlap (%) 21.6%
Genomic Region Intergenic
Retrocopy Summary DNAJB1P2, located on chr3:113041234-113041816, is a retrocopy of the parental gene DNAJB1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name DNAJB1
Full Name DnaJ heat shock protein family (Hsp40) member B1
Also known as HSPF1|Hdj1|Hsp40|RSPH16B|Sis1
Coordinate chr19:14514769-14530597
Strand -
Gene summary This gene encodes a member of the DnaJ or Hsp40 (heat shock protein 40 kD) family of proteins. DNAJ family members are characterized by a highly conserved amino acid stretch called the 'J-domain' and function as one of the two major classes of molecular chaperones involved in a wide range of cellular events, such as protein folding and oligomeric protein complex assembly. The encoded protein is a molecular chaperone that stimulates the ATPase activity of Hsp70 heat-shock proteins in order to promote protein folding and prevent misfolded protein aggregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes DNAJB1P2
Bonobo Pan paniscus DNAJB1P2
Gorilla Gorilla gorilla DNAJB1P2
Orangutan Pongo abelii DNAJB1P2
Gibbon Nomascus leucogenys DNAJB1P1
Green monkey Chlorocebus sabaeus DNAJB1P2
Crab-eating macaque Macaca fascicularis DNAJB1P1
Rhesus Macaca mulatta DNAJB1P1
Baboon Papio anubis DNAJB1P1
Golden snub-nosed monkey Rhinopithecus roxellana DNAJB1P1
Marmoset Callithrix jacchus DNAJB1P3
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>DNAJB1P2
AAGACAAGATCTGGACCATTGAAGTGAAAACACGGTGGAAAGAGGGACCAAAATGACCTTCCCCAAGCAAGGAAGGAGACCAAACCTCTAAAAACATTCCAGCTGACATCGTCTTTGTTTTAAAGGACAAGCCACATAGTATTTTTAAGAGAAATGGCTCTGATGTCATCTATCCTGCCAGGATCAGCATTTGGAAGGCTCTGTGTGGCTGCACAGTGAACATCCCACTCTGGACGGAAAGACCATACCCATCGTTTTCAAGGAAGTCATCAGGCCTGGCATGCAGTGAAAAGCCCCTGGAGAAGACTTCCCTCTCCCTAAAGTGCCCAAGAAATGTGGGGACTTCATTATTGAGTTTGAAGTGATCTTCCCCTAATGGATTCCCCAGATGTCAAGAACTGTACTTGAGCAGGTTCTTCCAATATAGCTACCTGCATTCCCCAAGGACTAACCAGGAAGCTTTCCAGAGCTCAAGGATTTCTGGACCGTTCTCCAGTTGACCATGAGAGGACAGGTGGGCCCAGGGAAGTCTTTCAGACTGCCGAATGTTTTCCATGGACTATATTACAATCTTTCAAAGTCA
>NM_001300914.2
AGAAGCTTCTAGCATGTCTGGGGCTGCCCCTCCCCGGGCGCCTCCTCCCGCGGCCCCGAGCAGCCCCGGGGTGCGGTGCATGGGGGTGGGGGAGCCGGGGGTGACGACGGGGACGGCGCGGCGGAGCCCGCTGCGGACCCGGGCTCACCTGGGCTCGGCCGCCGGGGTCCGCGGGGCGGCGCCTCCGGCTCAGCTGCGGGGCGAGGGGTTGTGAATGCAGGAGCCGACCCCGTTCGTGGGCTTGGGGGCTGGGTTGGGATAATTCCCGGGAAGTGATGACCTGGCCCCGGCAGGGCACGCAGGAGGCAGCGGCCGCCCAGGTCCGGAGAGCGGGGCCGCCTCGGAGGGCCTAAAGGGGAGTGGCCCCAGTGGCGGTAGCGGCGGTGGTGCCAATGGTACCTCTTTCAGCTACACATTCCATGGAGACCCTCATGCCATGTTTGCTGAGTTCTTCGGTGGCAGAAATCCCTTTGACACCTTTTTTGGGCAGCGGAACGGGGAGGAAGGCATGGACATTGATGACCCATTCTCTGGCTTCCCTATGGGCATGGGTGGCTTCACCAACGTGAACTTTGGCCGCTCCCGCTCTGCCCAAGAGCCCGCCCGAAAGAAGCAAGATCCCCCAGTCACCCACGACCTTCGAGTCTCCCTTGAAGAGATCTACAGCGGCTGTACCAAGAAGATGAAAATCTCCCACAAGCGGCTAAACCCCGACGGAAAGAGCATTCGAAACGAAGACAAAATATTGACCATCGAAGTGAAGAAGGGGTGGAAAGAAGGAACCAAAATCACTTTCCCCAAGGAAGGAGACCAGACCTCCAACAACATTCCAGCTGATATCGTCTTTGTTTTAAAGGACAAGCCCCACAATATCTTTAAGAGAGATGGCTCTGATGTCATTTATCCTGCCAGGATCAGCCTCCGGGAGGCTCTGTGTGGCTGCACAGTGAACGTCCCCACTCTGGACGGCAGGACGATACCCGTCGTATTCAAAGATGTTATCAGGCCTGGCATGCGGCGAAAAGTTCCTGGAGAAGGCCTCCCCCTCCCCAAAACACCCGAGAAACGTGGGGACCTCATTATTGAGTTTGAAGTGATCTTCCCCGAAAGGATTCCCCAGACATCAAGAACCGTACTTGAGCAGGTTCTTCCAATATAGCTATCTGAGCTCCCCAAGGACTGACCAGGGACCTTTCCAGAGCTCAAGGATTTCTGGACCTTTCTACCAGTTGTGGACCATGAGAGGGTGGGAGGGCCCAGGGAGGGCTTTCGTACTGCTGAATGTTTTCCAGAGCATATATTACAATCTTTCAAAGTCGCACACTAGACTTCAGTGGTTTTTCGAGCTATAGGGCATCAGGTGGTGGGAACAGCAGGAAAAGGCATTCCAGTCTGCCCCACTGGGTCTGGCAGCCCTCCCGGGATGGGCCCACATCCACCTCCAGTCCCTGGCCAGGGGTGAGAGGCAGACCAGCAGATGGACTTGATCCCTCTGTGTCTTTTTGCTTCTGGCTGGTAGATAATGTCAACCTGCAGTCTTGATTCCCAGACCCTGTACACTCCTCCTTTTCTGTTGTGTGATCAGTTTGTGCTTTATTCTGTATTTGTCTCCCATGTCTTGCTCTTCTCCTGGAGAATTCTGTCTTCTCTTTGGCCATCTCAAATTGAGAACCTAAACTATTCCTGCAGAACTGCCTGGTTGGCGTCCACAAGCAATACCTCTCGTTCCAGCAGGACCAAGGGAGCCAGCCTCCAGTGAGTGACTCCAGCAAGTGCAGCCACCTCTCCCTTGATGGTCTGGGAGCCTGGCCTCAGCAAGGGGCCTTCCTGACCTCTGGCTCCAGTGAAGCTGAATGTCCTCACTTTGTGGGTCACACTCTTTACATTTCTGTAAGGCAATCTTGGCACACGTGGGGCTTACCAGTGGCCCAGGTAATTTTTTGTTTCATGGACTATGGACTCTTTCAAAGGGATCTGATCCTTTTGAATTTTGCACAGCCCTAGATACAATCCCTTTTGATAAAAGGGTCTTTGCTTCTGATTACAGGAGCACTGTGGAACGTCTGTAAATATGTTTTTATAATTCCATGTATAGTTGGTGTACACTCAAAACCTGTCCCCGGCAGCCAGTGCTCTCTGTATAGGGCCATAATGGAATTCTGAAGAAATCTTGGGGAGGGAAGGGGAGTTGGAACAAATGTCTGTTCCCTGGAGGCCAGTCCAGTGCTCAGACCTTTAGACTCATTGTAAGTTGCCACTGCCAACATGAGACCAAAGTGTGTGACTAGTCAATGAAGTGCGACAGCATTAAAGACTGATGCTAAACCTCA

Publications

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