Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name RABGGTBP1
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:113360264-113363030  UCSC
Coordinates (T2T) chr3:116081404-116084170  UCSC
Coordinates (hg19) chr3:113079111-113081877  UCSC
Strand +
Parental Sequence NM_004582.4
Parental seq. overlap 1127 bp
Parental seq. overlap (%) 62.5%
Genomic Region Intragenic (CFAP44)
Retrocopy Summary RABGGTBP1, located on chr3:113360264-113363030, is a retrocopy of the parental gene RABGGTB. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name RABGGTB
Full Name Rab geranylgeranyltransferase subunit beta
Also known as GGTB
Coordinate chr1:75786256-75795086
Strand +
Gene summary This gene encodes the beta-subunit of the enzyme Rab geranylgeranyl-transferase (RabGGTase), which belongs to the protein prenyltransferase family. RabGGTase catalyzes the post-translational addition of geranylgeranyl groups to C-terminal cysteine residues of Rab GTPases. Three small nucleolar RNA genes are present in the intronic regions of this gene. Alternately spliced transcript variants have been observed for this gene. A pseudogene associated with this gene is located on chromosome 3. [provided by RefSeq, Jan 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes RABGGTBP1
Bonobo Pan paniscus RABGGTBP1
Gorilla Gorilla gorilla RABGGTBP1
Orangutan Pongo abelii RABGGTBP1
Gibbon Nomascus leucogenys RABGGTBP1
Green monkey Chlorocebus sabaeus RABGGTBP1
Crab-eating macaque Macaca fascicularis RABGGTBP1
Rhesus Macaca mulatta RABGGTBP1
Baboon Papio anubis RABGGTBP1
Golden snub-nosed monkey Rhinopithecus roxellana RABGGTBP1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>RABGGTBP1
CATGTTATTATCAAGTGAGATACACCAGACACCTTATTATTGTAGAAACATGTAGATTGTATCACATCCTATGGCTCAAAGAAAGATGATTATGAATACTATATGTCTGAGTATTTGAGAATGAGTGGTGTCTATTGGGGTTTGACAGTATTGGATCTCATGGGACAACTTCACTGCATGAATAGTGAAGAAATTCTGACATTTATTAAGTCTTGCCAACATGAGTTTGGTAGAATAAGTGCTAATATCAGACATGATCCTCATCTTTTATACACTGTTAGTGCTGTCCAGATTCTTACTCTGTATGATAGTATTAATGTTATCGATGTAAAAAAGTTGTGGAATATGTTCCAAGTCTATGGAAAGAAGATGTTTCTCTTGCTGGAGACTTTTGGGGTCCCACTGAGCAGCTGCTCTAACTGGAGCTAATGGTCTGCTGGAAGTTCCAGCGTGCACTGTGGTAGTTTTATCAGCATACAGAATTACTGGACCAGAGGGGGCCAGCCTGAAAGATAAGGGATGAACACAGTGCAGGGCAGAGAGACCAACTGTTTCATAGGATGGGAAAAATCTACTTTTATAAAGTAGGGGGAAATTGATACAAGATTCTCTTTTTGTGTGGTGGAAACTGGCTCTCTTGGGGAAGCTTGATGCTACTAATATAAAAAAAAAAAAGGCAGTTGAATTTGTTTTATCTGTGTATGAATTTTGATGGTGGATTTGGTTGCAGACCAGGTTCTGAATTCCATGCTGGGCACATTTATTGTTGCACAGGATTCCTGGCTATTACCAAGTCAGTTGCATCAAGTAAATTATGATTTACTTGGTTAGTGGTTTTGTGAATGAGTTACCCTTGGGTGGATTTAATGGAAGGCCAGGGAAGTTAGCAGGTGTATGCTATTCATGGTGGGTGTTGGCTTTCCTAAAGATCACTGGAAGCCTTCACTGGATTGAGAGAGATAAACCGCGTATGTAATTTCATCTGTCAGTCCTACTTTTGGCATGCCTGAAGAAGTGCTTCAGAGGGTGAATATTCAGCCTGAGCTAGTAAGCTAGATTCACTGAGGCAAAAGTTGCGTACTATAGTATAATTTTGCCAACTCAACATGTCTGTATTTGAAATGCTTATGAAATCAAAAAATGACTACTATTATTTTGTGTATTGTGTTAAAGTAATTTTATAATTTATAAGAAATTATATAATTATACATATTGTAGAATAAAGACCTGTAAAGACCTGTATTTTATTTTCTGCTTTATATTTTGAAGACCTGCTATTCTGACCACAATTTTTTTTTACCAGAAAACAAACACCAATTTTATTAATATAATAGCAACAGAAAGGGTTTCTAATTTCTCAGAAGGCATGAAACCAGCACAAGTGTTATAAGATTAGGCCAATTTTTGTTTATACTTCAGTGTATCTGTTATTCATGTCTCTATAAAAGAAAACTTAAAAGAACTCTTGGGTTCTACTTTATTTCTTCCCCATGTATTCCTTTCATGTGTTCTATAACAACAGTTGATGTAAAACAATTTGTGTCAACAAGAATCTTAACTGATTAAAAGGGATAAACCCCACATACAAATTAAAAGATGCCCAAAATAAATGGCTATTGAAATTTT
>NM_004582.4
CCTTTCCCTGTTAGACATGGGCACTCCACAGAAGGATGTTATTATCAAGTCAGATGCACCGGACACTTTGTTATTGGAGAAACATGCAGATTATATCGCATCCTATGGCTCAAAGAAAGATGATTATGAATACTGTATGTCTGAGTATTTGAGAATGAGTGGCATCTATTGGGGTCTGACAGTAATGGATCTCATGGGACAACTTCATCGCATGAATAGAGAAGAGATTCTGGCATTTATTAAGTCTTGCCAACATGAATGTGGTGGAATAAGTGCTAGTATCGGACATGATCCTCATCTTTTATACACTCTTAGTGCTGTCCAGATTCTTACGCTGTATGACAGTATTAATGTTATTGACGTAAATAAAGTTGTGGAATATGTTAAAGGTCTACAGAAAGAAGATGGTTCTTTTGCTGGAGATATTTGGGGAGAAATTGACACAAGATTCTCTTTTTGTGCGGTGGCAACTTTGGCTTTGTTGGGGAAGCTTGATGCTATTAATGTGGAAAAGGCAATCGAATTTGTTTTATCCTGTATGAACTTTGACGGTGGATTTGGTTGCAGACCAGGTTCTGAATCCCATGCTGGGCAGATCTATTGTTGCACAGGATTTCTGGCAATTACAAGTCAGTTGCATCAAGTAAATTCTGATTTACTTGGCTGGTGGCTTTGTGAACGACAATTACCCTCAGGCGGGCTCAATGGAAGGCCGGAGAAGTTACCAGATGTATGCTACTCATGGTGGGTCCTGGCTTCCCTAAAGATAATTGGAAGACTTCATTGGATTGATAGAGAGAAACTGCGTAATTTCATTTTAGCATGTCAAGATGAAGAAACGGGGGGATTTGCAGACAGGCCAGGAGATATGGTGGATCCTTTTCATACCTTATTTGGAATTGCTGGATTGTCACTTTTGGGAGAAGAACAGATTAAACCTGTTAATCCTGTCTTTTGCATGCCTGAAGAAGTGCTTCAGAGAGTGAATGTTCAGCCTGAGCTAGTGAGCTAGATTCATTGAATTGAAAGTTGCATAGTATAGTTTTGCCATTTTAACATTTCTGTATTTGAAGTGCTTATCGAATCTAAAAGTGACTACTGTTAATATTTTGTATATTGTGTTAAATTAATTTTAATAAATTATATAATTATACATATTGTAAAATAAAGACCGGTATTTTATTTTCTGCTTTTTATTCTGAAGTCCTGTTATTCTGACTACAGTTCTTTGTGTATACTTCTGTGTCTGTTATGTTCAATAACTGAGCTAACATAAAATAACTCTAGGTTTCTACTTGATTTTTCCCCCATGTATACCTTTCATCTGTTCTATAGCAAGTTGATGTAAATTGGTTTGTCAACAAGAATGTTAACTGATGAAAGTGGATAGAACCCATACATGAATTAAATGATGCACAAAATAAATGGCTGTTGAAATTTGGAAATGA

Publications

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