Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name PARLP1
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr3). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:120028712-120030071  UCSC
Coordinates (T2T) chr3:122748394-122749753  UCSC
Coordinates (hg19) chr3:119747559-119748918  UCSC
Strand +
Parental Sequence NM_018622.7
Parental seq. overlap 1225 bp
Parental seq. overlap (%) 81%
Genomic Region Intragenic (GSK3B)
Retrocopy Summary PARLP1, located on chr3:120028712-120030071, is a retrocopy of the parental gene PARL. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name PARL
Full Name presenilin associated rhomboid like
Also known as PRO2207|PSARL|PSARL1|PSENIP2|RHBDS1
Coordinate chr3:183826488-183884901
Strand -
Gene summary This gene encodes a member of the rhomboid family of intramembrane serine proteases that is localized to the inner mitochondrial membrane. The encoded protein regulates mitochondrial remodeling and apoptosis through regulated substrate proteolysis. Proteolytic processing of the encoded protein results in the release of a small peptide, P-beta, which may transit to the nucleus. Mutations in this gene may be associated with Parkinson's disease. [provided by RefSeq, May 2016]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes PARLP1
Bonobo Pan paniscus PARLP1
Gorilla Gorilla gorilla PARLP1
Orangutan Pongo abelii PARLP1
Gibbon Nomascus leucogenys PARLP2
Green monkey Chlorocebus sabaeus PARLP3
Crab-eating macaque Macaca fascicularis PARLP1
Rhesus Macaca mulatta PARLP1
Baboon Papio anubis PARLP1
Golden snub-nosed monkey Rhinopithecus roxellana PARLP1
Marmoset Callithrix jacchus PARLP2
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>PARLP1
AGGCCATGGTGGGGCAGAGGTTGGGAAGATGGCCTGGTGAGGCTGGGCAGAGAGAGGTTGGGGCAGCGACCAGGCGTGGTCTCCGCCAGTGGGCGGCCGCAGCTGCAAGGAACTCACTGAGGCCCTAGCCCCGCCACGGCTGCTCAGACGCAGGTTTGGCTTCTTCGCAAAAATGTGGATTCAGAAAAGCACCCAGGAAGGCTGAACCTCAAAGATCAGACACAGGCACAAGTGGTGAAGCATACAAGAGAAGTGCTTTGGTTCCTCCTGTGGAAGAAACGGCCTTTTATCCTTCTTTGTATCCTATAGGGACTCTCATAAAATCTTTATTTTTTACTGTTGGGTTTACAGGCTGTGCATTTGGATCAGCTACTATTTGGCAATATGAATCACTGAAATCCAGGGTCCAGAGTTATTTTGATGATATAAAAGCTGACGGTTGGGATAGCATAAGATCACAAAAAAGAGACTTCAGAAAGGAGATTAACAAGTGGTAGAATAACCTAAGCGATGGCCACCAGACTATGACAGGTTATCACAGCTGCAAATGAATGTCTTTGTATTCTGTTTATAGAGAGTACCTTCTCTGCAGCGGACAATGATCAGATATTTCGCATCTAATCCAGCCTCAAAAGCCCTTTCTTTTCCAATGTTGCTGTCAACATTCAGTCATTTCTCCTTATTTCACATGGCAGCAAATATCTTATGTTTTGTGGAGCTTCGCCTCCAGCACAGTGAACATTCTGGATCAAGAGCAGTGTTATTATCTGCAGGTGTTATTTCCAATTGTGTCAGTTATGTGTGTAAAGTTGCCACAGGAAGATAGGGACCATCACTTGGTGCATCTGGCACCATCATGATGGTCTTTGCAGCTGTCTGCACTAAGATCCCAGAAGGGAGGCTTGCCATTATTTCCCTTCAGATGTTCACATTCATAGCAGAGAATGCCCTAAAAGCCATTATGGCCATGGATACAGCAGAAATCTTCATGGGATGGAAATTTTTTTATCATGCAGTGCATCCTGGGGGAGCTCTCTTTGGAATATGGTATGTTACTTATGGTCATTAACTGTTTTGGAAGAACAGGGAGCTTCTAGTGAAAATCTGGCACGAAATGAGGACTAATGGCCCCCAAAAAAGGAGGTGGCTCTAAGTAAAACTGGGATTGGACAGTACTGGTGTATCTGGTCCATGATGCCTGAGAGCCACAGGAACACATGGGCCCTAGAGTGACCACAGCTATGCTCTGGCTTGAAAGACACCAGCATCTGGCCTCCCAGTGTTTTCAGCTGTGTCCCCCAGTCTGTCTTTTAAAAGGTGAATTATGACAAAGTTGTGAAATAAAGGTTTATATCTAGTT
>NM_018622.7
AAGGTCGGGCCATGGTGGGGCAGAGGTTGGGAAGAtggcgtggcgaggctgggcgcagagaggctggggctgcggccaggcgtggggtgcgtcggtggGCGGCCGCAGCTGCGAGGAGCTCACTGCGGTCCTAACCCCGCCGCAGCTCCTCGGACGCAGGTTTAACTTCTTTATTCAACAAAAATGCGGATTCAGAAAAGCACCCAGGAAGGTTGAACCTCGAAGATCAGACCCAGGGACAAGTGGTGAAGCATACAAGAGAAGTGCTTTGATTCCTCCTGTGGAAGAAACAGTCTTTTATCCTTCTCCCTATCCTATAAGGAGTCTCATAAAACCTTTATTTTTTACTGTTGGGTTTACAGGCTGTGCATTTGGATCAGCTGCTATTTGGCAATATGAATCACTGAAATCCAGGGTCCAGAGTTATTTTGATGGTATAAAAGCTGATTGGTTGGATAGCATAAGACCACAAAAAGAAGGAGACTTCAGAAAGGAGATTAACAAGTGGTGGAATAACCTAAGTGATGGCCAGCGGACTGTGACAGGTATTATAGCTGCAAATGTCCTTGTATTCTGTTTATGGAGAGTACCTTCTCTGCAGCGGACAATGATCAGATATTTCACATCGAATCCAGCCTCAAAGGTCCTTTGTTCTCCAATGTTGCTGTCAACATTCAGTCATTTCTCCTTATTTCACATGGCAGCAAATATGTATGTTTTGTGGAGCTTCTCTTCCAGCATAGTGAACATTCTGGGTCAAGAGCAGTTCATGGCAGTGTACCTATCTGCAGGTGTTATTTCCAATTTTGTCAGTTACGTGGGTAAAGTTGCCACAGGAAGATATGGACCATCACTTGGTGCATCTGGTGCCATCATGACAGTCCTCGCAGCTGTCTGCACTAAGATCCCAGAAGGGAGGCTTGCCATTATTTTCCTTCCGATGTTCACGTTCACAGCAGGGAATGCCCTGAAAGCCATTATCGCCATGGATACAGCAGGAATGATCCTGGGATGGAAATTTTTTGATCATGCGGCACATCTTGGGGGAGCTCTTTTTGGAATATGGTATGTTACTTACGGTCATGAACTGATTTGGAAGAACAGGGAGCCGCTAGTGAAAATCTGGCATGAAATAAGGACTAATGGCCCCAAAAAAGGAGGTGGCTCTAAGTAAAACTGGGATTGGACAGTAGTGGTGCATCTGGTCCTTGCCGCCTGAGAGCCCCAGGAGACATCGGCTAGAGTGACCATGGCTATGCTCCCGTCTGGAAGATGCCAGCATCTGGCCTCCCACTGTTTTCAGCTGTGTCCCCCAGTCCGTGTCTTTTTAGAATGTGAATGATGATAAAGTTGTGAAATAAAGGTTTCTATCTAGTTTGTAAGCAGATGTGTGTGTTCTCTCTTTAAGGGGCCGACACGGCTCTGGCATTTTGCTTTGGTTGTTGCATTGACAGGACCTGGGGAGAGTGCACCCTGAAAGGCCTGATCAGAACATGAAGGC

Publications

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