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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name GSTM5P1
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr1). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:12257375-12258482  UCSC
Coordinates (T2T) chr3:12255566-12256673  UCSC
Coordinates (hg19) chr3:12298874-12299981  UCSC
Strand -
Parental Sequence NM_000851.4
Parental seq. overlap 993 bp
Parental seq. overlap (%) 63.2%
Genomic Region Intergenic
Retrocopy Summary GSTM5P1, located on chr3:12257375-12258482, is a retrocopy of the parental gene GSTM5. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name GSTM5
Full Name glutathione S-transferase mu 5
Also known as GSTM5-5|GTM5
Coordinate chr1:109711751-109718268
Strand +
Gene summary Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs. Diversification of these genes has occurred in regions encoding substrate-binding domains, as well as in tissue expression patterns, to accommodate an increasing number of foreign compounds. [provided by RefSeq, Jul 2008]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes GSTM5P1
Bonobo Pan paniscus GSTM5P1
Gorilla Gorilla gorilla GSTM5P1
Orangutan Pongo abelii LOC100453263P1
Gibbon Nomascus leucogenys GSTM5P1
Green monkey Chlorocebus sabaeus GSTM5P1
Crab-eating macaque Macaca fascicularis GSTM5P1
Rhesus Macaca mulatta GSTM5P1
Baboon Papio anubis LOC100997115P1
Golden snub-nosed monkey Rhinopithecus roxellana LOC104656071P1
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>GSTM5P1
GTCTGCAGAATCTGCACCAACCAGCACCATGCCCATCACACTGGGGTACGGGGACATCCACGGGCTGGCACATGCCATCCACCTGCTCCTTGAATACACAGACTCAAGCTACGAGGAAAAGAAGTACACAATGGGGGACTCTCCTGACTATGACAGAAGCTAGTAGCTGAATTAAAAATTCAAGCTGGGCCTGGACTTTCCCAATCTGCCCTACTTGTTTGATGGGGCTCACAAGATCACCCAGAGCAACGCCATCCTGCGCCACATTTCCTGCAAGCACAGCCTGTGTGAGGAGACAGAAGAGGAGAAGATTCGTGTGGACATTTCGGAGAACCAGACCATGGACAACCTGATGCAGCTGGCCATGATCTGCTACATCCCAGAATTTGAGAAACTGAAGCCAAAGTACCTGGAGGAACTCCCTGAAAAGCTAAAGCTCTACTCACAGTTTCTGGGGAAGTGGCCATGGTTCGCATGAGACAAGATCACCTATGTGGATTTCCTTGCCTATGACATCCTTGACCTGAACTGTATATTTGACCCCAGCTGCCTGGACGCCTTCCCAAACCTGAAGGACTTCATGTCCTGAATTGAGGGTTTGAAGAAGATCTCTGCCTACATGAAGTCCAGCCAATGCCTCCAAGGTCCTTTGTTTGGGAAGTCAGCTATGTGGAACAGTAAATAGGGCCCCGTGATGCCAGAAGATGGGAGGGAGGAGCCGACCCTGCTGCCTGGGAGCCTGGAGAACACTGGAGAACAGCCCGACTCCCTGAACCAGACTTCTTCCTTTTTCCTTGTTTCCACTCTCTTCTTTTCCCCAAGGCCTCATTGGCTTCCTTTCTTCTAACATGATCCCTCCCCACATCGAGGATCTTTAAAGCTTCAGCTCCCCACTCTCCTCCATCAAAGTCCCCCTCCTAACATCTCCCTTTTCCTGCACTAACACCAACCTGACTGCTTTCCCTATCAGTGCTTATCTCTTCTTTGAGAAGCTGGACTGATCCCTGAGCTCCCCAGCACTGTCCTCAAAGACCATCTGCGGGCCCTGCTCCCTTTGCTGGGTCCCTACTCCAGCCCTGTGTGATGCCCAGTAAAGCCTGAACCATGA
>NM_000851.4
CTCTCAAAGTCTGAGCCCCGCTCCGCTGATGCCTGTCTGCAGAATCCGCACCAACCAGCACCATGCCCATGACTCTGGGGTACTGGGACATCCGTGGGCTGGCCCACGCCATCCGCTTGCTCCTGGAATACACAGACTCAAGCTATGTGGAAAAGAAGTACACGCTGGGGGACGCTCCTGACTATGACAGAAGCCAGTGGCTGAATGAAAAATTCAAGCTGGGCCTGGACTTTCCCAATCTGCCCTACTTGATTGATGGGGCTCACAAGATCACCCAGAGCAATGCCATCCTGCGCTACATTGCCCGCAAGCACAACCTGTGTGGGGAGACAGAAGAGGAGAAGATTCGTGTGGACATTTTGGAGAACCAGGTTATGGATAACCACATGGAGCTGGTCAGACTGTGCTATGACCCAGATTTTGAGAAACTGAAGCCAAAATACTTGGAGGAACTCCCTGAAAAGCTAAAGCTCTACTCAGAGTTTCTGGGGAAGCGGCCATGGTTTGCAGGAGACAAGATCACCTTTGTGGATTTCCTTGCCTATGATGTCCTTGACATGAAGCGTATATTTGAGCCCAAGTGCTTGGACGCCTTCCTAAACTTGAAGGACTTCATCTCCCGCTTTGAGGGTTTGAAGAAGATCTCTGCCTACATGAAGTCCAGCCAATTCCTCCGAGGTCTTTTGTTTGGAAAGTCAGCTACATGGAACAGCAAATAGGGCCCAGTGATGCCAGAAGATGGGAGGGAGGAGCCAACCTTGCTGCCTGCGACCCTGGAGGACAGCCTGACTCCCTGGACCTGCCTtcttcctttttccttctttctactctcttctcttcCCCAAGGCCTCATTGGCTTCCTTTCTTCTAACATCATCCCTCCCCGCATCGAGGCTCTTTAAAGCTTCAGCTCCCCACTGTCCTCCATCAAAGTCCCCCTCCTAACGTCTTCCTTTCCCTGCACTAACGCCAACCTGACTGCTTTTCCTGTCAGTGCTTTTCTCTTCTTTGAGAAGCCAGACTGATCTCTGAGCTCCCTAGCACTGTCCTCAAAGACCATCTGTATGCCCTGCTCCCTTTGCTGGGTCCCTACCCCAGCTCCGTGTGATGCCCAGTAAAGCCTGAACCATGCCTGCCATGTCTTGTCTTATTCCCTGAGGCTCCCTTGACTCAGGACTGTGCTCGAATTGTGGGTGGTTTTTTGTCTTCTGTTGTCCACAGCCAGAGCTTAGTGGAtgggtgtgtgtgtgtgtgtgttgggggtggtgATCAGGCAGGTTCATAAATTTCCTTGGTCATTTCTGCCCTCTAGCCACATCCCTCTGTTCCTCACTGTGGGGATTACTACAGAAAGGTGCTCTGTGCCAAGTTCCTCACTCATTCGCGCTCCTGTAGGCCGTCTAGAACTGGCATGGTTCAAAGAGGGGCTAGGCTGATGGGGAAGGGGGCTGAGCAGCTCCCAGGCAGACtgccttctttcaccctgtcctgatagacttccctgatctagatatccttcgtcatgacacttctcaataaaacgtatcccaccgtattgtaa

Publications

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