Imagem 1

Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name CARMIL2P1
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr16). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:129631966-129632467  UCSC
Coordinates (T2T) chr3:132376404-132376905  UCSC
Coordinates (hg19) chr3:129350809-129351310  UCSC
Strand -
Parental Sequence NM_001013838.3
Parental seq. overlap 456 bp
Parental seq. overlap (%) 10.2%
Genomic Region Intergenic
Retrocopy Summary CARMIL2P1, located on chr3:129631966-129632467, is a retrocopy of the parental gene CARMIL2. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name CARMIL2
Full Name capping protein regulator and myosin 1 linker 2
Also known as CARMIL2b|IMD58|LRRC16C|RLTPR
Coordinate chr16:67645004-67657569
Strand +
Gene summary This gene encodes a member of the CARMIL (capping protein, Arp2/3, myosin-I linker) family of proteins. The encoded protein interacts with and negatively regulates the heterodimeric capping protein and promotes cell migration. Reduced expression of this gene has been observed in human psoriasis patients. Mutations in this gene cause a human immunodeficiency syndrome characterized by smooth muscle tumors and impaired T-cell function. [provided by RefSeq, May 2017]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes CARMIL2P1
Bonobo Pan paniscus CARMIL2P1
Gorilla Gorilla gorilla CARMIL2P1
Orangutan Pongo abelii CARMIL2P1
Green monkey Chlorocebus sabaeus RLTPRP1
Crab-eating macaque Macaca fascicularis RLTPRP1
Rhesus Macaca mulatta CARMIL2P1
Baboon Papio anubis CARMIL2P1
Golden snub-nosed monkey Rhinopithecus roxellana CARMIL2P1
Marmoset Callithrix jacchus CARMIL2P1
Gibbon Nomascus leucogenys Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>CARMIL2P1
CTGCAACCTGGAAGACAGTGGGGCAGCAGTTGAATGCAGAGCTCAGGAGCCATGGTTGGGGCCAACAGGATGGCCCAGGCCCTCCTTCCCCTGGTCAAAGCCCAAGGCCCTGCAGAGCCGGCCCCTCCCCAGGCAGCCTGGGCCTCCTGGAGGACCCTTGTTTCAGCCCCAGGAATGAAGATGGCCAGCTGAGGCTGCAGCCTCTCTCGGCAGGGCCGTGAGCGGTGTCTGTGCTTGAGGACCAGCTCCAGGCCCCTGCTGAACAGCCCCTGCGACTGCAGCGCTTCCCCGTCTTCAAATGCAGGCCGAAGTTCAAGGCACCTCCATCCCCAAGGCTAGGATCCAGCCTTGGAACCAAGCCTCTGCCCCCATAGCCCACAGAGCCCTCCAGCCCTGAGCGGAGCCCACCCTCCCCAGCCACAGACCATAGAGGCAGCGGCCCCAATCCCTGACCCTGTCCTCTCCTGATGCATGAGATTATTTTATTAAAAAAACTCAAAGA
>NM_001013838.3
AGGTGGCTGCCGTGCGGGTCTGGGCCCCAGGCTTCCTGTGTGCGCGCTCGTCCTCTGCTGTTTCCCGCCGGAGCTCGTTGGGCCTCCCCGGCCCGCCCGGCCCATGGCCCAGACCCCCGACGGCATCTCCTGTGAGCTCCGAGGCGAGATCACCAGGTTCCTGTGGCCCAAAGAGGTGGAGCTGCTGCTGAAAACCTGGCTACCCGGGGAGGGTGCTGTGCAAAACCATGTCCTGGCACTGCTACGATGGAGAGCCTACCTGCTGCACACCACCTGCCTCCCGCTGAGGGTGGACTGCACGTTCAGCTACCTGGAGGTCCAGGCCATGGCGCTGCAGGAGACACCCCCTCAGGTCACCTTTGAGCTGGAGTCCCTGCGTGAGCTGGTCCTGGAGTTTCCTGGTGTGGCCGCCCTGGAACAGCTGGCCCAGCACGTGGCTGCAGCCATCAAGAAGGTCTTCCCTCGCTCGACCCTTGGGAAGCTATTCCGGAGGCCCACACCAGCCTCCATGCTGGCTCGGCTGGAGAGAAGCAGCCCCTCGGAGTCCACTGACCCCTGCAGCCCCTGTGGTGGCTTCTTGGAGACATACGAGGCTCTGTGTGACTACAATGGCTTCCCTTTCCGAGAGGAGATTCAGTGGGACGTGGACACCATTTACCATCGCCAGGGCTGCCGCCATTTCAGCCTGGGAGACTTCAGCCACCTCGGCAGTCGGGACCTGGCCTTGAGTGTGGCTGCCCTGTCCTACAACCTGTGGTTCCGGTGCCTCTCCTGTGTGGACATGAAGCTGAGCCTTGAGGTCTCAGAACAGATTCTGCACATGATGAGTCAGTCATCACACCTGGAGGAGCTGGTGCTGGAGACCTGCAGCCTGAGGGGAGACTTTGTCCGACGACTGGCCCAGGCGCTGGCGGGACACTCAAGCTCTGGGCTGCGGGAGCTCAGCCTCGCGGGGAACCTGCTGGATGACCGAGGCATGACTGCACTCAGCAGACACCTCGAGCGTTGTCCAGGAGCCCTGAGGAGACTCAGCCTGGCCCAGACAGGGTTGACACCGCGAGGAATGAGGGCTCTGGGCCGGGCACTGGCCACCAATGCCGCCTTCGACTCCACCCTGACCCACCTGGACCTTTCTGGGAATCCTGGGGCGCTGGGGGCCTCCGAGGACAGTGGGGGCCTCTATAGCTTCCTGAGCCGTCCTAACGTACTGTCGTTCCTGAATCTCGCAGGCACCGACACTGCCCTGGACACTGTGAGGGGGTGCTCCGTGGGGGGATGGATGACCGGCAGGGCGGACTGGAGGGCGGGACGGGGAGGGCTCGGTCCCCCCGCGGGTGTAGCCAACAGCCTCCCCCCGCAGCTCTTCGCAGCGGTATCCCGAGGCTGCTGCACCAGCCTTACCCACCTCGACGCTTCGAGGAACGTCTTCTCCCGCACGAAGTCCCGCGCCGCGCCGGCCGCGCTGCAGCTCTTCCTCAGCCGCGCGCGGACGCTGCGGCACCTGGGCCTGGCGGGCTGCAAGCTGCCGCCCGACGCGCTCAGAGCCCTTTTGGATGGCCTCGCGCTCAACACGCACCTCCGCGACCTGCACCTGGACCTCAGCGCTTGCGAGCTGCGCTCGGCCGGCGCCCAGGTGATACAAGACTTAGTGTGCGACGCAGGCGCTGTGAGCTCCCTGGATCTGGCGGATAACGGCTTCGGCTCAGACATGGTGACTCTGGTGCTGGCCATCGGGAGAAGCCGGTCCCTGAGACATGTGGCGCTTGGAAGGAACTTCAACGTCCGGTGCAAGGAGACCCTGGACGACGTCCTGCACCGGATTGTCCAGCTCATGCAGGACGACGATTGTCCTCTTCAGTCTCTGTCGGTGGCTGAGTCTCGGCTGAAGCTGGGTGCCAGCGTCCTACTCCGGGCCCTAGCCACCAATCCTAACCTGACCGCGCTGGATATCAGCGGCAACGCCATGGGGGACGCGGGCGCCAAGTTGCTGGCCAAGGCGCTGCGGGTCAACTCGAGGCTCCGGTCTGTGGTCTGGGACCGGAACCACACATCTGCTTTGGGTCTGCTGGACGTGGCGCAGGCGCTGGAGCAGAACCACAGCCTGAAGGCCATGCCTCTGCCACTGAACGACGTGGCCCAGGCGCAGCGCAGCCGCCCGGAACTGACAGCACGTGCAGTCCATCAGATCCAAGCCTGTCTCTTGAGGAACAACCGCGCAGACCCTGCCTCTTCTGACCACACGACCCGCCTTCAGCCACTTGGTCTGGTCTCAGACCCCTCAGAGCAGGAAGTGAATGAATTGTGTCAGTCGGTGCAGGAGCATGTGGAGCTGCTGGGCTGTGGGGCTGGGCCCCAGGGTGAAGCCGCTGTGCGCCAGGCCGAGGATGCCATCCAAAATGCCAACTTCTCTCTCAGCATTCTCCCCATTCTATATGAAGCTGGAAGCTCCCCAAGCCATCACTGGCAGCTTGGGCAGAAGCTGGAGGGCCTTCTGAGACAGGTGGGCGAGGTCTGCCGCCAGGACATCCAGGACTTCACTCAGGCCACACTGGACACAGCAAGGAGCCTCTGCCCACAGATGCTGCAGGGATCCAGCTGGAGGGAGCAGCTAGAGGGGGTCCTGGCAGGCTCGAGGGGCCTCCCGGAGCTGCTCCCAGAGCAGCTGCTGCAAGATGCCTTCActaggctcagGGACATGCGGCTATCAATCACGGGGACCTTGGCAGAGAGCATTGTGGCTCAGGCTTTGGCAGGCCTGAGTGCAGCCCGGGATCAGCTGGTGGAGAGTCTGGCTCAGCAGGCAACAGTGACAATGCCCCCTGCCCTACCAGCACCGGATGGAGGTGAGCCCAGCCTCCTTGAGCCTGGGGAATTGGAAGGTCTTTTCTTCCCCGAGGAGAAGGAAGAGGAGAAGGAGAAGGATGACAGTCCTCCACAGAAATGGCCTGAGCTCAGCCACGGTCTTCACCTGGTCCCCTTCATTCACAGTGCTGCTGAGGAAGCGGAGCCGGAGCCCGAGCTGGCGGCTCCGGGAGAAGATGCAGAGCCGCAGGCGGGGCCGTCCGCGCGCGGCTCTCCGAGCCCTGCCGCCCCTGGGCCCCCGGCCGGCCCGCTGCCCCGCATGGACCTGCCACTGGCGGGGCAGCCCCTGCGCCATCCGACCCGGGCCCGGCCGCGGCCGCGCCGCCAGCACCACCACCGCCCGCCGCCGGGGGGCCCCCAGGTACCCCCAGCCTTGCCGCAGGAAGGGAATGGGCTCAGTGCCCGCGTGGACGAGGGCGTGGAGGAATTCTTCTCCAAAAGGCTGATCCAGCAGGATCGCCTCTGGGCCCCCGAGGAGGACCCGGCCACTGAGGGGGGCGCCACTCCTGTCCCCCGTACACTGCGAAAGAAGCTGGGCACCCTCTTTGCCTTCAAGAAGCCTCGTTCAACGCGGGGTCCACGGACTGATCTAGAGACCAGCCCTGGGGCAGCTCCCCGAACCCGAAAAACTACATTTGGCGACCTACTGCGGCCGCCAACCCGTCCCAGCCGTGGTGAGGAGCTTGGTGGGGCTGAGGGGGACACCAGCAGCCCTGACCCTGCCGGCAGGAGCCGACCTCGCTACACAAGAGATAGCAAGGCCTACTCGATGATACTGCTGCCTGCCGAGGAGGAGGCAACGCTGGGTGCCAGACCCGACAAGCGGCGGCCCCTGGAGCGGGGAGAAACAGAACTGGCTCCATCCTTTGAACAGCGGGTACAAGTAATGCTGCAGAGGATAGGCGTCAGCCGAGGCAGCGGGGGTGCCGAAGGCAAGAGGAAGCAAAGCAAAGATGGCGAGATCAAGAAAGCTGGCTCAGATGGTGACATTATGGACAGTTCCACGGAGGCCCCTCCCATCTCGATCAAGTCCCGCACCCACTCTGTGTCTGCTGACCCTTCCTGCAGACCTGGCCCAGGGAGCCAGGGGCCTGAGTCTGCCACCTGGAAGACACTGGGGCAGCAGTTGAATGCGGAGCTCAGGAGCCGTGGTTGGGGCCAACAGGATGGTCCAGGCCCTCCCTCCCCTGGTCAAAGCCCAAGTCCCTGCAGAACCAGCCCCTCCCCAGACAGCCTGGGCCTCCCAGAGGACCCTTGCTTGGGCCCCAGAAATGAAGATGGCCAGCTGAGGCCGAGGCCTCTCTCGGCAGGGCGGCGAGCAGTGTCTGTGCATGAGGACCAGCTCCAGGCCCCTGCTGAACGGCCCCTGAGGCTGCAGCGCTCCCCCGTCCTCAAACGCAGGCCAAAACTCGAGGCACCTCCATCCCCAAGCCTAGGATCTGGCCTTGGAACCGAGCCTCTGCCCCCACAGCCCACAGAGCCCTCCAGCCCTGAGCGGAGCCCACCCTCCCCAGCCACAGACCAAAGAGGCGGCGGCCCCAATCCCTGATCCTCTCCTCTCCTGCCGCATGAGATTATTTTATTAAAAAACTCAAAGGAA

Publications

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