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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name GSTO3P
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr10). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:130827637-130828429  UCSC
Coordinates (T2T) chr3:133571471-133572263  UCSC
Coordinates (hg19) chr3:130546481-130547273  UCSC
Strand +
Parental Sequence NM_004832.3
Parental seq. overlap 729 bp
Parental seq. overlap (%) 89.6%
Genomic Region Intergenic
Retrocopy Summary GSTO3P, located on chr3:130827637-130828429, is a retrocopy of the parental gene GSTO1. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name GSTO1
Full Name glutathione S-transferase omega 1
Also known as GSTO 1-1|GSTTLp28|HEL-S-21|P28|SPG-R
Coordinate chr10:104254173-104267455
Strand +
Gene summary The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes GSTO1P1
Bonobo Pan paniscus GSTO1P1
Gorilla Gorilla gorilla GSTO1P1
Orangutan Pongo abelii GSTO1P1
Gibbon Nomascus leucogenys GSTO1P1
Green monkey Chlorocebus sabaeus GSTO1P1
Crab-eating macaque Macaca fascicularis GSTO1P1
Rhesus Macaca mulatta GSTO1P1
Baboon Papio anubis GSTO1P1
Golden snub-nosed monkey Rhinopithecus roxellana GSTO1P1
Marmoset Callithrix jacchus GSTO1P2
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>GSTO3P
CAGCTTGGCCTGCGCTGCGCTGCGATGTTAGAGGAGTCAGCCAGGAGCCCGGGGAAGGGAAGCACGCCCCTGGGGCTGGTCCCAGAGGGCCTGATCTGCATTTGCAGCATGAGGTTCTGCCCGTTTGCTGAGAGGACGCATCTGGTTCTGAAGGCCGAGGGAATCAGGCATGAAGTAATCTATATCAACCTGAAAGATAAGCCTGAGTGGTTCTTTAAGAAAAATCCCTTTAGTTTGGTGCCAGTTCTGGAAAACAGTCAGGGTCAGCTGATCTACGAGTCTGCCATCACCTGTGAGTACCTGGATGAAGCATACTCAGGGAAGAAGCTGTTGCCGGATGACCCCTATGACAAAGCTTGCCAGAAGATGGTCTTTGAGTTGTTTTCTAAGGTGCCATCTTTGGTAGGAAGCTTCCTTAGAACCCAAAATAAGGAAGATGGTGCTGGCCTGAAAGAAGCATTGTGTAAAGAATTTAGCAAGCTAGAGGAGGTTCTGATTAATAAGAAGACAACCTTCTTTGGTGGCAGTTCCATCTCTATGATTGACTACGTCATCTGGCCCTCGTTTGAACGGCTGGAAGCAATGAAGTTAAATGAGTGTGTAGAACACACTCCAGAACTTAAACTGTGGATGGCAGCCATGAGGGAAGATCCCACAGTCTCAGCCCTGCTCACTGGTGTGAAGGACTGGCAAGGTTTCACAGAGCTCTACTTACAGCCTGGAGGCCTGTGACTATGGGCTCTGAAGGGGGCTGGAGTCAGCAATAAAGCTATGTCTGATGTTTTCCTTCACT
>NM_004832.3
GCAAACCCCAGAGGAGCTCGGCCTGCGCTGCGCCACGATGTCCGGGGAGTCAGCCAGGAGCTTGGGGAAGGGAAGCGCGCCCCCGGGGCCGGTCCCGGAGGGCTCGATCCGCATCTACAGCATGAGGTTCTGCCCGTTTGCTGAGAGGACGCGTCTAGTCCTGAAGGCCAAGGGAATCAGGCATGAAGTCATCAATATCAACCTGAAAAATAAGCCTGAGTGGTTCTTTAAGAAAAATCCCTTTGGTCTGGTGCCAGTTCTGGAAAACAGTCAGGGTCAGCTGATCTACGAGTCTGCCATCACCTGTGAGTACCTGGATGAAGCATACCCAGGGAAGAAGCTGTTGCCGGATGACCCCTATGAGAAAGCTTGCCAGAAGATGATCTTAGAGTTGTTTTCTAAGGTGCCATCCTTGGTAGGAAGCTTTATTAGAAGCCAAAATAAAGAAGACTATGCTGGCCTAAAAGAAGAATTTCGTAAAGAATTTACCAAGCTAGAGGAGGTTCTGACTAATAAGAAGACGACCTTCTTTGGTGGCAATTCTATCTCTATGATTGATTACCTCATCTGGCCCTGGTTTGAACGGCTGGAAGCAATGAAGTTAAATGAGTGTGTAGACCACACTCCAAAACTGAAACTGTGGATGGCAGCCATGAAGGAAGATCCCACAGTCTCAGCCCTGCTTACTAGTGAGAAAGACTGGCAAGGTTTCCTAGAGCTCTACTTACAGAACAGCCCTGAGGCCTGTGACTATGGGCTCTGAAGGGGGCAGGAGTCAGCAATAAAGCTATGTCTGATATTTTCCTTCACTAA

Publications

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