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Example: RPL12P6, GAPDH, ENSG00000237984

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Summary

Retrocopy Name BCL2L12P1
Plot displaying the genomic locations of a retrocopy (in chr3) and its respective parental gene (in chr19). Each line represents a retrocopy.
Species Homo sapiens
Coordinates (hg38) chr3:131526471-131526868  UCSC
Coordinates (T2T) chr3:134270190-134270587  UCSC
Coordinates (hg19) chr3:131245315-131245712  UCSC
Strand +
Parental Sequence NM_001282520.1
Parental seq. overlap 381 bp
Parental seq. overlap (%) 25.6%
Genomic Region Intergenic
Retrocopy Summary BCL2L12P1, located on chr3:131526471-131526868, is a retrocopy of the parental gene BCL2L12. Retrocopies of protein-coding genes, also known as processed pseudogenes, are intriguing genomic elements with implications in genome evolution and diseases. While some retrocopies are non-functional, there are examples of retrocopies (retrogenes) acquiring regulatory roles or exhibiting neofunctionalization unrelated to their parental genes.

Parental Gene

Gene Name BCL2L12
Full Name BCL2 like 12
Also known as -
Coordinate chr19:49664834-49673916
Strand +
Gene summary This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Homology

Species Scientific Name Retrocopy
Chimpanzee Pan troglodytes BCL2L12P1
Bonobo Pan paniscus BCL2L12P1
Gorilla Gorilla gorilla BCL2L12P1
Orangutan Pongo abelii Without Homology
Gibbon Nomascus leucogenys Without Homology
Green monkey Chlorocebus sabaeus Without Homology
Crab-eating macaque Macaca fascicularis Without Homology
Rhesus Macaca mulatta Without Homology
Baboon Papio anubis Without Homology
Golden snub-nosed monkey Rhinopithecus roxellana Without Homology
Marmoset Callithrix jacchus Without Homology
Mouse lemur Microcebus murinus Without Homology
Mouse Mus musculus Without Homology
Rat Rattus norvegicus Without Homology
Chinese hamster Cricetulus griseus Without Homology
Rabbit Oryctolagus cuniculus Without Homology
Pig Sus scrofa Without Homology
Cow Bos taurus Without Homology
Sheep Ovis aries Without Homology
Dolphin Tursiops truncatus Without Homology
Horse Equus caballus Without Homology
Dog Canis familiaris Without Homology
Panda Ailuropoda melanoleuca Without Homology
Cat Felis catus Without Homology
Pale spear-nosed bat Phyllostomus discolor Without Homology
Velvety free-tailed bat Molossus molossus Without Homology
Greater mouse-eared bat Myotis myotis Without Homology
Kuhl's pipistrelle Pipistrellus kuhlii Without Homology
Greater horseshoe bat Rhinolophus ferrumequinum Without Homology
Egyptian rousette Rousettus aegyptiacus Without Homology
Sloth Choloepus didactylus Without Homology
Tasmanian Devil Sarcophilus harrisii Without Homology
Opossum Monodelphis domestica Without Homology
Platypus Ornithorhynchus anatinus Without Homology
Chicken Gallus gallus Without Homology
Turkey Meleagris gallopavo Without Homology
Zebra Finch Taeniopygia guttata Without Homology
Budgerigar Melopsittacus undulatus Without Homology
Painted Turtle Chrysemys picta Without Homology
Lizard Anolis Carolinensis Without Homology
Frog Xenopus tropicalis Without Homology
Zebrafish Danio rerio Without Homology
Drosophila Drosophila melanogaster Without Homology

Expression

Related Sequence

>BCL2L12P1
GGAGTTGAGTGGAGGAGATGGCAAGTTGAGCGGAGGAGGTGGCAGTGGGGCCCCAGATCAGGTGCCTCCATGGCAGGCTCTGAAGAGCTGGGGCTCCGGGAAGACACGCTGAGGGTCCTAGCTGCCTTCCTTAGGCGTGGTGAGGCTGCTGGGTCTCCTGTTCCAAATCCACCTAGAAGCCATGCCCAAGAAGAGCCAACAGACTTCCTGAGCCGCCTTCGAAGATGTCTTCCCTGCTCCCTGGGGCGAGGAGCAGCCCCCTCTGAGTCCCCTCGGCCTTGGTCTCTGCCCATCCGCCCCTGCTATGGTTCAGAGCCTGGCCCAGCTACTCCAGACTTCTATGCCTTGGTGGCCCAGCGGCTGGAACAGCAAGAGCAACTGAAATCTCCGCCTAGCCC
>NM_001282520.1
AAGTAAGTATCCCCACTTTCAGGGTAGCATCCTCTTTCCCTAGTTATTTCAGTGCAGAATCGATTCACGTGTAAGCCTCTACCTCCTGCACTTACCCCAATGTAGACCCCCTTCCACAGTCCCCCTACAGAAGATCTCCCAAAACATTTCCAACACAGAACTTCCATTCAATTCCCCTCCGACTGCCCGCCTCCCTCCTCCAGGACAGAGCACGCCCCAGGTTTCGAGACTGAACTACCCCCATCTACGGAGTCCACCCCTCCCTCTCTAGAACCCCCTCAGTGTAGACGCCTCCTCTTTTCCTCTTTCCTCCCTACTTTTTCTAGTTTTTCTGCAGCCGACCTCCAGCGTCGGCCACTGTAGCTCCTTCCTTGCTCCACTTTCCCCAGAGTACACAGCCTGCCTTTCCACTCTCCGTGCAGACCCATCCTCTTTCCCGCTCCTCGCTCTCGGACGCCACCAACGCTCTCCCGGGCTCTTCCGCGTTACCTACGATGGAAGGTCGGGGCGTGCGGGCAGCTGGAACCCACCCCTGTCTTGGAGCTCCGGGTAGCTCTCAAACTCGAGGCTGCGCACCCCCTTTCCCGTCAGCTGAGCTCTAGAGCGCTGGGGCTTTCTTTTTGATCGACTTCTTGAAATAAAACCAACTTTATCATTCTTTGGGTAACAGACCCAAAAGCCGATGGGACGGCCCGCTGGGCTGTTCCCGCCCCTATGCCCTTTTTTGGGTTTCCGGCCAGAGGCATGCTGGGAGCGTCACATGCAAATTGAGCGTGCACCCAGCGTTCCGCCCTTTCTACGCTGGGCCGGTTATCGACCCGGCCCAGTGCGCAGGCGCGGGAAAGTTGAACTAATAAAGTTTGTACGAGTTCAGTGGAGGAGACCGCAAGTTGAGTGGAGGAGGCGGCGGTGGGGCCCCGGACCAGGTGCCTCCATGGCAGGCTCTGAAGAGCTGGGGCTCCGGGAAGACACGCTGAGGGTCCTAGCTGCCTTCCTTAGGCGTGGTGAGGCTGCCGGGTCTCCTGTTCCAACTCCACCTAGAAGCCCTGCCCAAGAAGAGCCAACAGACTTCCTGAGCCGCCTTCGAAGATGTCTTCCCTGCTCCCTGGGGCGAGGAGCAGCCCCCTCTGAGTCCCCTCGGCCTTGCTCTCTGCCCATCCGCCCCTGCTATGGTTTAGAGCCTGGCCCAGCTACTCCAGACTTCTATGCTTTGGTGGCCCAGCGGCTGGAACAGCTGGTCCAAGAGCAGCTGAAATCTCCGCCCAGCCCAGGAGGGCATCCTGGCTGTTTCACCCGTGGACTTGAACTTGCCATTGGACTGAGCTCTTTCTCAGAAGCTGCTACAAGATGACACCTCATGTCCCTGCCCTCTTCGTGTGCTTTTCCAAGTCTTCCTATTCCACTCAGGGCTGTGGGGTGGTGGTTGCCCTACCTGTTTTTGCCAAAAATAAATTGTTTAAAACTTTTCTTATTAAAAACGTTACAAAGTA

Publications

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